CN101143175A - New jinji preparation for treating male and female pelvic inflammation and production method thereof - Google Patents

Abstract

The invention provides a novel drug preparation of Jinji for remedying the pelvic inflammation of men and women and the producing method of the drug preparation. The first contribution of the invention lies in developing the application range of the former Jinji product to ensure that the Jinji product can not only be used for remedying the pelvic inflammation of women but also can be used for remedying the pelvic inflammation of men, and the curative effect is good, and the drug acts fast. The second contribution of the invention lies in providing people with more selections of dosage types, wherein the preparations of cavity administration such as clysis liquid, water gel, a suppository etc., direct administration at a focus or direct administration at a sub-focus have good curative effect and act fast, and the disease does not easily recrudesce after cure; the oral preparations of a sweet pill, a condensed pill, a water pill, a tablet, a dispersed tablet, a granule, a capsule, a soft capsule, a drop pill, oral liquid etc. are convenient for taking and are applicable to the persons with different consuming standards. The third contribution of the invention lies in that the function of far infrared deep auxiliary treatment is introduced into the novel drug preparation of Jinji by the nanometer disposal, which further improves the general curative effect of the product.

Description

A kind of new jinji preparation and production method thereof for the treatment of male and female pelvic inflammation

Technical field

The present invention relates to a kind of new purposes for the treatment of the pharmaceutical preparation and the production method thereof of male and female pelvic inflammation and having increased preparation.

Background technology

Uterus, adnexa (fallopian tube and ovary) and connective tissue on every side thereof, pelvic peritoneum that pelvic inflammatory disease is commonly referred to as female internal genital organs are inflamed.Inflammation can be limited to a position, also can fall ill simultaneously at several positions.Pathogenic process has acute and chronic two kinds.Primary disease can transfer chronic inflammatory disease to by acute attack, and with the passing of time delay shows effect repeatedly, but vicious cycle again causes the emergency case pathological changes.The patient often feels stomachache, lumbago, leucorrhoea grow in quantity, and severe patient can cause infertility.This sick sickness rate height, big to human body harm, Therapeutic Method commonly used both at home and abroad at present has uses menstrual period such as antibiotic, lateral fornix block technique, uterine cavity injection, hot compress and physical therapy etc., also can undergo surgery in case of necessity, some Chinese patent medicine oral formulations are also arranged, these treatment measures can both be played certain curative effect, but part also all comes with some shortcomings, mainly be that curative effect is not ideal enough, can not effect a radical cure up hill and dale rapidly as oral medicine, and operative therapy also cause wound easily.

The disease that the male is equivalent to pelvic inflammatory disease has prostatitis, seminal vesiculitis, deferentitis and connective tissue on every side thereof, pelvic peritoneum to be inflamed.Inflammation can be limited to a position, also can fall ill simultaneously at several positions.Pathogenic process has acute and chronic two kinds.Primary disease can transfer chronic inflammatory disease to by acute attack, and with the passing of time delay shows effect repeatedly, but vicious cycle again causes the emergency case pathological changes.Wherein, the most common pilosity is prostatitis, and clinical symptoms shows as frequent micturition, urgent micturition, plays inflammatory phenomena such as stream nebulousurine morning, and severe patient can cause azoospermia, necrospermia, uremia, male infertility etc.At present clinical do not have specific drug to this disease, adopts this disease of operation micro-wave therapeutic, and expense is higher, and disease is gone into difficult acceptance.People urgently wish a kind of Chinese medicine appearance of the infertility that can cure male prostatitis and cause because of prostatitis.

Relevant patent: a kind of medicine and production method thereof for the treatment of pelvic inflammatory disease of application number CN200510055523.7 denomination of invention, disclose a kind of serial manufacture method of golden pheasant oral formulations, this product has the advantage to pelvic inflammatory disease is with strong points, evident in efficacy, prescription is uncomplicated, moderate.Its weak point is, does not consider focus or the direct administration of inferior focus.

Far infrared and human body are closely related: any object of earth surface all has and absorbs ultrared function, also all be simultaneously far infrared contain body and emitter.Human body also has the ability of the micro-far-infrared electromagnetic wave of emission, measures according to science that the far infrared have only the 8-15 micron is the easiest to produce harmonious resonance with human body.60-70% is made of hydrone in the human body, when the far infrared of 8-15 micron acts on human body, after producing ＂ resonance absorption ＂ effect, make and be not easy absorbed big hydrone group's generation resonance in the human body and make the micel depolymerization, be reassembled into less water clusters, (be that hydrone is activated, molecularization), the polluter that is adsorbed on the water clusters surface is removed, the hydrone that is attached to cell activity and surface is increased, cell activity and surface tension have been increased, the metabolism ability of blood is improved, and blood circulation improves, and especially microcirculation is significantly improved.

