CN101152141B - Biological activity additive agent used for shampoo, producing and using method of the same - Google Patents

Abstract

The present invention discloses a biological activity additive used in a shampoo and manufacturing and using methods. Leather whistle, polygonum multiflorum, neem leaves, rice bran, silk sericin, wheat bran and soybean meal are evenly mixed. The product is gained by heating, cooling, fermenting, alcohol extracting and concentrating the mixture and then mixing the mixture with Chinese spicebush oil. The additive is added to the matrix formula of the prior art; the biological activity shampoo is gained by producing with regular processing. The effectiveness of the hair cleaning product is effectively improved. The present invention adopts overall solid biotransformation technology to process various prescription medicines. The irritation of raw materials is reduced; the biological activity of the raw materials is kept; the biological activity is easier to be absorbed by the hair and the effectiveness of the activity extract is fully played. The Chinese spicebush oil is used as oily material, so the impact of chemical synthesis of oily material on hair is avoided. The dosage of the shampoo with activity additive is obviously reduced; but the effect is better than commercial selling products.

Description

A kind of bioactive additive and preparation and using method that is used for shampoo

Technical field

The invention belongs to daily use chemicals product technical field, be specifically related to a kind of bioactive additive that is used for shampoo.The invention still further relates to the preparation and the using method of this additive simultaneously.

Background technology

Along with fast development of social economy, people's living standard improves constantly, and consumer is also more and more higher to washing the requirement of protecting the maintenance product.Existing shampoo mostly is the chemosynthesis series products on the market, and life-time service also can pollute environment not only bad for healthy simultaneously.Though and Chinese herbal medicine class shampoo composition is natural, have certain health-care effect, also there are abundant, the problems such as clean result is undesirable, function singleness of foam in existing product.How to overcome above-mentioned shortcoming, when guaranteeing clean result, realize the health environment-friendly of production and use, just become the focus of art technology research and development, but solution is not well arranged in the prior art as yet.

The application of the development of bioscience technology and modern analysis measuring technology not only makes conversion technology bring into play important effect in the structural modification of natural drug active component, and its utilization at the whole solid-state conversion aspect of natural drug has more potentiality.Whole solid-state conversion method not only can produce many noval chemical compounds, and transformation efficiency is doubled and redoubled, and realizes serialization, the automatization of entire reaction course.The whole solid-state conversion technology of natural drug is to utilize microorganism to be catalyst, and step during the efficient catalytic natural drug is synthetic or number step react or its chemical constituent is carried out structural modification, lower with toxigenicity, active stronger natural product.In recent years, the application of whole solid-state microbial transformation (fermentation) technology in the natural drug research and development is more extensive.For the active skull cap components of labyrinth, utilize chemosynthesis to carry out structural modification and exist shortcomings such as yield is low, poor, the by-product of reaction specificity is many, particularly some reaction (as the fracture of ehter bond etc.), utilize that present chemical means is difficult to be realized.And solid-state whole conversion technology can remedy the deficiency of chemosynthesis, can transform to produce new combined native compound group, changes the function curative effect of medicine, for drug screening provides shortcut.The active component of natural drug often content is very low, synthetic difficulty and along with the dynamics of drug development utilization continues to increase, natural wild resource storage capacity constantly descends.In recent years, be reactor with the microorganism, it is synthetic or finish some committed step in the building-up process to carry out the orientation of natural active matter, with this biotransformation and biosynthesis that promotes active skull cap components, is subjected to the extensive attention of Related Research Domain.

Summary of the invention

The objective of the invention is at the deficiencies in the prior art, a kind of all-natural bioactive additive that is used for shampoo is provided, it is added in the existing shampoo prescription, protect effect to strengthen washing of product.

Another object of the present invention provides a kind of method for preparing aforesaid biologically-active additive.

The present invention also aims to provide the using method of aforesaid biologically-active additive.

Purpose of the present invention is achieved by following technical proposals.

A kind of bioactive additive that is used for shampoo is made by following raw material: 1～16 part of Oleum Linderae, 5～20 parts of Semen Sapindi Delavayis, 1～8 part of Radix Polygoni Multiflori, 2～8 parts of leaf of Azadirachta Indica A., 40～80 parts in Testa oryzae, 0.3～4 part of silkworm silk, 5～20 parts in Testa Tritici, 2～15 parts of Semen Glycines powderes.

