CN101204527A - Medicaments composite for recurrent oral ulcer and preparation method thereof - Google Patents
Medicaments composite for recurrent oral ulcer and preparation method thereof Download PDFInfo
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- CN101204527A CN101204527A CNA2007101783371A CN200710178337A CN101204527A CN 101204527 A CN101204527 A CN 101204527A CN A2007101783371 A CNA2007101783371 A CN A2007101783371A CN 200710178337 A CN200710178337 A CN 200710178337A CN 101204527 A CN101204527 A CN 101204527A
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Abstract
The invention discloses a drug combination for treating recurrent oral ulcer, which is mainly composed of twelve species of traditional Chinese medicines of radix asparagi, dwarf lilyturf tuber, rehmanniae radix, orange fruit, dendrobium, radix scrophulariae, plantain seed, artemisia capillaris, forsythia, honeysuckle, Bletilla striata, and licorice. The drug combination of the invention has the effect of nourishing yin and clearing heat, dehumidifying and healing furuncle, and is used for treating recurrent oral ulcer. The drug combination is characterized by quick results, good efficacy, few recurrences, no side effects, simple manufacture and extensive using value.
Description
Technical field
Belong to Chinese medicine preparation technique field, a kind of specifically Chinese medicine preparation for the treatment of recurrent oral ulceration and preparation method thereof.
Background technology
(recurrent oral ulceration ROU) refers to that specially a class is agnogenio to recurrent oral ulceration, repeatedly outbreak but self limiting, lonely that produce, circular or oval-shaped ulcer are arranged.Recurrent oral ulceration is a modal disease in the diseases of oral mucosa, is commonly encountered diseases, the frequently-occurring disease of society now, can influence people's feed, speech.Recurrent oral ulceration more influences people's quality of life.The first place that oral ulcer prevalence (20%) occupies diseases of oral mucosa.Recurrent oral ulceration cause of disease complexity is still not really clear and definite so far.No matter from falling ill to treatment, individual variation is all bigger.Some oral ulcer patient clinical manifestation is similar, but its predisposing factors is far different, and through same treatment, effect is also inequality.Illustrate that the oral ulcer morbidity is relevant with many-sided factor.The etiology of relevant recurrent oral ulceration has both at home and abroad at present: viral infection; Bacterial infection; Digestive system disease and dysfunction; Hormonal change; The neural factor of spirit; Inherited genetic factors; The variation of immunologic function etc.
The clinical vitamin commonly used of oral ulcer, antimicrobial drug, amcinonide are treated, and short run effect is obvious, but the relapse rate height is easy to generate Drug resistance simultaneously, and some local medicine that uses also has damage to normal structure.Compare with Western medicine, many advantages are then arranged by the middle medicine composite preparation of theory of Chinese medical science prescription.Theory of Chinese medical science thinks, mostly recurrent oral ulceration is that heart deficiency of stomach-YIN gives birth to that the heat folder is wet to be caused.In recent years; some prepare the treatment by Chinese herbs recurrent oral ulceration; as " a kind of preparation method for the treatment of the Chinese medicine paster of recurrent oral ulceration and HSV stomatitis " that the CN1562143A patent application proposes, it is the patch by five kinds of Chinese medicine preparations such as Margarita, artificial Calculus Bovis, Indigo Naturalis, Borneolum Syntheticum, Talcum.And for example " a kind of Chinese medicine composition for the treatment of recurrent oral ulceration " of CN1682909A patent application proposition is the preparation by Lasiosphaera Seu Calvatia, Alumen, Borneolum Syntheticum, Radix Glycyrrhizae and Indigo Naturalis preparation.Different Chinese medicine preparations, different dosage forms, the preparation effect that makes also has difference.
Summary of the invention
The objective of the invention is to overcome present weak point at the treatment bed-wetting, a kind of instant effect is provided, good effect is drawn materials conveniently the pharmaceutical composition of the treatment bed-wetting that expense is cheap, side effect is little.
