CN101147779A - Composition containing nucleotide, its preparation method and its use - Google Patents
Composition containing nucleotide, its preparation method and its use Download PDFInfo
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Abstract
The present invention discloses a medicine composition containing nucleotide. Said medicine composition contains (by weight portion) 50-150 portions of nucleotide, 3-55 portions of Chinese medicine extract, 0.1-20 portions of soybean oligopeptide and/or 0-16 portions of vitamin, 0-0.04 portion of folic acid and/or 0-2 portions of zinc, the above-mentioned Chinese medicine extract is one of flowery knotweed root extract, lyceum berry extract and ginkgo leaf extract or their mixture. Said medicine composition has the several health-care functions of raising immunity of human body and delaying senility.
Description
Technical field
The present invention relates to a kind of compositions that contains nucleotide, Its Preparation Method And Use particularly contains at least a compositions in nucleotide and Chinese medicine, the polypeptide, Its Preparation Method And Use.
Background technology
Nucleotide is important low molecular compound in the organism, has many physiological functions, removes the precursor as DNA, RNA, also participates in the metabolism of body internal protein, saccharide and fat as the adjusting material of physiology, biochemical process.Generally speaking, body can be by endogenous synthetic various nucleotide, but many studies show that in recent years, when body ramp, internal organs fail or be subjected to the immunity challenge, some organs, tissue as intestinal, lymph, the synthetic nucleotide of medullary cell can not satisfy the needs of body tissue and cellular metabolism, and need supplemented with exogenous nucleotide is to guarantee its tissue growth and normal function.Therefore, the Nutrition of nucleotide more and more causes concern.The therapeutical effect of nucleotide also more and more causes the attention of medical educational circles simultaneously.
Nucleotide can be kept immune normal function, as improving the resistance of body to antibacterial, fungal infection, increases antibody and produces, and strengthens cell immunocompetent, stimulates lymphocytosis effect etc.Studies show that nucleotide can be kept the gastrointestinal tract normal function, participate in regulating the protein synthesis of liver, nucleotide also has antioxidation.The nitrogen oxygen atom of nucleotide base can be caught the free radical that forms in the oxidizing process, reduces the cell membrane that caused by lipid peroxidation and the damage of various DNA.
Chinese medicine can the enhancing human body immunity ability, disease preventing and treating, the Chinese medicine disease, do not emphasize with medicine facedown virulence factor, focus on bringing into play the resistance against diseases of body self, adjust the functional status of body, the effect of this and nucleotide is similar, therefore, the two is combined, can improve action effect.
Chinese patent application 03117840.5 discloses a kind of supportive atypical pneumonia and safe fat-reducing dietotherapeutic product and manufacture method of preventing and treating, by compound Chinese medicine, and compound vitamin, compound microelement and compound nucleotide are formed.According to the traditional Chinese medical science " pestilence is great dryness and great heat all; lung yin loses greatly; calentura is cold to be controlled " and " lung deficiency of YIN of the spleen and stomach obesity " common principle and burning, cough, fat, the fat liver, the control of cardiovascular and cerebrovascular vessel and other respiratory system disease need consume more Multivitamin, trace element and nucleotide antiviral help the doctor trained in Western medicine facts such as the synthetic raising of interferon resistance immunity, original creation Chinese and western medical and nutrition dietary therapy combine its strong point of union in one, and legal dietotherapeutic, meet " Diet cures more than the doctors " but good disease preventing and treating purpose of deep-rooted consumer psychology phase is not especially also having control SARS specific drug, huge crowd prevention for a long time and control crowd are huge equally, age and SARS prevalence height correlation and the obesity of being growing on and on make under the stem reality of fat-reducing main forces safe fat-reducing its medical social benefit and market huge.The supportive atypical pneumonia and the safe fat-reducing dietotherapeutic product prevented and treated that are used to prevent and treat atypical pneumonia and other disease of respiratory system and fat and serial complication of this application, restrain by compound Chinese medicine 80-140, compound vitamin 0-0.6 gram, compound microelement 0-18 milligram, compound nucleotide 0-1.2 restrains composition; Or by weight the corresponding equal number umber that is scaled of the gram number of each component equal number is formed.
