WO2017084170A1 - Medication for invigorating spleen and militating stomach and preparation method therefor - Google Patents

Medication for invigorating spleen and militating stomach and preparation method therefor Download PDF

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WO2017084170A1
WO2017084170A1 PCT/CN2015/098952 CN2015098952W WO2017084170A1 WO 2017084170 A1 WO2017084170 A1 WO 2017084170A1 CN 2015098952 W CN2015098952 W CN 2015098952W WO 2017084170 A1 WO2017084170 A1 WO 2017084170A1
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stomach
spleen
powder
bupleurum
mesh
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PCT/CN2015/098952
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French (fr)
Chinese (zh)
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黎钧陶
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黎钧陶
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods

Definitions

  • the invention relates to a medicine and a preparation method thereof, in particular to a spleen and stomach pill and a preparation method thereof.
  • Stomach disease is a common and frequently-occurring disease, but it has always been a chronic disease that humans cannot completely eradicate.
  • various drugs for treating stomach diseases have appeared on the market, including western medicine and proprietary Chinese medicine.
  • Western medicine has a single effect, high price, and has many side effects. Some patients may have adverse reactions.
  • Chinese medicines on the market can play a role in treating stomach diseases, some preparation methods of gastric medicine are cumbersome and limited in efficacy, not only effective. Slow, and easy to relapse after treatment.
  • the object of the present invention is to overcome the deficiencies of the prior art and provide a spleen and stomach pill which is inexpensive, has few side effects, has remarkable therapeutic effects, and is not easy for a patient to relapse; and provides a spleen which is simple and easy to prepare, or even self-preparable. And stomach pill preparation method.
  • a spleen and stomach pill characterized in that it consists of the following raw materials by weight: 6.7 to 15% of Hedyotis diffusa, 2% to 5% of Bupleurum, 3% to 7% of chayote, and 3% of clove ⁇ 6%, Atractylodes 1% to 3%, jellyfish 4% to 9%, Xiangfu 22.5% to 26%, Pseudostellariae 1% to 3%, Glycyrrhiza uralensis 2% to 3%, and white peony 3% to 6 %, turtle shell 2% to 5%, armor 2% to 3%, meat 2% to 4%, Wannian 4% to 6%, jaundice 8% to 12%, black peony 2% to 4%, stone grease 3 % to 10% and oysters 3% to 6%.
  • the spleen and stomach pill is characterized in that it consists of the following raw materials by weight: Hedyotis diffusa 9%, Bupleurum 3%, Chayote 4%, clove 5%, Atractylodes 1%, sea bream 5%, fragrant 26%, Pseudostellariae 1%, licorice 2%, white 5%, turtle 3%, armor 2%, 3% meat, 5%, jaundice 12%, 3% medicine 6% stone fat and 5% oyster.
  • All of the above medicinal materials powders may be mixed to form a pellet.
  • the preparation method of the spleen and stomach pill the powder of the Hedyotis diffusa of the step (2) is passed through a 100 mesh sieve, and the whitewash snake herb powder of less than 100 mesh is taken.
  • the powder of Bupleurum in the step (3) is passed through a 100 mesh sieve, and the Bupleurum drug is less than 100 mesh. powder.
  • the powder of the mixed raw material of the step (4) is passed through a 100 mesh sieve to take a powder of less than 100 mesh.
  • the step (2) of Hedyotis diffusa was dried at 100 ° C for 30 minutes.
  • the medicament of the present invention is administered three times a day, three times a day, and about one hour after a meal. 3 to 4 weeks for a course of treatment. Children are halved.
