CN101129478B - Wormkillers of methylamino avermectin benzoate for animals, method of preparing the same and application of the same - Google Patents
Wormkillers of methylamino avermectin benzoate for animals, method of preparing the same and application of the same Download PDFInfo
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- CN101129478B CN101129478B CN2007101203906A CN200710120390A CN101129478B CN 101129478 B CN101129478 B CN 101129478B CN 2007101203906 A CN2007101203906 A CN 2007101203906A CN 200710120390 A CN200710120390 A CN 200710120390A CN 101129478 B CN101129478 B CN 101129478B
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Abstract
The invention discloses a methylamine avermectin benzoate insecticide for animals and making method and application, which is characterized by the following: dissolving the insoluble methylamine avermectin benzoate in the water to form powder, particle and tablet; fitting for preventing multiple internal and external parasitism; reducing toxicity, high activity and securing the usage; avoiding the usage of toluene, xylene and carbinol; reducing the pollution; accelerating the health cultivation.
Description
[technical field]
The present invention relates to the veterinary drug technical field, more specifically, the present invention relates to emamection benaoate Veterinary Insecticides, their preparation method and application.
[background technology]
Affirm (Merck Co.), matrine etc. are used widely in pesticide.
For example CN00102704.2 discloses a kind of propargite pesticide, and it is to be that main component and compositions such as The suitable solvent, emulsifying agent are made cream with avilamycin and matrine, is made for the efficient insecticide miticide composition.Insects such as control plant aphid mite pest and Noctuidae larva, the prevention effect highly significant.
CN200510007412.9 discloses a kind of Pesticidal combination that contains Affirm (Merck Co.) and matrine, and said composition can be widely used for preventing and treating the disease and pest of various crops such as vegetable, Oryza sativa L., Cotton Gossypii, fruit tree.
At present, veterinary drug in China, especially in the fisheries drug insecticide, most traditional organophosphor, chrysanthemum esters cream preparations of still using, its main cause is that the dissolubility of its former medicine in water is very little even insoluble, can only adopt organic solvents such as organic solvent toluene, dimethylbenzene, methanol that former medicine is processed into cream preparation, wherein organic solvent accounts for 70-80%, adopts the ester plastic bottle to carry out packing and selling.Annual this type of nearly up to ten thousand tons organic solvent is executed is spread across fish pond, shrimp pond, reservoir etc., causes the severe contamination of water environment and residual.But this type of organic solvent is not only inflammable, explosive, increase to produce, stores, the cost and the danger of transportation, and poisonous and harmful, uses inconvenience, and residual period is long, is difficult for degrading, and the health of animal and human's class is had potential threat.
Therefore, also need a kind of Veterinary Insecticides safe and reliable, easy to use at present.
[summary of the invention]
[one] technical problem that will solve
In order to address the above problem, first purpose of the present invention provides a kind of emamection benaoate Veterinary Insecticides compositions.
Second purpose of the present invention provides a kind of emamection benaoate Veterinary Insecticides preparation of compositions method.
The 3rd purpose of the present invention is the purposes of emamection benaoate Veterinary Insecticides compositions.
[two] technical scheme
The present invention is achieved through the following technical solutions.
The present invention relates to a kind of Veterinary Insecticides compositions, it is characterized in that it is by forming in the following component of weight portion:
A, one or more are selected from the active component 0.1-30 weight portion of emamection benaoate, matrine and eucalyptus oil;
B, auxiliary agent 1-20 part;
C, synergist 1-50 part
D, stabilizing agent 10-80 part.
Preferably, described Veterinary Insecticides compositions is by forming in the following component of weight portion:
A, one or more are selected from the active component 0.1-20 weight portion of emamection benaoate, matrine and eucalyptus oil;
B, auxiliary agent 2-16 weight portion;
C, synergist 1-40 weight portion
D, stabilizing agent 10-60 weight portion.
More preferably, described Veterinary Insecticides compositions is by forming in the following component of weight portion:
A, one or more are selected from the active component 0.2-20 weight portion of emamection benaoate, matrine and eucalyptus oil;
B, auxiliary agent 6-12 weight portion;
C, synergist 10-25 weight portion
D, stabilizing agent 20-36 weight portion.
According to meaning of the present invention, described active component should be appreciated that it is to kill ectozoic effective ingredient in the animal body.
At present, people know, emamection benaoate is the trim of avilamycin, and its toxicity is 1/3rd of avilamycin, and activity is more than 10 times of avilamycin, it mainly is stomach poison function, and have certain action of contace poison concurrently, do not have extremely ovum function, no carcinogenic, teratogenesis, mutagenic action, safe in utilization, convenient, efficient, therefore be with a wide range of applications.Described emamection benaoate for example is the product of being produced by Jiamusi Xing Yu company, Weiyuan, Hebei company.
