CN106344772A - traditional Chinese medicine composition for treating rhinitis, external preparation and preparation method thereof - Google Patents
traditional Chinese medicine composition for treating rhinitis, external preparation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating rhinitis, an external preparation and a preparation method of the traditional Chinese medicine composition for treating rhinitis, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from, by weight, 15 parts of flos magnoliae liliflorae, 5 parts of as arum, 12 parts of ligusticum sinense oliver, 10 parts of Chinese parsnip root, 15 parts of radix angelicae, 10 parts of ligusticum wallichii, 6 parts of rhizome, 9 parts of notopterygium root, 6 parts of liquorice, 15 parts of cocklebur fruit, 10 parts of caulis akebiae, 9 parts of mint, 30 parts of centipeda minima, 12 parts of scutellaria baicalensis, 9 parts of herba eupatorii, 12 parts of rhizoma acori graminei, and 10 parts of fistular onion stalk. The traditional Chinese medicine composition provided by the invention for treating rhinitis has obvious effect, and is free from side effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, more specifically, it is related to the Chinese medicine composition of the treatment of rhinitis.
Background technology
Rhinitis (rhinitis) refers to the inflammation of nasal membrane and submucous tissue.Show as hyperemia or edema, suffer from
Person often occurs nasal obstruction, flows clear water tears, rhinocnesmus, throat is uncomfortable, the symptom such as cough.It is divided into acute rhinitises, chronic rhinitiss (chronic
Simple rhinitises, chronic hypertrophic rhinitiss), allergic rhinitis, atrophic rhinitises, medicamentous rhinitiss, rhinitis sicca etc..
The traditional Chinese medical science is commonly referred to as allergic rhinitis, allergic rhinitis with sneezing or stuffy nose.Have a stuffy nose i.e. nose nose running with watery discharge, sneezing is that stopping up is because itching and gas blowout is uttered a word in nose
And have a stuffy nose when light when weight, or bilateral nose key replace block, recurrent exerbation, do not recover for a long time, or even hyposmia be characterized chronic
Cacorhinia.The traditional Chinese medical science thinks that rhinitis is many and causes because of visceral dysfunction, along with affection of exogenous wind-cold, pathogen invasion and attack nose key.This disease often twines
Continuous difficulty heals, and is first weakened body resistance and evil love, is second that exopathogen is objective long, fire-transformation burn Tianjin and expectorant turbid block nose key.Therefore vital organs of the human body work(
Can lack of proper care for this, mainly include lung, spleen, kidney deficient.Spleen pertaining to the earth, is the mother of lung, the source of studentsization deficiency of the lung absolutely of insufficiency of the spleen then lung；Kidney
Belong to water, Jinsui River alternate, and lung improving inspiration by invigorating kidney-QI is attributed to kidney, the two interacts.Therefore, treatment rhinitis first needs to effect a permanent cure, it is important that temperature compensation lung
Gas, invigorating the spleen and benefiting QI, warming and recuperating the kidney-YANG.Healthy energy is the basis of eliminating evil, and righting so eliminating evil, is controlled rhinitis so, treated other serious diseases
Also such.
In prior art, cn102988560a discloses a kind of medicine for rhinitis, including the raw material of following mass fraction: Fructus Xanthii
(stir-fry) 16-20 part, Herba Schizonepetae 10-14 part, Rhizoma Chuanxiong 8-10 part, Herba Menthae 6-12 part, Radix Saposhnikoviae 4-8 part, Cortex Phellodendri 5-9 part, Herba Asari 6-10 part,
Herba Pogostemonis 6-12 part, Herba Centipedae 3-7 part, Spica Prunellae 6-8 part, Ramulus Cinnamomi 6-10 part, Radix Bupleuri 4-8 part, Radix Gentianae 3-5 part.
Cn101590107a discloses a kind of rhinitis ointment, belongs to Chinese medicine technical field, is made up of effective raw material that following weight forms:
Herba Centipedae 45-55 part, Flos Magnoliae 3-9 part, Radix Gentianae 8-15 part, Radix Angelicae Dahuricae 2-5 part, Herba Asari 2-5 part, glycyrrhizic acid 0.1-0.6 part and
Baicalin 0.5-2 part, prepares paste making agent according to a conventional method after above-mentioned raw materials are pulverized.But above-mentioned Chinese medicine yet suffers from
The problem that treatment rhinitis effect is bad, administration is inconvenient.