  • Hedyotis diffusa whole grass containing chlorophyll, locust citrate, deacetic acid, chlorophyll citrate, scorpion citrate, chicken vine vine, chicken vine vine, methyl ester, 6 -O-p-hydroxycinnamoyl guanidinium methyl ester, 6-O-p-methoxycinnamoyl hydrazide, 6-O-feruloyl guanidine vine 2-methyl-3-hydroxyindole, 2-methyl-3-methoxyindole, 2-methyl-3-hydroxy-4-methoxyindole, etc., and ursolic acid, ⁇ -Valley Sterol, triacontane, stigmasterol, oleanolic acid, ⁇ -sitosterol- ⁇ -glucoside, p-coumaric acid, and the like. Modern pharmacological studies have shown that white snake grass can enhance the body's immunity, antibacterial and anti-inflammatory effects, and provide new treatment directions for stomach diseases.
  • the present invention has the following technical effects:
  • the spleen and stomach pill of the invention has a wide therapeutic range and can treat stomach pain and gastric ulcer. Patients with stomach problems in the society have received satisfactory results after taking this medicine. After 3-4 weeks of application, the symptoms are cured, the pain of surgery is relieved, and there is little recurrence.
  • the spleen and stomach pill of the invention can eliminate qi, qi, help digestion, relieve phlegm, relieve pain, stop bleeding, build muscle, protect gastric mucosa, inhibit gastric acid secretion, and promote ulcer healing.
  • the spleen and stomach pill of the present invention are mainly composed of traditional Chinese medicines, and have medicinal properties and no toxic side effects.
  • the preparation method of the spleen and stomach pill of the invention is simple and easy, can be mass-produced, and can be self-formed and used, which greatly reduces the treatment cost of the patient.
  • the spleen and stomach pill of the present embodiment are composed of the following raw materials in the following percentage by weight: Hedyotis diffusa 9%, Bupleurum 3%, Chayote 4%, clove 5%, Atractylodes 1%, jellyfish 5% 26%, fragrant ginseng 1%, ginseng ginseng 1%, licorice root 2%, white peony 5%, turtle 3%, armor 2%, 3% meat, 5%, jaundice 12%, medicinal 3%, stone fat 6% and 5% oysters.
  • the preparation method is as follows:
  • the Hedyotis diffusa is dried at 100 ° C for 30 minutes, and powdered, and passed through a 100 mesh sieve to obtain a white flower snake tongue herbal powder of less than 100 mesh.
  • the method for taking the spleen and stomach pill of the present embodiment is: taking the drug 3 g each time, three times a day, and taking it about 1 hour after the meal. 3 to 4 weeks for a course of treatment. Children are halved.
  • the spleen and stomach pill of the present embodiment are composed of the following raw materials in the following percentage by weight: Hedyotis diffusa 8%, Bupleurum 2%, Chayote 6%, clove 3%, Atractylodes 3%, jellyfish 9% 26% of fragrant scent, 1% of ginseng ginseng, 3% of licorice licorice, 6% of white peony, 5% of turtle shell, 2% of armor, 2% of oyster meat, 4% of evergreen, 12% of radix, 2% of black peony, stone fat 3% and 3% oysters.
  • Example 2 The preparation method and administration method of the spleen and stomach pill of Example 2 were the same as those in Example 1.
  • the spleen and stomach pill of the present embodiment are composed of the following raw materials in the following percentage by weight: Hedyotis diffusa 12%, Bupleurum 5%, Chayote 3%, clove 6%, Atractylodes 3%, Begonia 4% 23%, fragrant ginseng 3%, ginseng ginseng 2%, white peony 3%, turtle shell 2%, armor 3%, oyster meat 4%, Wannian 6%, jaundice 8%, black peony 4%, stone fat 3% and 6% oysters.
  • Example 3 The preparation method and administration method of the spleen and stomach pill of Example 3 were the same as those in Example 1.
  • Mr. Fang suffering from stomach ulcers for a long time. Eat no appetite, vomiting sour water. Often treated in the outpatient clinic, no significant effect. After the stomach pain was aggravated, it was not relieved. After trying to take the spleen and stomach pill of the first embodiment of the present invention for one week, the patient's pain was relieved and continued to be taken for two months, and the symptoms of the patient disappeared. There was no recurrence after follow-up.
  • Mr. Du has long suffered from stomach ulcers.
