CN101791354A - Medicine composition used for interfering in and preventing birth defects and improving memory - Google Patents
Medicine composition used for interfering in and preventing birth defects and improving memory Download PDFInfo
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Abstract
The invention relates to a medicine composition used for interfering in and preventing birth defects and improving memory, which comprises atractylis ovata, teasel root, mistletoe, eucommia, astragalus, medlar, harms, vitamin A, beta-carotene, vitamin B complex, vitamin C, vitamin D, vitamin E, major elements (calcium, potassium and magnesium) and trace elements (zinc, selenium, iron, chromium, copper, molybdenum and manganese). The invention is mainly applicable to pregestational women, pregnant women and breast-feeding women, and is effective in the aspects of interfering in and preventing birth defects and improving memory, and in addition, the invention simultaneously has the health care and benefiting effect, and can not generate any side effect even through long-time application.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field; In particular for interfering and prevention birth defect and the pharmaceutical composition that improves memory.
Background technology: birth defect is meant that fetus is in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprise that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to the embryo, interfere and the generation that prevents birth defect, reach the purpose that lowers the birth defect sickness rate, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese.
The Rhizoma Atractylodis Macrocephalae is a kind of QI invigorating class natural Chinese medicine, and invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, the edema spontaneous perspiration, frequent fetal movement etc., modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor.Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae with the absorption, particularly compatibility gold that promote the medicine active ingredient, stone class medicine to promote the absorption and the utilization of mineral; The Rhizoma Atractylodis Macrocephalae is the article that can be used for health food.
Radix Dipsaci is a kind of deficiency tonifying kind natural Chinese medicine, has liver and kidney tonifying, strengthening the tendons and bones, antiabortive leak-stopping, the continuous discharging the retained water effect of curing the wound; The clinical sexual impotence erectile problem that is used for the treatment of, the seminal emission enuresis; Soreness of waist and knee joint, arthralgia due to cold-dampnes; Metrostaxis, frequent fetal movement; The muscles and bones folding is hindered diseases such as carbuncle skin infection; Modern pharmacological research confirms that Radix Dipsaci has: 1, vitamin antagonist E deficiency disease; 2, promote developing womb, significantly suppress uterotonic effect; 3, antiabortive leak-stopping effect; 4, anti-aging effects; 5, promote bone injury healing, function of resisting osteoporosis; 6, immunoregulation effect; 7, hemostasis, analgesic activity; 8, antiinflammatory, antibacterial, anti-trichomonal effect etc.
Herba Taxilli is a kind of wind-damp dispelling bone and muscle strengthening class natural Chinese medicine, wind-damp dispelling is arranged, invigorating the liver and kidney, bone and muscle strengthening, the effect of antiabortive unit; The clinical rheumatic arthralgia that is used for the treatment of, soreness of waist and knee joint; Caused by liver and kidney deficiency, blastokinesis uneasiness, vaginal bleeding during pregnancy hematochezia, edema during pregnancy, diseases such as lack of lactation after delivery; Modern pharmacological research confirms that Herba Taxilli has: 1, blood pressure lowering, and the effect of diastole arteria coronaria and increase coronary flow, anticoagulant and antithrombotic form, and the antiarrhythmic effect; 2, sedation; 3, diuresis; 4, resisting pathogenic microbes effect; 5, antifatigue effect; 6, effect for reducing blood fat; 7, enhance immunity effect etc.
The Cortex Eucommiae is a kind ofly can as the deficiency tonifying kind natural Chinese medicine of health food invigorating the liver and kidney be arranged, bone and muscle strengthening, antiabortive effect; The clinical lumbago due to renal deficiency that is used for the treatment of, sexual impotence, frequent fetal movement, vaginal bleeding during pregnancy, diseases such as tire bob; Modern pharmacological research confirms that the Cortex Eucommiae has: 1, antifatigue effect; 2, antioxidation; 3, delaying senility function; 4, the strong endothelial system of excited net, the enhancing non-specific immunity function has two-way Accommodation to humoral immunization and cellular immunization; 5, antitumor action; 6, maincenter sedation; 7, the uterus there is inhibitory action; 8, effect such as antibiotic, antiinflammatory, analgesia.