A kind ofly prepare the above-mentioned method that is used for the bioactive additive of shampoo, may further comprise the steps:

1, takes by weighing each raw material for standby by described weight portion;

2, silkworm silk is carried with 200 times decocting in water, obtains silkworm silk sericin aqueous solution;

3, Semen Sapindi Delavayi, Radix Polygoni Multiflori, leaf of Azadirachta Indica A., Testa oryzae, Testa Tritici, Semen Glycines powder and silkworm silk sericin aqueous solution is even, with water proof Steam Heating 0.5～1h, after placement is cooled to 20～40 ℃, adding is the little aspergillosis kind of main flora with common rhizopus, Mucor, yeast and rice-koji bacterium, stirs;

4, the material that stirs is packed in the container, placing room temperature is 30～45 ℃ fermenting house, ferments 3～15 days, after the fermentation ends material is dried;

5, the material after the fermentation is with 60%～85% alcohol reflux 3 times, recovery ethanol, and being concentrated to relative density is 1.25 ± 0.05, it is standby to obtain bioactive substance;

6, bioactive substance is mixed with Oleum Linderae, be the required bioactive additive that is used for shampoo.

The using method of bioactive additive of the present invention: this additive is added in the matrix formulations of existing shampoo, and then adopts common process to be prepared into the shampoo of biologically active, can strengthen the effect that has hair washing product now effectively.

Bioactive additive of the present invention selects natural drug to make up, through whole solid-state biotransformation, make and produce synergism between each efficacy of drugs, reduced the zest of medicine, strengthened the bioactive functions of product, effects such as having black hair, hair strengthening, removing scurf and relieving itching, antifungal, preserve moisture, uvioresistant, antioxidation and nutrition are moistened.Wherein:

Testa oryzae, kind skin for grass rice Oryza sativa L. wherein contains the required nutrient substance of skin such as abundant vitamin A, vitamin E, aminoacid and nicotinic acid, and these materials have moisture preserving function, can effectively prevent and treat scaly dry skin, slow down aging, prevent pigmentation.Though Testa oryzae skin care item fine particle wherein unlike clean liquid can produce foam like that because the natural frosted granule that has in its material can be gone out unnecessary aging cutin, make hair, skin feel softness, not dry and astringent.

Radix Polygoni Multiflori, be the tuber of polygonum multiflorum thunb Polygonummul tiflorum Thunb, wherein contained lecithin is the component of cerebral tissue, hemocyte and other cell membrane, often edible Radix Polygoni Multiflori, poliosis, baldness there are therapeutical effect, can anti-loss and black beard and hair; Contain abundant nutrition in the Radix Polygoni Multiflori, it is plain to comprise that crude fat, protein, starch, vitamin, aminoacid, inorganic salt and trace do not have, and hair is had protection, moisture-keeping function.

The sericin peptide of contained sericin gained after enzyme hydrolysis is to the affinity and the nursing role of hair in the silkworm silk sericin, the sericin peptide not only has good film property, can form one deck protectiveness transparent membrane in hair surface, improve the gloss and the elasticity of hair greatly, and porous replenishes the hair desired nutritional to hair inside; Simultaneously, also have hygroscopicity, antistatic behaviour, the shape-retaining ability that curls preferably, help making hair to keep normal, healthy and state attractive in appearance.

Leaf of Azadirachta Indica A. is the leaf of Meliaceae plant chinaberry Melia azedarach L. or Fructus Toosendan Melia toosendanSieb.et Zucc, discover and contain a kind of wide spectrum, efficient, pollution-free, noresidue and harmless active substance---(seal) chinaberry element in the chinaberry leaf, can prevent that microorganism from growing in hair with unique sterilization functions.

Semen Sapindi Delavayi [being the peel of sapindaceous plant Yunnan Fructus Sapindi Mukouossi Sapindus delavayi (Franch.) Radlk], among the people with peel hair washing to boil water, can be used for treating mange, head louse.Measure by analysis, the main active substances of Semen Sapindi Delavayi is a sapindoside, mainly is distributed in the peel, and wherein sapindoside A is that disaccharidase saponin, sapindoside B are the trisaccharide saponin.Modern study shows: the active component of Semen Sapindi Delavayi has antibacterial action, especially fungus is had stronger killing action; External can be treated tinea pedis; Experiment in vitro shows the strong inhibition tyrosinase activity; Be used for shampoo and can eliminate dandruff and can antipruriticly wait effect, but the extract sugar content of Semen Sapindi Delavayi is bigger, and enrichment is arranged on hair, the zest of extract is bigger simultaneously, causes Semen Sapindi Delavayi well not developed.