The present invention also provides this preparation of drug combination method.
Pharmaceutical composition of the present invention can be used for infantile enuresis.
Compound prescription of the present invention can form by following prepared: medicinal 8～10 times of water gagings decoct three times in distinguishing the flavor of Radix Asparagi, Radix Ophiopogonis etc. 12, be followed successively by 2 hours, 1.5 hour, 1 hour, filter, it is 1.08～1.10 extractum (80～85 ℃ of heat are surveyed) that filtrate is concentrated into relative density, adding ethanol makes extractum contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, being concentrated into relative density is 1.30～1.32 extractum (50～55 ℃ of heat are surveyed), drying.
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
3～9 parts in 8～23 portions of Radix Glycyrrhizaes of Radix Asparagi 15～45 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 8～23 portions of Flos Loniceraes of 8～23 parts of Fructus Forsythiaes of 5～15 portions of Herba Artemisiae Scopariaes of 8～23 portions of Semen Plantaginiss of 6～18 portions of Radix Scrophulariaes of 5～15 parts of Herba Dendrobiis of 10～30 parts of Fructus Aurantiis of 6～18 parts of Radix Rehmanniae, 6～18 parts of Radix Ophiopogonis
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
5～8 parts in 11～19 portions of Radix Glycyrrhizaes of Radix Asparagi 23～38 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 11～19 portions of Flos Loniceraes of 11～19 parts of Fructus Forsythiaes of 8～13 portions of Herba Artemisiae Scopariaes of 11～19 portions of Semen Plantaginiss of 9～15 portions of Radix Scrophulariaes of 8～13 parts of Herba Dendrobiis of 15～25 parts of Fructus Aurantiis of 9～15 parts of Radix Rehmanniae, 9～15 parts of Radix Ophiopogonis
Pharmaceutical composition of the present invention is prepared from by following optimum weight part proportion raw material:
6 parts in 15 portions of Radix Glycyrrhizaes of Radix Asparagi 30 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 15 portions of Flos Loniceraes of 15 parts of Fructus Forsythiaes of 10 portions of Herba Artemisiae Scopariaes of 15 portions of Semen Plantaginiss of 12 portions of Radix Scrophulariaes of 10 parts of Herba Dendrobiis of 20 parts of Fructus Aurantiis of 12 parts of Radix Rehmanniae, 12 parts of Radix Ophiopogonis
Pharmaceutical composition of the present invention can add the medicine acceptable carrier when being prepared into medicament: starch, sucrose, lactose, mannitol, glycerol, cyclodextrin, calcium carbonate, surfactant, agar, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical composition of the present invention can be any pharmaceutically useful dosage form, comprising: tablet, capsule, granule, oral liquid, pill, powder, powder, drop.Preferred dosage form is capsule, tablet, granule.
The wherein said Radix Asparagi of pharmaceutical composition of the present invention is the root of liliaceous plant Radix Asparagi Asparagus cochin-chinensis (LouH) Merr..Main product in Guizhou, ground such as Sichuan, Anhui.
Be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl. Radix Ophiopogonis.Main product in Jiangxi, ground such as Anhui, Zhejiang, Fujian, Sichuan, Guizhou, Yunnan, Guangxi.
The Radix Rehmanniae is the root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Main product in Henan, Liaoning, Hebei, Shandong, zhejiang and other places.
Fructus Aurantii is rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus trifoliata (L.) Raf,, mellow fruit nearly such as Citrus aurantium Linn. Citrus aurantium L., fragrant circle C.wilsonii Tanaka or Citrus aurantium L. var. amara Engl. C.aurantium L.Var.amara Engl..Main product in Jiangxi, Sichuan, Hunan, zhejiang and other places.With Fructus Aurantii (parched) is good.
