CN101199796A - External antidiarrhoeal medicament, preparing method and function thereof - Google Patents
External antidiarrhoeal medicament, preparing method and function thereof Download PDFInfo
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- CN101199796A CN101199796A CNA2007101854273A CN200710185427A CN101199796A CN 101199796 A CN101199796 A CN 101199796A CN A2007101854273 A CNA2007101854273 A CN A2007101854273A CN 200710185427 A CN200710185427 A CN 200710185427A CN 101199796 A CN101199796 A CN 101199796A
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Abstract
The invention relates to an externally-used anti-diarrhea medicine preparation which contains Rhizoma Coptidis, Cortex Fraxini, Pulsatilla chinensis, Cortex Phellodendri, Rhizoma Sparganii, Rhizoma curcumae Aeruginosae, Eugenia caryophyllata, Fructus Piperis Longi, Fructus Piperis, Cortex Cinnamomi Cassiae, Fructus Evodiae, Radix Paeoniae Rubra, Radix Paeoniae Alba, Galla Chinensis, Root of Garden Burnet, Fructus Schisandrae Chinensis, Indigo Naturalis, Radix Angelicae Sinensis, fried Plantain Seed, Rhizoma Atractylodis Macrocephatae, Massa Fermentata, hawthorn, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli and Radix Glycyrrhizae. The drugs are screened, processed, dipped, extracted, filtered and condensed into liquid medicine. The liquid medicine is smeared on the pelmas. The invention has the advantages that the medicine is convenient for use, can release children from the suffering by injection and medicine-taking and can not cause inflammation, hypersusceptibility and pruritus on the skin.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of treatment antidiarrheal medicine and its production and use.
Background technology
Diarrhoea is meant with times of defecation and increases, just thin down, or be the disease of feature as water sample.According to World Health Organization's regulation, every day, rare stool equaled or exceeded (no matter having or do not have mucus and blood) three times, was called diarrhoeal diseases.Diarrhoeal diseases occupies second common frdquently encountered disease in China, is only second to respiratory tract infection, and the primary disease four seasons all have, being summer and autumn many, infant is more below two years old sees, the traditional Chinese medical science think infantile diarrhea and spleen wet suffer from a deficiency of the kidney relevant, unhygienic diet in addition, due to diseases caused by exogenous pathogenic factor six climate exopathogens or the gastrointestinal infection, the lighter only shows as times of defecation and increases, and per ten times is yellow or yellow green surplus ten time, scattered paste shape or egg soup sample, the general situation of whole body is good; Weight person defecates and can reach tens of every day, and critically ill signs such as dehydration, acidosis can appear in General Symptomies such as the companion feels sick, vomiting, heating, stomachache.
At present, conventional therapy is based on the doctor trained in Western medicine antiinflammatory, and it is essential to have an injection, infuse, just not saying price is temporarily high, in the face of transfusion is thin because of children's's blood vessel, syringe needle is difficult to prick the situation of head, foot, and what bring children's is to wail, and what leave the head of a family for is anxious.In recent years, " baby one pastes spirit " (being fourth osmanthus youngster's umbilicus card) listing, it is exactly a kind of in motherland's medical treasure-house, but because of its prescription single, therapeutic domain has certain limitation, and this method is to the effect that is affected by the cold, suffered from diarrhoea of general umbilicus, but for because of bacterial epidemic diarrhea, the more serious infant of red-white dysentery but is willing and yet unable to help, moreover this method symptoms such as red swelling of the skin, allergy, pruritus can occur to most infant.
Summary of the invention
The objective of the invention is deficiency, a kind of treatment antidiarrheal external used medicine is provided at the prior art problem.
Another goal of the invention of the present invention provides the preparation method and the purposes of this medicine.
