CN101199768A - Medicament compound treating brain shrink and senile dementia - Google Patents
Medicament compound treating brain shrink and senile dementia Download PDFInfo
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- CN101199768A CN101199768A CNA2007101652958A CN200710165295A CN101199768A CN 101199768 A CN101199768 A CN 101199768A CN A2007101652958 A CNA2007101652958 A CN A2007101652958A CN 200710165295 A CN200710165295 A CN 200710165295A CN 101199768 A CN101199768 A CN 101199768A
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Abstract
Disclosed is a drug combination for treating encephalatrophy and senile dementia. The combination contains Radix Polygoni Multiflori, Fructus Schisandrae, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Calami, vitamin B complex, and microelements such as chrome, zinc and selenium. The invention has good effect in treating encephalatrophy and senile dementia and also has the effect of healthcare and benefit.
Description
One, technical field: the present invention relates to medical technical field, in particular for the pharmaceutical composition of treatment brain atrophy and senile dementia.
Two, background technology: said composition comprises Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei and compound vitamin B and trace element chromium, zinc, selenium, and wherein compound vitamin B comprises vitamin B
1, B
6, B
12And folic acid.
Radix Polygoni Multiflori belongs to the deficiency tonifying kind medicine, enriches blood, and the effect of benefit essence, tcm clinical practice is used for blood deficiency insomnia, visual deterioration, spasm of muscles and vessels; The early whitening of beard and hair of damage of essence blood deficiency senilism, dizziness and blurred vision, tinnitus is hard of hearing, diseases such as weakness of the waist and knees.Modern study confirms that Radix Polygoni Multiflori can reduce the aged relevant enzyme of the different partitioned organization midbrain of brain--monoamine oxidase, MAO (Type B), and replenishes composition---the lecithin that constitutes nervous tissue, therefore has the protection cerebral tissue, nourishing the brain and improving intelligence, the effect of hypermnesis.
Schizandra astringing lung-QI and relieving cough class medicine is used for the chronic cough dyspnea due to deficiency on the tcm clinical practice, spontaneous sweating, and Tianjin wound is thirsty, and interior-heat disappears and drinks, emission and spermatorrhea, incessant chronic diarrhea, diseases such as severe palpitation, insomnia and dreamful sleep.Modern study confirms that Fructus Schisandrae Chinensis can strengthen central nervous system's excitement and process of inhibition, increases lability of nervous process, promotes the mutual balance of two kinds of nervous process, can improve people's intellectual activity, increases work efficiency.
Fructus Lycii belongs to nourishing YIN and supplementing blood class medicine, is used for the treatment of caused by liver and kidney deficiency on the tcm clinical practice, the soreness of the waist and knees due to the asthenia of essence and blood, diseases such as giddy, tinnitus, seminal emission, night sweat.Modern study confirms that the benefiting action of Fructus Lycii is obvious, and especially lycium barbarum polysaccharide has pharmacological action widely, as enhance immunity, and anti-cancer and inhibiting tumor, fat-reducing liver-protecting, slow down aging improves functions such as memory; Also influential to neuroendocrine regulating networks and hemopoietic system.
Fructus Corni is one of principal agent of Chinese medicine LIUWEI DIHUANG WAN, has liver and kidney tonifying, and the arresting seminal emission arresting sweating is Gu effects such as collapse are used for soreness of the waist and knees, have a dizzy spell, disease such as tinnitus, sexual impotence, seminal emission, frequent micturition, the enuresis, sweating, menorrhagia on the tcm clinical practice.Modern study confirms that Fructus Corni contains iridoids, triterpene acids, tannin class and plurality of active ingredients such as carotene and retinoid; The diabetes patient is had the effect of blood sugar lowering value and saccharifying serum albumin content, and to metabolism disorder of blood lipid and diabetic renal papillary necrosis, tool has some improvement simultaneously, and strengthening by means of tonics is arranged, the pharmacological action that anticancer antibiotic, blood pressure lowering etc. are complicated.