  • the upper abdomen showed paroxysmal dull pain during the seasons, and increased after eating. It was accompanied by acid reflux, belching, bloating, nausea, vomiting, and tar-like stool.
  • acid reflux has been treated conservatively in the outpatient clinic, the effect is not significant.
  • the symptoms of the patient gradually eased, and then the treatment was continued for two courses, and the patient's symptoms were completely unsatisfactory. After telephone follow-up, the patient has no recurrence so far.

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Abstract

A medication for invigorating the spleen and militating the stomach and preparation method therefor. The medication for invigorating the spleen and militating the stomach is prepared from herba hedyotis diffusae, radix bupleuri, sechium edule, flos caryophylli, rhizoma atractylodis macrocephalae, os sepiellae seu sepiae, rhizoma cyperi, radix pseudostellariae, radix glycyrrhizae praeparata, radix paeoniae alba, plastrum testudinis, carapax trionycis, fructus corni, rohdea japonica, radix astragali, radix linderae, halloysitum rubrum, and concha ostreae.

Description

健脾和胃丸及其制备方法Jianpi Hewei Pill and preparation method thereof 技术领域Technical field
本发明涉及一种药物及其制备方法,具体地,涉及一种健脾和胃丸及其制备方法。The invention relates to a medicine and a preparation method thereof, in particular to a spleen and stomach pill and a preparation method thereof.
背景技术Background technique
胃病是一种常见的多发病,但一直是人类无法彻底根除的顽症,目前市场上出现了各种各样的治疗胃病的药物,包括西药和中成药。西药疗效单一,价格昂贵,副作用大,有的患者会出现不良反应;市面上的中成药虽然能起到一定的治疗胃病的作用,但有的胃药的制备工艺繁琐,药效有限,不仅见效慢,且治疗后容易复发。Stomach disease is a common and frequently-occurring disease, but it has always been a chronic disease that humans cannot completely eradicate. At present, various drugs for treating stomach diseases have appeared on the market, including western medicine and proprietary Chinese medicine. Western medicine has a single effect, high price, and has many side effects. Some patients may have adverse reactions. Although Chinese medicines on the market can play a role in treating stomach diseases, some preparation methods of gastric medicine are cumbersome and limited in efficacy, not only effective. Slow, and easy to relapse after treatment.
发明内容Summary of the invention
本发明的目的是克服现有技术的不足,提供一种价格低廉、副作用小、治疗效果显著且患者不易复发的健脾和胃丸;还提供一种简单易行、甚至可以自行配制的健脾和胃丸制备方法。The object of the present invention is to overcome the deficiencies of the prior art and provide a spleen and stomach pill which is inexpensive, has few side effects, has remarkable therapeutic effects, and is not easy for a patient to relapse; and provides a spleen which is simple and easy to prepare, or even self-preparable. And stomach pill preparation method.
本发明解决所述技术问题采用的技术方案是:The technical solution adopted by the present invention to solve the technical problem is:
一种健脾和胃丸,其特征在于,其由以下重量份的原料组成:白花蛇舌草7%~15%、柴胡2%~5%、佛手瓜3%~7%、丁香3%~6%、白术1%~3%、海螵蛸4%~9%、香附22.5%~26%、太子参1%~3%、炙甘草2%~3%、白芍3%~6%、龟板2%~5%、鳖甲2%~3%、萸肉2%~4%、万年青4%~6%、黄芪8%~12%、乌药2%~4%、石脂3%~10%和牡蛎3%~6%。A spleen and stomach pill, characterized in that it consists of the following raw materials by weight: 6.7 to 15% of Hedyotis diffusa, 2% to 5% of Bupleurum, 3% to 7% of chayote, and 3% of clove ~6%, Atractylodes 1% to 3%, jellyfish 4% to 9%, Xiangfu 22.5% to 26%, Pseudostellariae 1% to 3%, Glycyrrhiza uralensis 2% to 3%, and white peony 3% to 6 %, turtle shell 2% to 5%, armor 2% to 3%, meat 2% to 4%, Wannian 4% to 6%, jaundice 8% to 12%, black peony 2% to 4%, stone grease 3 % to 10% and oysters 3% to 6%.