Content of the invention
The Chinese medicine composition of the treatment rhinitis that the present invention provides is my late grandfather's succession, book on Chinese herbal medicine refining, 70 years experiences of former generation, this
People makes and innovates, has no side effect, not containing hormone for 30 years.
Present invention firstly provides a kind of Chinese medicine for treating rhinitis compositionss, include following component by weight: pungent
Sprout spend 15 parts, 5 parts of Herba Asari, 12 parts of Rhizoma Ligustici, 10 parts of Radix Saposhnikoviae, 15 parts of the Radix Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiong, 6 parts of Rhizoma Cimicifugae, 9 parts of Rhizoma Et Radix Notopterygii, 6 parts of Radix Glycyrrhizae,
15 parts of Fructus Xanthii, 10 parts of Caulis Akebiae, 9 parts of Herba Menthae, 30 parts of Herba Centipedae, 12 parts of Radix Scutellariae, 9 parts of Herba Eupatorii, 12 parts of Rhizoma Acori Graminei, Bulbus Allii Fistulosi 10
Part.
The Chinese medicine composition of the present invention also offer can be applied in preparation treatment sinusitis, allergic rhinitises, chronic rhinitiss, do
Cheese rhinitis, rhinitis sicca, medicamentous rhinitiss, chronic hypertrophic rhinitiss, vasomotor rhinitiies, nasal polyp, barotrauma
Property rhinitis or nasal mucosa etc. in medicine.
The present invention also proposes a kind of external preparation of the treatment rhinitis being prepared by above-mentioned Chinese medicine composition.
The preparation method of the described external preparation for the treatment of rhinitis, comprises the steps:
1st step, the weight that the component in addition to Bulbus Allii Fistulosi in Chinese medicine composition is taken half adds more than 55 degree jowar wines close
Envelope dip；
2nd step, the weight of the remaining half of the component in addition to Bulbus Allii Fistulosi in Chinese medicine composition is pulverized, and add water sealing
Dip；
3rd step, individually takes Bulbus Allii Fistulosi to add more than 55 degree jowar wine sealing dips；
4th step, respectively by the medicinal liquid obtaining in the 1st step, the 2nd step, the 3rd step and normal saline according to volume ratio 50:30:
10:10 mixes, the external preparation of the rhinitis that obtains medical treatment.
In the 1st described step, the dip time is more than 49 days；Chinese medicine is that 1000ml joined by 1000 grams of Chinese medicines with the weight ratio of wine
Wine.
In the 2nd described step, the dip time is more than 49 days；Water refers to the dew of the early morning appearance on outdoor Folium Nelumbinis；In
Medicine is that 1000ml dew joined by 1000 grams of Chinese medicines with the weight ratio of dew.
In the 3rd described step, the dip time is more than 30 days；Bulbus Allii Fistulosi is that 1000ml joined by 1000 grams of Chinese medicines with the weight ratio of wine
Bulbus Allii Fistulosi.
In the present invention,
Flos Magnoliae is spent, and pungent-warm dissipates, and awakening consciousness reaches in its property, external enwergy removing cold and wind pathogen, interior energy liter reaches lung stomach clearing heat in QI system,
Kind clearing the nasal passage, for controlling the key medicine of nasosinusitis headache, nasal obstruction watery nasal discharge；Rhizoma Chuanxiong, activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain, controls air-cooled head
Pain is revolved dizzy, altogether for monarch drug.
Herba Asari, pungent scattered temperature is led to, fragrance reaches thoroughly, dissipate ailment said due to cold or exposure；Rhizoma Ligustici, can be except the heresy of cold-damp and wind-expelling pain-stopping between skin meridians；
Radix Saposhnikoviae, for diseases caused by exogenous pathogenic factor exterior syndrome, rubella itch, rheumatic arthralgia, tetanus just, insufficiency of the spleen leading to overabundance of dampness；The Radix Angelicae Dahuricae, clearing throat, rash of inducing sweat,
The Herba Menthae of dispersing the stagnated live-QI to relieve the stagnation of QI, reuses dispeiling pathogenic wind and removing dampness, detumescence and apocenosis pain relieving, altogether for ministerial drug.
Herba Eupatorii, blood-activating and qi-promoting, wind-expelling pain-stopping, share its evacuation of pus analgesic effect of enhancing with the Radix Angelicae Dahuricae and be adjuvant drug.
Rhizoma Et Radix Notopterygii, warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, have a headache lossless, cold-damp numbness, upper limb rheumatalgia.
Fructus Xanthii, dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving.
