CN105250537A - Method for preparing drug composition granules for treating mycoplasma pneumonia - Google Patents
Method for preparing drug composition granules for treating mycoplasma pneumonia Download PDFInfo
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- CN105250537A CN105250537A CN201510840841.8A CN201510840841A CN105250537A CN 105250537 A CN105250537 A CN 105250537A CN 201510840841 A CN201510840841 A CN 201510840841A CN 105250537 A CN105250537 A CN 105250537A
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Abstract
The invention discloses a method for preparing drug composition granules for treating mycoplasma pneumonia, and relates to technical field of traditional Chinese medicine. The method comprises the following steps that 1, sugarless paste is prepared, wherein materials are prepared, 32 parts of herba houttuyniae, 32 parts of rhizoma belamcandae, 25 parts of cacumen platycladi, 20 parts of radix scutellariae, 25 parts of lemna minor, 25 parts of pericarpium citri reticulatae, 12 parts of herba ephedrae and 12 parts of tree peony bark are cleaned and weighed, and decocting, concentrating, drying and powder mixing are conducted; 2, dextrin is prepared; 3, granules are prepared. A prepared transitional Chinese medicine composition is combined with erythrocin to treat the mycoplasma pneumonia in children, the defervescence time, cough disappearance time and lung rales disappearance time of patients can be effectively shortened, and pain of children patients is relieved.
Description
The application is the divisional application that applicant proposes " denomination of invention is: a kind of pharmaceutical composition and application thereof for the treatment of mycoplasma pneumonia, and the applying date is December in 2013 22 days, and application number is: 2013107102228 ".
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of mycoplasma pneumonia, particularly relate to a kind of method preparing the Chinese medicine composition for the treatment of mycoplasma pneumonia, belong to technical field of Chinese medicines.
Background technology
Mycoplasma pneumoniae is the pathogenic former of mycoplasma pneumonia in children, this is a kind of between antibacterial and virus " microorganism of pleuropneumonia sample ", the immune impairment of multisystem is caused after infection, the impaired of body's immunity is healed difficult to the recurrent exerbation and delay that cause other accompanying infections and mycoplasma pneumoniae pneumonia, and serious mycoplasma pneumonia can cause infant dead.In the past traditional Therapeutic Method first-selected macrolide antibiotics, particularly azithromycin, because its tissue penetration is strong, in lung tissue concentration higher, can infiltrate in cell thus effectively kill pathogen.But because the pathogenesis of mycoplasma pneumonia is relevant with direct toxic action and immune impairment, therefore application Macrocyclolactone lactone kind medicine easily occurs that treatment is not thorough, can not remove cause of disease completely, cause the state of an illness easily to recur.And in recent years along with the increase of mycoplasma infection sickness rate, antibiotic abuse, makes the drug resistance of human body increase, thus causes therapeutic effect constantly to reduce.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to, by prescription again after studying Chinese medicine pharmacology, provide a kind of pharmaceutical composition and application thereof for the treatment of mycoplasma pneumonia.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for mycoplasma pneumonia, be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 26-40 part, Rhizoma Belamcandae 26-40 part, Cacumen Platycladi 18-30 part, Radix Scutellariae 15-25 part, Herba Spirodelae 18-30 part, Pericarpium Citri Reticulatae 18-30 part, Herba Ephedrae 8-16 part, Cortex Moutan 8-16 part.
Preferably, described a kind of pharmaceutical composition for the treatment of mycoplasma pneumonia, is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 30-35 part, Rhizoma Belamcandae 30-35 part, Cacumen Platycladi 22-28 part, Radix Scutellariae 18-22 part, Herba Spirodelae 22-28 part, Pericarpium Citri Reticulatae 22-28 part, Herba Ephedrae 10-14 part, Cortex Moutan 10-14 part.
In the present invention's most preferred embodiment, the pharmaceutical composition of described treatment mycoplasma pneumonia is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 32 parts, Rhizoma Belamcandae 32 parts, Cacumen Platycladi 25 parts, Radix Scutellariae 20 parts, 25 parts, Herba Spirodelae, Pericarpium Citri Reticulatae 25 parts, 12 parts, Herba Ephedrae, Cortex Moutan 12 parts.
The pharmaceutical composition of any one treatment mycoplasma pneumonia above-mentioned, it is oral liquid, granule, tablet or capsule; Preferably, the pharmaceutical composition of any one treatment mycoplasma pneumonia above-mentioned, it is granule.
Found by experimental study, the effect highly significant of medicine composite for curing mycoplasma pneumonia of the present invention.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of aforementioned pharmaceutical compositions in the medicine of preparation treatment mycoplasma pneumonia.Especially it should be noted that, pharmaceutical composition of the present invention is more suitable for the medicine preparing treatment mycoplasma pneumonia in children.