In order to reach effect better, active additive of the present invention also makes up with Oleum Linderae.Oleum Linderae is the seed of canella Emmenopterys henryi oliv. Lindera communis Hemsl., makes through squeezing and refining.But soap system, refining oils and fats, or, pharmaceutically be commonly used for the substrate of suppository as the oleaginous base of cosmetics.Oleum Linderae has dissipating blood stasis for subsidence of swelling, hemostasis and pain-relieving, effects such as detoxifcation.The furuncle carbuncle that is used for the treatment of among the people, traumatic hemorrhage, treating swelling and pain by traumatic injury and fracture etc.

Have following advantage with respect to prior art the present invention:

1, adopts whole solid-state conversion technology to handle each prescription drug, reduced the zest of crude drug, kept the biological activity that each raw material had, make active component easier, given full play to the effect of activity extract for hair absorbs.

2, with natural Oleum Linderae as the oiliness material, replaced the oiliness material of chemosynthesis in the conventional shampoo, avoided of the harmful effect of the oiliness material of chemosynthesis to hair.

Effect when 3, the shampoo that has added active additive of the present invention obviously is better than not adding at aspects such as washing performance, moisture retention, reparation, grease resistance, antistatic, black hair performance and elasticity.

4, its consumption of shampoo that has added active additive of the present invention obviously reduces, and be generally 2/3～1/2, but clean result is better.

The specific embodiment

Embodiment 1

Prepare a kind of bioactive additive that is used for shampoo, take by weighing each raw material for standby by proportioning shown in the table 1; Silkworm silk is carried with 200 times decocting in water, obtained silkworm silk sericin aqueous solution; Semen Sapindi Delavayi, Radix Polygoni Multiflori, leaf of Azadirachta Indica A., Testa oryzae, Testa Tritici, Semen Glycines powder and silkworm silk sericin aqueous solution is even, stir, with water proof Steam Heating 0.5h, after placement is cooled to 20 ℃, adding is the little aspergillosis kind of main flora with common rhizopus, Mucor, yeast and rice-koji bacterium, stirs; The material that stirs is packed in the bamboo basket, and placing room temperature is 45 ℃ fermenting house, ferments 3 days, after the fermentation ends material is dried; Material after the fermentation reclaims ethanol with 60% alcohol reflux 3 times, and being concentrated to relative density is 1.25 ± 0.05, and it is standby to obtain bioactive substance; Bioactive substance is mixed with Oleum Linderae, be the required bioactive additive that is used for shampoo.

Embodiment 2

Repeat embodiment 1, following difference is arranged: proportioning raw materials is as shown in table 1; With steam water proof heating 40 minutes, after placement is cooled to 30 ℃; Placing room temperature is 35 ℃ fermenting house, ferments 7 days, after the fermentation ends material is dried; Material after the fermentation is with 70% alcohol reflux 3 times.

Embodiment 3

Repeat embodiment 1, following difference is arranged: proportioning raw materials is as shown in table 1; With steam water proof heating 50 minutes, after placement is cooled to 35 ℃; Placing room temperature is 40 ℃ fermenting house, ferments 11 days, after the fermentation ends material is dried; Material after the fermentation is with 85% alcohol reflux 3 times.

Embodiment 4

Repeat embodiment 1, following difference is arranged: proportioning raw materials is as shown in table 1; With steam water proof heating 1h, after placement is cooled to 40 ℃; Placing room temperature is 45 ℃ fermenting house, ferments 15 days, after the fermentation ends material is dried; Material after the fermentation is with 75% alcohol reflux 3 times.

