CN101168025A - 一种防治老年性痴呆的药物组合物 - Google Patents
一种防治老年性痴呆的药物组合物 Download PDFInfo
- Publication number
- CN101168025A CN101168025A CNA2007101656338A CN200710165633A CN101168025A CN 101168025 A CN101168025 A CN 101168025A CN A2007101656338 A CNA2007101656338 A CN A2007101656338A CN 200710165633 A CN200710165633 A CN 200710165633A CN 101168025 A CN101168025 A CN 101168025A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- folium ginkgo
- radix polygalae
- rhizoma curcumae
- curcumae longae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 76
- 229940079593 drug Drugs 0.000 title claims abstract description 41
- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 206010039966 Senile dementia Diseases 0.000 title abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 122
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 86
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 86
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 61
- 238000000034 method Methods 0.000 claims abstract description 58
- 230000008569 process Effects 0.000 claims abstract description 37
- 238000002360 preparation method Methods 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims abstract description 13
- 241000218628 Ginkgo Species 0.000 claims description 85
- 238000011282 treatment Methods 0.000 claims description 78
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- 239000008194 pharmaceutical composition Substances 0.000 claims description 37
- 239000000284 extract Substances 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 34
- 239000004148 curcumin Substances 0.000 claims description 30
- 229940109262 curcumin Drugs 0.000 claims description 30
- 235000012754 curcumin Nutrition 0.000 claims description 30
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 30
- 239000002671 adjuvant Substances 0.000 claims description 29
- 239000012141 concentrate Substances 0.000 claims description 24
- 239000000706 filtrate Substances 0.000 claims description 19
- VZRKWGPIZJDNHC-UHFFFAOYSA-N Polygalic acid Natural products CC1(C)CCC2(CCC3=C(CCC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O VZRKWGPIZJDNHC-UHFFFAOYSA-N 0.000 claims description 18
- VZRKWGPIZJDNHC-LUNVCWBOSA-N Polygalic acid Polymers CC1(C)CC[C@@]2(CCC3=C(CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O)[C@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2C1)C(O)=O VZRKWGPIZJDNHC-LUNVCWBOSA-N 0.000 claims description 18
- 238000010828 elution Methods 0.000 claims description 17
- 239000007924 injection Substances 0.000 claims description 17
- 238000002347 injection Methods 0.000 claims description 17
- 239000008187 granular material Substances 0.000 claims description 16
- 239000002775 capsule Substances 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 12
- 239000003826 tablet Substances 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 10
- 238000005352 clarification Methods 0.000 claims description 10
- 239000011347 resin Substances 0.000 claims description 10
- 229920005989 resin Polymers 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 7
- 239000003463 adsorbent Substances 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 229930182490 saponin Natural products 0.000 claims description 5
- 150000007949 saponins Chemical class 0.000 claims description 5