The Radix Astragali is a kind ofly can have tonifying Qi and lifting yang as the QI invigorating class natural Chinese medicine of health food, and benefit is defended consolidating superficial resistance, holder skin ulcer granulation promoting, the effect of diuretic detumescent; Clinical deficiency-weakness of spleen-QI card, syndrome of qi failing to control blood, the middle Qi collapse syndrome of being used for the treatment of, syndrome of qi deficiency of spleen and lung, the two cards that lose of QI and blood, syndrome of fever due to qi deficiency, the empty hyperhidrosis card of body, deficiency of vital energy edema syndrome, the numb card of arthralgia due to stagnation of blood, apoplexy sequela, diabete, carbuncle with the passing of time do not steep or burst after disease such as do not close up for a long time, modern pharmacological research confirms that the Radix Astragali has: 1, enhancing human body immunity and two-ways regulation body's immunity; 2, anti-senescence function; 3, increase the effect of intelligence and reinforcement learning and memory; 4, antifatigue effect; 5, oxygen lack resistant function; 6, radiation resistance; 7, anti-cold effect; 9, antimutagenic effect; 10, tumor-inhibiting action; 11, antibiotic, antiviral, antiinflammatory action; 12, protect the liver, protect kidney, diuresis, protect the stomach effect; 13, promote osteogenesis effect; 14, estrogenic promoting action is arranged; 15, effects such as heart tonifying, blood vessel dilating, blood pressure lowering; 16, promote protein synthesis; 17, blood sugar regulation effect; 18. prolong the effect in zooblast life-span etc.
Fructus Lycii be a kind of be food be again the natural Chinese medicine of medicine, liver and kidney tonifying is arranged, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight, the effect of nourishing the lung to arrest cough is flat tonic thing simply; Ancient Chinese medicine is classified Fructus Lycii as on Chinese medicine product, wherein " book on Chinese herbal medicine converge with speech " to evaluation high especially, think that it has the advantage of tens kinds of Chinese medicines concurrently, claims it: " gas can be filled, and blood can be mended, Yang Kesheng, the moon can be grown, fire can fall, rheumatism can be gone "; Be mainly used in Liver and kidney two void, the soreness of the waist and knees of asthenia of essence and blood is had a dizzy spell, early whitening of beard and hair, visual deterioration, diseases such as sexual hypofunction; Modern pharmacological research confirms that Fructus Lycii has: 1, the effect of enhance immunity and conciliation immunity; 2, anti-cancer and inhibiting tumor effect; 3, remove harmful free radical in the body, fat-reducing liver-protecting effect; 4, hypoglycemic activity; 5, resisting fatigue and high temperature resistance effect; 6, strengthen the animal heart, cerebral tissue catalase, the activity of lactic acid dehydrogenase can make superoxide dismutase activity rising in the old human blood, and lipid peroxide content reduces, hematopoietic stem cell is strengthened, have the effect of defying age and stimulation animal growth; 7, promote the function of intelligence and improvement memory; 8, protection reproductive system effect; 9, antimutagenic effect etc.; The Fructus Lycii nature and flavor are gentle, have many useful value to promoting human physiological metabolism's function.
