CN101185730A

CN101185730A - Ache relieving mixture for treating urarthritis

Info

Publication number: CN101185730A
Application number: CNA2007101004298A
Authority: CN
Inventors: 申海莉; 方昭云; 马玉凤
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-11-21
Filing date: 2007-04-04
Publication date: 2008-05-28
Anticipated expiration: 2027-04-04
Also published as: CN101185730B

Abstract

The invention relates to a pain-relieving mixture for the treatment of gouty arthritis, which pertains to the field of pharmaceutical formulations, the technology is characterized in that: the parts by weight of the raw materials are: 6 to 10 percent amur corktree bark, 12 to 16 percent sevenlobed yam rhizome, 4 to 6 percent rhubarb, 8 to 12 percent Japanese honeysuckle stem, 6 to 9 percent Indian iphigenia bulb, 12 to 16 percent spreading hedyotis herb, 6 to 10 percent glabrous greenbrier rhizome, 4 to 6 percent frankincense, 4 to 6 percent myrrh, 6 to 10 percent clematis root, 6 to 10 percent largeleaf gentian root and 6 to 9 percent earthworm, and the sum of the percentages of the components of the raw materials is equal to 100 percent. The invention can effectively alleviate the symptoms of gouty arthritis, prevent and treat the repeated attacks of gouty arthritis, lower blood uric acid, have no toxicity or side effects and have definite efficacy.

Description

The flat ache relieving mixture of treatment gouty arthritis

Technical field

The present invention relates to the pharmaceutical formulation field, specifically a kind of flat ache relieving mixture that is used for the treatment of gouty arthritis.

Background technology

Gouty arthritis is because purine metabolic disturbance causes the too much or drainage minimizing of uricopoiesis, cause uric acid increase in serum and the body fluid, urate crystal, be deposited on the inflammatory reaction that joint part causes, blood uric acid increases makes that it shows effect repeatedly, the pathologic basis of protracted course of disease.Modern medicine adopts colchicine and/or nonsteroidal anti inflammatory medicine and/or glucocorticoid medicine to treat the outbreak of its acute symptom, catabasis is adopted medicine (allopurinol) that suppresses uricopoiesis and medicine (probenecid, sulphinpyrazone, the benzbromarone) uric acid reducing that promotes urate excretion, the outbreak of prevention gouty arthritis.But can cause that owing to said medicine many untoward reaction such as erythra, gastrointestinal reaction, hepatic and renal function damage, bone marrow depression even respiration inhibition have influenced their application.Therefore Chinese medicine has its uniqueness and superiority in the treatment of hyperuricemia and gouty arthritis, is bringing into play important effect.Yet up to the present, the treatment hyperuricemia produced in batches of more satisfactory and typing, the Chinese patent medicine preparation of the acute and chronic gouty arthritis of control are not seen both at home and abroad as yet.

Summary of the invention

In order to overcome the deficiency of above-mentioned technology, the invention provides a kind of symptom that both can effectively improve gouty arthritis, prevent and treat the outbreak repeatedly of gouty arthritis, can reduce blood uric acid again, no obvious toxic-side effects, determined curative effect, the flat ache relieving mixture of Chinese traditional compound medicine with low cost.

The technical solution adopted for the present invention to solve the technical problems is: adopting Cortex Phellodendri, Rhizoma Dioscoreae Septemlobae, Radix Et Rhizoma Rhei, Caulis Lonicerae, Pseudobulbus cremastrae seu pleiones, Herba Hedyotidis Diffusae, Rhizoma Smilacis Glabrae, Olibanum, Myrrha, Radix Clematidis, Radix Gentianae Macrophyllae, Pheretima is that feedstock production forms.Clean said medicine is selected, mix by a certain percentage, decoct then, remove slag filtrate, sterilization makes mixture after refining; Its technical characterictic is: with the weight portion of cleaning is that Cortex Phellodendri 6-10%, castor are separated 12-16%, Radix Et Rhizoma Rhei 4-6%, Caulis Lonicerae 8-12%, Pseudobulbus cremastrae seu pleiones 6-9%, Herba Hedyotidis Diffusae 12-16%, Rhizoma Smilacis Glabrae 6-10%, Olibanum 4-6%, Myrrha 4-6%, Radix Clematidis 6-10%, Radix Gentianae Macrophyllae 6-10%, Pheretima 6-9% uniform mixing (each raw material components percentage ratio sum equals absolutely), soaked 3-10 hour, decoct then more than 60 minutes, through routine remove slag filtration, high pressure, sterilization, after refining, make filtrate.