Chinese patent application 200410021847.4 discloses a kind of control poultry animal and human being grippe and virosis dietotherapeutic nucleic acid gene Chinese medicine and western medicine goods and manufacture method, by composite nucleic acid, compound nucleotide, compound Chinese medicine, compound Western medicine is that arbitrary class to the interval complex of whole and corresponding parts by weight in the compound vitamin four class complex is formed, is used as capsule, tablet, oral liquid or nutritional solution medicine; As capsule, tablet, oral liquid or nutritional solution medicine host; As varieties of food items, beverage, additive of flavourings; Consumption is pressed GMP-and is produced normal needs.Having broad-spectrum antiviral, influenza is Chinese medicine alleged " day row cold (tremble with fear) pestilence " infection, without any side effects and dose limitation, be applicable to control poultry animal and human being grippe and other virus and virosis thereof, have that mouthfeel is good, consumption is few, instant effect, wide in variety, taking convenience, shelf life is promptly guaranteed the quality with long shelf-life, the raw material source is wide, production technology is simple, be beneficial to large-scale low-cost production, finally be beneficial to consumers in general and country, national and whole mankind Community health, the mankind prevented and treated virosis new effective measure is provided.This a kind of control poultry animal and human being grippe and virosis dietotherapeutic nucleic acid gene Chinese medicine and western medicine goods, by composite nucleic acid (RNA1-10 part+DNA1-10 part) 2-20 part, compound nucleotide (purine class nucleotide IMP0.2-2 part, GMP0.2-2 part, AMP0.2-2 part, dAMP0.2-2 part, in dGMP0.2-2 part any is to whole+miazines nucleotide UMP0.2-2 part, CMP0.2-2 part, TMP0.2-2 part, dCMP0.2-2 part, in dTMP0.2-2 part any is to whole) 0.4-20 part, compound Chinese medicine (Semen phaseoli radiati 0.2-2 part, Radix Ginseng 0.2-2 part, Folium Perillae 0.2-2 part, Pericarpium Citri Reticulatae 0.2-2 part, Radix Glycyrrhizae 0.2-2 part) 1-10 part, compound Western medicine are compound vitamin (vitamin A 0.1-1 part, vitamin B2 0.1-1 part, vitamin C 0.8-8 part) the arbitrary class in 1-10 part four class complex to the interval complex of whole and corresponding parts by weight is formed.
Therefore, developing the new compositions that contains nucleotide, is very significant with immunocompetence, the treatment disease that improves human body.
Summary of the invention
The object of the present invention is to provide a kind of compositions that contains nucleotide, its by nucleotide and Chinese medicine and or the compatibility of polypeptide and vitamin, trace element, regulate body self function from different aspects, enhancing human body immunity power, the ability of while enhancing body antioxidation and removing oxygen-derived free radicals, slow down aging.
Another object of the present invention is to provide the above-mentioned preparation of compositions method that contains nucleotide.
A further object of the present invention is to provide the above-mentioned purposes of compositions on preparation health food, treatment and prevention various diseases medicine, food and cosmetics additive etc. that contains nucleotide.
To achieve these goals, the technical solution used in the present invention is: a kind of compositions that contains nucleotide comprises at least:
Nucleotide: 50-150 weight portion;
Chinese medicine extract: 3-55 weight portion;
Described Chinese medicine extract is one or more combination of Radix Polygoni Multiflori, Fructus Lycii, Folium Ginkgo extract, and its consumption is:
Radix Polygoni Multiflori extract: 1.5-25 weight portion;
Fructus Lycii extract: 1-20 weight portion;
Folium Ginkgo extract: 0.5-10 weight portion;
In the described compositions, also further comprise soybean oligopeptide 0.1-20 weight portion;
Also comprise in the compositions of the present invention: vitamin 0-16 weight portion;
Described Vitamin U is elected vitamin E and vitamin B as
6One or both of combination, its content is respectively: vitamin E 0-15 weight portion, vitamin B
6The 0-1 weight portion.