In addition, because far heat effect has caused a series of physiological effecies then.

1) activated the activity of biomacromolecule.Here should particularly point out, the electron energy level that region of ultra-red photon energy (1.6-0.001 electron-volt) can not activating molecules makes material generation ionization so can not resemble the ultraviolet.Infra-red radiation can only activating molecules vibration level.Energy difference between vibration level is generally below 1 electron-volt.That is to say,, therefore molecular structure is changed because the atomic bond energy of far infrared energy formation molecule is little.However, at the far infrared photon, make especially under the effect of 2-6 micron far infrared photon, the molecular entergy level of organism is excited and is in higher vibration level, this has just activated the activity of biomacromolecules such as nucleic acid protein, thereby brought into play biomacromolecule and regulated active functions such as organism metabolism, immunity, helped the restore peace weighing apparatus of function of human body, the purpose of reach diseases prevention, curing the disease.

2) blood circulation of promotion and improvement part and whole body.After far infrared acted on skin, most of energy was absorbed by skin, and absorbed energy is converted into heat energy, caused the skin temperature rise, and heat sensor in the chafe by the thalamus reflection, makes vascular smooth muscle relaxation, vasodilation, and blood circulation is strengthened.On the other hand, because heat effect causes the release of vaso-active substance, antiotasis reduces, shallow small artery, shallow blood capillary and superficial vein expansion, and blood circulation is accelerated, and blood circulation is improved.

3) strengthen metabolism.If disorder has taken place in the metabolism of human body, caused that the exchange of inside and outside material is not normal, so, various diseases will not made an appointment with and arrived.Such as the disorder of water-electrolyte metabolism, seriously will threat to life; Diabetes due to the carbohydrate metabolism disturbance; Disorders of lipid metabolism causes cardiovascular disease, obesity; The gout that protein metabolism disorder causes etc.By far heat effect, can increase the vigor of cell, regulate neuro-humoral mechanism, add excitometabolic, make intravital mass exchange be in plateau.

4) improve immunologic function.Immunity is a kind of physiology protective reaction of human body, and it comprises two kinds of cellular immunization and humoral immunization, and the human body resist the disease is had important role.Through clinical observation, far infrared really can improve the phagocytic function of macrophage, and mediator's somatic cell immunity and humoral immune function help the health of human body.

5) antiinflammatory, its analgesic mechanism are as follows:

A) far heat effect is reacted by neurohumoral answer, eliminated the pathological process of inflammation, make that to suffer that originally destructive physiological equilibrium's state adds quick-recovery normal, improved the resistance against diseases of local and whole body, simultaneously can activate immune cell function, strengthen the phagocytic function of leukocyte and netted chrotoplast, reached antiinflammatory bacteriostatic purpose.

B) infrared heat effect increases skin temperature, and the sympathetic nerve feeling ability lowers, and the vasodilator active substance discharges, vasodilation, blood flow is accelerated, and blood circulation improves, and has strengthened histotrophic nutrition, enlivened tissue metabolism, improve the cell oxygen-supplying amount, improved the blood supply oxygen supply state of focal zone, strengthened the regeneration capacity of cell, control development of inflammation and made its localization, quickened the reparation of focus.

C) far heat effect has been improved microcirculation, has set up side Zhi Xunhuan, strengthen cell membrane stability, regulated ionic concentration, improved osmotic pressure, accelerate the discharge of the metabolite of noxious substance, quickened the absorption of exudate, caused disappearing of inflammation edema.

6) analgesic activity.Infrared heat effect has reduced the irritability of teleneuron; Sanguimotor improvement, disappearing of edema alleviated the chemistry and the mechanical stimulus of teleneuron; Far heat effect has improved the threshold of pain, more than all, all play lenitive effect.

The unique deficiency of far infrared is too shallow and influence the further performance of above-mentioned effect to the penetration depth of human body, and the penetration depth of far infrared in human body is meant the ultrared intensity decreases degree of depth during to initial intensity 50% that enters human body.Visible light and near infrared penetration depth are about 1 centimetre, and far infrared then only is the 0.05-1 millimeter.The wavelength of far infrared is longer, and then penetrance is poorer.

Summary of the invention:

The purpose of this invention is to provide a kind of good effect, the produce effects Chinese medicine preparation that cures mainly male and female pelvic inflammation fast, easy to use.

