CN101129977A

CN101129977A - Orally taken traditional Chinese medicine decoction for treating cirrhosis

Info

Publication number: CN101129977A
Application number: CNA2007100162913A
Authority: CN
Inventors: 毕庆双
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-08-29
Filing date: 2007-08-29
Publication date: 2008-02-27

Abstract

The invention discloses an oral-administration Chinese medicinal broth for treating cirrhosis, wherein the active constituents include the following raw material herbs (by weight portion): Chinese angelica root 6-12, radix salvia miltiorrhiza 10-20, processed turtle shell 25-30, peach kernel 8-15, zedoary 6-9, earthworm 5-10, curcuma root 3-9, lycopus 6-12, field thistle 4. 5-9, notoginseng 10-20, red peony root 6-12 and licorice root 5-8. The medicament should be decocted in water for the oral dose.

Description

A kind of Chinese medicine decoction of orally for curing hepatocirrhosis

Technical field

The present invention relates to a kind of Chinese medicine decoction of orally for curing hepatocirrhosis, belong to the field of Chinese medicines.

Background technology

Liver cirrhosis is a hepatitis interstitialis chronica, the formation of liver cirrhosis is because for a long time under harmful factors (as ethanol, hepatitis virus, Developmental and Metabolic Disorder) effect, hepatic necrosis, degeneration and inflammatory reaction, thereby stimulate the liver sternzellen, the Fibrotic material of a lot of formation of secretion, in the course of time, liver develops to liver cirrhosis from fibrosis.It is a kind of common chronic disease of clinical manifestation.Liver cirrhosis can be divided into compensatory cirrhosis and decompensated liver cirrhosis by course of disease development.

Liver cirrhosis is by causing that reason can be divided into: 1, the liver cirrhosis that causes of viral hepatitis, be liver cirrhosis after the viral hepatitis; 2, alcoholic cirrhosis; 3, parasitic liver cirrhosis; 4, biliary cirrhosis; 5, drug intoxication liver cirrhosis; 6, metabolic liver cirrhosis; 7, congestive cirrhosis (chronic heart failure); 8, nutritional cirrhosis; 9, congenital syphilis liver cirrhosis; 10, agnogenic liver cirrhosis.

On " Chinese Medical Association the tenth secondary whole nation viral hepatitis and hepatopathy academic conference " that hold in Beijing in May, 2005, talk about in well-known expert's specialist paper: the liver cirrhosis of present 20%-30% can develop into decompensated liver cirrhosis; 6%-15% can develop into hepatocellular carcinoma.And five-year survival rate: compensatory cirrhosis is 55%, and decompensated liver cirrhosis is 14%, and dying from hepatitis B dependency hepatopathy every year is 300,000-500,000 people.Therefore the treatment of liver cirrhosis is very urgent.Liver cirrhosis can be by therapy of combining Chinese and Western medicine and the positive partner treatment of patient; strengthen maintenance; delay and reduce liver function and lose compensatory, protection and recover liver function; adjust albumen ratio; blocking-up and reverse hepatic fibrosis, liver cirrhosis prevent the appearance of liver failure and hepatocarcinoma, improve life quality; prolong the patient and receive a mandate, reduce case fatality rate.Domestic and international state-of-the-art treatment means is at present: (1) combination of Chinese and Western medicine protects the liver, antiviral therapy; (2) liver value of moving; (3) splenectomy; (4) spleen is got involved; (5) artificial liver etc.More than several treatment meanss have operative therapy expense costliness, side effect is big, the deficiency of late result difference.

Summary of the invention

The present invention overcomes the deficiency of existing method, and a kind of Chinese medicine decoction of orally for curing hepatocirrhosis is provided, and all selects natural Chinese medicinal herb for use, from effective treatment liver cirrhosis.

Technical scheme of the present invention is: the Chinese medicine decoction of this kind orally for curing hepatocirrhosis, it is characterized in that, make raw materials of effective components and be: Radix Angelicae Sinensis 6～12, Radix Salviae Miltiorrhizae 10～20, Carapax Trionycis (processed) 25～30, Semen Persicae 8～15, Rhizoma Curcumae 6～9, Pheretima 5～10, Radix Curcumae 3～9, Herba Lycopi 6～12, Herba Cirsii 4.5～9, Radix Notoginseng 10～20, Radix Paeoniae Rubra 6～12 and Radix Glycyrrhizae 5～8 by following weight portion.

Preparation and instructions of taking: be decocted in water for oral dose, potion on the one, potion is taken at twice, and ten days is a course of treatment.