Described matrine is a kind of root by the plant Radix Sophorae Flavescentis, stem, the fruit a kind of alkaloid through organic solvent extraction such as ethanol, it is a kind of low toxicity vegetable insecticide, insect had tag and stomach poison function, with sale such as 1% alcoholic solution, 0.2% water preparations, described matrine for example is the product that the Bi Chuan of Chifeng, Inner Mongol plant pesticide factory produces in the market.
Colourless or the yellowish supernatant liquid of described eucalyptus oil has special aroma, and is little like Camphora, acrid in the mouth, cold.Has bactericidal action.For example described eucalyptus oil for example is the product of the new spice company limited of Huaian, Jiangsu China.
When described emamection benaoate, matrine, eucalyptus oil are commercially available products, need not to handle and just can use.
Except the above-mentioned active component of listing, the present invention can also use and can realize the object of the invention normally used other active component in animal husbandry, for example:
In Veterinary Insecticides compositions of the present invention, except using described active component, also use other component, comprising auxiliary agent, synergist, stabilizing agent.
According to meaning of the present invention, described auxiliary agent should be appreciated that it is to increase the solubilization of active ingredient degree, strengthens the material of storage, transportation stability etc.
According to an embodiment of the invention, be one or more auxiliary agents that are selected from beta-schardinger dextrin-, silwet organosilicon auxiliary agent, Polyethylene Glycol, carboxymethyl cellulose, sodium carbonate, sodium bicarbonate, citric acid, malic acid, boric acid at the auxiliary agent described in the Veterinary Insecticides compositions of the present invention.
Wherein, beta-schardinger dextrin-is a product sold on the market, and for example the good swallow chemical industry in Hangzhou company limited is with specification trade mark H110MA product sold, the Yuyao City sky all trade Co., Ltd with specification trade mark AP03B product sold.
Silwet organosilicon auxiliary agent is the GE organosilicon agricultural agent of U.S. GE (GE) exploitation, be that surfactant with alkoxy-modified poly-trisiloxanes is a base, it can greatly reduce the surface tension of water, therefore be excellent spreading agent, the blade face of moistening each kind of plant has extremely strong resistance of rainwater washing against and penetrating power easily, can significantly improve the effective rate of utilization of pesticide, toxicity is little, and is environmentally safe.Product sold has Silwet408, Silwet806, Silwet618, Silwet625, Silwet L-77 etc. at present.
Carboxymethyl cellulose is a kind of cellulose ether.Pure strain white or little yellow fibers sprills or granule, odorless, tasteless, nontoxic, product sold for example is the product of the production code member 7249103716 of the big chemical industry company limited production in sky, Hebei in the market.
Preferably, be one or more auxiliary agents that are selected from silwet organosilicon auxiliary agent, beta-schardinger dextrin-and Polyethylene Glycol at the auxiliary agent described in the Veterinary Insecticides compositions of the present invention.
More preferably, be the auxiliary agent of silwet organosilicon and beta-schardinger dextrin-at the auxiliary agent described in the Veterinary Insecticides compositions of the present invention.
Except the above-mentioned auxiliary agent of listing, the present invention can also use and can realize the object of the invention normally used other auxiliary agent, for example sodium bicarbonate, sodium carbonate, citric acid, malic acid, boric acid etc. in animal husbandry.
According to meaning of the present invention, described synergist should be appreciated that it is to reduce surface tension, increases drug solubility, improves the effective ingredient result of use, reduces the material of effective ingredient use amount.
According to an embodiment of the invention, be one or more synergists that are selected from sodium lauryl sulphate, dodecylbenzene sodium sulfonate, azone, NP-40 (NPE), silwet organosilicon auxiliary agent at the synergist described in the Veterinary Insecticides compositions of the present invention.
Preferably, described synergist is one or more synergists that are selected from sodium lauryl sulphate, azone, NP-40, silwet organosilicon auxiliary agent.
More preferably, described synergist is one or more synergists that are selected from sodium lauryl sulphate, azone, silwet organosilicon auxiliary agent.
Except the above-mentioned synergist of listing, the present invention can also use and can realize the object of the invention normally used other synergist in animal husbandry, for example magnesium sulfate, sodium sulfate, agricultural organosilicon auxiliary agent etc.
Above-mentioned these synergists that use among the present invention all are product solds on market.
According to an embodiment of the invention, be one or more stabilizing agents that are selected from Matrii Sulfas Exsiccatus, soluble starch, glucose at the stabilizing agent described in the Veterinary Insecticides compositions of the present invention.