Radix Puerariae has that the famine of separating is brought down a fever, the effect of rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, the record that all useful Radix Puerariae of successive dynasties Chinese medicine books and the treatment of other medicine compatibility are quenched one's thirst, modern study confirms that Radix Puerariae extract also has the obvious suppression effect to human serum albumin's nonenzymatic glycosylation, has shown that Radix Puerariae has a good application prospect aspect diabetes and the complication thereof preventing and treating.
Fructus Hordei Germinatus belongs to the class medicine that helps digestion, and has promoting digestion and invigorating the stomach, the effect of galactopoiesis relieving distension.Tcm clinical practice is used for rice and flour dyspepsia card, the hypochondriac pain of irritability stasis or incoordination between the liver and stomach, abdominal pain etc.
The May medicine for promoting blood circulation and dispelling blood stasis has promoting digestion and removing stagnation, is good for the stomach the effect of circulation of qi promoting dissipating blood stasis; Tcm clinical practice is used for the meat food stagnation and stagnates old man's lumbago, skelalgia, hypertension, hyperlipidemia, diseases such as coronary heart disease, angina pectoris and women's prolonged lochia; Discovered that Fructus Crataegi had the obvious suppression effect to the old and feeble material monoamine oxidase, MAO (Type B) in the human brain in 1985.
Codonopsis's deficiency tonifying kind medicine, the effect that QI invigorating is arranged, promote the production of body fluid, nourishes blood, pharmacological research confirms that Radix Codonopsis has the function of enhancing human body immunity, and the raising resisting stress capability is arranged, and Fructus Alpiniae Oxyphyllae, anti-aging effects are arranged.Heart tonifying arranged, resist myocardial ischemia, the effect of blood pressure regulation; Influential spleen promotes erythropoietic effect.
The Radix Astragali is the key medicine of invigorating the spleen and replenishing QI, and holding concurrently can ascending up spleen-Qi and Yang, again can replenishing and restoring lung-QI, and the clinical cards such as syndrome of deficiency of spleen qi, syndrome of deficiency of lung qi, spontaneous sweating due to deficiency of QI, deficiency of qi and blood that are used for are tonify deficiency QI invigorating class conventional Chinese medicines simply.The Radix Astragali mainly contains glycoside, and polysaccharide, flavone, aminoacid, trace element etc., modern study confirm its pharmacological action hypoglycemia that can raise, and reduces hyperglycemia; Blood fat reducing can recover insulin sensitivity, improves the insulin resistant that glucocorticoid brings out; Coronary artery dilator and peripheral blood vessel bring high blood pressure down, and reduce thrombosis; Promote organism metabolism, resisting fatigue promotes serum and the proteinic renewal of liver; Tangible diuresis is arranged, remove the nephritis urine protein, improve the anemia hemogram; The excited breathing strengthens and the adjusting immunity; And defying age arranged, anti-hypoxia, radioprotective, effect such as protect the liver; Also has estrogen-like effects.
Radix Angelicae Sinensis have enrich blood, invigorate blood circulation, the effect of regulating menstruation, pain relieving, intestine moistening, coronary dilating, blood pressure lowering, effect for reducing blood fat are arranged, normal and QI invigorating YIN nourishing class medicine compatibility.
Bombyx Batryticatus belongs to suppressing the hyperactive liver to relieve the wind syndrome class medicine, has hot loosing and dispels the wind the effect of softening masses by salty flavor expectorant knot; Go into lung, liver two warps, can dispelling wind and heat pathogens to control exogenous wind, again can the endogenous wind stopping relieving convulsion to control endogenous wind, have the effect of dissipating phlegm and resolving masses concurrently.
Gastrodia suppressing the hyperactive liver to relieve the wind syndrome class medicine, all having a dizzy spell, the disease of liver-wind stirring up internally no matter deficiency and excess all has good effect, has the effect of dispelling wind and removing obstruction in the collateral concurrently, Shang Kezhi partially, aching all over the head, rheumatic arthralgia disease.
