CN101190241A - Ganoderrma tsugae extracting technique and preparations thereof - Google Patents
Ganoderrma tsugae extracting technique and preparations thereof Download PDFInfo
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- CN101190241A CN101190241A CNA2006100980236A CN200610098023A CN101190241A CN 101190241 A CN101190241 A CN 101190241A CN A2006100980236 A CNA2006100980236 A CN A2006100980236A CN 200610098023 A CN200610098023 A CN 200610098023A CN 101190241 A CN101190241 A CN 101190241A
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- ganoderma tsugae
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Abstract
The invention discloses an extraction technique of ganoderma tsugae. The ganoderma tsugae is first extracted once by 30-50% alcohol solution, and then extracted by water for two times, then filtered, the filtrates are merged and concentrated, and then added with grosvenor momordica sweet agent the weight of which is 0.1-0.5% of that of the total oral liquid to prepare into the oral liquid every 100 ml of which contains component equal to 10g of ganoderma tsugae; or the concentrated solution is spray dried or vacuum dried to get extract powder after pulverization, and mixed with appropriate quantity of ganoderma tsugae to prepare tablet or capsule. This method can significantly improve the extraction rate of the product and get high effective components; moreover, this method does not damage the effective components or erode the equipment.
Description
The invention relates to the extraction process and the preparation thereof of Ganoderma tsugae.Adopt water extraction method or 70% ethanol extraction method commonly used, the functional component Ganodenic acid of its water miscible functional component ganoderan and pure dissolubility all can not extract simultaneously.
Purpose of the present invention is exactly to overcome under the situation of above-mentioned shortcoming, in order to improve the extraction ratio of Ganoderma tsugae functional component, provides a kind of new Ganoderrma tsugae extracting technique.Simultaneously, purpose of the present invention also will be made preparations such as sheet, capsule, oral liquid according to the resulting extract of new technology.
Extraction process of the present invention is based on following principle and realizes:
After Ganoderma tsugae cut into slices, earlier with 50～70% alcohol solution dippings after 10～50 minutes, ethanol has very strong permeability, porous is in the Ganoderma tsugae fibrous tissue, adopt low temperature (being no more than 90 ℃) reflux, extract, again, the functional component Ganodenic acid of the pure dissolubility of major part can be extracted, the water miscible functional component ganoderan of a part can be extracted again, reuse water extraction secondary just can extract most Ganodenic acids and ganoderan.
The inventive method is as described below:
Ganoderma tsugae is cleaned, cut into slices, add 50～70% alcoholic solution of 8～15 times of amounts of suitable Ganoderma tsugae weight, soaked 10～50 minutes, just heating (90 ℃) reflux, extract, is 1～3 hour, filters; Get residue, the water extraction secondary of 8～15 times of amounts of reuse filters respectively.Merge three times filtrate, vacuum reclaims ethanol, and to be concentrated into concentrated solution weight be 20～150% of Ganoderma tsugae weight.
Concentrated solution is passed through tube centrifuge centrifugal filtration, add water to 10 times (as Ganoderma tsugae are 1kg, promptly add water to 10L, and this volume also is the preparation total amount) of the suitable Ganoderma tsugae weight of volume, add the quite mangosteen sweetener of preparation total amount 0.1～0.5%, heated and boiled 30 minutes is cooled to room temperature, filters with 0.45 μ m membrane filter, with the fill of tubular type bottle, gland seals, and sterilization promptly gets the Ganoderma tsugae oral liquid.
To be ground into fine powder behind concentrated solution spray drying or the vacuum drying, add the Ganoderma tsugae micropowder, additional proportion is: the Ganoderma tsugae weight that is used to extract: Ganoderma tsugae micropowder=1～3: 1, and fill capsule or pelletizing press sheet behind the mixing.
