CN101375906B - Pharmaceutical combination for preventing birth-defect and improving memory - Google Patents
Pharmaceutical combination for preventing birth-defect and improving memory Download PDFInfo
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- CN101375906B CN101375906B CN2008102231753A CN200810223175A CN101375906B CN 101375906 B CN101375906 B CN 101375906B CN 2008102231753 A CN2008102231753 A CN 2008102231753A CN 200810223175 A CN200810223175 A CN 200810223175A CN 101375906 B CN101375906 B CN 101375906B
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Abstract
A medicament combination used for preventing birth defects and improving memory comprises Atractylodes rhizome, radix codonopsitis, vitamin A, beta-carotene, vitamin B complex, vitamin C, vitamin D, vitamin E, as well as major elements of calcium, potassium and magnesium and trace elements of zinc, selenium, iron, chromium, copper, molybdenum, iodine and manganese. The medicament combination is mainly suitable for pregestational women, pregnant women and nursing mothers, and is very effective in preventing the birth defects and improving the memory. Meanwhile, the medication combination has healthcare and nutritional efficacies, and causes no side effect even after long-term administration.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field; In particular for prevention birth defect and the pharmaceutical composition that improves memory.
Background technology: birth defect is meant that fetus is in parent and in the organ formative process of birth back; Disorderly by the embryo due to the various factors effect and paedomorphosis, comprise that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo receives the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care; Through eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate; Simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese.
The Rhizoma Atractylodis Macrocephalae is a kind ofly can invigorating the spleen and benefiting QI be arranged as the QI invigorating class natural Chinese medicine of health food, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine article, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein; Can alleviate lipid peroxidation; Reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function, and SOD activity improving trend is arranged; Enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, and Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly removes free radical, shows anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell; And external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis; Chromatin concentrates, and cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor; The compatibility Rhizoma Atractylodis Macrocephalae is to promote the absorption of medicine active ingredient in prescription for traditional Chinese medical science custom, and particularly compatibility gold, stone class medicine are to promote the absorption and the utilization of mineral.
Radix Codonopsis is a kind ofly can invigorating the spleen and replenishing QI be arranged, the effect of promoting the production of body fluid and nourishing blood as the deficiency tonifying kind natural Chinese medicine of health food; Clinically be used to treat deficiency of QI in middle-JIAO, lung qi loses empty, gas Tianjin two void, and blood deficiency or QI and blood be two disease such as to lose; With induce sweat, the same usefulness of dispelling pathogen in the interior medicine, set upright with eliminating evil; Modern pharmacological research confirms that Radix Codonopsis has: 1, strong effect, and Radix Codonopsis ability resisting fatigue and raising heat-resisting ability have two-way conciliation effect to excited and inhibition; 2, hypermnesis effect; 3, anti-aging effects; The enhance SOD activity effect; 4, radioprotective, resisting oxygen lack; 5, raise immunity; 6, reconcile gastrointestinal motility, improve digestive function; The effect of anti-gastric-ulcer stomach function regulating mucosa injury; 7, effects such as heart tonifying, expansion peripheral blood vessel, resisting myocardial ischemia, adjust blood pressure, inhibition thrombosis; 8, increase erythrocyte, hemoglobin and leukocytic effect; 9, antitumaous effect etc.
Vitamin A is also claimed retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If VAD is prone to premature labor or fetal congenital deformity.Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group is participated in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the necessary energy of brain cell activity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide is claimed niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes in all kinds of biochemical reaction of catalysis body, all to need pantothenic acid to participate in, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose metabolism that is synthetic and fatty and sugar; To hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect; It is the necessary vitamin of intelligence of bringing into normal play; Not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid is participated in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is a neurotransmitter important in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and NTD; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C is claimed ascorbic acid again, and vitamin C and collagen in close relations not only has the vessel softening effect; The effect that purifies the blood in addition; Prevent arteriosclerosis, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food; Simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C is prone to have virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, and function is consistent, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption; The then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child; Become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest.Have the effect of eliminating free radical, slow down aging, prevention maxicell property hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell property hemolytic anemia and red blood cell life span shortening can take place also.