The Acorus class medicine of having one's ideas straightened out has the effect of resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach; Effects such as calmness, convulsion, analgesia, improvement memory are arranged, certain antidepressant activity is arranged; " Chongqing hall random notes " have following description to Rhizoma Acori Graminei: " the comfortable gas of Rhizoma Acori Graminei, the smooth mind, happy mood, beneficial will, panacea are also ".
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises a variety of vitamin, wherein vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, the massed learning ability; Vitamin B in addition
1Also has in conjunction with plumbous the effect of detoxifcation Plumbum removing; Suppress acetylcholine esterase, improve the function of cholinergic nerve; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of egg amino acid, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, homotype half light amino acid is a kind of neural plain poison, can cause the self murder of brain.
Trace element chromium is insulin " a collaborative hormone ", to have the effect of active organochromium compounds " glucose tolerance factor " form enhancing insulin, mainly be to keep normal carbohydrate metabolism of body and lipid metabolism, following symptom can occur when not enough: weaken glucose tolerance, increase the weight of hyperglycemia, glucose in urine, hypoglycemia, the circulation of acceleration insulin, reduce Insulin receptor INSR quantity, reduce the insulin binding ability, lose weight, increase fat content, increase vision pressure etc.The chromium of two kinds of valence states of stable existence in the environment, i.e. trivalent chromium and Cr VI, trivalent chromium has physiologically active, uses useful and harmlessly in an amount of scope, and Cr VI is a kind of strong oxidizer, and human body is had toxic and side effects.
Zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid; It is the necessary material that various zinc rely on enzyme, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Can promote that proinsulin is converted into insulin by activating protaminase; Zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve.
Selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Scarce selenium makes insulin secretion reduce impaired glucose tolerance; Selenium also has the strong anti-oxidation function in addition, and prevention of cardiac is anticancer by enhance immunity recognition system removing cancerous cell, weakens the effects such as toxicity of harmful metal ion.
China's Ministry of Public Health Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae have been listed in be food be again medicine and the article list that can be used for health food, Bombyx Batryticatus, Rhizoma Acori Graminei all belong to non-toxic type Chinese medicine.
Application contains vitamin B
1, B
6, B
12, folic acid and trace element chromium, zinc, selenium and Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei be known as the compositions of active princlple, but with vitamin B
1, B
6, B
12, folic acid and trace element chromium, zinc, selenium and Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei compatibility be as the pharmaceutical composition of treatment brain atrophy and senile dementia report as yet.
The paathogenic factor of brain atrophy and senile dementia has multiple, but all accumulate closely related after all with neurotoxin and brain aging goods and materials gradual, when accumulating of neurotoxin and brain aging goods and materials acquires a certain degree, can make speeding up of apoptosis amount, quantity increases, transfer the quantity die when brain cell and reach the symptom that 10 of human brain total amount will show brain atrophy when above,, will develop into the degree of senile dementia when brain atrophy continues to develop and can not be controlled.The medicine of current treatment brain atrophy and senile dementia has multiple, but because the rule of treatment is different with target spot the part that do not comply with one's wishes is arranged all.