In another embodiment of the present invention, described compositions also comprises folic acid 0-0.04 weight portion and/or organic zinc 0-2 weight portion.Organic zinc wherein includes but not limited to zinc gluconate, zinc glycyrrhizate, zinc lactate, amino-acid zinc, zinc citrate, zinc glycinate, zinc glutamate, zinc lysine, yeast zinc.
As a kind of selection, the present invention contains the compositions of nucleotide, comprises at least:
Nucleotide: the 50-150 weight portion,
Soybean oligopeptide 0.1-20 weight portion.
Nucleotide of the present invention can adopt disclosed various nucleotide in the prior art, wherein mainly contains: 5 '-cytidylic acid, 5 '-adenylic acid, 5 '-uridine monophosphate disodium, 5 '-guanosine monophosphate disodium etc.Radix Polygoni Multiflori, Fructus Lycii, Folium Ginkgo extract also can adopt disclosed various extracts in the prior art.Described soybean oligopeptide is to utilize bean cake or soybean protein isolates to be raw material, utilize biotechnology soybean protein controlledly, optionally to be hydrolyzed into the soybean oligopeptide of small-molecular weight, general that be made up of 2-6 aminoacid, molecular weight is at the hybrid peptide product of 200-800Dalton, and preferred molecular weight is 300-700Dalton.
Compositions of the present invention can be prepared as medicines such as capsule, tablet, granule, suspensoid or mixture dosage form commonly used; Also can be health food common formulations such as capsule, tablet, oral liquid or powder; Perhaps as varieties of food items, cosmetics, additive of flavourings.Making capsule with above-mentioned composition is example, the 200-400mg/ grain.Nucleotide content is preferably 25-90g/100g in the compositions that obtains, and general flavone content is preferably 1-9mg/g.
Preparation of compositions method of the present invention is: sieve after the raw material detection is qualified, take by weighing, mix the back by formula ratio and prepare finished product according to common process.
The compositions that contains nucleotide of the present invention is used to improve the immunocompetence of human body can be used as health product, medicine or cosmetics and food additive, enhancing body antioxidation and remove ability such as oxygen-derived free radicals.
Among the present invention, nucleotide is as the precursor substance of forming DNA, RNA, except the various processes that participate in life, plays an important role promoting animal growth, keep liver function, regulate the esters metabolism and improve aspects such as immunity.A large amount of experimentatioies show nucleotide can improve antibody horizontal, increase helper T lymphocyte number, help since nucleotide lack the IgM that causes, IgG secretory cell number recovery, regulate body the balance of antigenic Th1 and Th2 reaction, cytokine γ-IFN and the IL-2 that Tn1 is produced raise the enhancing human body immunity function.
Radix Polygoni Multiflori is the tuber of polygonum multiflorum thunb Polygonum multiflorum Thunb., bitter in the mouth, sweet, puckery, the property wet, have the effect of invigorating the liver and kidney, benefiting essence-blood, strengthening bone and muscle, black beard and hair, be mainly used in the Liver and kidney essence and blood lose empty, have a dizzy spell, disease such as soreness of the waist and knees.Fructus Lycii is the dry mature fruit of Fructus Lycii, and liver, kidney channel are equalled, returned to sweet in the mouth, property, has effects such as nourishing the liver and kidney, replenishing vital essence to improve eyesight, is mainly used in that asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, blurred vision are not clear etc.Folium Ginkgo is the dried leaves of Ginkgoaceae Ginkgo plant.Folium Ginkgo extract has expansion coronary vasodilator, cerebral blood flow increasing amount, anti-platelet activating factor, prevention and multiple medical values such as treatment asthmatic tracheitis, bacteria growing inhibiting.In recent years the research of Radix Polygoni Multiflori, Fructus Lycii and Folium Ginkgo is further goed deep into, the above-mentioned three kinds of Chinese medicine extract of a large amount of research bibliographical informations have the effect of removing oxygen-derived free radicals, increase the lipid peroxidation of superoxide dismutase (SOD) vigor in the serum, reduction serum lipid peroxide (LPO) content, antagonism cell membrane; And body specificity and nonspecific immunity are had facilitation, have immune enhancing function.