Caulis Akebiae, for stranguria, edema, vexed dark coloured urine, aphtha of the mouth and tongue.
Herba Centipedae, acrid in the mouth, warm in nature, dispersing wind-cold, clearing the nasal passage, cough-relieving.
Radix Scutellariae bitter in the mouth, cold in nature, there are heat clearing and damp drying, eliminating fire and detoxication, hemostasis.
Bulbus Allii Fistulosi, for affection of exogenous wind-cold, yin-cold excess, refusing yang, in outer, faint pulse, is fainted inverse, diarrhoea, external application for curing carbuncle sore furunculosis.
Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription, for making.
All medicines share, reinforcement and elimination in combination, heat clearing and damp drying and non-impairment of YIN, enriching yin boost qi and do not hinder heresy, and nourishing blood and promoting blood circulation blood stasis dispelling disappears
Swollen, clear the nasal passage, thus reach the optimum curative effect of " treating both the principal and secondary aspects of a disease ".
The Chinese medicine that the present invention provides is adapted to scope: sinusitis, allergic rhinitises, chronic rhinitiss, caseous rhinitis, dry
Dry property rhinitis, medicamentous rhinitiss, chronic hypertrophic rhinitiss, vasomotor rhinitiies, nasal polyp, barotraumatic rhinitis etc. cause
Nasal obstruction watery nasal discharge, nasopharynx be dried, nose gas is smelt as of rotten fish, feel oppressed the crowd such as obstructed.
Jowar wine in the present invention is also referred to as sorghum wine.
The external preparation for the treatment of rhinitis proposed by the present invention directly sprays nose, can improve the drug level of nasal mucosa local, profit
The microcirculation being enriched with nose mucosa, quick absorption, allow medicine directly produce drug effect in focal zone；Avoid contained therein effective
Scattering and disappearing of composition, makes medicine through disease institute, more effectively plays its curative effect, improve the blood circulation of nose film, instant effect, the course for the treatment of
Short.
The using method of this volatile oil, nasal cavity sprays into administration.Once every nostril 1～2 is pressed, and chronic rhinitiss, sinusitis are daily
Using 2～3 times；The spray in every 2～3 hours of allergic rhinitis, acute rhinitises is with once.
Beneficial effect
The Chinese medicine that the present invention provides be used for treating rhinitis have effect substantially, the effect of have no side effect.
Specific embodiment
Embodiment 1
Treatment rhinitis Chinese medicine composition, be made up of following component by weight: Flos Magnoliae spend 15 parts, 5 parts of Herba Asari, Artemisia
12 parts of basis, 10 parts of Radix Saposhnikoviae, 15 parts of the Radix Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiong, 6 parts of Rhizoma Cimicifugae, 9 parts of Rhizoma Et Radix Notopterygii, 6 parts of Radix Glycyrrhizae, 15 parts of Fructus Xanthii, Caulis Akebiae 10
Part, 9 parts of Herba Menthae, 30 parts of Herba Centipedae, 12 parts of Radix Scutellariae, 9 parts of Herba Eupatorii, 12 parts of Rhizoma Acori Graminei, 10 parts of Bulbus Allii Fistulosi.
The preparation method of the external preparation of traditional Chinese medicine composition for treating rhinitis, comprises the steps:
1st step, the weight that the component in addition to Bulbus Allii Fistulosi in Chinese medicine composition is taken half adds more than 55 degree jowar wines close
Envelope dip 49 days；Chinese medicine is that 1000ml wine joined by 1000 grams of Chinese medicines with the weight ratio of wine；
2nd step, the weight of the remaining half of the component in addition to Bulbus Allii Fistulosi in Chinese medicine composition is pulverized, plus outdoor lotus
The dew sealing dip that early morning on leaf occurs 49 days；Chinese medicine is that 1000ml dew joined by 1000 grams of Chinese medicines with the weight ratio of dew；
3rd step, individually takes Bulbus Allii Fistulosi to add more than 55 degree jowar wines and seals dip 30 days；Bulbus Allii Fistulosi is 1000 grams with the weight ratio of wine
1000ml Bulbus Allii Fistulosi joined by Chinese medicine；
4th step, respectively by the medicinal liquid obtaining in the 1st step, the 2nd step, the 3rd step and normal saline according to volume ratio 50:30:
10:10 mixes, the external preparation of the rhinitis that obtains medical treatment.
Reference examples 1
Difference with embodiment 1 is not add Herba Eupatorii in pharmaceutical composition.