Summary of the invention: in order to overcome the shortcoming and defect of existing treatment brain atrophy and senile dementia disease drug, the purpose of this invention is to provide a kind of compositions, said composition is passed through vitamin B
1, B
6, B
12, folic acid and trace element chromium, zinc, selenium increases the effect of Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei treatment brain atrophy and senile dementia, replenish by Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei simultaneously and strengthen compound vitamin B and trace element chromium, zinc, selenium, the effect of treatment brain atrophy and senile dementia; Because the result of broad research, the inventor has found vitamin B
1, B
6, B
12, folic acid and trace element chromium, zinc, selenium and Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei novel combination, this novel combination has synergy for treatment brain atrophy and senile dementia.And single with compound vitamin B and trace element chromium, zinc, selenium and Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei Chinese medicine composition, its effect is all not as good as this compositions.And the effective ingredient of each component has the addition complementary action to the health care tonification of human body.Radix Polygoni Multiflori as the used dosage of this compositions has invigorating the liver and kidney, the black hair that nourishes blood, the effect of making light of one's life by commiting suicide and prolonging life, and can reduce the enzyme relevant---monoamine oxidase, MAO (Type B) in the different dividing tissues of brain with brain aging, the Fructus Schisandrae Chinensis nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, arresting seminal emission antidiarrheal, the effect of mind tranquilizing and the heart calming; Can improve people's intellectual activity, increase work efficiency; Fructus Lycii has enhance immunity, anti-cancer and inhibiting tumor, fat-reducing liver-protecting, blood sugar lowering, effects such as resisting fatigue and high temperature resistance, slow down aging, improvement memory; Fructus Corni has liver and kidney tonifying, and Gu the arresting seminal emission arresting sweating is the effect of collapse and improvement sugar, fat, proteometabolic complicated pharmacological action; Radix Puerariae has the effect of expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, and separates the effect that ethanol is poisoned and suppressed the albumin nonenzymatic glycosylation; Fructus Hordei Germinatus has promoting digestion and invigorating the stomach, the effect of galactopoiesis relieving distension; Fructus Crataegi has blood circulation promoting and blood stasis dispelling, promoting digestion and removing stagnation, be good for the stomach, the effect of circulation of qi promoting dissipating blood stasis and suppress the effect of old and feeble material monoamine oxidase, MAO (Type B) in the human brain, the effect that Radix Codonopsis has QI invigorating, promotes the production of body fluid, nourishes blood has Fructus Alpiniae Oxyphyllae, anti-aging effects; The Radix Astragali has invigorating the spleen and replenishing QI, blood sugar regulation, blood fat reducing, recovery insulin sensitivity, improves insulin resistant and defying age, anti-hypoxia, radioprotective that glucocorticoid brings out, effect such as protects the liver; Radix Angelicae Sinensis have enrich blood, invigorate blood circulation, effect such as the effect of regulating menstruation, pain relieving, intestine moistening and coronary dilating, blood pressure lowering, blood fat reducing; Bombyx Batryticatus can dispelling wind and heat pathogens to control exogenous wind, again can the endogenous wind stopping relieving convulsion to control endogenous wind, have the effect of dissipating phlegm and resolving masses concurrently; Rhizoma Gastrodiae is to having a dizzy spell, and the card of liver-wind stirring up internally no matter deficiency and excess all has good effect, has the effect of dispelling wind and removing obstruction in the collateral concurrently; Rhizoma Acori Graminei has effects such as the effect of resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach and calmness, convulsion, analgesia, improvement memory and antidepressant activity etc.Vitamin B and for example
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
6Most important to the maincenter neurodevelopment; Also can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be the necessary vitamin of intelligence of bringing into normal play, and be used for various megaloblastic anemias and neural disease; Folic acid participates in the synthetic of aminoacid and nucleic acid, protects heart and antitumaous effect in addition; Trace element chromium (trivalent chromium), zinc, selenium are essential trace element; Folic acid, vitamin B
6, B
12Can work in coordination with and remove the intravital a kind of neurotoxin of people---homotype aminothiopropionic acid.Vitamin B
1, B
6, B
12, folic acid, be water soluble vitamins, in an amount of dosage range, use all useful and harmless.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the compositions that is used for the treatment of brain atrophy and senile dementia, it comprise Radix Polygoni Multiflori as active component, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni,, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei and vitamin B
1, B
6, B
12, folic acid and trace element chromium, zinc, selenium.
Radix Polygoni Multiflori of the present invention, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Hordei Germinatus, Fructus Crataegi, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei can be with its extract as raw material; Compound vitamin B each component of the present invention and trace element trivalent chromium, zinc, selenium can be with pharmaceutical grade or the food additive grade raw materials as this compositions.