Semen sojae atricolor is the main source of high quality protein, it not only contains rich in protein, also contain soybean oligopeptide, cellulose, hemicellulose, pectin, mannan, Folium Cocoe, locust beam gum, soluble fiber etc., can prevent alimentary tract cancer and other diseases, soy oligosaccharide comprises that stachyose, cottonseed sugar can be suppressed the growth of Putrefying bacteria in the body by the intravital bacillus bifidus utilization of people.In addition, also have biological active substanceies such as lecithin, unsaturated fatty acid in the Semen sojae atricolor, health is also had significant beneficial effect.Soybean protein can significantly reduce absorbance, tissue fat amount, body fat amount and the serum lipid concentrations of food fat, and edible soyabean protein can make with energy metabolism has the thyroxin and the thyrotropin that are closely connected to keep higher level.Soybean oligopeptide (also claiming soybean peptide, soybean polypeptide, soybean active peptide etc.) not only has higher nutritive value, and has biological activitys such as antioxidation, enhancing body immunity, cholesterol reducing, inhibition ACE and promotion microorganisms grow.
Vitamin E (V
E) be the important fatsoluble vitamin that has extensive physiological function in the human body, except promoting reproduction, keep central nervous system, cardiovascular system and unify outside the function of skeletal muscle, also have the effect of immunomodulator.V
EBy strengthening humoral immunization, improve cell-mediated immune responses, influence phagocytic function etc. and act on and influence immune status.Studies show that and replenish V
ECan improve immunoglobulin level in the blood, strengthen ability vaccine or other antigen generation antibody; Splenocyte quantity is significantly increased, and splenocyte also significantly strengthens the reaction of mitogen ConA, and the NK cytoactive is also with taking in V
EThe increase of content and strengthening; V
ECan influence multiple type nuclear leukocyte in the blood, pulmonary macrophage, peritoneal macrophage function, so influence cytophagously engulf, sterilizing ability.V
EThe mechanism of action complexity, studies show that it may is to influence some cell cluster selectively as immunostimulant, also may be since its anti-oxidant properties by keeping or changing the immunocyte membrane fluidity and regulate PGE
2Synthetic and regulate immunoreation.
Vitamin B
6(VB
6) be a kind of vitamin B group that pyrrole diindyl alcohol or pyrrole diindyl aldehyde obtain pyrrole diindyl amine that contains, be the constituent of some coenzyme in the human body, participate in multiple metabolic response, especially substantial connection is arranged with amino acid metabolism, by the cell growth essential; In addition, VB
6In the organism immune response system, the animal economy immune state there is protective effect, can keeps normal cellular immunization as essential cofactor.Bibliographical information, VB
6Thymic weight alleviates during shortage, and lymphocytic maturation, propagation and cytoactive all are suppressed; Anthroposcopy finds that healthy elderly lacks VB
6The time IL-2 and lymphocytic propagation all be suppressed, lack VB
6The people to the habituation of tetanus vaccine and antityphoid vaccine.