Table 1 proportioning raw materials (unit: kg)

Raw material	Example 1	Example 2	Example 3	Example 4
					Semen Sapindi Delavayi	2	1.5	1.0	0.5
Radix Polygoni Multiflori	0.1	0.4	0.6	0.8

Leaf of Azadirachta Indica A.	0.4	0.6	0.2	0.8
					Testa oryzae	4	5	6	8
Silkworm silk	0.2	0.03	0.1	0.4
					Testa Tritici	0.5	1.0	1.5	2
Semen Glycines powder	0.2	1.5	0.6	1.0

Oleum Linderae

0.1

0.6

1.0

1.6

Embodiment 5～8

The bioactive additive that makes with embodiment 1～4 disposes shampoo; concrete proportioning sees Table 2: with bioactive additive and polyoxyethylenated alcohol sodium sulfate (AES); ammonium lauryl sulfate (K12A); Oleum Cocois acyl group CAB (CAB); dihydro Adeps Bovis seu Bubali phosphorus benzene bis-acid potassium amide (TAB-2); glycol stearate (pearlescent flake); coconut monoethanolamide (CMEA); 16 octadecyl aliphatic alcohol (16/18 alcohol); disodiumedetate (EDTA-2Na); citric acid is mixed in proportion; be heated to 70～80 ℃; material is fully dissolved; add the finely dispersed quaternized cationic cellulose of water (JR-400) again; quadripolymer (S-951); the two stearates (638 thickening agent) of polyethylene glycol 6000; stirring cools to 30～50 ℃; add Kazon then successively; essence; the D-L-pantothenylol; stir, promptly obtain the shampoo of required biologically active.

Table 2. shampoo material proportion (unit: kg)

(the bioactive additive that obtains of proportioning 1,2,3,4 corresponding respectively embodiment 1,2,3,4 wherein.

	Example 5	Example 6	Example 7	Example 8
					Composition	Proportioning 1	Proportioning 2	Proportioning 3	Proportioning 4
Bioactive additive	1.2	0.8	0.5	1.5
					Polyoxyethylenated alcohol sodium sulfate (AES)	1.2	1.4	1.6	1.8
Ammonium lauryl sulfate (K12A)	0.7	0.6	0.5	0.4
					Oleum Cocois acyl group CAB (CAB)	0.5	0.6	0.4	0.3
Dihydro Adeps Bovis seu Bubali phosphorus benzene bis-acid potassium amide (TAB-2)	0.05	0.04	0.06	0.07
					Glycol stearate (pearlescent flake)	0.1	0.15	0.2	0.25
Coconut monoethanolamide (CMEA)	0.25	0.2	0.15	0.1
					16 octadecyl aliphatic alcohol	0.01	0.015	0.015	0.02

(16/18 alcohol)
					Quaternized cationic cellulose (JR-400)	0.02	0.05	0.08	0.12
The two stearates (638 thickening agent) of polyethylene glycol 6000	0.18	0.14	0.10	0.06
					Disodiumedetate (EDTA-2Na)	0.02	0.015	0.01	0.01
Quadripolymer (S-951)	0.04	0.03	0.02	0.01
					The D-L-pantothenylol	0.08	0.06	0.04	0.03
Citric acid	0.005	0.005	0.005	0.005

Essence	0.04	0.04	0.04	0.04
					Kazon	0.01	0.01	0.01	0.01
Deionized water	Add to 10	Add to 10	Add to 10	Add to 10

The trial effect of the shampoo of example 9 biologically actives

1, object of study: removing scurf and relieving itching.

Crowd on probation: 2003 grades, 2004 grades schoolgirls of Chinese medicine institute of Yunnan University of Traditional Chinese Medicine.

Trial scheme: experiment is divided into four experimental grouies and a matched group, every group 40 people, and experimental group uses the biological shampoo of embodiment 5～8 preparations of randomly drawing, and matched group uses the medium-to-high grade shampoo on the market, washes every day once, uses continuously two months.

Result on trial:

	Experimental group one	Experimental group two	Experimental group three	Experimental group four	Matched group
						Alleviate	15	15	16	13	10
Obviously improve	20	22	21	23	10
						Invalid	5	3	3	4	20

The result shows:

Add the shampoo that medicine tunning of the present invention and Oleum Linderae make and have the removing scurf and relieving itching effect.

2, object of study: anti-alopecia, black hair.

Crowd on probation: 2003 grades, 2004 grades schoolgirls of Chinese medicine institute of Yunnan University of Traditional Chinese Medicine.

Trial scheme: experiment is divided into four experimental grouies and a matched group, every group 40 people, and experimental group uses the biological shampoo of embodiment 5～8 preparations of randomly drawing, and matched group uses the medium-to-high grade shampoo on the market, washes every day once, uses continuously one month.