Long-term toxicity test for animals
1. experimental technique: take wistar rat to be subjects, by high dose group, middle dose group, low dose group administration agent
Amount is respectively 0.632g (1.67ml)/kg, 0.316g (0.84ml)/kg, 0.158g (0.42ml)/kg, is respectively equivalent to people and faces
Bed day intends 80,40,20 times of consumption 0.0079g (0.021ml)/kg.Continuous via intranasal application instills administration 3 months, continues after drug withdrawal
Observe 21 days.
2. observation item: the general status such as the appearance sign of (1) animal, behavioral activity, appetite, defecation；(2) red thin
The hematological indices such as born of the same parents, leukocyte, platelet and bone marrow nucleated cell；(3) glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, alkaline phosphatase
Enzyme, lactic acid dehydrogenase, creatinine, blood urea nitrogen, total serum protein, albumin, blood glucose, T-CHOL, globulin, triglyceride and gallbladder
The blood parameters such as red pigment；(4) heart, liver,kidney,spleen, lung, brain, thymus, bladder, adrenal gland, uterus, ovary, testis, epididymis,
Dirty system number such as prostate, seminal vesicle etc.；(5) heart, liver,kidney,spleen, lung, brain, thymus, spleen, adrenal gland, stomach, large intestine, small intestinal,
Bladder, uterus, ovary, testis, epididymis, pancreas, prostate, seminal vesicle, bone marrow, hypophysis cerebri, aorta, trachea, thyroid, first
The other gland of shape, optic nerve, sciatic nerve, lymph node, spinal cord, nasal mucosa
Deng organ-tissue pathology.
3. result shows: the general status of each group rat are good, and body weight, food ration, dirty system number are without exception, blood
Learn, blood biochemical analysis index shows no obvious abnormalities, histopathology finds no abnormal change.The prompting present invention
Treatment rhinitis external preparation no obvious toxic and side effects, show, under this experimental condition, to treat rhinitis simultaneously
External preparation toxic effects dosage ＞ 0.632g/kg.It is thus regarded that by the clinical dosage drafted, administration way
The external preparation of footpath and course for the treatment of application for the treatment of rhinitis should be safe.
The test of pesticide effectiveness
Test medicine: the sample in embodiment 1 and reference examples 1.
High dose 0.632g (1.67ml)/kg, low dosage 0.158g (0.42ml)/kg, via intranasal application instills administration, often
Day is once.Dexamethasone 0.05g/kg, via intranasal application instills administration, once a day.
1st, the impact to the histamine rhinitis of rat
Result shows, 2 samples of external preparation for the treatment of rhinitis cause Rat Nasal Mucosa permeability to increase to histamine all to be had
Significantly inhibitory action, the inhibitory action of embodiment 1 is notable compared with reference examples 1, and result is as follows.
Impact to the histamine rhinitis of rat
* compare p < 0.01, # with blank control group and compare p < 0.01 with reference examples 1
2nd, the impact to Cavia porcelluss wing of nose allergy
Result shows, 2 samples all have bright to Cavia porcelluss wing of nose allergy (delayed reaction) that 2,4- chloronitrobenzene induces
Aobvious inhibitory action, compared with reference examples 1 substantially, result is as follows for the inhibitory action of embodiment 1.
Impact to Cavia porcelluss wing of nose allergy
* compare p < 0.01, # with blank control group and compare p < 0.01 with reference examples 1
3rd, the impact to rat allergic rhinitises
Result shows, 2 samples all have obvious inhibiting effect, the inhibitory action of embodiment 1 to rat allergic rhinitises
Compared with reference examples 1 substantially, result is as follows.
Impact to rat allergic rhinitises
* compare p < 0.01, # with blank control group and compare p < 0.01 with reference examples 1
4th, the impact to mouse skin capillary permeability
Result shows, the capillary permeability increase that 2 samples cause to histamine has obvious inhibitory action, embodiment
Compared with reference examples 1 substantially, result is as follows for 1 inhibitory action.
The impact to mouse skin capillary permeability for the DITONG BIYAN SHUI
* compare p < 0.01, # with blank control group and compare p < 0.01 with reference examples 1
5th, anti-inflammation test
1) xylol causes the impact of mice auricle swelling
Result shows, the auricle edema that sample xylol causes has obvious inhibitory action, the inhibitory action of embodiment 1
Compared with reference examples 1 substantially, result is as follows.
