CN101171014B - 可用作hcv抑制剂的蝶啶类物质及其制备方法 - Google Patents
可用作hcv抑制剂的蝶啶类物质及其制备方法 Download PDFInfo
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- CN101171014B CN101171014B CN2006800158663A CN200680015866A CN101171014B CN 101171014 B CN101171014 B CN 101171014B CN 2006800158663 A CN2006800158663 A CN 2006800158663A CN 200680015866 A CN200680015866 A CN 200680015866A CN 101171014 B CN101171014 B CN 101171014B
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- alkyl
- hydrogen
- compound
- alkyl group
- hcv
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 230000009265 virologic response Effects 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物编号 | LCMS数据 |
1 | m/z:397,398,399,400 RT:2.30 |
13 | m/z:455,456,457,458,RT:4.06 |
21 | m/z:565,566,567,568,RT:3.12 |
6 | m/z:462,463,464,465,RT:2.73 |
3 | m/z:453,454,455,456,RT:3.45 |
2 | m/z:411,412,413,414,RT=2,49 |
4 | m/z:481,482,483,484,RT=4.23 |
5 | m/z:487,488,489,490,RT:3.49 |
7 | m/z:411,412,413,414,RT:2.49 |
8 | m/z:396,397,398,399,RT:4.52 |
9 | m/z:410,411,412,413,RT:4.59 |
12 | m/z:466,467,468,469,RT:3.31 |
10 | m/z:410,411,412,413,RT:4.70 |
化合物编号 | LCMS数据 |
11 | m/z:364,365,366,367,RT=2.67 |
14 | m/z:419,420,RT:4.27 |
15 | m/z:411,412,413,414,RT:2.49 |
22 | m/z:501,502,RT:3.50 |
19 | m/z:330,RT:1.40 |
18 | m/z:335,336,337,RT:2.37 |
25 | m/z:367,368,369,RT:2.44 |
24 | m/z:353,354,355,RT:2.29 |
化合物编号 | HCV复制子活性(μM) |
1 | 0.352 |
13 | 4.9 |
21 | 0.058 |
6 | 18 |
3 | 2.2 |
27 | 3.0 |
2 | 3.65 |
4 | 0.48 |
5 | 0.99 |
7 | 0.95 |
8 | >32 |
9 | 11 |
12 | >32 |
10 | 11 |
11 | >32 |
14 | 8.7 |
15 | 3.56 |
22 | 1.96 |
化合物编号 | HCV复制子活性(μM) |
19 | 12 |
18 | 1.5 |
23 | 0.52 |
25 | 48 |
24 | 0.78 |
26 | 2.0 |
化合物21(ng/ml或g/ml) | |||
时间 | 血浆 标准偏差 | 心脏 标准偏差 | 肝脏 标准偏差 |
0.5124824 | 220 ±100166 ±16021.7 ±6.720.3 ±5.15.52 ±1.20BQL1) | 678 ±258557 ±40392.9 ±49.983.6 ±35.929.1 ±6.0BQL1) | 4057 ±17302937 ±1852611 ±131627 ±189201 ±59BQL1) |
Cmax(ng/ml)Tmax(h)t1/2(2-8h)(h)AUC(0- 8h)(ng.h/ml)AUC0-inf(ng.h/ml)组织/血浆比率 | 2200.52.9309332- | 6780.53.4111912623.82) | 40570.53.569657973242) |
Claims (17)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68039305P | 2005-05-12 | 2005-05-12 | |
US60/680,393 | 2005-05-12 | ||
EP05106212 | 2005-07-07 | ||
EP05106212.3 | 2005-07-07 | ||
EP06075854.7 | 2006-04-06 | ||
EP06075854 | 2006-04-06 | ||
PCT/EP2006/062289 WO2006120251A1 (en) | 2005-05-12 | 2006-05-12 | Pteridines useful as hcv inhibitors and methods for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101171014A CN101171014A (zh) | 2008-04-30 |
CN101171014B true CN101171014B (zh) | 2012-02-15 |
Family
ID=39391315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2006800158663A Expired - Fee Related CN101171014B (zh) | 2005-05-12 | 2006-05-12 | 可用作hcv抑制剂的蝶啶类物质及其制备方法 |
Country Status (2)
Country | Link |
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CN (1) | CN101171014B (zh) |
ZA (1) | ZA200709694B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114984019B (zh) * | 2022-07-15 | 2023-08-22 | 山东中医药大学 | 一种铁死亡抑制剂化合物及在肝损伤修复领域的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1333757A (zh) * | 1998-08-28 | 2002-01-30 | 西奥斯股份有限公司 | 作为药物的喹唑啉衍生物 |
US20040038856A1 (en) * | 2002-05-17 | 2004-02-26 | Sarvajit Chakravarty | Treatment of fibroproliferative disorders using TGF-beta inhibitors |
-
2006
- 2006-05-12 CN CN2006800158663A patent/CN101171014B/zh not_active Expired - Fee Related
-
2007
- 2007-11-09 ZA ZA200709694A patent/ZA200709694B/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1333757A (zh) * | 1998-08-28 | 2002-01-30 | 西奥斯股份有限公司 | 作为药物的喹唑啉衍生物 |
US20040038856A1 (en) * | 2002-05-17 | 2004-02-26 | Sarvajit Chakravarty | Treatment of fibroproliferative disorders using TGF-beta inhibitors |
Also Published As
Publication number | Publication date |
---|---|
CN101171014A (zh) | 2008-04-30 |
ZA200709694B (en) | 2009-06-24 |
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