所述的健脾和胃丸,其特征在于,其由以下重量份的原料组成:白花蛇舌草9%、柴胡3%、佛手瓜4%、丁香5%、白术1%、海螵蛸5%、香附26%、太子参1%、炙甘草2%、白芍5%、龟板3%、鳖甲2%、萸肉3%、万年青5%、黄芪12%、乌药3%、石脂6%和牡蛎5%。The spleen and stomach pill is characterized in that it consists of the following raw materials by weight: Hedyotis diffusa 9%, Bupleurum 3%, Chayote 4%, clove 5%, Atractylodes 1%, sea bream 5%, fragrant 26%, Pseudostellariae 1%, licorice 2%, white 5%, turtle 3%, armor 2%, 3% meat, 5%, jaundice 12%, 3% medicine 6% stone fat and 5% oyster.
所述的健脾和胃丸的制备方法,其特征在于,包括以下几个步骤:The preparation method of the spleen and stomach pill is characterized in that it comprises the following steps:
(1)将所有原料药材按其重量份称量;(1) Weigh all raw materials in their weight;
(2)将白花蛇舌草烘干,并打成粉末;(2) drying the white flower Hedyotis and making it into a powder;
(3)将柴胡打成粉末;(3) Beating Bupleurum into powder;
(4)将药材佛手瓜、丁香、白术、海螵蛸、香附、太子参、炙甘草、白芍、龟板、鳖甲、萸肉、万年青、黄芪、乌药、石脂和牡蛎经过混合后,蒸煮、晒干,然后均打成粉末;(4) After mixing the medicinal materials of chayote, clove, atractylodes, jellyfish, fragrant, ginseng, licorice, white peony, turtle shell, armor, oyster meat, evergreen, scutellaria, peony, stone fat and oyster , cooked, dried, and then powdered;
(5)将以上全部的药材粉末全部混合,制成丸子即可。(5) All of the above medicinal materials powders may be mixed to form a pellet.
所述的健脾和胃丸的制备方法,所述步骤(2)的白花蛇舌草的粉末过100目筛,取小于100目的白花蛇舌草药粉。所述步骤(3)的柴胡的粉末过100目筛,取小于100目的柴胡药 粉。所述步骤(4)的混合原料的粉末过100目筛,取小于100目的药粉。所述步骤(2)的白花蛇舌草在100℃中烘干30分钟。The preparation method of the spleen and stomach pill, the powder of the Hedyotis diffusa of the step (2) is passed through a 100 mesh sieve, and the whitewash snake herb powder of less than 100 mesh is taken. The powder of Bupleurum in the step (3) is passed through a 100 mesh sieve, and the Bupleurum drug is less than 100 mesh. powder. The powder of the mixed raw material of the step (4) is passed through a 100 mesh sieve to take a powder of less than 100 mesh. The step (2) of Hedyotis diffusa was dried at 100 ° C for 30 minutes.
本发明的药物,服用本药每次3克,每天三次,餐后约1小时服用。3~4周为1个疗程。小儿减半。The medicament of the present invention is administered three times a day, three times a day, and about one hour after a meal. 3 to 4 weeks for a course of treatment. Children are halved.