The invention has the beneficial effects as follows that processing technique is simple, the drug mixture cost of material of being produced is low, take the no obvious toxic-side effects in back, determined curative effect, not only symptom and sign are obviously improved, joint motion is flexible, and blood uric acid reduces to normally, and total effective rate is 93%.

The specific embodiment

Embodiment 1:

It is that feedstock production forms that the present invention adopts Cortex Phellodendri, Rhizoma Dioscoreae Septemlobae, Radix Et Rhizoma Rhei, Caulis Lonicerae, Pseudobulbus cremastrae seu pleiones, Herba Hedyotidis Diffusae, Rhizoma Smilacis Glabrae, Olibanum, Myrrha, Radix Clematidis, Radix Gentianae Macrophyllae, Pheretima.Its components based on weight percentage Cortex Phellodendri 8, castor separate 14, Radix Et Rhizoma Rhei 5, Caulis Lonicerae 10, Pseudobulbus cremastrae seu pleiones 8, Herba Hedyotidis Diffusae 14, Rhizoma Smilacis Glabrae 8, Olibanum 5, Myrrha 5, Radix Clematidis 8, Radix Gentianae Macrophyllae 8, Pheretima 7, get above-mentioned raw materials total amount double centner, selected clean uniform mixing, steeped 3-10 hour with the 20000mI water logging at ambient temperature, decoct then more than 60 minutes, remove slag through routine after the technologies such as filtration, high pressure, sterilization, gained filtrate is stand-by.

Therapeutic Principle of the present invention: the gout acute stage, mostly be damp-heat accumulation, impregnated in the muscle joint, the heresy of the diseases caused by exogenous pathogenic factor rheumatism of holding concurrently again, and the invasion and attack meridians, QI-blood circulation is not smooth, stagnation of QI and blood may bring about pain.Pathological factor is the turbid malicious expectorant stasis of blood, controls with promoting blood circulation and stopping pain, clearing away heat-damp and promoting diuresis, reduces phlegm that it is turbid to dispel, and makes vital QI recovered after pathogens eliminated.The clear damp-heat in lower-JIAO of Cortex Phellodendri is separated damp and hot sore in the component of the present invention, the clean source of clear stream; Radix Et Rhizoma Rhei leads to intestinal detoxifcation, eliminating blood stasis and inducing menstruation, logical stool, diuresis, makes heresy that outlet be arranged; Rhizoma Dioscoreae Septemlobae divides sharp pure and impure, Rhizoma Smilacis Glabrae detoxification and promoting urination, relaxes through collateral dredging, but two medicines all removing dampness and detoxicating, the merit of easing joint movement is arranged, and with Radix Et Rhizoma Rhei compatibility using pungent drugs for dispersion and bitter drugs for purgation before and after two the moon, turbid poison is gone out with defecation; Pseudobulbus cremastrae seu pleiones, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, and contain the colchicine composition in the Pseudobulbus cremastrae seu pleiones bulb, the treatment acute gouty arthritis has specially good effect; Olibanum, Myrrha removing blood stasis promoting the circulation of QI to relieve pain have rapid, powerful analgesic activity; Caulis Lonicerae has the merit of heat-clearing and toxic substances removing, dredge the meridian passage, can eliminate the wind heat of meridians and numbness is treated in pain relieving; Radix Clematidis is apt to away and is not kept, and can declare logical twelve channels and collaterals, makes the stasis in patient's meridians open-minded, and the stagnation of QI and blood may bring about pain symptom is improved; Radix Gentianae Macrophyllae expelling wind and removing dampness collateral dredging closes the power that Radix Clematidis is strengthened diffusing impediment and relieving pain; The salty-cold heat clearing away of Pheretima, and can attack and scurry the meridians reducing swelling and alleviating pain.All medicines generally have the effect of analgesic, analgesia, antiinflammatory, antibacterial, uric acid resisting in the modern pharmacological research demonstration side, can remove joint effectively and swell and ache, thereby alleviate the acute gouty arthritis symptom.

But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (weight portion) is realized.Its processing technique is identical with embodiment 1.