Radix Et Caulis Acanthopanacis Senticosi is a kind ofly can invigorating QI and tranquilization be arranged as the natural Chinese medicine of health food, the strong waist of kidney tonifying, and the effect of promoting blood circulation to remove obstruction in the collateral, ancient Chinese medicine is classified Radix Et Caulis Acanthopanacis Senticosi as on Chinese medicine product; Clinical be used for the treatment of insufficiency of the spleen weak, inappetence, deficiency of vital energy edema, shortness of breath and palpitation, the insomnia, dreaminess, forgetful, kidney deficiency and bodily weakness, soreness of the waist and knees, children's Chi Hang, thoracic obstruction pain, anemofrigid-damp arthralgia, diseases such as treating swelling and pain by traumatic injury; Modern pharmacological research confirms that Radix Et Caulis Acanthopanacis Senticosi has: 1, brain-strengthening, and Radix Et Caulis Acanthopanacis Senticosi is all influential with inhibition to the excitement of nervus centralis, can improve mental work efficient; 2, antioxidation, anti-aging effects; 3, anoxia enduring, anti-stress effect; 4, convulsion, antifatigue effect; 5, improve immunity, function of increasing leukocyte; 6, promote the sexual maturity effect; 7, promote the anabolic effect of protein and nucleic acid; 8, hypoglycemic activity; 9, influence energy metabolism, carbohydrate metabolism, lipid metabolism effect; 10, antitumor action; 11, function of resisting myocardial ischemia; 12, blood vessel dilating, the blood pressure regulation effect; 13, antiplatelet aggregation, anti thrombotic action; 14, anti-centrifugal, anti-radiation function; 15, antiinflammatory, detoxifcation, antibiotic, antivirus action etc.
Vitamin A also claims retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If vitamin A deficiency is prone to premature labor or fetal congenital deformity; Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C claims ascorbic acid again, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, the effect that purifies the blood in addition, prevent arteriosclerosis, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C easily has virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, wherein the activity of alpha-tocopherol is the highest, have the effect of eliminating free radical, slow down aging, prevention maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell hemolytic anemia and red blood cell life span shortening can take place also.
Calcium is the macroelement that body weight for humans is wanted, and mainly plays two aspects, the one, constitute sclerous tissueses such as bone tooth; The 2nd, constitute the material of specific function with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can influence the growth of its body constitution and fetus or infant, and calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Potassium participates in the metabolic activity of cell, for the normal activity of some enzyme provides suitable condition, its outstanding effect is to keep the normal irritability of myocardial cell, self-disciplining and conductivity, is regulating acid-base balance, keeps osmotic pressure and keeps the water balance aspect to play an important role; Hypokalemia and hyperkalemia all can produce severe impairment to human body, and the lighter can cause tired, irritated, and weight person can cause arrhythmia, even dead.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart in addition and is prevented and treated the function etc. of diabetes in addition.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; Anemia of pregnant woman's zinc deficiency can influence the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, Myoglobin, and the ingredient of cytochrome etc. participates in transporting and the Tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain ferrum in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is a free radical the most dangerous in the human body; Iron deficiency is common in infant, anemia of pregnant woman and wet nurse, causes iron deficiency anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends, and iron deficiency also can exert an influence to other system of human body; As the nervous system iron deficiency, can affect the nerves conduction and make the child occur that intelligence reduces and behavior disorder.
Chromium is a kind of essential trace element, has only trivalent chromium can be used for the supplement of chromium, and it can strengthen and promote the physiological action of insulin, and it can harden by prevention of arterial, and raise immunity promotes growth promoter; Scarce chromium can cause growth promoter to be stagnated, and quickens old and feeble.
Copper in human body mainly the form with the copper-containing metal enzyme play a role, participate in utilization, hemopoietic, phospholipid synthetic of ferrum, a series of metabolic processes such as collagenic connective tissue formation; The shortage of copper can cause collagen cross-linking obstacle in the connective tissue, heart disease and anemia, leukopenia, and arterial wall elasticity weakens, albinism etc.
Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of ferrum, promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RVA are synthetic.
Application contains the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese compatibility be used to interfere and prevention birth defect and the pharmaceutical composition that improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to interfere with the prevention birth defect as yet, rarely seen report that folic acid prevention neural tube defects is arranged; But its target spot is few, and the link shortcoming needs perfect.Do not see as yet and will interfere the effect of remembering with prevention birth defect and improvement and be used for same medicine person.