Xylol causes the impact of mice auricle swelling
* compare p < 0.01, # with blank control group and compare p < 0.01 with reference examples 1
2) impact to mice granuloma induced by implantation of cotton pellets
Result shows that sample all can substantially suppress the hypertrophy of chronic granuloma, and the inhibitory action of embodiment 1 is bright compared with reference examples 1
Aobvious, result is as follows.
Impact to mice granuloma induced by implantation of cotton pellets hypertrophy
* compare p < 0.01, # with blank control group and compare p < 0.01 with reference examples 1
Clinical experiment
Treatment of rhinitis
1st, experimental technique: take randomised controlled trials method
Hospital outpatient allergic rhinitis patients totally 180, all meet the perennial allergic nose of Chinese Medical Association's formulation
Inflammation diagnostic criteria.It is divided into 2 groups using randomized, treatment group 90, matched group 90.Using the embodiment of the present invention 1 preparation for treating
Group, man 50, female 40,17～45 years old age, average 28.3 ± 9.6 years old, the course of disease 2～4 years, average 3.1 ± 1.2 years；Comparison
Group 90, man 45, female 45,23～46 years old age, average 27.1 ± 8.6 years old, the course of disease 2～4 years, average 3.2 ± 1.3 years,
All patients all have the sings and symptomses such as different degrees of sneeze, watery nasal discharge, nasal obstruction, concha nasalis enlargement, symptom, the classification score of sign
Standard executes according to perennial allergic rhinitises' Standardization of diagnosis and curative effect that Chinese Medical Association works out.The sex of patient, year between each group
There are no significant for the differences such as age, the course of disease (p ＞ 0.05).
2nd, diagnostic criteria
Including standard: allergic rhinitis patients, there is no smoking or stop smoking in more than 2 years.
Exclusion standard: gestation, apositia, polyphagia, unstable angina pectoriss, arrhythmia, do not have treat thyroid
Pathological changes, symptomatic hepatopathy, Gallbladder disease and any serious pathological changes, insulin therapy, oral hormone treatment.
3rd, administrated method and dosage
Therapeutic Method: equal 5 days of two groups of courses for the treatment of.
Treatment group: (1) present invention treats the external preparation 2 every time of the treatment rhinitis of allergic rhinitises, three times a day.
(2) conventional treating allergic rhinitis.
Matched group: conventional treating allergic rhinitis.
Conventional treating allergic rhinitis:
Light: ketotifen once a day, each 1mg
In: once a day, each 1mg adds beclometasone Normal therapeutic dose once a day to ketotifen
Weight: ketotifen once a day, each 1mg, plus daily 2 times of beclometasone Normal therapeutic dose
4th, observation project and index
(1), the change of observation item clinical symptoms and sign；
(2), criterion of therapeutical effect
Allergic rhinitis: the perennial allergic nose that symptom, the classification score standard of sign are worked out according to Chinese Medical Association
Scorching Standardization of diagnosis and curative effect executes, and gained integration is by following equation calculating curative effect: integration decline index=(amass after integrating before treating-treating
Point) treat front integration × 100%.Effective: integration declines index >=66%；Effective: integration declines index >=26%；Invalid: integration
Decline index ＜ 25%；Effective and effective percentage rate is designated as total effective rate.
(3), therapeutic outcome
Allergic rhinitis: two groups of comparitive study observation and treatment are after 5 days, effective 58 for the treatment of group, effective 30, invalid 2,
Total effective rate 97.8%.Effective 42 of matched group, effective 34, invalid 14, total effective rate 84.4%.Two groups of total effective rates are poor
Different have significance (p ＜ 0.01).Obvious untoward reaction in treatment group.
Nasal mucosa
Hospital outpatient nasal mucosa totally 90.It is divided into 3 groups using randomized, treatment group one 30, treatment group 2 30,
Matched group 30.It is used for treatment group one and treatment group two using the embodiment of the present invention 1 and reference examples 1 preparation, treatment group one: man 15
Example, female 15,18～43 years old age, average 28.2 ± 5.8 years old, the course of disease 2～3 years, average 2.3 ± 0.9 years；Treatment group two: man
10, female 20,17～41 years old age, average 28.6 ± 6.7 years old, the course of disease 2～3 years, average 2.4 ± 0.8 years；Matched group 30
Example, man 15, female 15,19～45 years old age, average 30.3 ± 5.7 years old, the course of disease 2～3 years, average 2.1 ± 0.5 years, owns
Patient all has different degrees of nasal mucosa sings and symptoms.Between each group, the difference such as the sex of patient, age, course of disease is all no aobvious
Work property (p ＞ 0.05).
