CN101396411A - Medicine composition for prenatal and postnatal care and preventing the birth defect and improving the memory - Google Patents
Medicine composition for prenatal and postnatal care and preventing the birth defect and improving the memory Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for preventing birth defects and improving memory for healthy birth and sound care, the composition comprises largehead atractylodes rhizome, ginseng, vitamin A, Beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and trace elements of zinc, selenium, iron, chromium, copper, molybdenum, iodine and manganese, the composition is mainly applicable to pre-pregnancy women, pregnant women and lactating mothers and can effectively prevent the birth defects and improve the memory for the healthy birth and the sound care; furthermore, the composition has the effects of health care and invigoration and does not have any side effects even in long-term application.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for prenatal and postnatal care prevention birth defect and improvement memory.
Background technology: birth defect is meant that fetus is in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprise that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese.
The Rhizoma Atractylodis Macrocephalae is a kind of QI invigorating class natural Chinese medicine, and invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, the edema spontaneous perspiration, frequent fetal movement etc., modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor.Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae with the absorption, particularly compatibility gold that promote the medicine active ingredient, stone class medicine to promote the absorption and the utilization of mineral; The Rhizoma Atractylodis Macrocephalae is the article that can be used for health food.
Radix Ginseng is a kind ofly can strongly invigorating primordial QI be arranged as the QI invigorating class natural Chinese medicine of health food, invigorating the spleen to benefit the lung, and promoting the production of body fluid to quench thirst, calming the nerves increases the effect of intelligence; The clinical deficiency of vital energy that is used for the treatment of is desired to take off, the faint pulse being about to disappear card; Temper is lost deficiency syndrome, the insufficiency of lung-QI card; The thirsty card of gas Tianjin two wounds, diabete; QI and blood is two loses, and expression is lost and supported all cards; Blood deficiency and yellow complexion, diseases such as sexual impotence; With induce sweat, the same usefulness of the medicine that uncharms such as dispelling pathogen in the interior, but strengthening body resistance and dispelling evil; Modern pharmacological research confirms that Radix Ginseng has: 1, strengthen central excitation and process of inhibition, and obvious with excitation especially; 2, improve learning and memory function, improve the effect of mental work work efficiency; 3, blood vessel dilating effect; 4, cardiotonic; 5, anti-scheming ischemia effect; 6, Antishock function; 7, improve hemorheological every index, hemopoietic; 8, excited hypothalamus-hypophysis-gonad axis effect; 9, excited hypothalamus-hypophysis-adrenal cortex axle effect; 10, the dicyclic ring thuja acid there is dual regulation; 11, promotion and conciliation immunologic function; 12, promote protein and nucleic acid anabolic effect; 13, reconcile carbohydrate metabolism and lipid metabolism effect; 14, delaying senility function; 15, hepatoprotective effect; 16, antitumor action; 17, antimutagenic effect; 18, anti-stress effect; 19, antifatigue effect; 20, antibacterial action; 21, anastalsis etc.
Vitamin A also claims retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If vitamin A deficiency is prone to premature labor or fetal congenital deformity; Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C claims ascorbic acid again, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, the effect that purifies the blood in addition, prevent arteriosclerosis, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C easily has virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, wherein the activity of alpha-tocopherol is the highest, have the effect of eliminating free radical, slow down aging, prevention maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell hemolytic anemia and red blood cell life span shortening can take place also.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; Anemia of pregnant woman's zinc deficiency can influence the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, Myoglobin, and the ingredient of cytochrome etc. participates in transporting and the Tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain ferrum in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is a free radical the most dangerous in the human body; Iron deficiency is common in infant, anemia of pregnant woman and wet nurse, causes iron deficiency anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends, and iron deficiency also can exert an influence to other system of human body; As the nervous system iron deficiency, can affect the nerves conduction and make the child occur that intelligence reduces and behavior disorder.
Chromium is a kind of essential trace element, has only trivalent chromium can be used for the supplement of chromium, and it can strengthen and promote the physiological action of insulin, and it can harden by prevention of arterial, and raise immunity promotes growth promoter; Scarce chromium can cause growth promoter to be stagnated, and quickens old and feeble.