Folic acid is vitamin B group, is that the human inner cell grows and breeds necessary material, if lack folic acid in the human body, can cause diseases such as heart disease, cerebral thrombosis, gastric ulcer, colorectal cancer; Also can influence hemopoietic function of bone marrow, cause nutritional anemia, especially the anemia of pregnant woman if folic acid nutritional labeling deficiency in the body will influence the fetal nerve allelotaxis, makes infant intelligence low, forms monster when serious.In addition, when body generation immunoreation, antigen makes lymphocyte sensitization, and the synthetic of DNA promptly increases, and folic acid necessary coenzyme during to be DNA synthetic.Bibliographical information, folic acid all has certain facilitation to cellular immunization, humoral immunization and the functions of neutrophils of body.
Zinc is essential trace element in the body, be distributed widely in the body tissue, be plurality of enzymes constituent and activity factors such as archaeal dna polymerase, RNA polymerase, alkali phosphatase, lactic acid dehydrogenase, carbonic anhydrase, hydroxyl enzyme, glutamte dehydrogenase, participate in nucleic acid and proteinic synthetic directly, energy metabolism and oxidation-reduction process.Zinc is a kind of important element that participates in immunologic function, and immunologic function is had nutrition and regulating action.Body zinc deficiency T lymphopenia, peripheral lymphoid organs atrophys such as thymus and spleen, lymph node, the T lymphocyte reaction is suppressed, and the lymphocytic cell surface adhesion molecule expression changes; Can reverse said process after the zinc supplement; During zinc deficiency, the bone marrow bone-marrow-derived lymphocyte generates and is suppressed, and bone-marrow-derived lymphocyte reduces in the spleen, and the antibody response of bone-marrow-derived lymphocyte also is suppressed.
The compositions that contains nucleotide of the present invention mainly is made up of nucleotide and Radix Polygoni Multiflori extract, Fructus Lycii extract, Folium Ginkgo extract.Nucleotide is as the precursor substance of body nucleic acid, mainly from endogenous synthetic, generally speaking, the synthetic nucleotide of body self can be satisfied the demand, if but body is under the situations such as rapid stage of growth promoter, internal organs decline or experience immunological stress, self synthetic nucleotide just can not satisfy the metabolism needs of tissue and cell, must be supplied with by external source.The compositions that contains nucleotide of the present invention is to the accumulation of middle-aged and elderly people interior free yl, the reduction of vascular smooth muscle elastic force, sclerosis of blood vessels and be subjected to that a series of immunity due to the reason such as environmental pollution reduce, the physiological characteristics that degeneration goes down appears in physiological function, nucleotide and Chinese medicine extract (for example: Radix Polygoni Multiflori extract, Fructus Lycii extract, Folium Ginkgo extract) compatibility are used, (for example: vitamin E, vitamin B be equipped with soybean oligopeptide, vitamin simultaneously
6) and trace element (for example: folic acid, zinc), collaborative the playing a role from different aspects: the energy activating cell, regulate body each system self function, improve immunity; Simultaneously can enhancing body antioxidation and removing oxygen-derived free radicals ability, slow down aging.
Describe the present invention in detail below in conjunction with specific embodiment.
The specific embodiment
Embodiment 1
Raw material nucleotide 60g, Folium Ginkgo extract 6g cross 80 mesh sieves respectively, and with HZD-1000 mixer mixing 30min, the fine powder behind the mix homogeneously is measured its functional component content; The fine powder of the mix homogeneously CFM-1200 fully-automatic capsule filling machine of packing into, filled capsules, and regulate every of loading amount between 0.35g ± 8%.Projects inspections such as microbiology, physics and chemistry are carried out by the standard code sampling in the sterilization back.