- 235000017709 saponins Nutrition 0.000 claims description 5
- 229920002101 Chitin Polymers 0.000 claims description 4
- 230000000274 adsorptive effect Effects 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 4
- 239000008394 flocculating agent Substances 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 239000000890 drug combination Substances 0.000 claims description 3
- 239000000469 ethanolic extract Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000005325 percolation Methods 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 239000010017 yuan zhi Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 210000004556 brain Anatomy 0.000 abstract description 5
- 230000003920 cognitive function Effects 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 230000002490 cerebral effect Effects 0.000 abstract 2
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 244000194101 Ginkgo biloba Species 0.000 abstract 1
- 241000146384 Glaux Species 0.000 abstract 1
- 230000009758 senescence Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 56
- 239000002994 raw material Substances 0.000 description 22
- 238000012360 testing method Methods 0.000 description 22
- 238000002474 experimental method Methods 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000000499 gel Substances 0.000 description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 12
- 238000007796 conventional method Methods 0.000 description 11
- 239000012528 membrane Substances 0.000 description 11
- 239000012679 serum free medium Substances 0.000 description 10
- 230000032683 aging Effects 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- -1 polypropylene Polymers 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 7
- 238000004321 preservation Methods 0.000 description 7
- 208000010877 cognitive disease Diseases 0.000 description 6
- 230000001537 neural effect Effects 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 230000009182 swimming Effects 0.000 description 6
- 238000012800 visualization Methods 0.000 description 6
- 238000012545 processing Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 239000012531 culture fluid Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 125000006850 spacer group Chemical group 0.000 description 4
- 210000000225 synapse Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 230000037323 metabolic rate Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- BWSIKGOGLDNQBZ-LURJTMIESA-N (2s)-2-(methoxymethyl)pyrrolidin-1-amine Chemical compound COC[C@@H]1CCCN1N BWSIKGOGLDNQBZ-LURJTMIESA-N 0.000 description 2
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 description 2
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 238000012347 Morris Water Maze Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007087 memory ability Effects 0.000 description 2
- 230000004898 mitochondrial function Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000003956 synaptic plasticity Effects 0.000 description 2
- 238000007492 two-way ANOVA Methods 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- CGFKUVFBSBKLTP-UHFFFAOYSA-N 1,3-dinitrobenzene hydrazine Chemical compound NN.[N+](=O)([O-])C1=CC=CC(=C1)[N+](=O)[O-] CGFKUVFBSBKLTP-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000008923 Qingkailing Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 108010064384 amyloid beta-protein precursor 695 (319-339) Proteins 0.000 description 1