The present invention is contributing aspect newly the quality-improving of golden pheasant series of products has following three under the prerequisite of not repelling relevant patent basic data.

First contribution of the present invention is, the ＂ golden pheasant ＂ of original special for treating female pelvic inflammation is increased male's pelvic inflammatory disease indication and names the new golden pheasant ＂ into ＂, and this new Jinji preparation can be used for the treatment of female pelvic inflammation and also can be used for treating male's pelvic inflammatory disease (prostatitis etc.).Use traditional Chinese medical science what is called herein: different diseases, as long as pathogenesis is identical, the principle of the treating different diseases with the same therapeutic principle of just can a method one side treating.Female pelvic inflammation and male's pelvic inflammatory disease are except that the men and women is different, and the cause of disease, pathogenesis, sick position are identical, meet the principle of above-mentioned treating different diseases with the same therapeutic principle.More particularly, this new Jinji preparation is not only applicable to female pelvic inflammation such as uterus, adnexa (fallopian tube and ovary) and the inflammation that connective tissue, pelvic peritoneum took place on every side thereof; Simultaneously, this Chinese medicine composition also is applicable to the inflammation that male's pelvic inflammatory disease such as prostatitis, seminal vesiculitis, deferentitis and connective tissue on every side thereof, pelvic peritoneum take place.

Second contribution of the present invention is, more select on dosage form, for people: wherein, cavity/canal drug administration preparations such as enema, lotion, ointment, hydrogel adhesive, vaginal tablet, suppository, the direct administration of inferior focus, medicine sees through the goldbeater's skin focus of can going directly by tissue fluid, and good effect, produce effects be fast, cure the back is difficult for recurrence; Oral formulations taking conveniences such as honey pill agent, concentrated pill, watered pill, tablet, dispersible tablet, granule, capsule, soft capsule, drop pill, oral liquid are suitable for the crowd without level of consumption.

New Jinji preparation of the present invention is by following ingredients (by weight): 10～30 parts of Radix Rosae Laevigataes, 20～40 parts of Caulis Spatholobis, Radix Flemingiae Philippinensis 10-30 part, 10～30 parts of Caulis Mahoniaes, 3～15 parts of Radix Zanthoxylis, 1～15 part of composition of Herba Andrographis, by to the pre-treatment of medical material, add the carrier of different dosage form, preparation program according to a conventional method, make honey pill agent, pellet, concentrated pill, watered pill, tablet, dispersible tablet, powder, granule, capsule, slow releasing capsule, soft capsule, drop pill, soft extract, the oral liquid of oral administration; The enema of cavity/canal drug administration, lotion, ointment, hydrogel adhesive, vaginal tablet, suppository.Say exactly:

Described preparation is preferably: 8 parts of Radix Rosae Laevigataes, 15 parts of Caulis Spatholobis, 8 parts of Radix Flemingiae Philippinensiss, 8 parts of Caulis Mahoniaes, 3 parts of Radix Zanthoxylis, 2.5 parts of preparations of Herba Andrographis: honey pill agent, concentrated pill, watered pill, tablet, dispersible tablet, granule, capsule, slow releasing capsule, soft capsule, drop pill, soft extract, oral liquid, enema, lotion, ointment, hydrogel adhesive, vaginal tablet, suppository.

Described a kind of new jinji preparation and production method thereof for the treatment of male and female pelvic inflammation: above Six-element, getting the Herba Andrographis of 1/25～10/25 amount, to be ground into fine powder standby, the Herba Andrographis of all the other five tastes and surplus adds water or ethanol decocts twice, the each decoction 2～3 hours, filter merging filtrate, it is that 1.15～1.25 clear paste is standby that filtrate is concentrated into relative density, get standby clear paste then and add standby Herba Andrographis fine powder and corresponding adjuvant, make different preparations respectively by the routine operation method of prior art.

And/or the Herba Andrographis of 1/25～10/25 amount that is used to pulverize can be extracted and be condensed into relative density with other medical material when preparation liquid, semi-solid form of administration be that 1.15～1.25 clear paste is standby; More preferably take microwave or supersound extraction, it is standby that the mode of vacuum concentration prepares extractum; With reduce to extract to greatest extent, concentration process is to the destruction of effective ingredient.

Another contribution of the present invention is, with the author at the number of patent application of first to file is: the core technology of the people who additionally has the far infrared health care function of CN200510125227.X and animal foodstuff medicine preparation and preparation method thereof is introduced the preparation of this patent.More particularly, (about 36 ℃ of human temperature) under the normal temperature condition absorbed heat energy from environment, simultaneously send wavelength 4～20 mu m range far infrareies, the material that people and animal can tolerate to environment.More preferably have adjuvant commonly used on the pharmaceutics of above-mentioned functions by the micronized mode of nanoscale, making under the prerequisite that does not increase any new adjuvant increases far infrared auxiliary treatment function outside the turnout.