All patients all confirm as the mucosal erosion such as nasal septum front end and concha nasalis inferior surface, make random packet, and set comparison
Group.Treatment group one 30, treatment group 2 30, matched group 30, treatment group adopts the external preparation 2 every time for the treatment of rhinitis,
Three times a day.Matched group with burn plus erythromycin ointment treated.The course for the treatment of 1 month.
Effective: no bleeding, the healing of rotten to the corn face, non-pigment calmness, no cicatrix；
Effective: no bleeding, the healing of rotten to the corn face, a small amount of pigmentation；
Invalid: bleeding, to have rotten to the corn face.
As can be seen that the external preparation of the treatment rhinitis of the present invention can effectively facilitate bronchia mucosal erosion in above table
Healing, treatment group one therapeutic effect is better than treatment group two, and has 11 Repeated Hemorrhage still in matched group, and nasal cavity function is extensive
Multiple normal only 19.
Claims (10)
1. a kind of Chinese medicine for treating rhinitis compositionss are it is characterised in that include following component by weight: Flos Magnoliae spends 15
Part, 5 parts of Herba Asari, 12 parts of Rhizoma Ligustici, 10 parts of Radix Saposhnikoviae, 15 parts of the Radix Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiong, 6 parts of Rhizoma Cimicifugae, 9 parts of Rhizoma Et Radix Notopterygii, 6 parts of Radix Glycyrrhizae, Fructus Xanthii
15 parts, 10 parts of Caulis Akebiae, 9 parts of Herba Menthae, 30 parts of Herba Centipedae, 12 parts of Radix Scutellariae, 9 parts of Herba Eupatorii, 12 parts of Rhizoma Acori Graminei and 10 parts of Bulbus Allii Fistulosi.
2. the Chinese medicine composition of the treatment rhinitis described in claim 1 preparation control for treatment by sinusitis, allergic rhinitises,
Chronic rhinitiss, caseous rhinitis, rhinitis sicca, medicamentous rhinitiss, chronic hypertrophic rhinitiss, vasomotor rhinitiies, breath
Application in the external used medicine of meat, barotraumatic rhinitis or nasal mucosa.
3. a kind of external preparation treating rhinitis is it is characterised in that include the Chinese medicine group of the treatment rhinitis described in claim 1
Compound.
4. a kind of preparation method of the external preparation treating rhinitis is it is characterised in that the external preparation of this treatment rhinitis is right
Require the external preparation of the treatment rhinitis described in 4, and this preparation method comprises the steps:
1st step, by the Chinese medicine composition of this treatment rhinitis, the component in addition to this Bulbus Allii Fistulosi take the weight of half add 55 degree with
Upper jowar wine seals dip, generates the first medicinal liquid；
2nd step, by the Chinese medicine composition of this treatment rhinitis, the weight of the remaining half of the component in addition to Bulbus Allii Fistulosi grinds to form
Powder, add water sealing dip, generates the second medicinal liquid；
3rd step, individually takes this Bulbus Allii Fistulosi to add more than 55 degree jowar wine sealing dips, generates the 3rd medicinal liquid；
4th step, respectively by this first medicinal liquid, this second medicinal liquid, the 3rd medicinal liquid and normal saline, according to volume ratio 50:30:
10:10 mixes, and obtains the external preparation of this treatment rhinitis.
5. the preparation method of the external preparation for the treatment of rhinitis according to claim 4 is it is characterised in that described the 1st step
In, this dip time is more than 49 days.
6. the preparation method of the external preparation for the treatment of rhinitis according to claim 4 is it is characterised in that described the 1st step
In, this component and the weight ratio of this jowar wine pulverized are 1:1.
7. the preparation method of the external preparation for the treatment of rhinitis according to claim 4 is it is characterised in that described the 2nd step
In, this dip time is more than 49 days.
8. the preparation method of the external preparation for the treatment of rhinitis according to claim 4 is it is characterised in that described the 2nd step
In, described water refers to the dew of the early morning appearance on outdoor Folium Nelumbinis.
9. the preparation method of the external preparation for the treatment of rhinitis according to claim 8 is it is characterised in that described the 2nd step
In, this component and the weight ratio of this dew pulverized are 1:1.
10. the preparation method of the external preparation for the treatment of rhinitis according to claim 4 is it is characterised in that described the 3rd step
In, the dip time is more than 30 days；This Bulbus Allii Fistulosi pulverized is 1:1 with the weight ratio of this jowar wine.
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Application publication date: 20170125 |