Result on trial:

	Experimental group one	Experimental group two	Experimental group three	Experimental group four	Matched group
						More obvious	15	18	15	14	4
Obviously	21	19	20	22	15
						Do not have	4	3	5	4	21

The result shows:

Add the shampoo that medicine tunning of the present invention and Oleum Linderae make and have black hair, hair strengthening effect.

3, object of study: oil-control ability, maintenance ability.

Crowd on probation: 2003 grades, 2004 grades schoolgirls of Chinese medicine institute of Yunnan University of Traditional Chinese Medicine.

Trial scheme: experiment is divided into four experimental grouies and a matched group, every group 30 people, and experimental group uses the biological shampoo of example 5～8 preparations of randomly drawing, and matched group uses the medium-to-high grade shampoo on the market, washes every day once, uses continuously one month.

Result on trial:

	Experimental group one	Experimental group two	Experimental group three	Experimental group four	Matched group
						More obvious	12	10	15	13	8
Obviously	14	17	14	13	9
						Do not have	4	3	1	4	13

The result shows:

Add the shampoo that medicine tunning of the present invention and Oleum Linderae make and have stronger oil-control ability and maintenance ability.

Claims (3)

1. bioactive additive that is used for shampoo, made by following method: it is standby to take by weighing 1～16 part of Oleum Linderae, 5～20 parts of Semen Sapindi Delavayis, 1～8 part of Radix Polygoni Multiflori, 2～8 parts of leaf of Azadirachta Indica A., 40～80 parts in Testa oryzae, 0.3～4 part of silkworm silk, 5～20 parts in Testa Tritici and 2～15 parts of Semen Glycines powderes; Silkworm silk is carried with 200 times decocting in water, obtains silkworm silk sericin aqueous solution; Semen Sapindi Delavayi, Radix Polygoni Multiflori, leaf of Azadirachta Indica A., Testa oryzae, Testa Tritici, Semen Glycines powder and silkworm silk sericin aqueous solution is even, with water proof Steam Heating 0.5～1h, after placement was cooled to 20～40 ℃, adding with common rhizopus, Mucor, yeast and rice-koji bacterium was the little aspergillosis kind of main flora, stirs; The material that stirs is packed in the container, and placing room temperature is 30～45 ℃ fermenting house, ferments 3～15 days, after the fermentation ends material is dried; Material after the fermentation reclaims ethanol with 60%～85% alcohol reflux 3 times, and being concentrated to relative density is 1.25 ± 0.05, and it is standby to obtain bioactive substance; Bioactive substance is mixed with Oleum Linderae, obtain the described bioactive additive that is used for shampoo.

2. one kind prepares the described method that is used for the bioactive additive of shampoo of claim 1, may further comprise the steps:

(1) it is standby to take by weighing 1～16 part of Oleum Linderae, 5～20 parts of Semen Sapindi Delavayis, 1～8 part of Radix Polygoni Multiflori, 2～8 parts of leaf of Azadirachta Indica A., 40～80 parts in Testa oryzae, 0.3～4 part of silkworm silk, 5～20 parts in Testa Tritici and 2～15 parts of Semen Glycines powderes;

(2) silkworm silk is carried with 200 times decocting in water, obtains silkworm silk sericin aqueous solution;

(3) Semen Sapindi Delavayi, Radix Polygoni Multiflori, leaf of Azadirachta Indica A., Testa oryzae, Testa Tritici, Semen Glycines powder and silkworm silk sericin aqueous solution is even, with water proof Steam Heating 0.5～1h, after placement is cooled to 20～40 ℃, adding is the little aspergillosis kind of main flora with common rhizopus, Mucor, yeast and rice-koji bacterium, stirs;

(4) material that stirs is packed in the container, placing room temperature is 30～45 ℃ fermenting house, ferments 3～15 days, after the fermentation ends material is dried;

(5) material after the fermentation is with 60%～85% alcohol reflux 3 times, recovery ethanol, and being concentrated to relative density is 1.25 ± 0.05, it is standby to obtain bioactive substance;

(6) bioactive substance is mixed with Oleum Linderae, be the required bioactive additive that is used for shampoo.

3. the described using method that is used for the bioactive additive of shampoo of claim 1 is characterized in that: described bioactive additive is added in the matrix formulations of existing shampoo, and then adopts common process to be prepared into the shampoo of biologically active.