A kind of external antidiarrheal of the present invention is the medicament of being made by the following materials based on weight medicine:
Rhizoma Coptidis 8～12, Cortex Fraxini 7～10, the Radix Pulsatillae 7～10, Cortex Phellodendri 6～9, rhizoma sparganic 6～9, Rhizoma Curcumae 6～9, Flos Caryophylli 6～9, Fructus Piperis Longi 6～9, Radix orixae japonicae 3～5, Cortex Cinnamomi 3～5, Fructus Evodiae 6～9, Radix Paeoniae Rubra 6～9, the Radix Paeoniae Alba 6～9, Galla Chinensis 6～9, Radix Sanguisorbae 6～9, Fructus Schisandrae Chinensis 6～9, Poria 6～9, Radix Angelicae Sinensis 6～9, Semen Plantaginis (parched) 6～9, the Rhizoma Atractylodis Macrocephalae 6～9, Massa Medicata Fermentata 8～12, Fructus Crataegi 8～12, Fructus Hordei Germinatus 8～12, Endothelium Corneum Gigeriae Galli 8～12, Radix Glycyrrhizae 3～6.
Above-mentioned component can be made said dosage form on any pharmaceutics.As decoction, tablet, powder, capsule, electuary, oral liquid, medicinal liquid etc., the preferred dosage form of the present invention is a medicinal liquid.
The preparation method of external antidiarrheal of the present invention may further comprise the steps:
(1) screening medical material: remove in each medical material go mouldy, damage by worms, composition such as impurity, guarantee medical material quanlity.
(2) block medical material is handled: with disintegrating machine it is ground into granularity 3～5mm.
(3) metering: accurately weigh each medical material consumption according to prescription.
(4) soak:,, medical material was soaked 1 hour in 1: 5 medicinal liquid ratio with the solvent of ethanol content 80%.
(5) extract for the first time, under normal pressure 80 degree temperature controls, fried in shallow oil 2 hours, extract medicinal liquid 70%.
(6) extract for the second time, increasing solvent is 4 times of crude drugs, fries in shallow oil 1 hour under the normal pressure 80 degree temperature controls, medical material is included medicinal liquid all collect.
(7) filter: extracting solution is filtered with 120 mesh filter screens.
(8) concentrate: medicinal liquid is condensed into 2 times of finished product medicinal liquids of crude drug amount.
Usage: medicinal liquid is embrocated in the vola.
External treatment of Chinese medicine is an important component part in motherland's medical treasure-house, is a kind of treatment method of equal importance with the internal treatment.The medicine external treatment is a kind of of external treatment of Chinese medicine, " absorption of medicine external treatment and mechanism " literary composition that " Journal of Traditional Chinese Medicine " fifth phase in 1991 delivers, absorption approach to the medicine external treatment is summarised as skin, through cave and mucosa three aspects, its mechanism of action has: improve immunologic function, improve blood circulation, regulate the function of nerve, body fluid and hormonal system etc.The medicine external treatment also can play internal organs negative and positive, tonneau QI and blood, the effects such as strengthening vital QI to eliminate pathogenic factors adjusted by the conduction of meridians except that medicine effect itself.The Chinese medicine meridian theory thinks that human five internal organs's six internal organs all have corresponding projection area at foot, so arranged, the saying at the end of the three yang channels of foots beginning of Three Yin Channels of Foot.The common infantile diarrhea traditional Chinese medical science thinks and suffers from a deficiency of the kidney relevantly with spleen is wet that and there is clear and definite demonstration in all caves of spleen kidney the intestines and stomach in the vola, be a feasible valid approach so utilize vola diagnosis and treatment infantile diarrhea.Know according to practice, every and vital organs of the human body diseases associated, reason that the medicine of external is used in must meeting and taboo can safe and effectively reach its purpose.Considering that the diarrhoeal diseases oncoming force is anxious during prescription, can not incur loss through delay this reality, at first broken cure the disease this individual medication traditional pattern of " steadily conditioning; dialectical increasing (subtracting) medicine " of the traditional Chinese medical science, use for reference the length that doctor trained in Western medicine is cured the disease, under the traditional scheme framework of " key spleen stomach function