By the present invention, the effective dose of Radix Polygoni Multiflori extract in whole crude drug concerning the adult is: 5000-30000mg/ days; The effective dose of Fructus Schisandrae Chinensis extrat is said the adult in whole crude drug: 2000-12000mg/ days; The effective dose of Fructus Lycii extract is said the adult in whole crude drug: 5000-30000mg/ days; The effective dose of Fructus Corni extract is 5000-30000mg/ days in whole crude drug concerning the adult; The effective dose of Radix Puerariae extract in whole crude drug concerning the adult is: 5000-30000mg/ days; The effective dose of Fructus Hordei Germinatus extract in whole crude drug concerning the adult is: 10000-30000mg/ days; The effective dose of Fructus Crataegi extract in whole crude drug concerning the adult is: 5000-30000mg/ days; The effective dose of Radix Codonopsis extract is 5000-30000mg/ days in whole crude drug concerning the adult; The effective dose of Radix Astragali extract in whole crude drug concerning the adult is: 5000-30000mg/ days; The effective dose of Radix Angelicae Sinensis extract in whole crude drug concerning the adult is: 3000-16000mg/ days; The effective dose of Rhizoma Gastrodiae extract in whole crude drug concerning the adult is: 3000-18000mg/ days; The effective dose of Bombyx Batryticatus extract in whole crude drug concerning the adult is: 3000-12000mg/ days; The effective dose of Rhizoma Acori Graminei extract in whole crude drug concerning the adult is: 6000-16000mg/ days; And vitamin B
1Effective dose concerning adult be 0.8-30mg/ days; Vitamin B
6Effective dose concerning adult be 0.5-50mg/ days; The effective dose of vitamin B12 concerning the adult is: 0.003-1mg/ days; The effective dose of folic acid is 0.4-5mg/ days concerning the adult; The effective dose of trace element trivalent chromium (in elemental chromium) is 0.015-1mg/ days concerning the adult; The effective dose of zinc (in element zinc) is 5-25mg/ days concerning the adult; The effective dose of selenium (in elemental selenium) is 0.015-0.4mg/ days concerning the adult.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is carrier for example, disintegrating agent, slow releasing agent, packs, excipient, filler, binding agent, lubricant, antioxidant, coloring agent, correctives, sweeting agent, sucrose succedaneum, flavouring agent, nutrition enhancer, surfactant, plasticizer, the PH regulator, freshener, suspending agent, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, each distinguish the flavor of medicament extract and vitamin B
1, B
6, B
12, folic acid and trace element trivalent chromium, zinc, selenium each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions has notable therapeutic effect to treatment brain atrophy and senile dementia, sufficient raw, and cost is low, and each component does not have incompatibility in the compositions, except that treatment brain atrophy and senile dementia, human body is still had the health care benefiting action.
Be described in detail the present invention below by reference example:
Embodiment 1:
Prescription: Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Hordei Germinatus: 15000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and wherein folic acid coats with microcapsule earlier, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Prescription: Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Crataegi: 12000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and wherein folic acid coats with microcapsule earlier, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Prescription: Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Crataegi: 12000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Methylpyridine chromium: 0.10mg (by elemental chromium)
Zinc citrate: 17mg (by element zinc)
Selenomethionine: 0.08mg (by elemental selenium)
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and wherein folic acid coats with microcapsule earlier, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Prescription: Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Hordei Germinatus: 15000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Methylpyridine chromium: 0.10mg (by elemental chromium)
Zinc citrate: 17mg (by element zinc)
Selenomethionine: 0.08mg (by elemental selenium)
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and wherein folic acid coats with microcapsule earlier, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 5:
Prescription: the Radix Astragali: 10000mg (by whole crude drug)
Radix Angelicae Sinensis: 5000mg (by whole crude drug)
Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Hordei Germinatus: 12000mg (by whole crude drug)
Rhizoma Gastrodiae: 8000mg (by whole crude drug)
Bombyx Batryticatus: 6000mg (by whole crude drug)
Rhizoma Acori Graminei: 10000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Said components is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and wherein folic acid coats with microcapsule earlier, makes 3 bag shot-like particles again.Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Prescription: Radix Codonopsis: 10000mg (by whole crude drug)
Radix Angelicae Sinensis: 5000mg (by whole crude drug)
Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Hordei Germinatus: 12000mg (by whole crude drug)
Rhizoma Gastrodiae: 8000mg (by whole crude drug)
Bombyx Batryticatus: 6000mg (by whole crude drug)
Rhizoma Acori Graminei: 10000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Said components is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and wherein folic acid coats with microcapsule earlier, makes 3 bag shot-like particles again.Obey every day 3 times, obey a bag at every turn.