Preferably, described stabilizing agent is one or more stabilizing agents that are selected from Matrii Sulfas Exsiccatus, soluble starch.
More preferably, described stabilizing agent is one or more stabilizing agents that are selected from soluble starch.
Except the above-mentioned stabilizing agent of listing, the present invention can also use and can realize the object of the invention normally used other stabilizing agent, for example kieselguhr, attapulgite, zeolite powder etc. in agricultural, animal husbandry.
These stabilizing agents that use among the present invention all are product solds on market.
Veterinary Insecticides compositions of the present invention is soluble powder, granule, tablet, hard capsule or soft capsule.
The preparation method of above-mentioned dosage form is that those skilled in the art know.
Described powder is to use suitable mixing disintegrating apparatus that Veterinary Insecticides compositions of the present invention is made uniform powder.Described mixing apparatus for example is the equipment that Qingzhou City absolute sincerity machine-building company limited in Shandong is produced.
Described granule is to use suitable equipment that Veterinary Insecticides compositions of the present invention is made granule, and described equipment for example is disk pelletizing machine, extruder etc.Described disk pelletizing machine is the disk pelletizing machine that Jingmen ten thousand safe mechanical company limiteies are produced.Described extruder is the extruder that the flourishing plant equipment of Changzhou factory produces.Those skilled in the art are easy to select according to actual needs.
Described tablet is to use forcing press at pressure 7kg/mg
2About the sheet that down Veterinary Insecticides compositions of the present invention is pressed into.This sheet diameter and thickness need select according to the purposes of this Veterinary Insecticides compositions, and therefore there is no particular limitation to this sheet diameter and thickness.Described forcing press is the zp-19 rotary tablet machine that Shanghai first pharmaceutical factory produces.Pressing conditions needs to require to determine with selected forcing press according to this Veterinary Insecticides compositions, tablet strength that those skilled in the art are easy to according to these conditions and just can determine by suitable test.
The invention still further relates to described Veterinary Insecticides preparation of compositions method, it is characterized in that this method comprises the steps:
At first, take by weighing one or more active components that the 0.1-20 weight portion is selected from emamection benaoate, matrine, the eucalyptus oil and evenly obtain a kind of mixture through mechanical mixture;
Then, take by weighing described auxiliary agent, the described synergist of 1-40 weight portion, the 10-60 weight portion stabilizing agent of 2-16 weight portion respectively, evenly obtain another kind of mixture through mechanical mixture;
At last, foregoing two kinds of mixture are carried out the mechanical agitation mix homogeneously, obtain described Veterinary Insecticides compositions.
The mechanical mixing equipment that uses in this method is the equipment that those skilled in the art know, for example two dimensional motion mixer, V-type high efficient mixed machine, cone-type mixer, trough-type mixture machine etc.
The invention still further relates to the purposes of described Veterinary Insecticides compositions in control poultry, aquatic animal endoparasite and ectoparasite nematicide, acarid, dactylogyrider, Gyrodactylus, Trichodina, latent whipworm, argulus, lernaean, Chinese flea.
The invention still further relates to the purposes of described Veterinary Insecticides on herding, culture fishery.
Veterinary Insecticides compositions of the present invention using method on herding, culture fishery is, described product uses in this product weight 1000-2000 water yield doubly and dissolves, to drink water, to throw something and feed, prevent and treat poultry, aquatic animal endoparasite and ectoparasite, as endoparasite and ectoparasites such as nematicide, acarid, dactylogyrider, Gyrodactylus, Trichodina, latent whipworm, argulus, lernaean, Chinese fleas according to modes such as concentration 0.01-0.05ppm dipping bath, full pool spilling heads according to 10-30ug/kg body weight spice.
[beneficial effect]
The present invention compared with prior art has following good effect:
The present invention changes dosage form by method for optimizing, and the raising utilization ratio of drug is not only safe in utilization, convenient, and has improved and used activity, and dissolution velocity is fast, even, stable, has reduced packing charges simultaneously.
The present invention realized with the new formulation target of water for oil, dosage form curing, high-load, functionalization, and easy to use, is the revolutionary renewal product of traditional cream insecticides, and the utmost point is beneficial to environmental conservation, healthy aquaculture, food safety.
[specific embodiment]
Further specify the present invention rather than limit its protection domain below by embodiment.
Embodiment 1
The Veterinary Insecticides preparation of compositions.