Summary of the invention: in order to overcome the shortcoming and defect of interfering with prevention birth defect and/or improvement memory medicine, the purpose of this invention is to provide a kind of compositions, said composition promotes the absorption and the utilization of vitamin, mineral by the Rhizoma Atractylodis Macrocephalae, and with Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, collaborative vitamin A, beta-carotene, the vitamin B of increasing of Radix Et Caulis Acanthopanacis Senticosi
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese improves memory and interferes effect with the prevention birth defect, passes through trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese and vitamin A, beta-carotene, vitamin B simultaneously
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi defying age, adjusting and enhance immunity, the intelligence that increases, mutation, antioxidation, antitumor, blood lipid-reducing blood sugar-decreasing, promotion developing womb, antiabortive leak-stopping, osteoporosis, liver and kidney tonifying, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, antifatigue effect are even chronic administration is also without any side effect; Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese novel combination, this novel combination has synergy for interfering with the prevention birth defect and improving memory; And singly use the Rhizoma Atractylodis Macrocephalae and Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity and physical strength reinforcing; Radix Dipsaci has the effect of liver and kidney tonifying, strengthening the tendons and bones, antiabortive leak-stopping; Herba Taxilli has wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the effect of antiabortive unit; The Cortex Eucommiae has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect; The Radix Astragali has the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, holder skin ulcer granulation promoting, diuretic detumescent; Fructus Lycii has liver and kidney tonifying, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight, the effect of nourishing the lung to arrest cough; Radix Et Caulis Acanthopanacis Senticosi has invigorating QI and tranquilization, the strong waist of kidney tonifying, and the effect of promoting blood circulation to remove obstruction in the collateral and brain-strengthening promote protein and the synthetic effect of nucleic acid; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element of enhance immunity vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace element-selenium acceleration bodies; Trace elements iron participates in transporting and the Tissue respiration process of the interior oxygen of body, is the only element that prevents iron deficiency anemia; Trace element chromium has prevention of arterial sclerosis, enhance immunity, antidotal function; Trace copper participates in utilization, hemopoietic, phospholipid synthetic of ferrum; Trace element molybdenum has anticancer, defying age, enhance immunity and anticariogenic function; Trace element manganese participates in the synthetic of protein, DNA and RNA; And for example vitamin A has the raising vision, prevents the effect of nyctalopia etc.; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; Vitamin D is regulated the metabolism of calcium and phosphorus; Macroelement potassium is kept the normal irritability of myocardial cell, self-disciplining and conductivity; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides and be used to interfere with the prevention birth defect and improve the pharmaceutical composition of memory, it comprises as the Rhizoma Atractylodis Macrocephalae of active component and Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese.
The Rhizoma Atractylodis Macrocephalae is a Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala koidz. rhizome, main product in Zhejiang, ground such as Hubei, Hunan, gather winter, dry or dry, give birth to or parching with earth, parched with bran use; The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Dipsacus asper Wall., ground such as main product Sichuan, Hubei, Hunan, Guizhou, and wild cultivating all has; The used Radix Dipsaci of the present invention can be with its extract as raw material.
The Herba Taxilli beginning is stated from " herbal classic ", and is parasitic on the original name Mulberry; Stem and branch with leaf for the evergreen undershrub Herba Taxilli of Loranthaceae Taxilluschinensis (DC.) Danser etc.; Ground such as main product Guangdong, Guangxi, Yunnan, the used Herba Taxilli of the present invention can be with its extract as raw material.
The Cortex Eucommiae is that the dry bark of Eucommiaceae deciduous tree plant Cortex Eucommiae Eucommia ulmoides Oliv. supplies to use, the Cortex Eucommiae is Chinese distinctive economic tree, be listed as China's one of three big famous medicines with Radix Ginseng, Cornu Cervi Pantotrichum, ground such as main product Sichuan, Guizhou, Yunnan, wild and cultivate and all have; The used Cortex Eucommiae of the present invention can be with its extract as raw material.
The Radix Astragali is that Radix Astragali (A.membranaceus) in the leguminous plant Astragalus (Astragalus spp) and Radix Astagali (A.m.var.mongholicus) are that the root of main plant 4-10 is for using; Mainly be distributed in areas such as China northeast, North China, northwest, also originate in ground such as Canada, India, the most famous with Radix Astagali, the Shanxi Radix Astragali is best in quality; The used Radix Astragali of the present invention can be with its extract as raw material.