regulating; warming middle-JIAO nourishing kidney ", antibiotic to strengthen, antibacterial, antiinflammatory antidiarrheal is choice drug, effect a permanent cure again and select tool cooperative effect medicine for use with Zhi Biao, recovery to function is strengthened, and has embodied " monarch; minister; assistant; make " this outline that traditional Chinese medical science prescription is followed, and has shown that more its medicine is to the special curative effect of multiple diarrheal.Particularly the various diarrheal of children's are treated especially medicine and wipe disease and remove, cure and obvious effective rate reaches 100%, also spleen and stomach function improvement after the antidiarrheal, the appetite showed increased.Above effect obtains, mainly ascribe the reasonability of prescription to, principal agent Rhizoma Coptidis in the side, its main function is pathogenic fire purging, dampness, detoxifcation etc., it includes main component is berberine, alkaloids such as coptisine, its pharmacology has bacteriostasis to various bacteria, dysentery bacterium particularly, higher with Shu Shi dysentery bacterium sensitivity, its clinical efficacy is not less than streptomycin and chloromycetin.According to reports, behind Rhizoma Coptidis composition compound recipe, antibacterial efficacy increases.In addition, cold medicines such as Cortex Fraxini, the Radix Pulsatillae, Cortex Phellodendri all are key medicines of anti-inflammation.At different reason symptom such as multiple diarrhoea hematodiarrhoea, cold-dysentery the time, helping is arranged between them, more be the effect that remedies.Medicines such as Flos Caryophylli, Fructus Piperis Longi, Cortex Cinnamomi have the warming middle-JIAO warming the kidney, and warming spleen and stomach for dispelling cold replenishes sun, the effect of warming the spleen and stomach.Medicines such as Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli have the effect of digestion-promoting spleen-invigorating stomach function regulating.In treatment diarrhoea prescription, their existing antidiarrheal helping effects more have antidiarrheal function simultaneously to recover health-care effect, and play the steady effect of the property of medicine cold and heat balance and the property of medicine in prescriptions.
Clinical effectiveness statistics of the present invention is as follows:
| Adult group | Children's's group | ||||||
| Symptom | Number of users | Treatment time | Effective percentage | Symptom | Number of users | Treatment time | Effective percentage |
| GENERAL TYPE diarrhoea | 50 | 2 days | 90％ | GENERAL TYPE diarrhoea | 150 people | 1 day | 100％ |
| Virus type diarrhoea | 20 | 2 days | 70％ | Popular type diarrhoea | 100 people | 2 days | 95％ |
| Enteritis colitis | 10 | 1.5 month | 70％ | ||||
The present invention has easy to use, reduces the misery that the child has an injection, takes medicine, and advantages such as red swelling of the skin, allergy, pruritus can not occur.
The present invention is adapted to: infantile diarrhea, adult diarrhea, enteritis, colon class etc.
The tool present embodiment
Embodiment 1:
Press following weight (part) proportioning weighting raw materials:
Rhizoma Coptidis 8g, Cortex Fraxini 7g, Radix Pulsatillae 7g, Cortex Phellodendri 6g, rhizoma sparganic 6g, Rhizoma Curcumae 6g, Flos Caryophylli 6g, Fructus Piperis Longi 6g, Radix orixae japonicae 3g, Cortex Cinnamomi 3g, Fructus Evodiae 6g, Radix Paeoniae Rubra 6g, Radix Paeoniae Alba 6g, Galla Chinensis 6g, Radix Sanguisorbae 6g, Fructus Schisandrae Chinensis 6g, Poria 6g, Radix Angelicae Sinensis 6g, Semen Plantaginis (parched) 6g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 8g, Fructus Crataegi 8g, Fructus Hordei Germinatus 8g, Endothelium Corneum Gigeriae Galli 8g, Radix Glycyrrhizae 3g.
Concrete production method may further comprise the steps:
(1) screening medical material: remove in each medical material go mouldy, damage by worms, composition such as impurity, guarantee medical material quanlity.
(2) block medical material is handled: with disintegrating machine it is ground into granularity 3mm.
(3) metering: accurately weigh each medical material consumption according to prescription.
(4) soak:,, medical material was soaked 1 hour in 1: 5 medicinal liquid ratio with the solvent of ethanol content 80%.
(5) extract for the first time, under normal pressure 80 degree temperature controls, fried in shallow oil 2 hours, extract medicinal liquid 70%.