At first, take by weighing 5 parts of 2 parts of emamection benaoates, matrines, 10 parts of eucalyptus oils in weight portion, the CH200A type trough type mixing machine that uses changzhou normal prosperous medicine machinery plant to produce carries out mix homogeneously, obtains a kind of mixture;
Then, 18 parts of the beta-schardinger dextrin-s, 8 parts of silwet organosilicon auxiliary agents, 20 parts of carboxymethyl celluloses, 10 parts of sodium lauryl sulphates, 8 parts of azones, 30 parts of citric acids, the sodium bicarbonate that take by weighing in weight portion adopt above-mentioned same CH200A type trough type mixing machine to carry out mix homogeneously for 30 parts, obtain another kind of mixture;
Again with mixture 1 and mixture 2 mix homogeneously, place and carry out extrusion modling after one hour again and obtain the tablet product, its diameter 2mm.According to test method common in the veterinary drug technical field, the efficient of using this product to kill argulus according to routine dose can reach 95%, and under same condition, the efficient of using single emamection benaoate to kill argulus is to reach 75%, matrine reaches 60%, and eucalyptus oil reaches 20%.
Embodiment 2
The Veterinary Insecticides preparation of compositions.
At first, take by weighing 1 part of 5 parts of emamection benaoates, matrine, 5 parts of eucalyptus oils in weight portion, the CH200A type trough type mixing machine that uses changzhou normal prosperous medicine machinery plant to produce carries out mix homogeneously, obtains a kind of mixture;
Then, 35 parts of 10 parts of 18 parts of 6 parts of silwet organosilicon auxiliary agents, Polyethylene Glycol, dodecylbenzene sodium sulfonate, the boric acid, the sodium bicarbonate that take by weighing in weight portion adopt above-mentioned same CH200A type trough type mixing machine to carry out mix homogeneously for 35 parts, obtain another kind of mixture;
Again with mixture 1 and mixture 2 mix homogeneously, place and carry out extrusion modling after one hour again and obtain the tablet product, its diameter 2mm.According to test method common in the veterinary drug technical field, the efficient of using this product to kill argulus according to routine dose can reach 98%, and under same condition, the efficient of using single emamection benaoate to kill argulus is to reach 73%, matrine reaches 60%, and eucalyptus oil reaches 19%.
Embodiment 3
The Veterinary Insecticides preparation of compositions.
At first, take by weighing 2 parts of 10 parts of emamection benaoates, matrines, 10 parts of eucalyptus oils in weight portion, the CH200A type trough type mixing machine that uses changzhou normal prosperous medicine machinery plant to produce carries out mix homogeneously, obtains a kind of mixture;
Then, 40 parts of 40 parts of 8 parts of 6 parts of silwet organosilicon auxiliary agents, azones, sodium bicarbonate, the citric acids, the soluble starch that take by weighing in weight portion adopt above-mentioned same CH200A type trough type mixing machine to carry out mix homogeneously for 80 parts, obtain another kind of mixture;
Again with mixture 1 and mixture 2 mix homogeneously, place and carry out extrusion modling after one hour again and obtain the tablet product, its diameter 2mm.According to test method common in the veterinary drug technical field, the efficient of using this product to kill argulus according to routine dose can reach 98%, and under same condition, the efficient of using single emamection benaoate to kill argulus is to reach 74%, matrine reaches 58%, and eucalyptus oil reaches 19%.
Embodiment 4
The Veterinary Insecticides preparation of compositions.
At first, take by weighing 5 parts of emamection benaoates, 10 parts of eucalyptus oils in weight portion, the CH200A type trough type mixing machine that uses changzhou normal prosperous medicine machinery plant to produce carries out mix homogeneously, obtains a kind of mixture;
Then, 8 parts of 4 parts of silwet organosilicon auxiliary agents, the azones, the beta-schardinger dextrin-that take by weighing in weight portion adopt above-mentioned same CH200A type trough type mixing machine to carry out mix homogeneously for 20 parts, obtain another kind of mixture;
Again with mixture 1 and mixture 2 mix homogeneously, place and carry out extrusion modling after one hour again and obtain the tablet product, its diameter 2mm.According to test method common in the veterinary drug technical field, the efficient of using this product to kill argulus according to routine dose can reach 99%, and under same condition, the efficient of using single emamection benaoate to kill argulus is to reach 74%, matrine reaches 58%, and eucalyptus oil reaches 19%.
Embodiment 5
The Veterinary Insecticides preparation of compositions.