Fructus Lycii is that the berry of Solanaceae machaka or dungarunga Fructus Lycii Lycium chinense Mill supplies to use; Ovalize spindle shape, dry finished product slightly is crushed, long 1.5-2cm, diameter 4-8mm, orange red to kermesinus, it is slightly sweet to distinguish the flavor of; Kind is more, and is big with lycium barbarum Lycium darbarum L. fruit, and matter is good to be celebrated; Be distributed in east Asia and Europe, all have all over China wild, more with ground such as Ningxia, Gansu, Qinghai, the Inner Mongol, Shaanxi cultivations; The used Fructus Lycii of the present invention can be with its extract as raw material.
Radix Et Caulis Acanthopanacis Senticosi is the dry root and rhizome of Araliaceae Radix Et Caulis Acanthopanacis Senticosi Acanthopanax senticosus (Rupr.Ef Maxim) Harms; Main product Heilungkiang, ground such as Jilin, Liaoning, Hebei, Shanxi, Shaanxi also produce, and cultivation all has with wild; The used Radix Et Caulis Acanthopanacis Senticosi of the present invention can be with its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), ferrum (Fe), chromium (Cr), copper (Cu), molybdenum (Mo) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element; Macroelement calcium among the present invention can be selected calcium acetate, calcium carbonate, calcium caseinate, calcium chloride, calcium citrate, calcium cirate malate, calcium gluconate, calcium lactate, calcium malate, calcium glycerophosphate etc. for use; Macroelement potassium can be selected potassium carbonate, dipotassium hydrogen phosphate, potassium chloride, potassium citrate, potassium gluconate, potassium lactate, potassium sulfate, potassium glycerinophosphate etc. for use; Macroelement magnesium can be selected magnesium carbonate, magnesium chloride, magnesium citrate, magnesium gluconate, magnesium lactate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate etc. for use; Trace element zinc can be selected zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc. for use; Trace element-selenium can be selected Selenomethionine, methoxybenzyl cyanic acid selenium, selenocarrageenan, selenocysteine, selenizing methionine, the two cyanic acid selenium of phenylene, sodium selenite, sodium selenate etc. for use; Trace elements iron can be selected Ferrous gluconate, ferrous lactate, ferric ammonium citrate, iron chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric phrophosphate, protohemin, ferrous succinate, ferrous sulfate etc. for use; Trace element chromium can be selected chromium trichloride, nicotinic acid chromium, chromium picolinate, chromium yeast etc. for use; Trace copper can be selected curpic carbonate, copper citrate, copper gluconate, copper sulfate etc. for use; Trace element molybdenum can be selected ammonium molybdate, sodium molybdate etc. for use; Trace element manganese can be selected manganese sulfate, manganese chloride, manganese gluconate, manganese glycerophosphate, manganese citrate etc. for use; Professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, the effective dose of Radix Dipsaci extract is counted 500-10000mg/ days with whole crude drug, the effective dose of Herba Taxilli extract is counted 500-10000mg/ days with whole crude drug, the effective dose of Cortex Eucommiae extract is counted 500-10000mg/ days with whole crude drug, the effective dose of Radix Astragali extract is counted 500-10000mg/ days with whole crude drug, the effective dose of Fructus Lycii extract is counted 500-10000mg/ days with whole crude drug, the effective dose of Radix Et Caulis Acanthopanacis Senticosi extract is counted 500-10000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of macroelement calcium is counted 250-1000mg with element calcium, the effective dose of potassium is counted 600-1200mg with element potassium, the effective dose of magnesium is counted 100-300mg with element magnesium, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of ferrum is counted 5-20mg/ days with elemental iron, the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum, and the effective dose of manganese is counted 1-3mg/ days with element manganese.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Dipsaci, Herba Taxilli, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, to interfering with the prevention birth defect and improving memory significant effect is arranged, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, except that interfering with the prevention birth defect and improving the memory, human body still there is the health care benefiting action.