Herba Dendrobii is the fresh or dry stem of orchid Dendrobium nobile Dendrobium nobile Lindl., Herba Dendrobii oculati Dendrobiumfimbriatum Hook.var.oculatum Hook., HERBA DENDROBII Dendrobium loddigesii Rolfe. or Herba Dendrobii Dendrobium candidum Wall.ex Lindl..Main product in Anhui, ground such as Henan, Sichuan, Yunnan, Guizhou.
Radix Scrophulariae is the root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Main product in Zhejiang, ground such as Hubei, Hunan, Anhui.
Semen Plantaginis is the dry mature seed of preceding Plantago asiatica L. of Plantaginaceae plant or Plantago depressa Willd Plantago depressa Willd..Main product in Jiangxi, ground such as Henan, Heilungkiang, Liaoning, Hebei.With Semen Plantaginis (parched with salt) is good.
Herba Artemisiae Scopariae is the seedling of feverfew Herba Artemisiae Scopariae Artemisia capillaris Thunb..Main product in Shaanxi, ground such as Hebei, Shanxi.With capillary wormwood is good.
Fructus Forsythiae is the dry fruit of Oleaceae plant Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl..Main product in Hebei, ground such as Shanxi, Henan, Shaanxi, Hubei, Sichuan.
Flos Lonicerae is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicerajaponica Thunb., Flos Lonicerae Lonicerahypoglauca Miq., Flos Lonicerae Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera DasystylaRehd. or the flower that band is just opened.Main product in Shandong, ground such as Henan, Hunan.
The Pseudobulbus Bletillae (Rhizoma Bletillae) is the tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata (Thunb.) Reiehb.f..Main product is in Guizhou, ground such as Sichuan, Hunan, Anhui.
Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Main product in the Inner Mongol, ground such as Gansu, Shaanxi, Shanxi, Liaoning, Qinghai, Xinjiang.With Radix Glycyrrhizae is good.
Dysfunction of the spleen in transportation, endogenous damp formation stagnates in middle Jiao, clear QI failing to ascend, turbid QI failing to descend, the contamination words then fester in the oral cavity; Turbid damp is sticky, and difficult speed is removed, dysfunction of the spleen in transportation, and the turbid damp difficultyization is so outbreak repeatedly is difficult to radical cure.Add this type of patient and take the antipyretic and antidotal type medicine for a long time, cause cloudy liquid impaired.Radix Asparagi, Radix Ophiopogonis, the Radix Rehmanniae, Radix Scrophulariae, Herba Dendrobii heat clearing away nourishing YIN in the prescription of the present invention, Fructus Forsythiae, Flos Lonicerae clearing away heat-fire; The dehumidifying of Herba Artemisiae Scopariae, Semen Plantaginis draws that the asthenic fire of heart stomach is damp and hot to be gone out from urine, and wet have the stagnation of QI with overabundant heat, so with the regulating QI of Fructus Aurantii alleviating distention in middle-JIAO; Pseudobulbus Bletillae (Rhizoma Bletillae) expelling pus and promoting granulation; The Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Full side's Yin-nourishing drug and the same usefulness of heat-clearing and diuresis-promoting drug, impairment of YIN is not grown and is not loved heresy clearly, plays nourishing YIN and clearing away heat altogether, and the merit of skin ulcer is held back in dehumidifying.
Beneficial effect of the present invention is:
1, selecting Chinese crude drug for use is raw material, and each component meets the pharmaceutical control and administration rules, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of to treat recurrent oral ulceration, gives full play to the little advantage of herbal toxic effect, nontoxic.
2, the present invention need not to decoct no bitterness sense, taking convenience.
3, instant effect of the present invention, good effect, recurrence is few, has no side effect, and makes simply, is with a wide range of applications.
Clinical observation shows with these invention treatment recurrent oral ulceration 78 examples, cure rate 84.62%, total effective rate 96.15%, mean treatment 3 days.Do blood, urine, just routine and hepatic and renal function inspection before and after the treatment, no abnormality seen changes, and does not find in the medication process that this medicine has tangible untoward reaction.Test shows this invention treatment recurrent oral ulceration instant effect, good effect, and recurrence is few, has no side effect.