The described turnout that makes increases far infrared auxiliary treatment functional mass outward including, but not limited to, natural crystal class, as: " multicolored stone " in rare ice stone, Sibin floating stone, the deep-sea, Muscovitum, Kaolin; Great soil group, as: Kaolin, Suzhou soil; The biological carbon class, as: Sargassum carbon, bamboo charcoal; Plant fiber's class, as: the petal fiber; The animal class, as: Margarita, Concha Margaritifera, Concha Haliotidis; Ceramic-like, as: the sinter of the oxide that the Mg-Al-Si-Zr-rare earth is, Mn-Fe-Co-Ni-Cu-Cr is metal, carbide, nitride, boride; Mineral-type, as: the petal fiber; The animal class, as: Margarita, Concha Margaritifera, Concha Haliotidis; Ceramic-like, metal, nonmetallic oxide, carbide, nitride, boride.

More preferably: breed the adjuvant commonly used on above-mentioned pharmaceutics among all kinds of: silicon dioxide (micropowder silica gel), titanium dioxide (titanium dioxide), kaolin, magnesium oxide, aluminium hydroxide.

Describedly make turnout increase far infrared auxiliary treatment function outward to be meant, enter the heat energy in the human body intestinal canal or the tract absorption external world when above-mentioned nanoscale adjuvant commonly used after, can discharge wavelength and be 4～14 microns far infrared, this infrared ray easily is absorbed by the body, and it is consistent with the atom and the vibrational frequency of molecule of human body cell, thereby can activate histiocyte, increase blood flow, promote microcirculation, the metabolic obstacle full scale clearances of impairment such as congestion is clean, tissue is brought back to life, improve the metabolism and the immunologic function of human body, the general curative effect of product is improved.

The invention has the beneficial effects as follows:

First contribution of the present invention is, " golden pheasant " of original special for treating female pelvic inflammation increased male's pelvic inflammatory disease indication and name is " new golden pheasant ", this new Jinji preparation can be used for the treatment of female pelvic inflammation and also can be used for treating male's pelvic inflammatory disease (prostatitis etc.), and good effect, instant effect.Second contribution of the present invention is, more select on dosage form, for people: wherein, cavity/canal drug administration preparations such as enema, hydrogel adhesive, suppository, the direct administration of inferior focus, medicine sees through the goldbeater's skin focus of can going directly by tissue fluid, and good effect, produce effects be fast, cure the back is difficult for recurrence; Oral formulations taking conveniences such as honey pill agent, concentrated pill, watered pill, tablet, dispersible tablet, granule, capsule, soft capsule, drop pill, oral liquid are suitable for the crowd without level of consumption.The 3rd contribution of the present invention is, handles by the nanorize of adjuvant, and far infrared deep layer auxiliary treatment function is introduced new Jinji preparation, makes the general curative effect of product be able to further raising.

The specific embodiment:

For further specifying the present invention, but not limited provide following embodiment,

1, the pre-treatment of medical material, can select a kind of in following four kinds of modes according to the characteristics of dosage form:

(1), one of pre-treatment of solid preparation medical material

1. get the 1/25-10/25 of Herba Andrographis total amount, with superfine communication technique it is ground into fine powder, with 100～120 ℃ of high pressure steam sterilization 30-60 minutes, it was standby to get intermediate products A;

2. get remaining Herba Andrographis with the soak with ethanol of volumetric concentration 60-80% 1 hour, the alcohol extraction that refluxes, the later solution of alcohol extraction reclaims ethanol, alcohol extraction part B;

3. Caulis Mahoniae, Radix Zanthoxyli decoct twice, each 2 on hour, and medicinal liquid filters, and merges leach cooking liquid twice, concentrate water

Put forward portion C;

4. with Radix Rosae Laevigatae, Caulis Spatholobi, after-filtration of Radix Flemingiae Philippinensis decocting in water, with the medicinal residues after the filter with the later medicinal residues of alcohol extraction

Decocting in water, each equal 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, concentrated to such an extent that water is carried part D;

5. the mixing thick paste E that merges above-mentioned B, C, D thick paste mixing is standby;

(2), two of the pre-treatment of solid preparation medical material

1. the 1/25-10/25 that gets the Herba Andrographis total amount is ground into fine powder, and with 100～120 ℃ of high pressure steam sterilization 30-60 minutes, it was standby to get intermediate products A;