Calcium is the macroelement that body weight for humans is wanted; Main two aspects that play a part; The one, constitute sclerous tissueses such as bone tooth; The 2nd, constitute the material of specific function with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can influence the growth of its body constitution and fetus or infant, and calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Potassium is participated in the metabolic activity of cell; For the normal activity of some enzyme provides suitable condition; Its outstanding effect is to keep the normal irritability of myocardial cell, self-disciplining and conductivity, is regulating acid-base balance, keeps osmotic pressure and keeps the water balance aspect to play an important role; Hypokalemia and hyperkalemia all can produce severe impairment to human body, and the lighter can cause tired, irritated, and weight person can cause arrhythmia, even dead.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another of magnesium function is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart and the function etc. of preventing and treating diabetes in addition in addition.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein); Generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc.; At present; Known these materials are participated in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin through activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; Anemia of pregnant woman's zinc deficiency can influence the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and MDA, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo does not receive the injury of superoxides, prevention of cardiac; Anticancer through enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, MG Myoglobin HMYO, and the ingredient of cytochrome etc. is participated in transporting and the Tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain ferrum in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is a free radical the most dangerous in the human body; Iron deficiency is common in infant, anemia of pregnant woman and wet nurse, causes iron deficiency anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends, and iron deficiency also can exert an influence to other system of human body; Like the nervous system iron deficiency, can affect the nerves conduction and make the child occur that intelligence reduces and behavior disorder.
Chromium is a kind of essential trace element, has only trivalent chromium can be used for the supplement of chromium, and it can strengthen and promote the physiological action of insulin, and it can harden by prevention of arterial, and raise immunity promotes growth promoter; Scarce chromium can cause growth promoter to be stagnated, and quickens old and feeble.
Copper mainly plays a role with the form of copper-containing metal enzyme in human body, participates in utilization, hemopoietic, phospholipid synthetic of ferrum, a series of metabolic processes such as collagenic connective tissue formation; The shortage of copper can cause collagen cross-linking obstacle in the connective tissue, heart disease and anemia, leukopenia, and arterial wall elasticity weakens, albinism etc.
Molybdenum is one of micro elements needed by human, and it is the formation element of plurality of enzymes, participates in the utilization of ferrum; Promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat; It participates in removing the murder by poisoning of poisonous aldehydes in the human body; Eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Iodine main synthetic thyroid of participating in human body is plain, and thyroxinic physiological function is to regulate the organism metabolism level, influences the generation of body heat energy, blood glucose and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause thyromegaly, and fetus and neonate iodine deficiency can cause deaf and dumb, dull-witted, of short and small stature, spastic paralysis, mental retardation, microcephaly in various degree.Serious disease such as low set ears.
Manganese is participated in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and in protein, DNA and RVA are synthetic, all works.
Application contains the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese compatibility be used to prevent birth defect and the pharmaceutical composition that improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention NTD is arranged; But its target spot is few, and the link shortcoming needs perfect.And will prevent the effect of birth defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention: in order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine; The purpose of this invention is to provide a kind of compositions; Said composition is passed through absorption and the utilization that the Rhizoma Atractylodis Macrocephalae promotes vitamin, mineral, and works in coordination with increase vitamin A, beta-carotene, vitamin B with Radix Codonopsis
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese improves the effect of memory and prevention birth defect, simultaneously through macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the effect of the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and Radix Codonopsis hypermnesis, antioxidation, defying age, enhance immunity, antitumor, hypoglycemic; Even chronic administration also has no side effect.Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese novel combination, this novel combination for the prevention birth defect with improve memory synergy arranged; And single with the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis and vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity and physical strength reinforcing; Radix Codonopsis has invigorating the spleen and replenishing QI, the effect that nourishes blood of promoting the production of body fluid and the effect of hypermnesis; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element of enhance immunity vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace element-selenium acceleration bodies; Trace elements iron is participated in transporting and the Tissue respiration process of the interior oxygen of body, is the only element that prevents iron deficiency anemia; Trace element chromium has prevention of arterial sclerosis, enhance immunity, antidotal function; Trace copper is participated in utilization, hemopoietic, phospholipid synthetic of ferrum; Trace element molybdenum has anticancer, defying age, enhance immunity and anticariogenic function; Trace iodine can be prevented and treated the goiter that iodine deficiency causes, can prevent fetus and neonate iodine deficiency to cause serious maldevelopment such as cretinism, mental retardation; Trace element manganese is participated in the synthetic of protein, DNA and RNA; And for example vitamin A has the raising vision, prevents the effect of nyctalopia etc.; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, and prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; Macroelement potassium is kept the normal irritability of myocardial cell, self-disciplining and conductivity; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the pharmaceutical composition that is used to prevent birth defect and improves memory, it comprises the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis and vitamin A, beta-carotene, vitamin B as active component
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can use its extract as raw material.