Embodiment 2-13
Method according to embodiment 1 prepares composition capsule of the present invention, and composition components and content are with reference to following table
| Nucleotide | Radix Polygoni Multiflori extract | Fructus Lycii extract | Folium Ginkgo extract | Soybean oligopeptide | Vitamin E | Vitamin B 6 | Folic acid | Zinc | |
| Embodiment 2 | 150 | 3 | |||||||
| Embodiment 3 | 135 | 1.5 | 2.5 | ||||||
| Embodiment 4 | 120 | 5 | 6 | 10 | 0.1 | 0.5 | |||
| Embodiment 5 | 100 | 8 | 8.5 | 7.5 | 12 | 7.5 | 0.05 | ||
| Embodiment 6 | 85 | 12 | 10 | 2 | 6 | 1.2 | 0.4 | 0.01 | 0.001 |
| Embodiment 7 | 50 | 25 | 20 | 0.5 | 20 | 15 | 1 | 0.04 | 2 |
| Embodiment 8 | 90 | 25 | 20 | 10 | 2 | 0.8 | 0.1 | ||
| Embodiment 9 | 140 | 20 | 10 | ||||||
| Embodiment 10 | 130 | 15 | 5 | 8 | 10 | ||||
| Embodiment 11 | 110 | 5 | 3 | 0.5 | 20 | ||||
| Embodiment 12 | 95 | 1.5 | 17 | 8 | 0.1 | 3 | 0.6 | 0，02 | 1 |
| Embodiment 13 | 80 | 10 | 18 |
Experimental example
Disease prevention and control center, Liaoning Province to the safety evaluatio result of the embodiment of the invention 6 compositionss is: the compositions that contains nucleotide of the present invention all greater than 15.00g/kgbw, belongs to innocuous substance to the large and small Mus per os maximum tolerated dose (MTD) of two kinds of sexes; The result is all negative for three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test); Experimental group that clinical examination in 30 days feeding trials of rat, internal organs weighing, blood biochemical are learned and checked, the hematological examination result shows every inspection item and matched group comparison, difference is not remarkable.The result of histopathologic examination shows, matched group and high dose group are female, male rat liver, kidney, stomach, intestinal, spleen, ovary and testis are not all found obvious damaging pathological change.It is safe that The above results is used from the toxicology angle proof compositions that contains nucleotide of the present invention.Adopt other embodiment to test and obtain essentially identical effect.
Disease prevention and control center, Liaoning Province to the functional evaluation result of the embodiment of the invention 6 compositionss is: Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell result of the test demonstration 1.05g/kgbw, 0.70g/kgbw experimental group phagocytic percentage (43.70%, 41.80%), relatively there were significant differences (P＜0.01) with sample solvent matched group (28.10%, 0.33) for phagocytic index (0.53,0.50), shows that the compositions that contains nucleotide of the present invention can strengthen the ability that Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell; Relatively there were significant differences (P＜0.01) for the antibody product (105.30,104.40) and the sample solvent matched group (82.00) of mice serum hemolysin measurement result demonstration 1.05g/kgbw, 0.70g/kgbw experimental group, shows and can improve mice serum antibody product; The antibody-producting cell testing result shows the hemolysis plaque number (1.96 * 10 of 1.05g/kgbw experimental group
3Individual/10
6Splenocyte) with sample solvent matched group (1.46 * 10
3Individual/10
6Splenocyte) relatively there were significant differences, shows to improve mouse antibodies cellulation quantity; NK cells in mice determination of activity result shows 1.05g/kgbw experimental group NK cytoactive (22.51%), and relatively there were significant differences with sample solvent matched group (19.50%), shows to improve the NK cells in mice activity.Adopt other embodiment to test and obtain essentially identical effect.