2. get remaining Herba Andrographis and add 5-8 times of water gaging with whole Radix Rosae Laevigataes, Caulis Spatholobi, Radix Flemingiae Philippinensis, Caulis Mahoniae, Radix Zanthoxyli, soaked 1 hour, decoct twice, each 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, water to carry part B standby:

(3), one of pre-treatment of liquid, semisolid and/or solid preparation medical material

1. Radix Rosae Laevigatae, Caulis Spatholobi, Radix Flemingiae Philippinensis, Caulis Mahoniae, Radix Zanthoxyli, Herba Andrographis add 5-8 times of water gaging, soaked 1 hour,

Decoct twice, each 2～3 hours, collecting decoction got water and carries part B:

2. water is carried part B and concentrated, the intermediate products fluid extract C that gets relative density 1.05-1.20/50-60 ℃ is standby;

(4), two of the pre-treatment of liquid, semisolid and/or solid preparation medical material

1. get Herba Andrographis with the soak with ethanol of volumetric concentration 60-80% 1 hour, the alcohol extraction that refluxes, the later solution of alcohol extraction reclaims ethanol, the alcohol extraction part A;

2. Caulis Mahoniae, Radix Zanthoxyli decoct twice, and each 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, concentrated to such an extent that water is carried part B:

3. with Radix Rosae Laevigatae, Caulis Spatholobi, after-filtration of Radix Flemingiae Philippinensis decocting in water, with the medicinal residues after the filter with the later medicinal residues of alcohol extraction

Decocting in water, each equal 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, concentrated to such an extent that water is put forward portion C;

4. A, B, C merging are concentrated, the intermediate products fluid extract D that gets 1.1 5～1.25/50～60 ℃ of relative densities is standby;

2, the preparation of described preparation:

(1) capsule preparation: get standby above-mentioned clear paste and add in standby Herba Andrographis fine powder and the corresponding adjuvant (an amount of Icing Sugar and dextrin), mixing, granulation, granulate, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent.

(2) slow releasing capsule preparation: get standby above-mentioned clear paste and add in the standby Herba Andrographis fine powder, mixing, dry below 80 ℃, pulverize, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel and obtain the finished product slow releasing capsule.

(3) granule preparation: get standby above-mentioned clear paste and add in the appropriate amount of auxiliary materials (an amount of Icing Sugar, dextrin and nanometer grade silica), mixing, in drying, pulverizing, granulation, packing below 80 ℃ promptly gets new JINJI KELI agent.

(4) preparation tablets: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding stone, mixing, dry below 80 ℃, pulverize, add microcrystalline Cellulose 20g, use 80% alcohol granulation, drying, granulate adds magnesium stearate 1g, mixing, tabletting, coating, promptly.

(5) pellet preparation: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize, add an amount of starch, with 65% ethanol and 1.2% soybean oil system soft material, the soft material that makes micropill mechanism ball, wet feed pushed the 0.8mm sieve aperture, and the wet grain of strip cuts off round as a ball, 50～60 ℃ of drying and mouldings are crossed 16～20 mesh sieves and are selected ball; Perhaps merge above-mentioned standby clear paste, spray drying, wet-milling granulation molding, mould placed add the great achievement ball in the coating pan, medicated powder: water is 1: 1.2, coating pan rotating speed 40r/min, capping selects ball, promptly.

(6) drop pill preparation: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize; Get the extract powder portion, two parts of PEG4000 and polyoxyethylene monostearate S-40 portion, mix homogeneously fuses in the water-bath, stir evenly, drip and in dimethicone, to become ball, drip apart from 5cm drip footpath 2.5mm/2mm, mix 80 ℃ of ointment temperature, liquid coolant height 70cm, promptly.

(7) soft extract preparation: get standby above-mentioned clear paste and an amount of syrup and Mel mixing, sterilization, fill, promptly.

(8) oral liquid preparation: get standby above-mentioned clear paste, add an amount of syrup or Mel, mix homogeneously, packing, sterilization, promptly.

(9) suppository preparation: get standby above-mentioned clear paste, proper amount of nano grade titanium dioxide, add to drip in an amount of distilled water that an amount of lactic acid is arranged and stir, make it dissolving, suspend fully, add the glycerol of 10 times of amounts and the gelatin solution of 20 times of amounts, stir evenly, be poured into and sterilized in advance and scribble in the duckbill vaginal suppository mould of liquid Paraffin, after cold slightly, scrape off and overflow part, treat to take out after the condensation, packing, promptly.Also can be made into rectal plug or make the author and be: the vaginal suppository that has cartilage in the carrying suppository of the cavity/canal drug administration of CN200410030518.6 at the number of patent application of first to file.