Radix Codonopsis is campanulaceae herbaceos perennial Radix Codonopsis (dry root of Codnhopsis pilosula (Franch) Nannf., wild or cultivation; Ground such as main product Shanxi, Shaanxi, Gansu, northeast; The used Radix Codonopsis of the present invention can use its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (BetaCarotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), ferrum (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element, and calcium (Ca), potassium (K), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate etc. for use; Macroelement potassium can be selected potassium carbonate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium gluconate, potassium sulfate, POTASSIUM GLYCEROPHOSPHATE, potassium lactate etc. for use; Macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium carbonate etc. for use; Trace element zinc can be selected zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc. for use; Trace element-selenium can be selected Selenomethionine, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenocarrageenan, selenocysteine, selenizing methionine, sodium selenate etc. for use; Trace elements iron can be selected Ferrous gluconate, ferrous lactate, ferric ammonium citrate, iron chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric phrophosphate, protohemin, ferrous succinate, ferrous sulfate etc. for use; Trace element chromium can be selected chromium trichloride, nicotinic acid chromium, chromium picolinate, chromium yeast etc. for use; Trace copper can be selected curpic carbonate, copper citrate, copper gluconate, copper sulfate etc. for use; Trace element molybdenum can be selected ammonium molybdate, sodium molybdate etc. for use; Trace iodine can be selected potassium iodate etc. for use; Trace element manganese can be selected manganese sulfate, manganese gluconate, manganese glycerophosphate, manganese chloride, manganese citrate etc. for use, and professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Receive the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 300-15000mg/ days with whole crude drug, and the effective dose of Radix Codonopsis extract is counted 300-10000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days; The effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days; The effective dose of macroelement calcium is counted 250-1000mg/ days with element calcium; The effective dose of potassium is counted 200-1200mg/ days with element potassium, and the effective dose of magnesium is counted 100-300mg/ days with element magnesium, and the effective dose of trace element zinc is counted 5-20mg/ days with element zinc; Selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, and the effective dose of ferrum is counted 5-20mg/ days with elemental iron.The effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium; The effective dose of copper is counted 0.5-1.5mg/ days with elemental copper; Molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum; The effective dose of iodine is counted 0.05-0.2mg/ days with elemental iodine, and the effective dose of manganese is counted 1-3mg/ days with element manganese.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser; For example; Oral formulations (like granule, powder, capsule, ball, sheet, dry syrup, liquid formulation); Or food such as food (like cookies); Mix and prepare with other known additives; This type additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, coating agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. prepare or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese each component can distinguish preparation, can the preparation of each component be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, and the effect of collaborative performance effect is arranged between the each component, to preventing birth defect and improving memory significant effect is arranged; Sufficient raw; Cost is low, and each component has no side effect in the compositions, no incompatibility; Except that prevention birth defect and improvement are remembered, human body still there is the health care benefiting action.
Subordinate list 1 is this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Codonopsis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg,
Calcium lactate (in element calcium) 600mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Codonopsis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Codonopsis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Codonopsis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Potassium iodate (in trace iodine) 0.1mg
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 300mg,
Radix Codonopsis 300mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 5mg,
Sodium selenate (in trace element-selenium) 0.015mg,
Ferric citrate (in trace elements iron) 5mg,
Potassium iodate (in trace iodine) 0.05mg,
Chromium yeast (in trace element chromium) 0.015mg,
Copper citrate (in trace copper) 0.5mg,
Sodium molybdate (in trace element molybdenum) 0.02mg,
Manganese citrate (in trace element manganese) 1mg,
Calcium lactate (in element calcium) 250mg,
Potassium lactate (in element potassium) 200mg
Magnesium lactate (in element magnesium) 100mg,
Retinol equivalent (vitamin A and/or beta-carotene) 250 μ g RE,
Vitamin D 0.0015mg,
Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Rhizoma Atractylodis Macrocephalae 15000mg,
Radix Codonopsis 10000mg,
Folic acid 1mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Vitamin B
120mg,
Vitamin B
220mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Zinc lactate (in trace element zinc) 20mg,
Sodium selenate (in trace element-selenium) 0.1mg,
Ferric citrate (in trace elements iron) 20mg,
Potassium iodate (in trace iodine) 0.2mg,
Chromium yeast (in trace element chromium) 0.15mg,
Copper citrate (in trace copper) 1.5mg,
Sodium molybdate (in trace element molybdenum) 0.06mg,
Manganese citrate (in trace element manganese) 3mg,
Calcium lactate (in element calcium) 1000mg,
Potassium lactate (in element potassium) 1200mg
Magnesium lactate (in element magnesium) 300mg,
Retinol equivalent (vitamin A and/or beta-carotene) 800 μ g RE,
Vitamin D 0.01mg,
Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn, serve on 2, withdrew 3, obeyed again 2.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: the young rat/mouse labyrinth test effect of this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis component and vitamin added elements component compares:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Codonopsis group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Codonopsis 50mg/ days | 12 | 18.5％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+ VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 15.2％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Codonopsis+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Codonopsis 50mg+ calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA sharp/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 13.8％ |
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis component and vitamin added elements component Aged Mice maze test effect compare:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Codonopsis group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Codonopsis 50mg/ days | 12 | 34.2％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 30.8％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Codonopsis+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Codonopsis 50mg+ calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ iodine 0.003mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 28.3％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table; Zinc, selenium, ferrum, iodine are in trace element, and calcium, potassium, magnesium are in element.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With associated materials statistics contrasts, birth defect youngster account for the newborn population sum 4-6% there were significant differences.