- 230000003005 anti-senility effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 239000012930 cell culture fluid Substances 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229940029329 intrinsic factor Drugs 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000012160 loading buffer Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000004540 pour-on Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
试验类型 | 时间 | 对照组N=10 | SAMP8对照组N=10 | AN=10 | BN=10 | CN=10 | DN=10 | EN=10 | FN=10 | GN=10 |
隐蔽平台试验反向试验可视平台试验 | Day1Day2Day3Day4Day5Day7Day8Day9Day10 | 54.71±4.4833.59±5.4233.34±14.52**3039±15.17**42.87±10.89**50.54±11.3740.66±14.51*30.34±18.99**29.67±5.23 | 59.12±1.8056.32±4.1755.31±1.6258.67±0.8958.45±0.5359.74±0.3859.56±0.5457.70±1.2835.16±10.35 | 57.70±6.0749.81±11.9250.81±12.9250.17±9.5751.25±11.3256.01±4.6051.38±8.8450.38±9.8435.06±12.41 | 59.59±1.2553.92±10.0651.81±10.9259.81±12.3157.64±10.2854.03±11.5549.58±10.4248.30±8.8434.78±10.96 | 55.87±8.8949.69±18.9249.91±11.12*46.81±8.72*50.34±10.6457.78±4.9148.38±10.1442.34±6.8234.91±8.30 | 58.50±6.0748.69±18.9245.53±11.26*44.53±11.18*46.95±13.73*58.01±5.6040.89±9.73*43.35±10.8432.18±8.35 | 51.70±10.0749.69±15.9247.74±15.60*46.57±11.90*45.87±16.26*52.08±8.8042.83±1432*40.34±6.8231.16±5.35 | 49.50±8.0748.69±18.9249.98±14.14*49.80±14.68*46.95±11.73*52.01±10.6048.14±8.6438.30±9.84*31.26±7.35 | 48.70±9.0747.69±17.9236.53±10.26**33.89±12.17**42.87±10.89**50.01±3.6038.79±9.73**35.81±8.84*30.16±6.35 |
组 | N | CellCounting(×104/ml) |
对照组模型组 | 1010 | 4.567±1.14**2.937±1.23 |
A | 10 | 3.067±0.84 |
B | 10 | 3.425±0.72 |
C | 10 | 4.121±1.26* |
D | 10 | 4.107±1.24* |
E | 10 | 4.208±1.35* |
F | 10 | 4.104±1.213* |
G | 10 | 4.508±1.598** |
组 | N | Axon Length | Cell body area |
对照组模型组FGAB | 101010101010 | 245.62±36.56**118.55±17.68227.22±57.01**227.78±55.59**162.89±34.04*148.42±47.64 | 963.92±314.95**365.43±67.33907.63±237.68**923.72±273.44**486.43±48.36*404.43±78.64 |
CDE | 101010 | 185.42±38.76*197.22±47.88*201.32±37.21* | 494.43±68.33*507.84±252.38*843.33±264.86** |
组 | N | OD |
对照组模型组FG | 10101010 | 1.178±0.03**0.945±0.031.095±0.04**1.125±0.03** |
A | 10 | 1.05±0.05 |
B | 10 | 0.968±0.07 |
C | 10 | 1.17±0.09* |
D | 10 | 0.99±0.08 |
E | 10 | 1.23±0.04** |
组 | N | LDH(IU/ml) |
对照组模型组FG | 10101010 | 408±159**717±165432±127**491±180* |
A | 10 | 631±160 |
B | 10 | 506±180* |
C | 10 | 651±140 |
D | 10 | 417±150** |
E | 10 | 421±180** |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101656338A CN101168025B (zh) | 2007-10-25 | 2007-10-25 | 一种防治老年性痴呆的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101656338A CN101168025B (zh) | 2007-10-25 | 2007-10-25 | 一种防治老年性痴呆的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101168025A true CN101168025A (zh) | 2008-04-30 |
CN101168025B CN101168025B (zh) | 2010-06-23 |
Family
ID=39388877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007101656338A Expired - Fee Related CN101168025B (zh) | 2007-10-25 | 2007-10-25 | 一种防治老年性痴呆的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101168025B (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103055014A (zh) * | 2012-12-31 | 2013-04-24 | 青岛华仁信息技术开发有限公司 | 一种预防老年痴呆症的银杏叶保健品及其制备方法 |