⑽ gel preparation: get standby above-mentioned clear paste, add in the 1000ml glue of making by 0.4% carbomer, fully after the dissolving, stir lentamente, and rapid condensation under the rearmounted low temperature, promptly.

(11) vaginal tablet preparation: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize; Add the potassium hydrogen tartrate of 3 times of amounts, the sodium bicarbonate of 2 times of amounts, the silicon dioxide of 1 times of amount, tabletting, promptly.

(12) emulsifiable paste preparation: with the spermol of 4 times of amounts, the stearyl alcohol of 2 times of amounts, through 80 ℃ of fusions of water-bath, mix homogeneously, insulation is as oil phase; Propylene glycol, the benzyl alcohol of 1 times of amount, the water of 2 times of amounts are heated to 80 ℃, dissolving, mix homogeneously is as water; Oil phase is under agitation slowly added water, stirring and emulsifying, be chilled to 40 ℃ stand-by; Get the standby above-mentioned clear paste and the propylene glycol of 2 times of amounts and be ground to transparence, add in the above-mentioned substrate, mix homogeneously, promptly.

(13) lotion, enema preparation: get standby above-mentioned clear paste, proper amount of nano level Kaolin, metronidazole 5g, sodium benzoate 3g and add in 1/4 distilled water, be stirred to moltenly, add distilled water to full dose, fill, sterilization, promptly.

Claims (7)

1. a new jinji preparation and production method thereof for the treatment of male and female pelvic inflammation, it is characterized in that, said preparation is by following ingredients (by weight): 10～30 parts of Radix Rosae Laevigataes, 20～40 parts of Caulis Spatholobis, 10～30 parts of Radix Flemingiae Philippinensiss, 10～30 parts of Caulis Mahoniaes, 3～15 parts of Radix Zanthoxylis, 1～15 part of composition of Herba Andrographis, by pre-treatment to medical material, the carrier that adds different dosage form, preparation program is according to a conventional method made the honey pill agent of oral administration, pellet, concentrated pill, watered pill, tablet, dispersible tablet, powder, granule, capsule, slow releasing capsule, soft capsule, drop pill, soft extract, oral liquid; The enema of cavity/canal drug administration, lotion, ointment, hydrogel adhesive, vaginal tablet, suppository.

2. a kind of new jinji preparation and production method thereof for the treatment of male and female pelvic inflammation as claimed in claim 1 is characterized in that this new Jinji preparation is not only applicable to female pelvic inflammation such as uterus, adnexa (fallopian tube and ovary) and the inflammation that connective tissue, pelvic peritoneum took place on every side thereof; Simultaneously, this new Jinji preparation also is applicable to the inflammation that male's pelvic inflammatory disease such as prostatitis, seminal vesiculitis, deferentitis and connective tissue on every side thereof, pelvic peritoneum take place.

3. the pre-treatment and the preparation of the medical material of a kind of new jinji preparation for the treatment of male and female pelvic inflammation as claimed in claim 1 and production method thereof, it is characterized in that, above Six-element, getting the Herba Andrographis of 1/25～10/25 amount, to be ground into fine powder standby, the Herba Andrographis of all the other five tastes and surplus adds water, or ethanol decocts twice, the each decoction 2～3 hours, filter merging filtrate, it is that 1.15～1.25 clear paste is standby that filtrate is concentrated into relative density, get standby clear paste then and add standby Herba Andrographis fine powder and corresponding adjuvant, make different preparations respectively by the routine operation method of prior art;

And/or the Herba Andrographis of 1/25～1 0/25 amount that is used to pulverize can be extracted and be condensed into relative density with other medical material when preparation liquid, semi-solid form of administration be that 1.15～1.25 clear paste is standby; More preferably take microwave or supersound extraction, it is standby that the mode of vacuum concentration prepares extractum.