Embodiment 7:
Prescription: the Radix Astragali: 10000mg (by whole crude drug)
Radix Angelicae Sinensis: 5000mg (by whole crude drug)
Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Crataegi: 12000mg (by whole crude drug)
Rhizoma Gastrodiae: 8000mg (by whole crude drug)
Bombyx Batryticatus: 6000mg (by whole crude drug)
Rhizoma Acori Graminei: 10000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Methylpyridine chromium: 0.10mg (by elemental chromium)
Zinc citrate: 17mg (by element zinc)
Selenomethionine: 0.08mg (by elemental selenium)
Said components is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and wherein folic acid coats with microcapsule earlier, makes 3 bag shot-like particles again.Obey every day 3 times, obey a bag at every turn.
Embodiment 8:
Prescription: Radix Codonopsis: 10000mg (by whole crude drug)
Radix Angelicae Sinensis: 5000mg (by whole crude drug)
Radix Polygoni Multiflori: 15000mg (by whole crude drug)
Fructus Schisandrae Chinensis: 5000mg (by whole crude drug)
Fructus Lycii: 20000mg (by whole crude drug)
Fructus Corni: 8000mg (by whole crude drug)
Radix Puerariae: 12000mg (by whole crude drug)
Fructus Crataegi: 12000mg (by whole crude drug)
Rhizoma Gastrodiae: 8000mg (by whole crude drug)
Bombyx Batryticatus: 6000mg (by whole crude drug)
Rhizoma Acori Graminei: 10000mg (by whole crude drug)
Vitamin B
1: 10mg
Vitamin B
6: 10mg
Vitamin B
12: 0.1mg
Folic acid: 1mg
Methylpyridine chromium: 0.10mg (by elemental chromium)
Zinc citrate: 17mg (by element zinc)
Selenomethionine: 0.08mg (by elemental selenium)
Said components is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and wherein folic acid coats with microcapsule earlier, makes 3 bag shot-like particles again.Obey every day 3 times, obey a bag at every turn.
Embodiment 1 and embodiment 5 or embodiment 2 and embodiment 6 alternately took treatment brain atrophy 50 examples, average medication 120 days, total effective rate 96% in per 10 days; Embodiment 3 and embodiment 7 or embodiment 4 and embodiment 8 alternately took treatment multi-infarct dementia 50 examples, average medication 150 days, total effective rate 92% in per 10 days.Effectively criterion is: 1, the dysmnesia function is improved; 2, the thinking understandability improves; 3, time, place, disturbance of orientation to person eliminate; 4, just control force enhancing of self care ability and two.
Claims (4)
1. pharmaceutical composition that is used for the treatment of brain atrophy and senile dementia is characterized in that it is made by weight ratio by following raw materials according:
Radix Polygoni Multiflori: 500-30000mg;
Fructus Schisandrae Chinensis: 200-12000mg;
Fructus Lycii: 5000-30000mg;
Fructus Corni: 5000-30000mg;
Radix Puerariae: 5000-30000mg;
Fructus Hordei Germinatus: 10000-30000mg;
Vitamin B
1: 0.8-30mg;
Vitamin B
6: 0.5-50mg;
Vitamin B
12: 0.003-1mg;
Folic acid: 0.4-5mg;
2. the pharmaceutical composition that is used for the treatment of brain atrophy and senile dementia according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Radix Polygoni Multiflori: 5000-30000mg;
Fructus Schisandrae Chinensis: 2000-12000mg;
Fructus Lycii: 5000-30000mg;
Fructus Corni: 5000-30000mg;
Radix Puerariae: 5000-30000mg;
Fructus Hordei Germinatus: 10000-30000mg and/or;
Fructus Crataegi: 5000-30000mg;
Vitamin B
1: 0.8-30mg;
Vitamin B
6: 0.5-50mg;
Vitamin B
12: 0.003-1mg;
Folic acid: 0.4-5mg;
Trivalent chromium (in trace element chromium): 0.015-1mg;
Zinc (in trace element zinc): 5-25mg;
Selenium (in trace element-selenium): 0.015-0.4mg.
