CN101193962A - 胺聚合物改性的纳米粒子载体 - Google Patents

胺聚合物改性的纳米粒子载体 Download PDF

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Publication number
CN101193962A
CN101193962A CN200680002418.XA CN200680002418A CN101193962A CN 101193962 A CN101193962 A CN 101193962A CN 200680002418 A CN200680002418 A CN 200680002418A CN 101193962 A CN101193962 A CN 101193962A
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CN
China
Prior art keywords
composition
colloid
particle
core
shell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200680002418.XA
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English (en)
Chinese (zh)
Inventor
J·F·布林利
T·A·乔
J·W·哈德
A·万德
J·M·赫维特
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Eastman Kodak Co
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Eastman Kodak Co
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Filing date
Publication date
Priority claimed from US11/036,814 external-priority patent/US7541017B2/en
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Publication of CN101193962A publication Critical patent/CN101193962A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C12/00—Powdered glass; Bead compositions
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C17/00—Surface treatment of glass, not in the form of fibres or filaments, by coating
    • C03C17/28—Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material
    • C03C17/32—Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material with synthetic or natural resins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200680002418.XA 2005-01-14 2006-01-13 胺聚合物改性的纳米粒子载体 Pending CN101193962A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/036,814 2005-01-14
US11/036,814 US7541017B2 (en) 2003-07-18 2005-01-14 Amine polymer-modified nanoparticulate carriers
US11/165,849 US20060293396A1 (en) 2005-01-14 2005-06-24 Amine polymer-modified nanoparticulate carriers
US11/165,849 2005-06-24

Publications (1)

Publication Number Publication Date
CN101193962A true CN101193962A (zh) 2008-06-04

Family

ID=36293406

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200680002418.XA Pending CN101193962A (zh) 2005-01-14 2006-01-13 胺聚合物改性的纳米粒子载体

Country Status (5)

Country Link
US (2) US20060293396A1 (https=)
EP (1) EP1836252A1 (https=)
JP (1) JP2008526995A (https=)
CN (1) CN101193962A (https=)
WO (1) WO2006076636A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104350109A (zh) * 2011-12-12 2015-02-11 威斯特法伦·威廉姆斯明斯特大学 官能化的硅纳米颗粒
CN109174033A (zh) * 2018-08-27 2019-01-11 南京师范大学 一种可安全进出红细胞的血液铅离子清除剂及其制备方法和应用
CN110075767A (zh) * 2019-04-18 2019-08-02 天津大学 长余辉水凝胶及制备方法

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FR2872061B1 (fr) * 2004-06-23 2007-04-27 Toulouse Inst Nat Polytech Composition solide divisee formee de grains a depot metallique atomique continu et son procede d'obtention
US20070292688A1 (en) * 2005-08-18 2007-12-20 Eastman Kodak Company Silylamine modified nanoparticulate carriers
US8660631B2 (en) 2005-09-08 2014-02-25 Bruker Biospin Corporation Torsional support apparatus and method for craniocaudal rotation of animals
US20080095699A1 (en) * 2006-10-20 2008-04-24 Shiying Zheng Imaging contrast agents using nanoparticles
US8203132B2 (en) 2005-09-08 2012-06-19 Carestream Health, Inc. Apparatus and method for imaging ionizing radiation
ES2391729T3 (es) 2005-10-14 2012-11-29 Vive Crop Protection Inc. Nanopartículas compuestas, nanopartículas y métodos para la producción de las mismas
JP2010506027A (ja) 2006-10-11 2010-02-25 フジフィルム・イメイジング・カラランツ・リミテッド 方法、組成物及びインク
US7833960B2 (en) * 2006-12-15 2010-11-16 International Flavors & Fragrances Inc. Encapsulated active material containing nanoscaled material
US20080193766A1 (en) 2007-02-13 2008-08-14 Northern Nanotechnologies Control of Transport to and from Nanoparticle Surfaces
US7645318B2 (en) 2008-05-07 2010-01-12 Vive Nano, Inc. Producing nanoparticles using nanoscale polymer templates
US20100208348A1 (en) * 2008-08-22 2010-08-19 Carestream Health, Inc. Tunable spectral filtration device
US8216961B2 (en) 2008-08-27 2012-07-10 Korea University Research And Business Foundation Nanoparticles including metal oxide having catalytic activity
IT1398194B1 (it) 2008-10-22 2013-02-14 Univ Degli Studi Torino Cianina funzionalizzata con braccio di legame silanico, procedimento per la sua preparazione e suoi usi
KR101177173B1 (ko) * 2009-10-17 2012-08-24 서울대학교산학협력단 생물학적 이미징을 위한 ｉｃｇ 도핑된 실리카 나노파티클 및 이의 제조방법
CN101696282B (zh) * 2009-10-23 2012-06-20 蚌埠市瑞洁科技有限责任公司 用于橡胶胶乳制品的补强填充剂及其制备方法与用途
US20130108552A1 (en) * 2010-03-01 2013-05-02 University Of Florida Research Foundation Inc. Near-ir indocyanine green doped multimodal silica nanoparticles and methods for making the same
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WO2012178184A2 (en) * 2011-06-23 2012-12-27 Children's Hospital Los Angeles Removable protective shell for imaging agents and bioactive substances
CN102516566B (zh) * 2011-12-16 2013-12-25 华中科技大学 一种生物可降解聚合物纳米粒子的制备方法
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
US9724279B2 (en) * 2012-10-26 2017-08-08 Syneurx International Corp. Core-shell particles, preparation process thereof, and composition containing the same
CN104383891B (zh) * 2014-12-02 2017-01-11 河海大学 一种壳聚糖-拟态薄水铝掺杂磁性吸附剂及其制备方法
EP4480902A3 (en) * 2015-03-16 2025-03-12 PDX Pharmaceuticals, Inc. Cross-linked polymer modified nanoparticles
CN105181662B (zh) * 2015-08-24 2018-04-03 西北大学 一种定性检测负载在多糖微球中功能纳米颗粒分布的方法
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Publication number Priority date Publication date Assignee Title
CN104350109A (zh) * 2011-12-12 2015-02-11 威斯特法伦·威廉姆斯明斯特大学 官能化的硅纳米颗粒
CN104350109B (zh) * 2011-12-12 2016-11-09 威斯特法伦·威廉姆斯明斯特大学 官能化的硅纳米颗粒
US10130588B2 (en) 2011-12-12 2018-11-20 Westfaelische Wilhelms-Universitaet Muenster Functionalised silicon nanoparticles
CN109174033A (zh) * 2018-08-27 2019-01-11 南京师范大学 一种可安全进出红细胞的血液铅离子清除剂及其制备方法和应用
CN109174033B (zh) * 2018-08-27 2021-07-27 南京师范大学 一种可安全进出红细胞的血液铅离子清除剂及其制备方法和应用
CN110075767A (zh) * 2019-04-18 2019-08-02 天津大学 长余辉水凝胶及制备方法

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Publication number Publication date
US20060293396A1 (en) 2006-12-28
US20080241266A1 (en) 2008-10-02
WO2006076636A1 (en) 2006-07-20
JP2008526995A (ja) 2008-07-24
EP1836252A1 (en) 2007-09-26

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