(6) extract for the second time, increasing solvent is 4 times of crude drugs, fries in shallow oil 1 hour under the normal pressure 80 degree temperature controls, medical material is included medicinal liquid all collect.
(7) filter: extracting solution is filtered with 120 mesh filter screens.
(8) concentrate: medicinal liquid is condensed into 2 times of finished product medicinal liquids of crude drug amount.
Usage: with patient's foot wash clean or clean with warm towel, treat that foot is done after, dip in medicinal liquid with cotton swab, evenly embrocate at the patient foot heart and (or be made into spray and use more convenient, be more conducive to keeping, carry), be advisable daily three times not flow, rush down to end and stop using, general children's once takes effect, the longest two days antidiarrheal, colon class patient every day three times, 15 days is a course of treatment, general three courses of treatment of promptly full healing.
Embodiment 2:
Press following weight (part) proportioning weighting raw materials:
Rhizoma Coptidis 12g, Cortex Fraxini 10g, Radix Pulsatillae 10g, Cortex Phellodendri 9g, rhizoma sparganic 9g, Rhizoma Curcumae 9g, Flos Caryophylli 9g, Fructus Piperis Longi 9g, Radix orixae japonicae 5g, Cortex Cinnamomi 5g, Fructus Evodiae 9g, Radix Paeoniae Rubra 9g, Radix Paeoniae Alba 9g, Galla Chinensis 9g, Radix Sanguisorbae 9g, Fructus Schisandrae Chinensis 9g, Poria 9g, Radix Angelicae Sinensis 9g, Semen Plantaginis (parched) 9g, Rhizoma Atractylodis Macrocephalae 9g, Massa Medicata Fermentata 12g, Fructus Crataegi 12g, Fructus Hordei Germinatus 12g, Endothelium Corneum Gigeriae Galli 12g, Radix Glycyrrhizae 6g.
Concrete production method may further comprise the steps:
(1) screening medical material: remove in each medical material go mouldy, damage by worms, composition such as impurity, guarantee medical material quanlity.
(2) block medical material is handled: with disintegrating machine it is ground into granularity 5mm.
(3) metering: accurately weigh each medical material consumption according to prescription.
(4) soak:,, medical material was soaked 1 hour in 1: 5 medicinal liquid ratio with the solvent of ethanol content 80%.
(5) extract for the first time, under normal pressure 80 degree temperature controls, fried in shallow oil 2 hours, extract medicinal liquid 70%.
(6) extract for the second time, increasing solvent is 4 times of crude drugs, fries in shallow oil 1 hour under the normal pressure 80 degree temperature controls, medical material is included medicinal liquid all collect.
(7) filter: extracting solution is filtered with 120 mesh filter screens.
(8) concentrate: medicinal liquid is condensed into 2 times of finished product medicinal liquids of crude drug amount.
Usage: with embodiment 1.
Claims (5)
1. external antidiarrheal is characterized in that: the medicament of being made by the following materials based on weight medicine: Rhizoma Coptidis 8～12, Cortex Fraxini 7～10, the Radix Pulsatillae 7～10, Cortex Phellodendri 6～9, rhizoma sparganic 6～9, Rhizoma Curcumae 6～9, Flos Caryophylli 6～9, Fructus Piperis Longi 6～9, Radix orixae japonicae 3～5, Cortex Cinnamomi 3～5, Fructus Evodiae 6～9, Radix Paeoniae Rubra 6～9, the Radix Paeoniae Alba 6～9, Galla Chinensis 6～9, Radix Sanguisorbae 6～9, Fructus Schisandrae Chinensis 6～9, Poria 6～9, Radix Angelicae Sinensis 6～9, Semen Plantaginis (parched) 6～9, the Rhizoma Atractylodis Macrocephalae 6～9, Massa Medicata Fermentata 8～12, Fructus Crataegi 8～12, Fructus Hordei Germinatus 8～12, Endothelium Corneum Gigeriae Galli 8～12, Radix Glycyrrhizae 3～6.
2. external antidiarrheal according to claim 1 is characterized in that: described medicament is a said dosage form on any pharmaceutics.