The present invention has the following advantages:
1, extraction ratio height of the present invention, after adopting the inventive method to extract, after measured, its extraction ratio (dry extract yield, polysaccharide extract rate, Ganodenic acid A extraction ratio etc.) is than water extraction method commonly used or 70% ethanol extraction method all high (extraction ratio of 70% ethanol extraction method gained Ganodenic acid A is slightly higher than the extraction ratio of the present invention extraction method).See following table for details:
The extraction ratio comparison sheet of three kinds of extraction processes of Ganoderma tsugae
| Extract recovery rate | Water extraction method (water is carried three times, each 2 hours) | (70% ethanol is carried three times, each 2 hours) followed the example of in alcohol extraction | Extraction method of the present invention |
| Dry extract yield (%) | 8.61 | 7.84 | 9.15 |
| Polysaccharide extract rate (%) | 59.24 | 39.20 | 62.52 |
| Ganodenic acid A extraction ratio (%) | 31.34 | 68.35 | 61.78 |
2, extracting method of the present invention uses (95%) ethanol only to be 24.6% of water extraction method commonly used, but follows the example of 3 times of saving (95%) ethanol than alcohol extraction commonly used.
3, extracting method of the present invention does not use strong acid and strong base, does not destroy the functional component in the Ganoderma tsugae, and extraction equipment is not had corrosivity yet.
4, the preparation (oral liquid, tablet, capsule etc.) of the inventive method preparation, functional component content height not only, and since extract and preparation process in do not use poisonous and harmful substance, human body is not produced murder by poisoning.
Example one:
With Ganoderma tsugae 300g, clean, cut into slices, add 70% alcoholic solution 3600mL, to soak after 30 minutes, heating (90 ℃) reflux, extract, 2 hours is filtered; Get residue, just water 3600mL extracts secondary respectively, filters.Merge three times filtrate, vacuum reclaims ethanol, and to be concentrated into concentrated solution weight be 300g.Use tube centrifuge centrifugal filtration, add water to about 3000mL, add the 3g mangosteen sweetener.Heated and boiled 30 minutes is cooled to room temperature, filters with 0.45 μ m membrane filter, and with the fill of 15mL tubular type bottle, gland seals, and sterilization promptly gets Ganoderma tsugae oral liquid (every bottle of oral liquid 15mL quite contains Ganoderma tsugae 1.5g).
Example two:
With Ganoderma tsugae 300g, clean, cut into slices, add 70% alcoholic solution 3600mL, to soak after 30 minutes, heating (90 ℃) reflux, extract, 2 hours is filtered; Get residue, just water 3600mL extracts secondary respectively, filters.Merge three times filtrate, vacuum reclaims ethanol, and to be concentrated into concentrated solution weight be 150g.With being ground into fine powder (the heavy 27.42g of fine powder) behind the concentrated solution vacuum drying, add Ganoderma tsugae micropowder 150g, become mixed powder behind the mixing.With this mixed powder fill capsule or pelletizing press sheet (every capsules or every contain mixed powder 0.2g, quite contain Ganoderma tsugae 0.5g).
Claims (11)
1. Ganoderrma tsugae extracting technique is characterized in that Ganoderma tsugae is cleaned, after the section, use earlier alcoholic solution, soaks the back and extracts 1 time, just uses the water extraction secondary, respectively filtration.Merge three times filtrate, vacuum reclaims ethanol, and concentrates.Concentrated solution is added mangosteen sweetener, be mixed with oral liquid, or will be ground into fine powder behind concentrated solution spray drying or the vacuum drying, add the Ganoderma tsugae micropowder, fill capsule or pelletizing press sheet behind the mixing.
2. according to claim 1, after it is characterized in that Ganoderma tsugae cut into slices, earlier with alcohol solution dipping 10～50 minutes.
3. according to claim 1, when it is characterized in that the Ganoderma tsugae sheet extracts for the first time, with 30～60% alcoholic solution.