4. as the pre-treatment and the preparation of the medical material of claim 1,3 described a kind of new jinji preparations for the treatment of male and female pelvic inflammation and production method thereof, it is characterized in that the pre-treatment of medical material can be selected a kind of in following four kinds of modes according to the characteristics of dosage form:

(1), the pre-treatment of solid preparation medical material (I)

1. get the 1/25-10/25 of Herba Andrographis total amount, with superfine communication technique it is ground into fine powder, with 100～120 ℃ of high pressure steam sterilization 30-60 minutes, it was standby to get intermediate products A;

2. get remaining Herba Andrographis with the soak with ethanol of volumetric concentration 60-80% 1 hour, the alcohol extraction that refluxes, the later solution of alcohol extraction reclaims ethanol, alcohol extraction part B;

3. Caulis Mahoniae, Radix Zanthoxyli decoct twice, each 2 on hour, and medicinal liquid filters, and merges leach cooking liquid twice, concentrates to such an extent that water is put forward portion C;

4. with Radix Rosae Laevigatae, Caulis Spatholobi, after-filtration of Radix Flemingiae Philippinensis decocting in water, with the later medicinal residues decocting in water of alcohol extraction, each equal 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, concentrated to such an extent that water is carried part D with the medicinal residues after the filter;

5. the mixing thick paste E that merges above-mentioned B, C, D thick paste mixing is standby;

(2), the pre-treatment of solid preparation medical material (II)

1. the 1/25-10/25 that gets the Herba Andrographis total amount is ground into fine powder, and with 100～120 ℃ of high pressure steam sterilization 30-60 minutes, it was standby to get intermediate products A;

2. get remaining Herba Andrographis and add 5-8 times of water gaging with whole Radix Rosae Laevigataes, Caulis Spatholobi, Radix Flemingiae Philippinensis, Caulis Mahoniae, Radix Zanthoxyli, soaked 1 hour, decoct twice, each 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, water to carry part B standby:

(3), the pre-treatment (I) of liquid, semisolid and/or solid preparation medical material

1. Radix Rosae Laevigatae, Caulis Spatholobi, Radix Flemingiae Philippinensis, Caulis Mahoniae, Radix Zanthoxyli, Herba Andrographis add 5-8 times of water gaging, soak 1 hour, decoct twice, and each 2～3 hours, collecting decoction got water and carries part B:

2. water is carried part B and concentrated, the intermediate products fluid extract C that gets relative density 1.05-1.20/50-60 ℃ is standby;

(4), the pre-treatment (II) of liquid, semisolid and/or solid preparation medical material

1. get Herba Andrographis with the soak with ethanol of volumetric concentration 60-80% 1 hour, the alcohol extraction that refluxes, the later solution of alcohol extraction reclaims ethanol, the alcohol extraction part A;

2. Caulis Mahoniae, Radix Zanthoxyli decoct twice, and each 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, concentrated to such an extent that water is carried part B:

3. with Radix Rosae Laevigatae, Caulis Spatholobi, after-filtration of Radix Flemingiae Philippinensis decocting in water, with the later medicinal residues decocting in water of alcohol extraction, each equal 2～3 hours, medicinal liquid filtered, and merges leach cooking liquid twice, concentrated to such an extent that water is put forward portion C with the medicinal residues after the filter;

4. A, B, C merging are concentrated, the intermediate products fluid extract D that gets 1.1 5～1.25/50～60 ℃ of relative densities is standby.

5. as claim 1, the 3 described a kind of new jinji preparation of male and female pelvic inflammation and preparations of production method thereof for the treatment of, it is characterized in that:

(1) capsule preparation: get standby above-mentioned clear paste and add in standby Herba Andrographis fine powder and the corresponding adjuvant (an amount of Icing Sugar and dextrin), mixing, granulation, granulate, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent;

(2) slow releasing capsule preparation: get standby above-mentioned clear paste and add in the standby Herba Andrographis fine powder, mixing, dry below 80 ℃, pulverize, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel and obtain the finished product slow releasing capsule;

(3) granule preparation: get standby above-mentioned clear paste and add in standby Herba Andrographis fine powder and the corresponding adjuvant (an amount of Icing Sugar and dextrin), mixing, in drying, pulverizing, granulation, packing below 80 ℃ promptly gets new JINJI KELI agent;

(4) preparation tablets: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize, add microcrystalline Cellulose 20g, use 80% alcohol granulation, drying, granulate adds magnesium stearate 1g, mixing, tabletting, coating, promptly;

(5) pellet preparation: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize, add an amount of starch, with 65% ethanol and 1.2% soybean oil system soft material, the soft material that makes micropill mechanism ball, wet feed pushed the 0.8mm sieve aperture, and the wet grain of strip cuts off round as a ball, 50～60 ℃ of drying and mouldings are crossed 16～20 mesh sieves and are selected ball; Perhaps merge above-mentioned standby clear paste, spray drying, wet-milling granulation molding, mould placed add the great achievement ball in the coating pan, medicated powder: water is 1: 1.2, coating pan rotating speed 40r/min, capping selects ball, promptly;