CN103211216A (zh) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | 一种辅助改善记忆力功能的保健食品及其制备方法 |
CN104000202A (zh) * | 2014-06-17 | 2014-08-27 | 史克勇 | 含有远志的保健食品 |
CN104041813A (zh) * | 2014-06-17 | 2014-09-17 | 史克勇 | 一种改善记忆保健品配方 |
CN105166896A (zh) * | 2015-09-06 | 2015-12-23 | 吉林大学 | 一种辅助改善记忆力的保健食品 |
CN106139019A (zh) * | 2016-08-10 | 2016-11-23 | 北京润康普瑞生物技术有限公司 | 一种改善痴呆症的中药组合物及其制备方法和应用 |
CN106237235A (zh) * | 2016-08-10 | 2016-12-21 | 北京润康普瑞生物技术有限公司 | 一种增强记忆力的中药组合物及其制备方法和应用 |
WO2021093087A1 (zh) * | 2019-11-14 | 2021-05-20 | 美国琛蓝营养制品股份有限公司 | 一种具有改善认知作用的中药组合物及其制备方法和中药制剂 |
WO2021093088A1 (zh) * | 2019-11-14 | 2021-05-20 | 美国琛蓝营养制品股份有限公司 | 一种具有改善认知作用的中药复合物或其制剂指纹图谱的建立方法 |
CN113855750A (zh) * | 2021-10-08 | 2021-12-31 | 苏同生 | 一种防治轻度认知损害的中药处方及制剂 |
CN114887018A (zh) * | 2018-10-30 | 2022-08-12 | 河西学院 | 一种苁蓉复合物及其制法 |
-
2007
- 2007-10-25 CN CN2007101656338A patent/CN101168025B/zh not_active Expired - Fee Related
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103055014A (zh) * | 2012-12-31 | 2013-04-24 | 青岛华仁信息技术开发有限公司 | 一种预防老年痴呆症的银杏叶保健品及其制备方法 |
CN103055014B (zh) * | 2012-12-31 | 2014-09-17 | 青岛华仁技术孵化器有限公司 | 一种预防老年痴呆症的银杏叶保健品及其制备方法 |
CN103211216A (zh) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | 一种辅助改善记忆力功能的保健食品及其制备方法 |
CN104000202A (zh) * | 2014-06-17 | 2014-08-27 | 史克勇 | 含有远志的保健食品 |
CN104041813A (zh) * | 2014-06-17 | 2014-09-17 | 史克勇 | 一种改善记忆保健品配方 |
CN105166896A (zh) * | 2015-09-06 | 2015-12-23 | 吉林大学 | 一种辅助改善记忆力的保健食品 |
CN106139019A (zh) * | 2016-08-10 | 2016-11-23 | 北京润康普瑞生物技术有限公司 | 一种改善痴呆症的中药组合物及其制备方法和应用 |
CN106237235A (zh) * | 2016-08-10 | 2016-12-21 | 北京润康普瑞生物技术有限公司 | 一种增强记忆力的中药组合物及其制备方法和应用 |
CN106139019B (zh) * | 2016-08-10 | 2019-10-01 | 北京润康普瑞生物技术有限公司 | 一种改善痴呆症的中药组合物及其制备方法和应用 |
CN106237235B (zh) * | 2016-08-10 | 2019-11-01 | 北京润康普瑞生物技术有限公司 | 一种增强记忆力的中药组合物及其制备方法和应用 |
CN114887018A (zh) * | 2018-10-30 | 2022-08-12 | 河西学院 | 一种苁蓉复合物及其制法 |
WO2021093087A1 (zh) * | 2019-11-14 | 2021-05-20 | 美国琛蓝营养制品股份有限公司 | 一种具有改善认知作用的中药组合物及其制备方法和中药制剂 |
WO2021093088A1 (zh) * | 2019-11-14 | 2021-05-20 | 美国琛蓝营养制品股份有限公司 | 一种具有改善认知作用的中药复合物或其制剂指纹图谱的建立方法 |
CN113855750A (zh) * | 2021-10-08 | 2021-12-31 | 苏同生 | 一种防治轻度认知损害的中药处方及制剂 |
Also Published As
Publication number | Publication date |
---|---|
CN101168025B (zh) | 2010-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101168025A (zh) | 一种防治老年性痴呆的药物组合物 | |
Soodi et al. | Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats | |
Wang et al. | Herba Cistanches: anti-aging | |
Feng et al. | Chinese medicines as a resource for liver fibrosis treatment | |
WO2016060525A1 (ko) | 쥐꼬리망초 속 식물의 추출물 또는 분획물을 포함하는 조성물 | |
EP3451859A1 (en) | Functionally reinforced desalted nutritional compositions from halophytes and preparation method thereof | |
WO2012124887A2 (en) | Composition comprising the extract of herbs for preventing or treating neurodegenerative disorders | |
Zhou et al. | Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice | |
WO2016153211A2 (ko) | 감귤류 과피 추출물의 제조방법 및 간 손상 예방, 개선 또는 치료용 조성물 | |
WO2012094834A1 (zh) | 一种防治糖代谢紊乱的复方中药提取物及其制备方法 | |
WO2016032249A1 (ko) | 모새나무 추출물 또는 이의 분획물을 유효성분으로 포함하는 신경염증 또는 퇴행성 뇌신경 질환의 예방 또는 치료용 약학적 조성물 | |
CN103301205B (zh) | 具有预防和治疗肝损伤作用的女贞子精制总苷及其制备方法和应用 | |