3. the pharmaceutical composition that is used for the treatment of brain atrophy and senile dementia according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Radix Codonopsis: 500-30000mg and/or;
The Radix Astragali: 500-30000mg;
Radix Angelicae Sinensis: 3000-16000mg;
Radix Polygoni Multiflori: 500-30000mg;
Fructus Schisandrae Chinensis: 2000-12000mg;
Fructus Lycii: 5000-30000mg;
Fructus Corni: 5000-30000mg;
Radix Puerariae: 5000-30000mg;
Fructus Hordei Germinatus: 10000-30000mg and/or;
Fructus Crataegi: 5000-30000mg;
Rhizoma Gastrodiae: 3000-18000mg;
Bombyx Batryticatus: 3000-12000mg;
Rhizoma Acori Graminei: 6000-16000mg;
Vitamin B
1: 0.8-30mg;
Vitamin B
6: 0.5-50mg;
Vitamin B
12: 0.003-1mg;
Folic acid: 0.4-5mg;
4. the pharmaceutical composition that is used for the treatment of brain atrophy and senile dementia according to claim 3 is characterized in that, it is made by important proportioning by following raw materials according:
Radix Codonopsis: 5000-30000mg and/or;
The Radix Astragali: 5000-30000mg;
Radix Angelicae Sinensis: 3000-16000mg;
Radix Polygoni Multiflori: 5000-30000mg;
Fructus Schisandrae Chinensis: 2000-12000mg;
Fructus Lycii: 5000-30000mg;
Fructus Corni: 5000-30000mg;
Radix Puerariae: 5000-30000mg;
Fructus Hordei Germinatus: 10000-30000mg and/or;
Fructus Crataegi: 5000-30000mg;
Rhizoma Gastrodiae: 3000-18000mg;
Bombyx Batryticatus: 3000-12000mg;
Rhizoma Acori Graminei: 6000-16000mg;
Vitamin B
1: 0.8-30mg;
Vitamin B
6: 0.5-50mg;
Vitamin B
12: 0.003-1mg;
Folic acid: 0.4-5mg;
Trivalent chromium (in trace element chromium): 0.015-1mg;
Zinc (in trace element zinc): 5-25mg;
Selenium (in trace element-selenium): 0.015-0.4mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101652958A CN101199768A (en) | 2006-11-06 | 2007-11-05 | Medicament compound treating brain shrink and senile dementia |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610138316 | 2006-11-06 | ||
| CN200610138316.2 | 2006-11-06 | ||
| CNA2007101652958A CN101199768A (en) | 2006-11-06 | 2007-11-05 | Medicament compound treating brain shrink and senile dementia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101199768A true CN101199768A (en) | 2008-06-18 |
Family
ID=39515251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101652958A Pending CN101199768A (en) | 2006-11-06 | 2007-11-05 | Medicament compound treating brain shrink and senile dementia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101199768A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327568A (en) * | 2011-09-30 | 2012-01-25 | 许士杰 | Medicine for treating senile dementia |
| CN103933304A (en) * | 2014-04-19 | 2014-07-23 | 闫超 | Traditional Chinese medicine formula for treating senile dementia and preparation method of traditional Chinese medicine formula |
-
2007
- 2007-11-05 CN CNA2007101652958A patent/CN101199768A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327568A (en) * | 2011-09-30 | 2012-01-25 | 许士杰 | Medicine for treating senile dementia |
| CN103933304A (en) * | 2014-04-19 | 2014-07-23 | 闫超 | Traditional Chinese medicine formula for treating senile dementia and preparation method of traditional Chinese medicine formula |
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Open date: 20080618 |