Copper in human body mainly the form with the copper-containing metal enzyme play a role, participate in utilization, hemopoietic, phospholipid synthetic of ferrum, a series of metabolic processes such as collagenic connective tissue formation; The shortage of copper can cause collagen cross-linking obstacle in the connective tissue, heart disease and anemia, leukopenia, and arterial wall elasticity weakens, albinism etc.
Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of ferrum, promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Iodine is the main synthetic thyroid element that participates in human body, and thyroxinic physiological function is to regulate the organism metabolism level, influences the generation of body heat energy, blood glucose and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause thyromegaly, and fetus and neonate iodine deficiency can cause deaf and dumb, dull-witted, of short and small stature, spastic paralysis, mental retardation, microcephaly in various degree, and low set ears etc. are disease seriously.
Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RVA are synthetic.
Application contains the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, the manganese compatibility pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention neural tube defects is arranged; But its target spot is few, and the link shortcoming needs perfect.And prenatal and postnatal care is prevented the effect of birth defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention: in order to overcome existing prenatal and postnatal care prevention birth defect and/or to improve the shortcoming and defect of remembering medicine, the purpose of this invention is to provide a kind of compositions, said composition promotes the absorption and the utilization of vitamin, mineral by the Rhizoma Atractylodis Macrocephalae, and with collaborative vitamin A, beta-carotene, the vitamin B of increasing of Radix Ginseng
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese improves the effect of memory and prevention birth defect, simultaneously by trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and improve learning and memory, promotion and conciliation immunity with Radix Ginseng, promote protein and nucleic acid is synthetic, the effect of conciliation carbohydrate metabolism and lipid metabolism, slow down aging, antitumor, mutation, even chronic administration is also without any side effect; Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and Radix Ginseng, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese novel combination, this novel combination is for prenatal and postnatal care prevention birth defect and improve memory synergy is arranged; And singly use the Rhizoma Atractylodis Macrocephalae and Radix Ginseng, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity and physical strength reinforcing; Radix Ginseng has strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, calming the nerves increases the effect of intelligence; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element of enhance immunity vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace element-selenium acceleration bodies; Trace elements iron participates in transporting and the Tissue respiration process of the interior oxygen of body, is the only element that prevents iron deficiency anemia; Trace element chromium has prevention of arterial sclerosis, enhance immunity, antidotal function; Trace copper participates in utilization, hemopoietic, phospholipid synthetic of ferrum; Trace element molybdenum has anticancer, defying age, enhance immunity and anticariogenic function; Trace iodine can be prevented and treated the goiter that iodine deficiency causes, can prevent fetus and neonate iodine deficiency to cause serious maldevelopment such as cretinism, mental retardation; Trace element manganese participates in the synthetic of protein, DNA and RNA; And for example vitamin A has the raising vision, prevents the effect of nyctalopia etc.; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; Vitamin D is regulated the metabolism of calcium and phosphorus.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory, it comprises as the Rhizoma Atractylodis Macrocephalae of active component and Radix Ginseng, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese.
The Rhizoma Atractylodis Macrocephalae is a Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala koidz. rhizome, main product in Zhejiang, ground such as Hubei, Hunan, gather winter, dry or dry, give birth to or parching with earth, parched with bran use; The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Radix Ginseng is the dry root of Araliaceae herbaceos perennial Radix Ginseng Panax ginseng C.A.Mey.; The grower is " Park Ginseng ", and wild survivor is " SHANSHEN "; Main product in Jilin, Liaoning, Heilungkiang and the Korea peninsula of China, ground such as former Soviet Union thing Berli Asia; Prove that after deliberation Radix Ginseng stem, leaf, flower, fruit all contain and the similar saponin component of Radix Ginseng, have similar pharmacological action to Radix Ginseng, the clinical Radix Ginseng that substitutes is widely used in diseases such as coronary heart disease, hyperlipidemia, diabetes, tumor; Commercially available Folium Ginseng mostly is the leaf of Araliaceae panax japonicus c.a.mey.var.major (burk.) c.y.wu et k.m.feng, and flavor efficacy is similar to Radix Ginseng; The used Radix Ginseng of the present invention can be with its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), ferrum (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element; Trace element zinc among the present invention can be selected zinc citrate for use, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine for use, methoxybenzyl cyanic acid selenium, selenocarrageenan, selenocysteine, the selenizing methionine, the two cyanic acid selenium of phenylene, sodium selenite, sodium selenate etc., trace elements iron can be selected Ferrous gluconate for use, ferrous lactate, ferric ammonium citrate, iron chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric phrophosphate, protohemin, ferrous succinate, ferrous sulfate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, chromium yeast etc., trace copper can be selected curpic carbonate for use, copper citrate, copper gluconate, copper sulfate etc., trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc., trace iodine can be selected potassium iodate etc. for use, trace element manganese can be selected manganese sulfate for use, manganese chloride, manganese gluconate, manganese glycerophosphate, manganese citrates etc. all have professional production factory and supplier.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 300-15000mg/ days with whole crude drug, and the effective dose of Radix Ginseng extract is counted 100-3000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, and the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of ferrum is counted 5-20mg/ days with elemental iron, the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum, the effective dose of iodine is counted 0.05-0.2mg/ days with elemental iodine, and the effective dose of manganese is counted 1-3mg/ days with element manganese.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, prevention birth defect and improvement memory there is significant effect, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, except that prevention birth defect and improvement memory, human body still there is the health care benefiting action.