US20220226413A1 (en) | Traditional chinese medicine composition with improving cognition effect, preparation method thereof and traditional chinese medicine preparation | |
Cheng et al. | LW-AFC, a new formula from the traditional Chinese medicine liuwei dihuang decoction, as a promising therapy for alzheimer's disease: Pharmacological effects and mechanisms | |
CN105535448A (zh) | 一种治疗儿童重症肌无力的中药组合物 | |
CN104306370B (zh) | 用于保肝治疗的药物组合物及其制备方法 | |
WO2020101442A1 (ko) | 견사단백질을 갖는 익힌 누에가공물 및 당귀 추출물을 함유하는 기억력 개선용 조성물 또는, 알츠하이머성 치매 예방 및 치료용 조성물 | |
KR0153003B1 (ko) | 펠로덴드론 아무렌스 루프레트 속에 속하는 식물의 나무 껍질과 크로톤 티그리엄(l)속에 속하는 식물의 탈지열매의 혼합물로 부터의 추출물 | |
WO2014157812A1 (ko) | 관절건강에 도움을 주거나 또는 류마티스 관절염 및 골관절염의 예방, 개선 또는 치료를 위한 조성물 | |
CN108129542A (zh) | C-3,28,29-三取代齐墩果烷三萜皂苷及其药物组合物 | |
CN102940621B (zh) | 甲基阿魏酸在制备预防和治疗肝纤维化药物中的应用 | |
WO2017048051A1 (ko) | 인지기능장애 또는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 | |
Nazmul et al. | Evaluation of hepatoprotective effect of a polyherbal formulation against carbon tetrachloride-induced hepatotoxicity in rats | |
CN104958582A (zh) | 一种淡竹叶提取物、含其制剂及用途 | |
WO2017191886A1 (en) | Functionally reinforced desalted nutritional compositions from halophytes and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING NORMAL UNIVERSITY Free format text: FORMER OWNER: ZHANG ZHANJUN Effective date: 20100505 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100875 ROOM 230, YING TUNG EDUCATION BUILDING, INSTITUTE OF COGNITIVE NEUROSCIENCE AND LEARNING, BEIJING NORMAL COLLEGE, NO.19,,XINJIEKOU OUTER STREET, HAIDIAN DISTRICT, BEIJING CITY TO: 100875 ROOM 230, YING TUNG EDUCATION BUILDING, INSTITUTE OF COGNITIVE NEUROSCIENCE AND LEARNING, BEIJING NORMAL COLLEGE, HAIDIAN DISTRICT, BEIJING CITY |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20100505 Address after: 100875 Beijing city Haidian District Beijing Normal University Research Institute of cognitive neuroscience and learning Yingdong education building room 230 Applicant after: Beijing Normal University Address before: 100875 Beijing city Haidian District Xinjiekou Avenue No. 19 Beijing Normal University cognitive education Yingdong building room 230 Applicant before: Zhang Zhanjun |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Beijing Taiyang Pharmaceutical Co., Ltd. Assignor: Beijing Normal University Contract record no.: 2010990000800 Denomination of invention: Medicine composition for preventing and treating senile dementia Granted publication date: 20100623 License type: Exclusive License Open date: 20080430 Record date: 20100930 |
|
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Zhanjun Inventor after: Liu Zhenquan Inventor after: Li Peng Inventor after: Liu Fei Inventor after: Zhang Peng Inventor after: Qi Hailiang Inventor after: Wu Bo Inventor before: Zhang Zhanjun Inventor before: Liu Zhenquan Inventor before: Wang Yongyan Inventor before: Li Peng Inventor before: Hu Yuanjie Inventor before: Xia Yujie Inventor before: Liu Fei Inventor before: Zhang Peng |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG ZHANJUN LIU ZHENQUAN WANG YONGYAN LI PENG HU YUANJIE XIA YUJIE LIU FEI ZHANG PENG TO: ZHANG ZHANJUN LIU ZHENQUAN LI PENG LIU FEI ZHANG PENG QI HAILIANG WU BO |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100623 Termination date: 20161025 |