白花蛇舌草,全草含车叶草甙,车叶草甙酸,去乙酸,基车叶草甙酸,都桷子甙酸,鸡屎藤次甙,鸡屎藤次甙甲酯,6-O-对-羟基桂皮酰鸡屎藤次甙甲酯,6-O-对-甲氧基桂皮酰鸡屎藤次甙甲酯,6-O-阿魏酰鸡屎藤次甙甲酯,2-甲基-3-羟基蒽醌,2-甲基-3-甲氧基蒽醌,2-甲基-3-羟基-4-甲氧基蒽醌等,以及熊果酸,β-谷甾醇,三十一烷,豆甾醇,齐墩果酸,β-谷甾醇-β-葡萄糖甙,对-香豆酸等。现代药理学研究证明,白花蛇草能增强机体的免疫力,抗菌消炎的作用,未治疗胃病提供的新的治疗方向。Hedyotis diffusa, whole grass containing chlorophyll, locust citrate, deacetic acid, chlorophyll citrate, scorpion citrate, chicken vine vine, chicken vine vine, methyl ester, 6 -O-p-hydroxycinnamoyl guanidinium methyl ester, 6-O-p-methoxycinnamoyl hydrazide, 6-O-feruloyl guanidine vine 2-methyl-3-hydroxyindole, 2-methyl-3-methoxyindole, 2-methyl-3-hydroxy-4-methoxyindole, etc., and ursolic acid, β-Valley Sterol, triacontane, stigmasterol, oleanolic acid, β-sitosterol-β-glucoside, p-coumaric acid, and the like. Modern pharmacological studies have shown that white snake grass can enhance the body's immunity, antibacterial and anti-inflammatory effects, and provide new treatment directions for stomach diseases.
与现有技术相比,本发明具有以下技术效果:Compared with the prior art, the present invention has the following technical effects:
1、本发明的健脾和胃丸治疗范围广,可以治疗胃痛、胃溃疡。社会上患有胃病的患者,经过服用本药,均收到满意的效果,应用3-4周,症状达到痊愈,免除手术的痛苦,并且少有复发。1. The spleen and stomach pill of the invention has a wide therapeutic range and can treat stomach pain and gastric ulcer. Patients with stomach problems in the society have received satisfactory results after taking this medicine. After 3-4 weeks of application, the symptoms are cured, the pain of surgery is relieved, and there is little recurrence.
2、本发明的健脾和胃丸能消滞、行气、助消化、解郁、止痛、止血、生肌、保护胃黏膜、抑制胃酸分泌、促进溃疡面愈合。2. The spleen and stomach pill of the invention can eliminate qi, qi, help digestion, relieve phlegm, relieve pain, stop bleeding, build muscle, protect gastric mucosa, inhibit gastric acid secretion, and promote ulcer healing.
4、本发明的健脾和胃丸主要是中药成分,药性平和、无毒副作用。4. The spleen and stomach pill of the present invention are mainly composed of traditional Chinese medicines, and have medicinal properties and no toxic side effects.
5、本发明的健脾和胃丸制备方法简单易行,既可批量化生产,又可自行配制使用,大大降低了患者的治疗成本。5. The preparation method of the spleen and stomach pill of the invention is simple and easy, can be mass-produced, and can be self-formed and used, which greatly reduces the treatment cost of the patient.
具体实施方式detailed description
下面结合具体实施例对本发明作进一步的说明,但本发明不受下述实施例的限定。The invention is further illustrated by the following specific examples, but the invention is not limited by the following examples.
实施例1Example 1
本实施例的健脾和胃丸按如下重量百分含量的原料配制组成:白花蛇舌草9%、柴胡3%、佛手瓜4%、丁香5%、白术1%、海螵蛸5%、香附26%、太子参1%、炙甘草2%、白芍5%、龟板3%、鳖甲2%、萸肉3%、万年青5%、黄芪12%、乌药3%、石脂6%和牡蛎5%。The spleen and stomach pill of the present embodiment are composed of the following raw materials in the following percentage by weight: Hedyotis diffusa 9%, Bupleurum 3%, Chayote 4%, clove 5%, Atractylodes 1%, jellyfish 5% 26%, fragrant ginseng 1%, ginseng ginseng 1%, licorice root 2%, white peony 5%, turtle 3%, armor 2%, 3% meat, 5%, jaundice 12%, medicinal 3%, stone fat 6% and 5% oysters.
其制备方法为:The preparation method is as follows:
(1)将所有原料药材按其重量份称量;(1) Weigh all raw materials in their weight;
(2)将白花蛇舌草在100℃中烘干30分钟,并打成粉末,并过100目筛,取小于100目的白花蛇舌草药粉。(2) The Hedyotis diffusa is dried at 100 ° C for 30 minutes, and powdered, and passed through a 100 mesh sieve to obtain a white flower snake tongue herbal powder of less than 100 mesh.