Further technical scheme of the present invention is: the Chinese medicine decoction of this kind orally for curing hepatocirrhosis, it is characterized in that, make raw materials of effective components and be: Radix Angelicae Sinensis 10, Radix Salviae Miltiorrhizae 15, Carapax Trionycis (processed) 28, Semen Persicae 14, Rhizoma Curcumae 8, Pheretima 8, Radix Curcumae 6, Herba Lycopi 10, Herba Cirsii 8, Radix Notoginseng 15, Radix Paeoniae Rubra 8 and Radix Glycyrrhizae 6 by following weight portion.

Pharmacological action:

Radix Salviae Miltiorrhizae can reduce the content of TGF-β 1RNA, suppresses hepatic stellate cell (HSC) and is converted into fibroblastic karyokinesis and propagation, and obviously suppress the pathologic increase of I, II and IV Collagen Type VI amount.Semen Persicae extract can effectively suppress the anabolism of matrix components such as collagen by activity that improves the hepatic tissue collagenase and the activation that suppresses hepatic stellate cell, promotes its catabolism.Pheretima then may be by reducing α-smooth muscle actin (α-SMA, be the sign of hepatic stellate cell activator), TGF-β 1, TIMP-1 protein expression and promote matrix metalloproteinase-13 (MMP-13) protein expression and suppress the formation of rat liver fibrosis tissue, the Lumbricus collagenase that itself the contains interstitial collagenase of can directly degrading.Radix Angelicae Sinensis then can significantly be suppressed to fibroblast proliferation, and it is synthetic to suppress the interior collagen of liver, promotes liver cell regeneration.Carapax Trionycis (processed) can be supported bright heat clearing away, suppressing the hyperactive liver to relieve the wind syndrome, hard masses softening and resolving.Control the consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly, lump in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, pediatric epilepsy scared.Simultaneously, Herba Lycopi, Herba Cirsii, Radix Paeoniae Rubra, Rhizoma Curcumae, Radix Curcumae etc. all can be by anti-liver injury, improve liver microcirculation, promote approach such as liver cell regeneration to participate in the different links of fibrosis.Radix Glycyrrhizae then with middle emergency, lung moistening, the detoxifcation, coordinating the actions of various ingredients in a prescription.Control weakness of the spleen and stomach, lack of appetite, the stomachache loose stool, the overstrain heating, the consumptive lung disease cough, cardiopalmus is fainted from fear; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.

After the present invention mixed said medicine, its drug effect synergism in the liver cirrhosis therapeutic process, had been obtained unexpected remarkable result.The Chinese medicine decoction of this kind orally for curing hepatocirrhosis is through clinical 50 example checkings, and effective percentage reaches more than 90%.

Model case:

Example one: the king so-and-so, man, 34 years old.Sensation stomachache is hard to bear suddenly before 3 years for the patient, goes examination in hospital to find the lobules of liver structure disturbance, and pseudolobuli forms.Be liver cirrhosis after diagnosing.Patient hepatocyte edema, the organizational structure disorder, and see proliferation of fibrous tissue, and the portal area lymphocytic infiltration, visible pseudolobuli forms.Give with the Chinese medicine decoction of this kind orally for curing hepatocirrhosis and treat after two months, the hepatocyte edema absorbs, and inflammation is clearly better, and fibrous tissue reduces, and pseudolobuli disappears.After continuing to strengthen treatment five courses of treatment, recovery from illness.

Example two: Dong so-and-so, man, 29 years old.The patient found liver cirrhosis before 4 years, and the examination in hospital result shows that liver function is undesired: glutamate pyruvate transaminase 136u/L, and hepatic fibrosis index obviously increases, and B ultrasonic shows: liver cirrhosis, splenomegaly.Be diagnosed as: " hepatitis cirrhosis third type active stage ".Give treatments such as Chinese medicine decoction with this kind orally for curing hepatocirrhosis protects the liver, antiviral, fibrosis.Liver power recovery is normal after one week, and hepatitis C virus does not duplicate after March, HCV-RNA Ocp/ml, and hepatic fibrosis index is normal, and B ultrasonic shows the spleen retraction after half a year, and stable disease reaches clinical cure substantially.

Example three: Zou so-and-so, woman, 30 years old.Found liver cirrhosis before 2 years, at examination in hospital, liver function AST/ALT:71/92u/l, Tbil/Dbil:88.6/46.3umol/L, A/G 29/45g/L, blood ammonia: 87.3umol/L, through multi-treatment, it is all ineffective to take a large amount of Chinese-western medicine preparations.The Chinese medicine decoction of oral this kind orally for curing hepatocirrhosis, one the course of treatment state of an illness take a turn for the better gradually, continue to take and consolidate curative effect, liver function recovery is normal after three courses of treatment.