(6) drop pill preparation: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize; Get the extract powder portion, two parts of PEG4000 and polyoxyethylene monostearate S-40 portion, mix homogeneously fuses in the water-bath, stir evenly, drip and in dimethicone, to become ball, drip apart from 5cm drip footpath 2.5mm/2mm, mix 80 ℃ of ointment temperature, liquid coolant height 70cm, promptly;

(7) soft extract preparation: get standby above-mentioned clear paste and an amount of syrup and Mel mixing, sterilization, fill, promptly;

(8) oral liquid preparation: get standby above-mentioned clear paste, add an amount of syrup or Mel, mix homogeneously, packing, sterilization, promptly;

(9) suppository preparation: get standby above-mentioned clear paste, add to drip in an amount of an amount of distilled water of lactic acid and stir, Deng dissolving fully, add the glycerol of 10 times of amounts and the gelatin solution of 20 times of amounts, stir evenly, be poured into and sterilized in advance and scribble in the duckbill vaginal suppository mould of liquid Paraffin, after cold slightly, scrape off and overflow part, treat to take out after the condensation, packing, promptly; Also can be made into the vaginal suppository that has internal skeleton, or rectal plug;

(10) gel preparation: get standby above-mentioned clear paste, add in the 1000ml glue of making by 0.4% carbomer, fully after the dissolving, stir lentamente, and rapid condensation under the rearmounted low temperature, promptly;

(11) vaginal tablet preparation: get standby above-mentioned clear paste and add in standby the Herba Andrographis fine powder and corresponding adjuvant, mixing, dry below 80 ℃, pulverize; Add the potassium hydrogen tartrate of 3 times of amounts, the sodium bicarbonate of 2 times of amounts, the silicon dioxide of 1 times of amount, tabletting, promptly;

(12) emulsifiable paste preparation: with the spermol of 4 times of amounts, the stearyl alcohol of 2 times of amounts, through 80 ℃ of fusions of water-bath, mix homogeneously, insulation is as oil phase; Propylene glycol, the benzyl alcohol of 1 times of amount, the water of 2 times of amounts are heated to 80 ℃, dissolving, mix homogeneously is as water; Oil phase is under agitation slowly added water, stirring and emulsifying, be chilled to 40 ℃ stand-by; Get the standby above-mentioned clear paste and the propylene glycol of 2 times of amounts and be ground to transparence, add in the above-mentioned substrate, mix homogeneously, promptly;

(13) lotion, enema preparation: get standby above-mentioned clear paste, metronidazole 5g, sodium benzoate 3g add in 1/4 distilled water, be stirred to moltenly, add distilled water to full dose, fill, sterilization, promptly.

6. a kind of new jinji preparation and production method thereof for the treatment of male and female pelvic inflammation as claimed in claim 1 is characterized in that, far infrared auxiliary treatment function introduced the preparation of this patent.More particularly, (about 36 ℃ of human temperature) under the normal temperature condition absorbed heat energy from environment, simultaneously send wavelength 4～20 mu m range far infrareies, the material that people and animal can tolerate to environment; More preferably have the adjuvant of using always on the pharmaceutics of above-mentioned functions, by the micronized mode of nanoscale, making under the prerequisite that does not increase any new adjuvant increases far infrared auxiliary treatment function outside the turnout.

7. as claim 1,4 described a kind of new jinji preparation and production methods thereof for the treatment of male and female pelvic inflammation, it is characterized in that, described make turnout increase outward far infrared auxiliary treatment functional mass including, but not limited to, the natural crystal class, as: " multicolored stone " in rare ice stone, Sibin floating stone, the deep-sea, Muscovitum, Kaolin; Great soil group, as: Kaolin, Suzhou soil; The biological carbon class, as: Sargassum carbon, bamboo charcoal; Plant fiber's class, as: the petal fiber; The animal class, as: Margarita, Concha Margaritifera, Concha Haliotidis; Ceramic-like, as: the sinter of the oxide that the Mg-Al-Si-Zr-rare earth is, Mn-Fe-Co-Ni-Cu-Cr is metal, carbide, nitride, boride; Mineral-type, as: the petal fiber; The animal class, as: Margarita, Concha Margaritifera, Concha Haliotidis; Ceramic-like, metal, nonmetallic oxide, carbide, nitride, boride;

More preferably: breed the adjuvant commonly used on above-mentioned pharmaceutics among all kinds of: silicon dioxide (micropowder silica gel), titanium dioxide (titanium dioxide), kaolin, magnesium oxide, aluminium hydroxide.