Subordinate list 1 is this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Ginseng component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Ginseng component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ginseng 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ginseng 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ginseng 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ginseng 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Manganese citrate (in trace element manganese) 1mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 300mg,
Radix Ginseng 100mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 5mg,
Sodium selenate (in trace element-selenium) 0.015mg,
Ferric citrate (in trace elements iron) 5mg,
Potassium iodate (in trace iodine) 0.05mg,
Chromium yeast (in trace element chromium) 0.015mg,
Copper citrate (in trace copper) 0.5mg,
Sodium molybdate (in trace element molybdenum) 0.02mg,
Manganese citrate (in trace element manganese) 1mg,
Retinol equivalent (vitamin A and/or beta-carotene) 250 μ g RE,
Vitamin D 0.0015mg,
Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Rhizoma Atractylodis Macrocephalae 15000mg,
Radix Ginseng 3000mg,
Folic acid 1mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Vitamin B
120mg,
Vitamin B
220mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Zinc lactate (in trace element zinc) 20mg,
Sodium selenate (in trace element-selenium) 0.1mg,
Ferric citrate (in trace elements iron) 20mg,
Potassium iodate (in trace iodine) 0.2mg,
Chromium yeast (in trace element chromium) 0.15mg,
Copper citrate (in trace copper) 1.5mg,
Sodium molybdate (in trace element molybdenum) 0.06mg,
Manganese citrate (in trace element manganese) 3mg,
Retinol equivalent (vitamin A and/or beta-carotene) 800 μ g RE,
Vitamin D 0.01mg,
Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 3, withdrew 5, obeyed again 3.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: be this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Ginseng component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Ginseng group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Ginseng 15mg/ days | 12 | 18.2％ |
| The C group | Vitamin+element set | Zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 15.3％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Ginseng+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Ginseng 15mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 13.9％ |
Subordinate list 2: be this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Ginseng component and the comparison of vitamin added elements component Aged Mice maze test effect:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Ginseng group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Ginseng 15mg/ days | 12 | 33.9％ |
| The C group | Vitamin+element set | Zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 31％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Ginseng+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Ginseng 15mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 28.2％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due; With associated materials statistics contrasts, birth defect youngster account for the newborn population sum 4-6% there were significant differences.
Can obviously find out from table 1, table 2, this compositions is by Chinese medicine component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component, the statistical result of mistake percentage rate, the function of this composition for improved memory is better than Chinese medicine component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1, a kind of pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Ginseng 100-3000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0-0.15mg,
Copper 0-1.5mg,
Molybdenum 0-0.06mg,
Iodine 0.05-0.2mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
2, the pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Ginseng 100-3000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
3, the pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Ginseng 100-3000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 0-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
4, the pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Ginseng 100-3000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 1-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
5, the pharmaceutical composition that is used for prenatal and postnatal care prevention birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Ginseng 100-3000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Chromium 0.015-0.15mg,
Copper 0.5-1.5mg,
Molybdenum 0.02-0.06mg,
Iodine 0.05-0.2mg,
Manganese 1-3mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
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