The specific embodiment
Embodiment 1
Radix Asparagi 12kg 12kg Radix Ophiopogonis Radix Rehmanniae 20kg Fructus Aurantii 10kg Herba Dendrobii 12kg Radix Scrophulariae 15kg Semen Plantaginis 10kg Herba Artemisiae Scopariae 15kg Fructus Forsythiae 15kg Flos Lonicerae 30kg Pseudobulbus Bletillae (Rhizoma Bletillae) 15kg Radix Glycyrrhizae 6kg
Medicinal 8～10 times of water gagings decoct three times in distinguishing the flavor of Radix Asparagi, Radix Ophiopogonis etc. 12, be followed successively by 2 hours, 1.5 hour, 1 hour, filter, it is 1.08～1.10 extractum (80～85 ℃ of heat are surveyed) that filtrate is concentrated into relative density, adding ethanol makes extractum contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, being concentrated into relative density is 1.30～1.32 extractum (50～55 ℃ of heat are surveyed), drying.Be ground into fine powder, encapsulated.Every capsules 0.5g.
Embodiment 2
Radix Asparagi 12kg 12kg Radix Ophiopogonis Radix Rehmanniae 20kg Fructus Aurantii 10kg Herba Dendrobii 12kg Radix Scrophulariae 15kg Semen Plantaginis 10kg Herba Artemisiae Scopariae 15kg Fructus Forsythiae 15kg Flos Lonicerae 30kg Pseudobulbus Bletillae (Rhizoma Bletillae) 15kg Radix Glycyrrhizae 6kg
Medicinal 8～10 times of water gagings decoct three times in distinguishing the flavor of Radix Asparagi, Radix Ophiopogonis etc. 12, be followed successively by 2 hours, 1.5 hour, 1 hour, filter, it is 1.08～1.10 extractum (80～85 ℃ of heat are surveyed) that filtrate is concentrated into relative density, adding ethanol makes extractum contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, being concentrated into relative density is 1.30～1.32 extractum (50～55 ℃ of heat are surveyed), drying.Be ground into fine powder, add appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating gets final product.Every 0.3g.
Embodiment 3
Radix Asparagi 15kg 15kg Radix Ophiopogonis Radix Rehmanniae 30kg Fructus Aurantii 12kg Herba Dendrobii 5kg Radix Scrophulariae 20kg Semen Plantaginis 15kg Herba Artemisiae Scopariae 20kg Fructus Forsythiae 20kg Flos Lonicerae 30kg Pseudobulbus Bletillae (Rhizoma Bletillae) 20kg Radix Glycyrrhizae 8kg
Medicinal 8～10 times of water gagings decoct three times in distinguishing the flavor of Radix Asparagi, Radix Ophiopogonis etc. 12, be followed successively by 2 hours, 1.5 hour, 1 hour, filter, it is 1.08～1.10 extractum (80～85 ℃ of heat are surveyed) that filtrate is concentrated into relative density, adding ethanol makes extractum contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, being concentrated into relative density is 1.30～1.32 extractum (50～55 ℃ of heat are surveyed), drying.Be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back gets final product.Every bag of 5g.
Claims (6)
1. a pharmaceutical composition for the treatment of recurrent oral ulceration is characterized in that raw material contains following medicaments in part by weight: 6～18 parts of Radix Asparagis, 6～18 parts of Radix Ophiopogonis, 10～30 parts in the Radix Rehmanniae, 5～15 parts of Fructus Aurantiis, 6～18 parts of Herba Dendrobiis, 8～23 parts of Radix Scrophulariaes, 5～15 parts of Semen Plantaginiss, 8～23 parts of Herba Artemisiae Scopariaes, 8～23 parts of Fructus Forsythiaes, 15～45 parts of Flos Loniceraes, 8～23 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 3～9 parts in Radix Glycyrrhizae.