4. according to claim 1, when it is characterized in that the Ganoderma tsugae sheet extracts for the first time, add the alcoholic solution of 2～15 times of amounts of suitable Ganoderma tsugae weight.
5. according to claim 1, when it is characterized in that the Ganoderma tsugae sheet is used ethanol extraction for the first time, heated (90 ℃) reflux, extract, 1～3 hour.
6. according to claim 1, it is characterized in that Ganoderma tsugae sheet second and when extracting for the third time, with the water of 2～15 times of amounts.
7. according to claim 1, when it is characterized in that Ganoderma tsugae extracting solution vacuum recovery ethanol also concentrates, concentrated solution weight should be 20～150% of Ganoderma tsugae weight.
8. according to claim 6, when it is characterized in that preparing the Ganoderma tsugae oral liquid, concentrated solution weight should be 60～150% of Ganoderma tsugae weight.
9. according to claim 6, it is characterized in that when being ground into fine powder behind Ganoderma tsugae concentrated solution spray drying or the vacuum drying, concentrated solution weight should be 20～60% of Ganoderma tsugae weight.
10. according to claim 1, when it is characterized in that preparing the Ganoderma tsugae oral liquid, add the quite mangosteen sweetener of preparation total amount 0.1～0.5%.
11. according to claim 1, when it is characterized in that preparing Ganoderma tsugae capsule or Ganoderma tsugae sheet, the ratio that adds the Ganoderma tsugae micropowder is: the Ganoderma tsugae weight that is used to extract: Ganoderma tsugae micropowder=1～3: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100980236A CN101190241A (en) | 2006-11-28 | 2006-11-28 | Ganoderrma tsugae extracting technique and preparations thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100980236A CN101190241A (en) | 2006-11-28 | 2006-11-28 | Ganoderrma tsugae extracting technique and preparations thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101190241A true CN101190241A (en) | 2008-06-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2006100980236A Pending CN101190241A (en) | 2006-11-28 | 2006-11-28 | Ganoderrma tsugae extracting technique and preparations thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258543A (en) * | 2011-08-25 | 2011-11-30 | 黔西南吉仁堂中药饮片厂 | Method for processing lucid ganoderma |
| CN102641307A (en) * | 2012-05-18 | 2012-08-22 | 毛景华 | Ganoderma lucidum granule and preparation method thereof |
| CN101747400B (en) * | 2008-12-17 | 2012-09-05 | 湖北工业大学 | Lanostane type triterpenoid with anti-tumor activity, preparation method and application |
| CN102703292A (en) * | 2012-06-29 | 2012-10-03 | 攀枝花市晨丰林业有限公司 | Composite process for extracting and producing truffle wine |
-
2006
- 2006-11-28 CN CNA2006100980236A patent/CN101190241A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101747400B (en) * | 2008-12-17 | 2012-09-05 | 湖北工业大学 | Lanostane type triterpenoid with anti-tumor activity, preparation method and application |
| CN102258543A (en) * | 2011-08-25 | 2011-11-30 | 黔西南吉仁堂中药饮片厂 | Method for processing lucid ganoderma |
| CN102258543B (en) * | 2011-08-25 | 2013-04-03 | 黔西南吉仁堂中药饮片厂 | Method for processing lucid ganoderma |
| CN102641307A (en) * | 2012-05-18 | 2012-08-22 | 毛景华 | Ganoderma lucidum granule and preparation method thereof |
| CN102641307B (en) * | 2012-05-18 | 2014-03-19 | 毛景华 | Ganoderma lucidum granule and preparation method thereof |
| CN102703292A (en) * | 2012-06-29 | 2012-10-03 | 攀枝花市晨丰林业有限公司 | Composite process for extracting and producing truffle wine |
| CN102703292B (en) * | 2012-06-29 | 2014-03-26 | 攀枝花市晨丰林业有限公司 | Composite process for extracting and producing truffle wine |
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Open date: 20080604 |