Embodiment	Cortex Phellodendri	Rhizoma Dioscoreae Septemlobae	Radix Et Rhizoma Rhei	Radix Ophiopogonis Teng	Pseudobulbus cremastrae seu pleiones	Herba Hedyotidis Diffusae	Rhizoma Smilacis Glabrae	Olibanum	Myrrha	Radix Clematidis	Radix Gentianae Macrophyllae	Pheretima
Embodiment	Cortex Phellodendri	Rhizoma Dioscoreae Septemlobae	Radix Et Rhizoma Rhei	Radix Ophiopogonis Teng	Pseudobulbus cremastrae seu pleiones	Herba Hedyotidis Diffusae	Rhizoma Smilacis Glabrae	Olibanum	Myrrha	Radix Clematidis	Radix Gentianae Macrophyllae	Pheretima	2	6	16	4	12	6	16	6	4	5	10	6	9
3	7	15	5	11	7	15	7	5	5	9	8	6	2	6	16	4	12	6	16	6	4	5	10	6	9
3	7	15	5	11	7	15	7	5	5	9	8	6	4	9	13	6	9	8	13	9	6	6	7	7	7
5	10	12	6	8	9	12	10	5	4	6	10	8	4	9	13	6	9	8	13	9	6	6	7	7	7

Below in conjunction with my institute, promptly the clinical preliminary test that carries out of Shandong Province Wendeng Central Hospital, Weihai City is done to describe in further detail to the present invention:

1, case is selected: this organizes 60 examples, male 50 examples, women 10 examples, age 25-60 year, 34.6 years old mean age; The course of disease is 2-18, average 5.8 years.

2, diagnostic criteria: formulate: more than the acute arthritis outbreak once, and in a day, reach a climax according to American Rheumatism Association's diagnostic criteria in 1977; Acute inflammation is confined to indivedual joints; Whole joint is kermesinus; First metatarsophalangeal joints swells and ache; One-sided tarsal joint acute inflammation; Tophus suspicious or that confirm is arranged; Hyperuricemia; The asymmetry arthroncus; Outbreak can stop voluntarily.All possess above-mentioned 6 above persons and can make a definite diagnosis.

3, exclusion standard: do not conform to above-mentioned diagnostic criteria person; Age at under-18s or more than 70 years old, gestation or women breast-feeding their children, allergic constitution and to this medicine allergy sufferers; Be associated with cardiovascular, cerebrovascular, liver, kidney and disease of hematopoietic system, insane; Late period arthritis severe deformity, stiff disability person; Can not stop using influences this medication effect medicine person.

4, criterion of therapeutical effect: produce effects: symptom and sign disappear, and joint motion is normal, and blood uric acid is reduced to normally.Effectively: symptom and sign are obviously improved, and joint motion is more preceding flexibly, and blood uric acid descends.Invalid: symptom and sign does not have improvement, the lab testing no change before and after the treatment.

5, Therapeutic Method: take flat ache relieving mixture 50ml at every turn, divide every day and take for early, middle and late three times, 2 weeks were a course of treatment.

6, therapeutic outcome: produce effects 14 examples, effective 42 examples, invalid 6 examples, obvious effective rate 23%, effective percentage 70%, inefficiency 7%, total effective rate is 93%.

Claims

1. flat ache relieving mixture that is used for the treatment of gouty arthritis, adopt Cortex Phellodendri Rhizoma Dioscoreae Septemlobae, Radix Et Rhizoma Rhei, Caulis Lonicerae, Pseudobulbus cremastrae seu pleiones, Herba Hedyotidis Diffusae, Rhizoma Smilacis Glabrae, Olibanum, Myrrha, Radix Clematidis, Radix Gentianae Macrophyllae, Pheretima is that feedstock production forms, it can obtain with following method: said medicine is selected clean, mix by a certain percentage, decoct then, remove slag filtrate, sterilization, after refining, make mixture, its technical characterictic is: raw material is formed weight portion and is: Cortex Phellodendri 6-10%, castor is separated 12-16%, Radix Et Rhizoma Rhei 4-6%, Caulis Lonicerae 8-12%, Pseudobulbus cremastrae seu pleiones 6-9%, Herba Hedyotidis Diffusae 12-16%, Rhizoma Smilacis Glabrae 6-10%, Olibanum 4-6%, Myrrha 4-6%, Radix Clematidis 6-10%, Radix Gentianae Macrophyllae 6-10%, Pheretima 6-9%, each raw material components percentage ratio sum equals absolutely.