Fudan University is to 40 normal adults, after pairing, be divided into intervention group and placebo group at random, the edible embodiment of the invention 6 compositionss, every day 2 times, each 2, take 3 months result of study: leukocytes phagocytic rate (57.5%) and leukocytes phagocytic index (1.94) significantly raise (P＜0.01) with test preceding (44.0,1.58) when intervention group was tested the 90th day, and were better than placebo group (P＜0.05), showed to strengthen the human leukocytes phagocytic activity; When intervention group is tested the 40th day and the 90th day before the level (21.25pg/ml, 36.06pg/ml) of serum il-2 and the test (6.92pg/ml) significantly raise (P＜0.05 and P＜0.01), and be better than placebo group (P＜0.01); When intervention group is tested the 10th day and the 90th day serum immunoglobulin IgG content (13.23g/L, 13.68g/L) with edible before (11.71g/L) relatively there were significant differences (P＜0.01); (10.09pg/ml) significantly raise (P＜0.05 and P＜0.01) before serum gamma interferon level (27.73pg/ml, 40.56pg/ml) and test when intervention group the 40th day and the 90th day; (10.97%) significantly raise (P＜0.05) before bone-marrow-derived lymphocyte content ratio (12.52%, 12.62%) and the test in blood when intervention group the 40th day and the 90th day.The above results has the effect of significant enhancing human body immunity power from the functional perspective proof compositions that contains nucleotide of the present invention.Adopt other embodiment to carry out above-mentioned human trial, obtain essentially identical effect.
Claims (8)
1. compositions that contains nucleotide comprises at least:
Nucleotide: 50-150 weight portion;
Chinese medicine extract: 3-55 weight portion;
Vitamin 0-16 weight portion;
Folic acid 0-0.04 weight portion and/or zinc 0-2 weight portion.
Described Chinese medicine extract is one or more combination of Radix Polygoni Multiflori, Fructus Lycii, Folium Ginkgo extract, and its consumption is:
Radix Polygoni Multiflori extract: 1.5-25 weight portion;
Fructus Lycii extract: 1-20 weight portion;
Folium Ginkgo extract: 0.5-10 weight portion.
2. the compositions that contains nucleotide according to claim 1 wherein also further comprises soybean oligopeptide 0.1-20 weight portion.
3. the compositions that contains nucleotide according to claim 1, wherein said vitamin are vitamin E and vitamin B
6One or both of combination, its content is respectively vitamin E 0-15 weight portion, vitamin B
6The 0-1 weight portion.
4. the compositions that contains nucleotide according to claim 1 and 2 wherein also comprises folic acid 0-0.04 weight portion and/or zinc 0-2 weight portion.
5. the compositions that contains nucleotide according to claim 1, wherein said Chinese medicine extract are Radix Polygoni Multiflori, Fructus Lycii, Folium Ginkgo extract three's combination.
6. a compositions that contains nucleotide comprises at least
Nucleotide: the 50-150 weight portion,
Soybean oligopeptide 0.1-20 weight portion.
7. any one described preparation of compositions method of claim 1-6 comprises that raw material detects to sieve after qualified, takes by weighing, mixes the back by formula ratio and prepare finished product according to common process.
8. any one described compositions of nucleotide that contains of claim 1-6 is in the purposes for preparing on health product, treatment and prevention various diseases medicine, food and the cosmetics etc.
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| CN113615837B (en) * | 2021-07-30 | 2022-07-01 | 陈玉松 | Nucleotide probiotic capsule for delaying senescence |
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| CN114931625A (en) * | 2022-05-09 | 2022-08-23 | 大连双迪科技股份有限公司 | Application of uridylic acid, adenylic acid and yeast peptide composition in anti-aging aspect |
| WO2023216952A1 (en) * | 2022-05-09 | 2023-11-16 | 陈玉松 | Anti-ageing use of uridylic acid, adenylic acid, and yeast peptide composition |
| CN115227706A (en) * | 2022-06-08 | 2022-10-25 | 珍奥集团股份有限公司 | Application of 5' -monophosphate nucleotide composition in preparation of fat-reducing and weight-losing functional food and medicine |
| CN115227706B (en) * | 2022-06-08 | 2023-12-29 | 陈玉松 | Application of nucleotide 5' -monophosphate composition in preparation of fat-reducing and weight-losing functional foods and medicines |
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| CN101147779B (en) | 2011-04-06 |
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