(3)将柴胡打成粉末,并过100目筛,取小于100目的柴胡药粉;(3) Beating Bupleurum into a powder and passing through a 100 mesh sieve to obtain a Bupleurum powder of less than 100 mesh;
(4)将药材佛手瓜、丁香、白术、海螵蛸、香附、太子参、炙甘草、白芍、龟板、鳖甲、萸 肉、万年青、黄芪、乌药、石脂和牡蛎经过混合后,蒸煮、晒干,然后均打成粉末,并过100目筛,取小于100目的药粉;(4) The medicinal materials of chayote, clove, atractylodes, jellyfish, fragrant, ginseng, licorice, white peony, turtle shell, armor, cockroach The meat, evergreen, scutellaria, black peony, stone fat and oyster are mixed, cooked, dried, and then powdered, and passed through a 100 mesh sieve to obtain a powder of less than 100 mesh;
(5)将以上药材粉末全部混合而成。(5) The above medicinal materials are all mixed.
本实施例的健脾和胃丸服用方法是:服用本药每次3克,每天三次,餐后约1小时服用。3~4周为1个疗程。小儿减半。The method for taking the spleen and stomach pill of the present embodiment is: taking the drug 3 g each time, three times a day, and taking it about 1 hour after the meal. 3 to 4 weeks for a course of treatment. Children are halved.
实施例2Example 2
本实施例的健脾和胃丸按如下重量百分含量的原料配制组成:白花蛇舌草8%、柴胡2%、佛手瓜6%、丁香3%、白术3%、海螵蛸9%、香附26%、太子参1%、炙甘草3%、白芍6%、龟板5%、鳖甲2%、萸肉2%、万年青4%、黄芪12%、乌药2%、石脂3%和牡蛎3%。The spleen and stomach pill of the present embodiment are composed of the following raw materials in the following percentage by weight: Hedyotis diffusa 8%, Bupleurum 2%, Chayote 6%, clove 3%, Atractylodes 3%, jellyfish 9% 26% of fragrant scent, 1% of ginseng ginseng, 3% of licorice licorice, 6% of white peony, 5% of turtle shell, 2% of armor, 2% of oyster meat, 4% of evergreen, 12% of radix, 2% of black peony, stone fat 3% and 3% oysters.
实施例2的健脾和胃丸的制备方法和服用方法同实施例1。The preparation method and administration method of the spleen and stomach pill of Example 2 were the same as those in Example 1.
实施例3Example 3
本实施例的健脾和胃丸按如下重量百分含量的原料配制组成:白花蛇舌草12%、柴胡5%、佛手瓜3%、丁香6%、白术3%、海螵蛸4%、香附23%、太子参3%、炙甘草2%、白芍3%、龟板2%、鳖甲3%、萸肉4%、万年青6%、黄芪8%、乌药4%、石脂3%和牡蛎6%。The spleen and stomach pill of the present embodiment are composed of the following raw materials in the following percentage by weight: Hedyotis diffusa 12%, Bupleurum 5%, Chayote 3%, clove 6%, Atractylodes 3%, Begonia 4% 23%, fragrant ginseng 3%, ginseng ginseng 2%, white peony 3%, turtle shell 2%, armor 3%, oyster meat 4%, Wannian 6%, jaundice 8%, black peony 4%, stone fat 3% and 6% oysters.
实施例3的健脾和胃丸的制备方法和服用方法同实施例1。The preparation method and administration method of the spleen and stomach pill of Example 3 were the same as those in Example 1.