2. require described a kind of pharmaceutical composition for the treatment of recurrent oral ulceration according to right 1, it is characterized in that raw material contains following medicaments in part by weight: 9～15 parts of Radix Asparagis, 9～15 parts of Radix Ophiopogonis, 15～25 parts in the Radix Rehmanniae, 8～13 parts of Fructus Aurantiis, 9～15 parts of Herba Dendrobiis, 11～19 parts of Radix Scrophulariaes, 8～13 parts of Semen Plantaginiss, 11～19 parts of Herba Artemisiae Scopariaes, 11～19 parts of Fructus Forsythiaes, 23～38 parts of Flos Loniceraes, 11～19 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 5～8 parts in Radix Glycyrrhizae.
3. require described a kind of pharmaceutical composition for the treatment of recurrent oral ulceration according to right 1,2, it is characterized in that the optimised quantity of each raw material is: 12 parts of Radix Asparagis, 12 parts of Radix Ophiopogonis, 20 parts in the Radix Rehmanniae, 10 parts of Fructus Aurantiis, 12 parts of Herba Dendrobiis, 15 parts of Radix Scrophulariaes, 10 parts of Semen Plantaginiss, 15 parts of Herba Artemisiae Scopariaes, 15 parts of Fructus Forsythiaes, 30 parts of Flos Loniceraes, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6 parts in Radix Glycyrrhizae.
4. require described pharmaceutical composition according to right 1-3, can be for being fit to medicinal various dosage forms.
5. the pharmaceutical composition that requires according to right 4 is capsule, tablet, granule.
6. according to the described raw material of right 1-3, its processing technology is: medicinal 8～10 times of water gagings decoct three times in distinguishing the flavor of Radix Asparagi, Radix Ophiopogonis etc. 12, are followed successively by 1.5 hours 2 hours, 1 hour, filter, it is 1.08～1.10 extractum (80～85 ℃ of heat are surveyed) that filtrate is concentrated into relative density, adds ethanol and makes extractum contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, being concentrated into relative density is 1.30～1.32 extractum (50～55 ℃ of heat are surveyed), drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101783371A CN101204527A (en) | 2007-11-29 | 2007-11-29 | Medicaments composite for recurrent oral ulcer and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101783371A CN101204527A (en) | 2007-11-29 | 2007-11-29 | Medicaments composite for recurrent oral ulcer and preparation method thereof |
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| CN101204527A true CN101204527A (en) | 2008-06-25 |
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| CNA2007101783371A Pending CN101204527A (en) | 2007-11-29 | 2007-11-29 | Medicaments composite for recurrent oral ulcer and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230356A (en) * | 2013-05-07 | 2013-08-07 | 贵州省赤水市金钗石斛产业开发有限公司 | Dendrobium nobile toothpaste |
| CN106071506A (en) * | 2016-08-25 | 2016-11-09 | 陈伊芸 | A kind of special antipyretic beverage of oral ulcer and preparation method thereof |
| CN106361909A (en) * | 2016-11-28 | 2017-02-01 | 广州中医药大学 | Drug for treating recurrent oral ulceration and preparation method thereof |
-
2007
- 2007-11-29 CN CNA2007101783371A patent/CN101204527A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230356A (en) * | 2013-05-07 | 2013-08-07 | 贵州省赤水市金钗石斛产业开发有限公司 | Dendrobium nobile toothpaste |
| CN106071506A (en) * | 2016-08-25 | 2016-11-09 | 陈伊芸 | A kind of special antipyretic beverage of oral ulcer and preparation method thereof |
| CN106361909A (en) * | 2016-11-28 | 2017-02-01 | 广州中医药大学 | Drug for treating recurrent oral ulceration and preparation method thereof |
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Open date: 20080625 |