Subordinate list 1 is this compositions and the Rhizoma Atractylodis Macrocephalae and the Rhizoma Atractylodis Macrocephalae and Radix Dipsaci component and vitamin component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this compositions and the Rhizoma Atractylodis Macrocephalae and the Rhizoma Atractylodis Macrocephalae and Radix Dipsaci component and vitamin component and the comparison of vitamin added elements component Aged Mice maze test effect.
Annotate: in this combination of Chinese medicine part, the Rhizoma Atractylodis Macrocephalae is a monarch drug, and Radix Dipsaci is a ministerial drug, and other Chinese medicine of respectively distinguishing the flavor of is to help, make it medicine on effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 12000mg,
Folic acid 0.4mg,
Vitamin B
68mg,
Vitamin B
120.02mg,
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 5000mg,
Radix Dipsaci 1000mg,
Herba Taxilli 2000mg,
Folic acid 0.3mg,
Vitamin B
65mg,
Vitamin B
120.005mg,
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 12000mg,
Radix Dipsaci 8000mg,
Cortex Eucommiae 5000mg,
Folic acid 0.35mg,
Vitamin B
63mg,
Vitamin B
120.008mg,
Earlier folic acid is coated with microcapsule, with starch, the polyvinyl pyrrolidone of other each component and appropriate amount, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9 again; Every day 3 times, each 3.
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 8000mg,
Radix Dipsaci 6000mg,
Herba Taxilli 3000mg,
Cortex Eucommiae 5000mg,
Folic acid 0.5mg,
Vitamin B
65mg,
Vitamin B
120.008mg,
Earlier folic acid is coated with microcapsule, with starch, the polyvinyl pyrrolidone of other each component and appropriate amount, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9 again; Every day 3 times, each 3.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 8000mg,
Radix Dipsaci 6000mg,
Herba Taxilli 3000mg,
Fructus Lycii 5000mg,
Folic acid
Vitamin B
60.45mg,
Vitamin B
126mg,
0.01mg，
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Rhizoma Atractylodis Macrocephalae 12000mg,
Radix Dipsaci 8000mg,
Herba Taxilli 8000mg,
Radix Astragali 6000mg,
Folic acid 0.5mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 7:
Rhizoma Atractylodis Macrocephalae 12000mg,
Radix Dipsaci 8000mg,
Herba Taxilli 8000mg,
Radix Et Caulis Acanthopanacis Senticosi 6000mg,
Folic acid 0.6mg,
Vitamin B
68mg,
Vitamin B
120.02mg,
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 7 days, withdrew 3 days, obeyed again 7 days.
Embodiment 8:
Rhizoma Atractylodis Macrocephalae 500mg,
Radix Dipsaci 500mg,
Herba Taxilli 500mg,
Radix Astragali 500mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Calcium 250mg,
Potassium 600mg,
Magnesium 100mg,
Zinc 5mg,
Selenium 0.015mg,
Ferrum 5mg,
Chromium 0.015mg,
Copper 0.5mg,
Molybdenum 0.02mg,
Manganese 1mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250 μ gRE,
Vitamin D 0.0015mg,
Vitamin E 5mg a-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 9:
Rhizoma Atractylodis Macrocephalae 500mg,
Radix Dipsaci 500mg,
Herba Taxilli 500mg,
Cortex Eucommiae 500mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Calcium 250mg,
Potassium 600mg,
Magnesium 100mg,
Zinc 5mg,
Selenium 0.015mg,
Ferrum 5mg,
Chromium 0.015mg,
Copper 0.5mg,
Molybdenum 0.02mg,
Manganese 1mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250 μ gRE,
Vitamin D 0.0015mg,
Vitamin E 5mg a-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 10:
Rhizoma Atractylodis Macrocephalae 500mg,
Radix Dipsaci 500mg,
Herba Taxilli 500mg,
Fructus Lycii 500mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Calcium 250mg,
Potassium 600mg,
Magnesium 100mg,
Zinc 5mg,
Selenium 0.015mg,
Ferrum 5mg,
Chromium 0.015mg,
Copper 0.5mg,
Molybdenum 0.02mg,
Manganese 1mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250 μ gRE,
Vitamin D 0.0015mg,
Vitamin E 5mg a-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 11:
Rhizoma Atractylodis Macrocephalae 500mg,
Radix Dipsaci 500mg,