3. external antidiarrheal according to claim 2 is characterized in that: described medicament is a medicinal liquid.
4. the preparation method of the described external antidiarrheal of claim 3 is characterized in that: may further comprise the steps:
(1) screening medical material: remove in each medical material go mouldy, damage by worms, composition such as impurity, guarantee medical material quanlity.
(2) block medical material is handled: with disintegrating machine it is ground into granularity 3～5mm.
(3) metering: accurately weigh each medical material consumption according to prescription.
(4) soak:,, medical material was soaked 1 hour in 1: 5 medicinal liquid ratio with the solvent of ethanol content 80%.
(5) extract for the first time, under normal pressure 80 degree temperature controls, fried in shallow oil 2 hours, extract medicinal liquid 70%.
(6) extract for the second time, increasing solvent is 4 times of crude drugs, fries in shallow oil 1 hour under the normal pressure 80 degree temperature controls, medical material is included medicinal liquid all collect.
(7) filter: extracting solution is filtered with 120 mesh filter screens.
(8) concentrate: medicinal liquid is condensed into 2 times of finished product medicinal liquids of crude drug amount.
5. the purposes of claim 1 or 3 described external antidiarrheals is characterized in that: medicinal liquid is embrocated in the vola.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101854273A CN101199796B (en) | 2007-12-14 | 2007-12-14 | External antidiarrhoeal medicament, preparing method and function thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101854273A CN101199796B (en) | 2007-12-14 | 2007-12-14 | External antidiarrhoeal medicament, preparing method and function thereof |
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| Publication Number | Publication Date |
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| CN101199796A true CN101199796A (en) | 2008-06-18 |
| CN101199796B CN101199796B (en) | 2010-11-17 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600283A (en) * | 2011-12-07 | 2012-07-25 | 中国人民解放军第二军医大学 | Chinese herbal compound preparation used for clearing heat, drying damp, resisting dysentery, tonifying deficiency, calming central nervous system and resisting diarrhoea and application thereof |
| CN102716240A (en) * | 2012-06-15 | 2012-10-10 | 李良 | Pulsatilla traditional Chinese medicine decoction for treating dysentery and preparation method of decoction |
| CN103690665A (en) * | 2013-12-12 | 2014-04-02 | 张宗升 | Natural medicine composition |
| CN103751628A (en) * | 2014-02-19 | 2014-04-30 | 单纪芬 | Traditional Chinese medicine paste for treating infantile diarrhea |
| CN108498489A (en) * | 2018-05-15 | 2018-09-07 | 湖南益好康生物科技有限公司 | A kind of formula and processing technology of children's note |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899455B (en) * | 2006-07-14 | 2010-05-12 | 左耀武 | External use plaster for treating child heat diarrhea and preparing method |
-
2007
- 2007-12-14 CN CN2007101854273A patent/CN101199796B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600283A (en) * | 2011-12-07 | 2012-07-25 | 中国人民解放军第二军医大学 | Chinese herbal compound preparation used for clearing heat, drying damp, resisting dysentery, tonifying deficiency, calming central nervous system and resisting diarrhoea and application thereof |
| CN102716240A (en) * | 2012-06-15 | 2012-10-10 | 李良 | Pulsatilla traditional Chinese medicine decoction for treating dysentery and preparation method of decoction |
| CN102716240B (en) * | 2012-06-15 | 2013-09-18 | 李良 | Pulsatilla traditional Chinese medicine decoction for treating dysentery and preparation method of decoction |
| CN103690665A (en) * | 2013-12-12 | 2014-04-02 | 张宗升 | Natural medicine composition |
| CN103751628A (en) * | 2014-02-19 | 2014-04-30 | 单纪芬 | Traditional Chinese medicine paste for treating infantile diarrhea |
| CN108498489A (en) * | 2018-05-15 | 2018-09-07 | 湖南益好康生物科技有限公司 | A kind of formula and processing technology of children's note |
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| Publication number | Publication date |
|---|---|
| CN101199796B (en) | 2010-11-17 |
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Granted publication date: 20101117 Termination date: 20111214 |