Can obviously find out from table 1, table 2; This compositions is through Chinese medicine component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component; The statistical result of mistake percentage rate, the function of this composition for improved memory is superior to Chinese medicine component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1. one kind is used to prevent birth defect and the pharmaceutical composition that improves memory, it is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Codonopsis 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0-0.15mg of elemental chromium,
Copper, in the copper 0-1.5mg of elemental copper,
Molybdenum, in the molybdenum 0-0.06mg of molybdenum,
Iodine, in the iodine 0.05-0.2mg of elemental iodine,
Manganese, in the manganese 0-3mg of element manganese,
Calcium, in the calcium 250-1000mg of element calcium,
Potassium, in the potassium 0-1200mg of element potassium,
Magnesium, in the magnesium 0-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
2. the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Codonopsis 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0-0.15mg of elemental chromium,
Copper, in the copper 0-1.5mg of elemental copper,
Molybdenum, in the molybdenum 0-0.06mg of molybdenum,
Iodine, in the iodine 0.05-0.2mg of elemental iodine,
Manganese, in the manganese 0-3mg of element manganese,
Calcium, in the calcium 250-1000mg of element calcium,
Potassium, in the potassium 0-1200mg of element potassium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
3. the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Codonopsis 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Copper, in the copper 0.5-1.5mg of elemental copper,
Molybdenum, in the molybdenum 0.02-0.06mg of molybdenum,
Iodine, in the iodine 0.05-0.2mg of elemental iodine,
Manganese, in the manganese 0-3mg of element manganese,
Calcium, in the calcium 250-1000mg of element calcium,
Potassium, in the potassium 0-1200mg of element potassium,
Magnesium, in the magnesium 0-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
4. the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Codonopsis 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Copper, in the copper 0.5-1.5mg of elemental copper,
Molybdenum, in the molybdenum 0.02-0.06mg of molybdenum,
Iodine, in the iodine 0.05-0.2mg of elemental iodine,
Manganese, in the manganese 0-3mg of element manganese,
Calcium, in the calcium 250-1000mg of element calcium,
Potassium, in the potassium 0-1200mg of element potassium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
5. the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Codonopsis 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Copper, in the copper 0.5-1.5mg of elemental copper,
Molybdenum, in the molybdenum 0.02-0.06mg of molybdenum,
Iodine, in the iodine 0.05-0.2mg of elemental iodine,
Manganese, in the manganese 1-3mg of element manganese,
Calcium, in the calcium 250-1000mg of element calcium,
Potassium, in the potassium 200-1200mg of element potassium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100903A (en) * | 1993-09-28 | 1995-04-05 | 李宝平 | Intestinal nutrient powder of traditional Chinese and Western medical combination and preparation method thereof |
| CN1190589A (en) * | 1998-02-17 | 1998-08-19 | 关天颖 | Complex ferrous sulfate tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100903A (en) * | 1993-09-28 | 1995-04-05 | 李宝平 | Intestinal nutrient powder of traditional Chinese and Western medical combination and preparation method thereof |
| CN1190589A (en) * | 1998-02-17 | 1998-08-19 | 关天颖 | Complex ferrous sulfate tablet |
Non-Patent Citations (1)
| Title |
|---|
| 邵玉芹等.克隆氏病患者头发中微量元素的测定及临床意义.《微量元素与健康研究》.1998,(第02期), * |
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