Cortex Eucommiae 500mg,
Radix Astragali 500mg,
Radix Et Caulis Acanthopanacis Senticosi 500mg,
Herba Taxilli 500mg,
Fructus Lycii 500mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Calcium 250mg,
Potassium 600mg,
Magnesium 100mg,
Zinc 5mg,
Selenium 0.015mg,
Ferrum 5mg,
Chromium 0.015mg,
Copper 0.5mg,
Molybdenum 0.02mg,
Manganese 1mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250 μ gRE,
Vitamin D 0.0015mg,
Vitamin E 5mg a-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 12:
Rhizoma Atractylodis Macrocephalae 15000mg,
Radix Dipsaci 10000mg,
Cortex Eucommiae 10000mg,
Radix Astragali 10000mg,
Radix Et Caulis Acanthopanacis Senticosi 10000mg,
Herba Taxilli 10000mg,
Fructus Lycii 10000mg,
Folic acid 0.8mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Vitamin B
120mg,
Vitamin B
220mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Calcium 1000mg,
Potassium 1200mg,
Magnesium 300mg,
Zinc 20mg,
Selenium 0.1mg,
Ferrum 20mg,
Chromium 0.15mg,
Copper 1.5mg,
Molybdenum 0.06mg,
Manganese 3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 800 μ gRE,
Vitamin D 0.01mg,
Vitamin E 150mg a-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 7 days, withdrew 10 days, obeyed again 7 days.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: be this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Dipsaci component and vitamin component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | ??0 | ??12 | ??21.6％ |
| The B group | Rhizoma Atractylodis Macrocephalae group | Rhizoma Atractylodis Macrocephalae 100mg | ??12 | ??18.9％ |
| The C group | The Rhizoma Atractylodis Macrocephalae+Radix Dipsaci group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Dipsaci 50mg/ days | ??12 | ??18.1％ |
| The D group | Folic acid+VB 6+VB 12Group | Folic acid 0.008mg+VB 60.08mg+??VB 120.0001mg | ??12 | ??17.8％ |
| The E group | The Rhizoma Atractylodis Macrocephalae+folic acid+VB 6+??VB 12Group | Rhizoma Atractylodis Macrocephalae 100mg+ folic acid 0.008mg+ VB 60.08mg+VB 120.0001mg | ??12 | ??15.3％ |
| The F group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ selenium 0.001mg+ ferrum 0.1mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | ??12 | ??16％ |
| The G group | The Rhizoma Atractylodis Macrocephalae+Radix Dipsaci+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Dipsaci 50mg+ calcium 10mg+ magnesium 5mg+ zinc 0.1mg+0.1mg+ selenium 0.001mg+ ferrum 0.1mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | ??12 | ??14.6％ |
Subordinate list 2: be this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Dipsaci component and vitamin component and the comparison of vitamin added elements component Aged Mice maze test effect:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | ??0 | ??12 | ??53.3％ |
| The B group | Rhizoma Atractylodis Macrocephalae group | Rhizoma Atractylodis Macrocephalae 100mg | ??12 | ??39.6％ |
| The C group | The Rhizoma Atractylodis Macrocephalae+Radix Dipsaci group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Dipsaci 50mg/ days | ??12 | ??36％ |
| The D group | Folic acid+VB 6+VB 12Group | Folic acid 0.008mg+VB 60.08mg+??VB 120.0001mg | ??12 | ??38.3％ |
| The E group | The Rhizoma Atractylodis Macrocephalae+folic acid+VB 6+??VB 12Group | Rhizoma Atractylodis Macrocephalae 100mg+ folic acid 0.008mg+ VB 60.08mg+VB 120.0001mg | ??12 | ??32％ |
| The F group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ selenium 0.001mg+ ferrum 0.1mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | ??12 | ??30％ |
| The G group | The Rhizoma Atractylodis Macrocephalae+Radix Dipsaci+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Dipsaci 50mg+ calcium 10mg+ magnesium 5mg+ zinc 0.1mg+0.1mg+ selenium 0.001mg+ ferrum 0.1mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | ??12 | ??29.5％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due; With associated materials statistics contrasts, birth defect youngster accounts for the 4-6% of newborn population sum, and there were significant differences.