Above-mentioned each Chinese crude drug is prepared into the preparation method of compound granule of the present invention, comprise the steps: to take by recipe quantity the Herba Houttuyniae 26-40 part cleaned up, Rhizoma Belamcandae 26-40 part, Cacumen Platycladi 18-30 part, Radix Scutellariae 15-25 part, Herba Spirodelae 18-30 part, Pericarpium Citri Reticulatae 18-30 part, Herba Ephedrae 8-16 part and Cortex Moutan 8-16 part, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:1 ~ 3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, clear paste powder and dextrin are dropped in trough type mixing machine, stirring 20 minutes, slowly adding 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule.
Chinese crude drug selected by the present invention has following pharmacologically active and function cures mainly:
Herba Houttuyniae: heat-clearing and toxic substances removing, inducing diuresis to remove edema; Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies; Select the drying water upper part of Saururaceae herbaceos perennial Herba Houttuyniae; Folium Bambusae: clearing heat and relieving fidgetness, diuresis of promoting the production of body fluid;
Rhizoma Belamcandae: heat-clearing and toxic substances removing, expectorant, sore-throat relieving; For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma; Select irides Rhizoma Belamcandae Belamcandachinensis(L.) dry rhizome of DC.;
Cacumen Platycladi: there is cooling blood for hemostasis, wet down of dispeling the wind, preventing phlegm from forming and stopping coughing, effect of Sweeling-eliminating medicine powder poison; Cure mainly spitting of blood, spit blood, epistaxis, hematuria, dysentery, discharging fresh blood stool, metrorrhagia, rheumatic arthralgia, cough with copious phlegm, erysipelas, mumps, scald; Select the dry browse of Cupressaceae plant Cacumen Platycladi Platycladusorientalis (L.) Franco;
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement; Select the dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi;
Herba Spirodelae: diaphoresis, dispels the wind, row water, heat clearing away, removing toxic substances.Row hot carbuncle when controlling, macule is not saturating, wind heat pain rash, skin pruritus, edema, amenorrhea, skin ulcer tinea, and erysipelas, scalds; Select the herb of the blue or green duckweed of plant and of its applications;
Pericarpium Citri Reticulatae: there is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm; Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach; Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool; Phlegm-damp stops up the cough and asthma of lung; Select the dry mature skin for rutaceae orange and variety thereof;
Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Be used for chill exterior syndrome, uncomfortable in chestly breath with cough, edema due to wind pathogen edema, rheumatic arthralgia, carbuncle of yin nature, sucutaneous nodule; Select as Ephedraceae plant plait Herba Ephedrae EphedrasinicaStapf, the herb stem of epheday intermedia EphedraintermediaSchrenketC.A.Mey. or ephedra equisetina EphedraequisetinaBge.;
Cortex Moutan: clearing away heat and cooling blood, blood circulation promoting competent silt; For maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury; Select the root bark of Ranunculaceae perennial machaka plant Paeonia suffruticosa PaeoniasuffruticosaAndr..
Compared with prior art, pharmaceutical composition associating erythromycin for treating mycoplasma pneumonia in children of the present invention, improves curative effect, reduces untoward reaction, especially effectively can shorten patient's fever time, cough extinction time, pulmonary's sound of vomiting sound extinction time, alleviate the misery of infant.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
the preparation of embodiment 1 Chinese medicine granules
Take the Herba Houttuyniae 32 parts cleaned up, Rhizoma Belamcandae 32 parts, Cacumen Platycladi 25 parts, Radix Scutellariae 20 parts, 25 parts, Herba Spirodelae, Pericarpium Citri Reticulatae 25 parts, 12 parts, Herba Ephedrae and Cortex Moutan 12 parts, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, clear paste powder and dextrin are dropped in trough type mixing machine, stirs 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging.
the preparation of embodiment 2 Chinese medicine granules
Take the Herba Houttuyniae 40 parts cleaned up, Rhizoma Belamcandae 27 parts, Cacumen Platycladi 20 parts, Radix Scutellariae 25 parts, 29 parts, Herba Spirodelae, Pericarpium Citri Reticulatae 18 parts, 10 parts, Herba Ephedrae and Cortex Moutan 15 parts, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, clear paste powder and dextrin are dropped in trough type mixing machine, stirs 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging.