Example four: grandson so-and-so, woman, 56 years old.Suffering from liver cirrhosis nearly ten years is interrupted over 10 years and takes Chinese medicine, the symptom fashion time difference, a month tired sx of cause also hypomnesis occurs, obnubilation, and delirium is multi-lingual, look into through outpatient service: AST:96, ALT138, TDil83.4, DBil57.2, A/G:27/46, B ultrasonic: liver cirrhosis, ascites, air spots, portal vein 1.5cm, the real light 0.73cm of gallbladder is double-deck, the thick 4.7cm of spleen.Give with the Chinese medicine decoction of this kind orally for curing hepatocirrhosis and treat, the check liver function is normal fully after four courses of treatment, and albumen is inverted and is obtained correcting, and ascites disappears, and portal vein attenuates, and spleen and spleen V recovery are normal.

The specific embodiment

Example one: a kind of Chinese medicine decoction of orally for curing hepatocirrhosis, make raw materials of effective components and be (unit: gram): Radix Angelicae Sinensis 6, Radix Salviae Miltiorrhizae 10, Carapax Trionycis (processed) 25, Semen Persicae 8, Rhizoma Curcumae 6, Pheretima 5, Radix Curcumae 3, Herba Lycopi 6, Herba Cirsii 4.5, Radix Notoginseng 10, Radix Paeoniae Rubra 6 and Radix Glycyrrhizae 5 by following weight.

Example two: a kind of Chinese medicine decoction of orally for curing hepatocirrhosis, make raw materials of effective components and be (unit: gram): Radix Angelicae Sinensis 12, Radix Salviae Miltiorrhizae 20, Carapax Trionycis (processed) 30, Semen Persicae 15, Rhizoma Curcumae 9, Pheretima 10, Radix Curcumae 9, Herba Lycopi 12, Herba Cirsii 9, Radix Notoginseng 20, Radix Paeoniae Rubra 12 and Radix Glycyrrhizae 8 by following weight.

System and instructions of taking: with example one.

Example three: a kind of Chinese medicine decoction of orally for curing hepatocirrhosis, make raw materials of effective components and be (unit: gram): Radix Angelicae Sinensis 2, Radix Salviae Miltiorrhizae 13, Carapax Trionycis (processed) 25, Semen Persicae 12, Rhizoma Curcumae 9, Pheretima 9, Radix Curcumae 8, Herba Lycopi 11, Herba Cirsii 7, Radix Notoginseng 17, Radix Paeoniae Rubra 10 and Radix Glycyrrhizae 7 by following weight.

System and instructions of taking: with example one.

Example four: a kind of Chinese medicine decoction of orally for curing hepatocirrhosis, make raw materials of effective components and be (unit: gram): Radix Angelicae Sinensis 10, Radix Salviae Miltiorrhizae 15, Carapax Trionycis (processed) 28, Semen Persicae 14, Rhizoma Curcumae 8, Pheretima 8, Radix Curcumae 6, Herba Lycopi 10, Herba Cirsii 8, Radix Notoginseng 15, Radix Paeoniae Rubra 8 and Radix Glycyrrhizae 6 by following weight.

Preparation and instructions of taking: with example one.

Claims

1. the Chinese medicine decoction of an orally for curing hepatocirrhosis, it is characterized in that, make raw materials of effective components and be: Radix Angelicae Sinensis 6～12, Radix Salviae Miltiorrhizae 10～20, Carapax Trionycis (processed) 25～30, Semen Persicae 8～15, Rhizoma Curcumae 6～9, Pheretima 5～10, Radix Curcumae 3～9, Herba Lycopi 6～12, Herba Cirsii 4.5～9, Radix Notoginseng 10～20, Radix Paeoniae Rubra 6～12 and Radix Glycyrrhizae 5～8 by following weight portion.

2. according to the Chinese medicine decoction of claim 1 described a kind of orally for curing hepatocirrhosis, it is characterized in that, make raw materials of effective components and be: Radix Angelicae Sinensis 10, Radix Salviae Miltiorrhizae 15, Carapax Trionycis (processed) 28, Semen Persicae 14, Rhizoma Curcumae 8, Pheretima 8, Radix Curcumae 6, Herba Lycopi 10, Herba Cirsii 8, Radix Notoginseng 15, Radix Paeoniae Rubra 8 and Radix Glycyrrhizae 6 by following weight portion.