回访调查Return visit survey
方先生,长期患有胃溃疡。吃饭无食欲,吐酸水。常在门诊吃药治疗,无明显效果。后因胃疼痛加重无法缓解,尝试着服用本发明实施例1的健脾和胃丸一个星期后,患者疼痛缓解,继续服用两个月,患者以上不适症状消失。随访至今未出现复发。Mr. Fang, suffering from stomach ulcers for a long time. Eat no appetite, vomiting sour water. Often treated in the outpatient clinic, no significant effect. After the stomach pain was aggravated, it was not relieved. After trying to take the spleen and stomach pill of the first embodiment of the present invention for one week, the patient's pain was relieved and continued to be taken for two months, and the symptoms of the patient disappeared. There was no recurrence after follow-up.
李女士,9年前患有胃溃疡伴轻度萎缩。上腹疼痛,尤其餐前空腹时症状明显,时常夜间痛醒,心口常伴有刺痛,烧心,反酸的症状。后经人介绍,服用了本发明实施例1的健脾和胃丸一个月后,患者不适症状逐渐缓解,再服用一个月,患者不适症状完全消失。随访,患者未出现过复发。Ms. Li, who suffered from a stomach ulcer with mild atrophy 9 years ago. Pain in the upper abdomen, especially in the fasting before the meal, the symptoms are obvious, often wake up at night, the heart is often accompanied by tingling, heartburn, acid reflux symptoms. Later, after taking the spleen and stomach pill of the first embodiment of the present invention for one month, the patient's symptoms were gradually relieved, and after taking another month, the patient's symptoms disappeared completely. At the follow-up, the patient did not have a recurrence.
杜先生,长期患有胃溃疡。上腹于季节交替时出现阵发性钝痛,饱食后加重,伴有反酸,嗳气,腹胀,恶心,呕吐,大便呈柏油样。一直在门诊作保守治疗,效果不显著。后在服用了本发明实施例2的健脾和胃丸一个星期后,患者症状逐渐缓解,再坚持治疗两个疗程,患者不适症状完全消息。电话随访,患者至今无复发。Mr. Du, has long suffered from stomach ulcers. The upper abdomen showed paroxysmal dull pain during the seasons, and increased after eating. It was accompanied by acid reflux, belching, bloating, nausea, vomiting, and tar-like stool. Has been treated conservatively in the outpatient clinic, the effect is not significant. After taking the spleen and stomach pill of the second embodiment of the present invention for one week, the symptoms of the patient gradually eased, and then the treatment was continued for two courses, and the patient's symptoms were completely unsatisfactory. After telephone follow-up, the patient has no recurrence so far.
梅女士,10年前患有胃溃疡。阵发性上腹烧灼样痛,饥饿时,夜间发生,进食后可缓 解,伴有反酸,烧心,排柏油样黑便。多次住院作保守治疗都无明显效果。服用了本发明实施例2的健脾和胃丸一个疗程后,以上不适症状逐渐缓解,再巩固治疗两个疗程后,不适症状完全消失。电话回访,至今无出现复发。 Ms. Mei, suffering from stomach ulcer 10 years ago. Paroxysmal upper abdomen burning pain, hunger, nighttime, can be slow after eating Solution, accompanied by acid reflux, heartburn, tar-like black stool. Multiple hospitalizations for conservative treatment had no significant effect. After taking a course of the spleen and stomach pill of the second embodiment of the present invention, the above symptoms were gradually relieved, and after the two courses of treatment were consolidated, the symptoms of discomfort completely disappeared. There was no recurrence after returning by telephone.

Claims (7)

  1. 一种健脾和胃丸,其特征在于,其由以下重量份的原料组成:白花蛇舌草7%~15%、柴胡2%~5%、佛手瓜3%~7%、丁香3%~6%、白术1%~3%、海螵蛸4%~9%、香附22.5%~26%、太子参1%~3%、炙甘草2%~3%、白芍3%~6%、龟板2%~5%、鳖甲2%~3%、萸肉2%~4%、万年青4%~6%、黄芪8%~12%、乌药2%~4%、石脂3%~10%和牡蛎3%~6%。A spleen and stomach pill, characterized in that it consists of the following raw materials by weight: 6.7 to 15% of Hedyotis diffusa, 2% to 5% of Bupleurum, 3% to 7% of chayote, and 3% of clove ~6%, Atractylodes 1% to 3%, jellyfish 4% to 9%, Xiangfu 22.5% to 26%, Pseudostellariae 1% to 3%, Glycyrrhiza uralensis 2% to 3%, and white peony 3% to 6 %, turtle shell 2% to 5%, armor 2% to 3%, meat 2% to 4%, Wannian 4% to 6%, jaundice 8% to 12%, black peony 2% to 4%, stone grease 3 % to 10% and oysters 3% to 6%.