the preparation of embodiment 3 Chinese medicine granules
Take the Herba Houttuyniae 26 parts cleaned up, Rhizoma Belamcandae 26 parts, Cacumen Platycladi 30 parts, Radix Scutellariae 18 parts, 20 parts, Herba Spirodelae, Pericarpium Citri Reticulatae 30 parts, 16 parts, Herba Ephedrae and Cortex Moutan 8 parts, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:2.5 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, clear paste powder and dextrin are dropped in trough type mixing machine, stirs 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging.
embodiment 4 Chinese medicine granules is studied the clinical trial of mycoplasma pneumonia in children
Mycoplasma pneumonia in children diagnostic criteria: heating, continuing vigorous is coughed, and x-ray finding is remarkable far beyond sign.Leukocyte normally or slightly increases mostly.Penicillin or cephalosporins invalid.Mycoplasma pneumoniae specific antibody (MP-IGM) is positive or cold agglutinin IGM is positive.
Children with mycoplasma pneumoniae pneumonia 35 example made a definite diagnosis by above-mentioned diagnostic criteria, man 19 example, female 16 example; 1 ~ 3 years old 4 age example, 4 ~ 7 years old 16 example, 8 ~ 16 years old 15 example; The course of disease 3 ~ 19 days.All cases all have cough, the heat that occurs together 19 example, and auscultation of lung has dry moist rales to change 28 examples, and all have x-ray to change, how to change in the form of sheets, following lung is common, and leukocyte raises 8 examples, and CK-MB raises 5 examples.Therapeutic Method: Chinese medicine granules of taking after mixing it with water (being prepared from according to the prescription of embodiment 1 and technique), each 1/3 bag of 1-3 year, each half bag of 4-7 year, each 1 bag of 8-15 year, equal 3 times/day oral.7 days courses for the treatment of.Erythromycin selected by antibiotic, and consumption is 30 ~ 50mg/kg every day.After treating a course for the treatment of, by following curative effect judging standard statistical result:
Effective: medication 24 hours clinical symptoms are clearly better, and 72 hours without clinical symptoms;
Effective: medication 48 hours clinical symptoms are clearly better, and 96 hours without clinical symptoms;
Invalid: medication 72 hours clinical symptoms are without being clearly better or increasing the weight of.
Therapeutic outcome: all infants are all cured, obvious effective rate is 97.43%.Symptom improve situation: treatment group bring down a fever 19 example, average fever time 2.50 ± 0.48 days; Cough-relieving 35 example, 4.87 ± 1.92 days average cough-relieving time; Pulmonary's sound of vomiting sound disappearance 27 example, average extinction time 3.3 ± 1.8 days.In addition, all infant blood, urine, stool routine examination, rabat, liver function, all no abnormal after myocardium enzyme treatment.
Claims (1)
1. prepare a method for the medicament composition granule agent for the treatment of mycoplasma pneumonia, it is characterized in that comprising following processing step:
Take the Herba Houttuyniae 32 parts cleaned up, Rhizoma Belamcandae 32 parts, Cacumen Platycladi 25 parts, Radix Scutellariae 20 parts, 25 parts, Herba Spirodelae, Pericarpium Citri Reticulatae 25 parts, 12 parts, Herba Ephedrae and Cortex Moutan 12 parts, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95%v/v ethanol makes alcohol content reach 75%v/v, stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, concentrated solution is sprayed, drying condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s,
Pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, drops in trough type mixing machine by clear paste powder and dextrin, stirs 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging, to obtain final product.
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| CN201310710222.8A CN103655965B (en) | 2013-12-22 | 2013-12-22 | A kind of pharmaceutical composition and application thereof for the treatment of mycoplasma pneumonia |
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| CN201310710222.8A Active CN103655965B (en) | 2013-12-22 | 2013-12-22 | A kind of pharmaceutical composition and application thereof for the treatment of mycoplasma pneumonia |
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| CN109620918A (en) * | 2019-01-17 | 2019-04-16 | 昆明市中医医院 | A kind of drug and preparation method thereof for treating pneumonia |
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| CN105477287A (en) * | 2015-12-24 | 2016-04-13 | 刘子成 | Traditional Chinese medicine preparation for treating weakened-body-resistance and verging-on-desertion type mycoplasmal pneumonia and preparation method thereof |
| CN105434974A (en) * | 2016-01-29 | 2016-03-30 | 山东电力中心医院 | Traditional Chinese medicine composition for treating mycoplasma pneumonia and preparation method |
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| CN101099787A (en) * | 2007-08-13 | 2008-01-09 | 张文芳 | Traditional Chinese medicinal composition with remarkable wide-spectrum antiviral action |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109620918A (en) * | 2019-01-17 | 2019-04-16 | 昆明市中医医院 | A kind of drug and preparation method thereof for treating pneumonia |
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