Can obviously find out from table 1, table 2, this compositions is by the Chinese medicine component in rat/mouse labyrinth test and the compositions and vitamin component and the contrast of vitamin added elements component, the statistical result of mistake percentage rate, the function of this composition for improved memory is better than Chinese medicine component or vitamin component and vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (10)
1. one kind is used to interfere the pharmaceutical composition of remembering with prevention birth defect and improvement, it is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 0-10000mg,
Herba Taxilli 0-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
2. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
3. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 0-10000mg,
Cortex Eucommiae 500-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
4. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 500-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
5. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 500-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
6. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 500-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
7. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 500-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 0-1000mg,
Potassium 0-1200mg,
Magnesium 0-300mg,
Zinc 0-20mg,
Selenium 0-0.1mg,
Ferrum 0-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
8. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 500-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Potassium 600-1200mg,
Magnesium 100-300mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 1-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
9. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 500-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 0-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Potassium 600-1200mg,
Magnesium 100-300mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 1-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
10. the pharmaceutical composition that is used to interfere and prevents birth defect and improvement memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Dipsaci 500-10000mg,
Herba Taxilli 500-10000mg,
Cortex Eucommiae 0-10000mg,
Radix Astragali 0-10000mg,
Fructus Lycii 500-10000mg,
Radix Et Caulis Acanthopanacis Senticosi 0-10000mg,
Folic acid 0.1-0.8mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Potassium 600-1200mg,
Magnesium 100-300mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Manganese 1-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010122961 CN101791354A (en) | 2009-03-13 | 2010-03-12 | Medicine composition used for interfering in and preventing birth defects and improving memory |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910079619.5 | 2009-03-13 | ||
| CN 201010122961 CN101791354A (en) | 2009-03-13 | 2010-03-12 | Medicine composition used for interfering in and preventing birth defects and improving memory |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010122961 Pending CN101791354A (en) | 2009-03-13 | 2010-03-12 | Medicine composition used for interfering in and preventing birth defects and improving memory |
Country Status (1)
| Country | Link |
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| CN (1) | CN101791354A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150861A (en) * | 2011-02-15 | 2011-08-17 | 辽宁盛生医药集团有限公司 | Nutritional supplement with functions of oxidation resistance and fatigue resistance |
| CN112998262A (en) * | 2021-01-12 | 2021-06-22 | 广东金海康医学营养品股份有限公司 | Pregnant woman and lactating woman nutrition supplement food formula |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101274006A (en) * | 2008-05-21 | 2008-10-01 | 北京冠五洲生物科学研究院 | Pharmaceutical combination of prepotency for preventing birth-defect and improving memory |
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2010
- 2010-03-12 CN CN 201010122961 patent/CN101791354A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101274006A (en) * | 2008-05-21 | 2008-10-01 | 北京冠五洲生物科学研究院 | Pharmaceutical combination of prepotency for preventing birth-defect and improving memory |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150861A (en) * | 2011-02-15 | 2011-08-17 | 辽宁盛生医药集团有限公司 | Nutritional supplement with functions of oxidation resistance and fatigue resistance |
| CN112998262A (en) * | 2021-01-12 | 2021-06-22 | 广东金海康医学营养品股份有限公司 | Pregnant woman and lactating woman nutrition supplement food formula |
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Application publication date: 20100804 |