  2. 根据权利要求1所述的健脾和胃丸,其特征在于,其由以下重量份的原料组成:白花蛇舌草9%、柴胡3%、佛手瓜4%、丁香5%、白术1%、海螵蛸5%、香附26%、太子参1%、炙甘草2%、白芍5%、龟板3%、鳖甲2%、萸肉3%、万年青5%、黄芪12%、乌药3%、石脂6%和牡蛎5%。The spleen and stomach pill according to claim 1, which is composed of the following raw materials by weight: Hedyotis diffusa 9%, Bupleurum 3%, Chayote 4%, clove 5%, Atractylodes 1% 5% of sea bream, 26% of fragrant scent, 1% of ginseng, 2% of licorice, 5% of white peony, 3% of tortoise shell, 2% of armor, 3% of oyster meat, 5% of evergreen, 12% of scutellaria 3% drug, 6% stone fat and 5% oyster.
  3. 权利要求1~2任一所述的健脾和胃丸的制备方法,其特征在于,包括以下几个步骤:The method for preparing spleen and stomach pill according to any one of claims 1 to 2, characterized in that it comprises the following steps:
    (1)将所有原料药材按其重量份称量;(1) Weigh all raw materials in their weight;
    (2)将白花蛇舌草烘干,并打成粉末;(2) drying the white flower Hedyotis and making it into a powder;
    (3)将柴胡打成粉末;(3) Beating Bupleurum into powder;
    (4)将药材佛手瓜、丁香、白术、海螵蛸、香附、太子参、炙甘草、白芍、龟板、鳖甲、萸肉、万年青、黄芪、乌药、石脂和牡蛎经过混合后,蒸煮、晒干,然后均打成粉末;(4) After mixing the medicinal materials of chayote, clove, atractylodes, jellyfish, fragrant, ginseng, licorice, white peony, turtle shell, armor, oyster meat, evergreen, scutellaria, peony, stone fat and oyster , cooked, dried, and then powdered;
    (5)将以上全部的药材粉末全部混合,制成丸子即可。(5) All of the above medicinal materials powders may be mixed to form a pellet.
  4. 如权利要求3所述的健脾和胃丸的制备方法,其特征在于,所述步骤(2)的白花蛇舌草的粉末过100目筛,取小于100目的白花蛇舌草药粉。The method for preparing spleen and stomach pill according to claim 3, wherein the powder of the sage of the step (2) is passed through a 100 mesh sieve, and the whitewash snake herb powder of less than 100 mesh is taken.
  5. 如权利要求3所述的健脾和胃丸的制备方法,其特征在于,所述步骤(3)的柴胡的粉末过100目筛,取小于100目的柴胡药粉。The method for preparing spleen and stomach pill according to claim 3, wherein the powder of Bupleurum in the step (3) is passed through a 100 mesh sieve to obtain a Bupleurum powder of less than 100 mesh.
  6. 如权利要求3所述的健脾和胃丸的制备方法,其特征在于,所述步骤(4)的混合原料的粉末过100目筛,取小于100目的药粉。The method for preparing spleen and stomach pill according to claim 3, wherein the powder of the mixed raw material of the step (4) is passed through a 100 mesh sieve to obtain a powder of less than 100 mesh.
  7. 如权利要求3所述的健脾和胃丸的制备方法,其特征在于,所述步骤(2)的白花蛇舌草在100℃中烘干30分钟。 The method for preparing spleen and stomach pill according to claim 3, wherein the step (2) of Hedyotis diffusa is dried at 100 ° C for 30 minutes.
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