At first, take by weighing 10 parts of emamection benaoates, 5 parts of eucalyptus oils in weight portion, the CH200A type trough type mixing machine that uses changzhou normal prosperous medicine machinery plant to produce carries out mix homogeneously, obtains a kind of mixture;
Then, 30 parts of 30 parts of 4 parts of silwet organosilicon auxiliary agents, sodium bicarbonate, the citric acids, the soluble starch that take by weighing in weight portion adopt above-mentioned same CH200A type trough type mixing machine to carry out mix homogeneously for 38 parts, obtain another kind of mixture;
Again with mixture 1 and mixture 2 mix homogeneously, places and pushing granulation after one hour again and obtain the granule product.According to test method common in the veterinary drug technical field, the efficient of using this product to kill argulus according to routine dose can reach 99%, and under same condition, the efficient of using single emamection benaoate to kill argulus is to reach 74%, matrine reaches 58 %, and eucalyptus oil reaches 19%.
Experimental example 1
Veterinary Insecticides compositions of the present invention to eliminating fish parasites diseases prevention and treatment effect test
10 mouthfuls of morbidities of picked at random fish pond, 0.05-0.2mg/l prevents and treats test by recommended drug concentration.Every 12 hours once parasitic mortality rates of statistics.In recommended density 0.05-0.2mg/l scope internal therapy sea, parasitic diseases such as freshwater fish China Sao, argulus, Gyrodactylus, dactylogyrider, Trichodina, latent whipworm have good therapeutic effect, the medicine effective percentage reaches more than 73%.
Mix bait by recommended dose 10-60 μ g/Kg fish body weight and throw something and feed to parasitizing the endoparasite and ectoparasite of common sea, freshwater fish, for example anthelmintic, Chinese Sao, anchor head Sao, argulus, Gyrodactylus, dactylogyrider, Trichodina, latent whipworm etc. have good killing effect.
Veterinary Insecticides compositions of the present invention has the safety range than broad, and the usefulness concentration to multiple Fish, all is very safe comprising Carassius auratus, Channel-catfish fish etc. less than 8-10ppm.
Claims (1)
1. Veterinary Insecticides preparation of compositions method is characterized in that its step is as follows:
Take by weighing 5 parts of 2 parts of emamection benaoates, matrines, 10 parts of eucalyptus oils in weight portion, the CH200A type trough type mixing machine that uses changzhou normal prosperous medicine machinery plant to produce carries out mix homogeneously, obtains mixture 1;
18 parts of the beta-schardinger dextrin-s, 8 parts of silwet organosilicon auxiliary agents, 20 parts of carboxymethyl celluloses, 10 parts of sodium lauryl sulphates, 8 parts of azones, 30 parts of citric acids, the sodium bicarbonate that take by weighing in weight portion adopt above-mentioned trough type mixing machine to carry out mix homogeneously for 30 parts, obtain mixture 2;
With mixture 1 and mixture 2 mix homogeneously, place and carry out extrusion modling after one hour again, obtain the Veterinary Insecticides compositions of diameter 2mm tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101203906A CN101129478B (en) | 2007-08-17 | 2007-08-17 | Wormkillers of methylamino avermectin benzoate for animals, method of preparing the same and application of the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101203906A CN101129478B (en) | 2007-08-17 | 2007-08-17 | Wormkillers of methylamino avermectin benzoate for animals, method of preparing the same and application of the same |
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| CN101129478A CN101129478A (en) | 2008-02-27 |
| CN101129478B true CN101129478B (en) | 2010-12-22 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101911955B (en) * | 2010-08-13 | 2014-11-26 | 云南省农业科学院农业环境资源研究所 | Biogenic acaricidal water suspension composition and preparation method thereof |
| CN102763670A (en) * | 2012-07-04 | 2012-11-07 | 河北威远生物化工股份有限公司 | Clothianidin synergistic suspending agent |
| CN102988376B (en) * | 2012-10-23 | 2014-11-26 | 四川农业大学 | Fishery medicine of eucalyptus oil abamectin sub-microemulsion |
| CN103548854A (en) * | 2013-10-16 | 2014-02-05 | 曾立雄 | Alkaloid compound preparation for water purification, sterilization, disinfection and disinsection |
| CN104920492A (en) * | 2015-06-12 | 2015-09-23 | 福建省德盛生物工程有限责任公司 | Low-volume spray containing eucalyptol |
| CN104997733A (en) * | 2015-07-14 | 2015-10-28 | 太原市康瑞宝兽药制造有限公司 | Preparation method of water-soluble fosfomycin calcium |
| CN105211114B (en) * | 2015-10-08 | 2018-10-19 | 福建省南安市东红制线有限公司 | A kind of plant pesticide composition containing matrine and eucalyptus oil |
| CN105815349A (en) * | 2016-04-13 | 2016-08-03 | 储志强 | Improved insecticidal pesticide |
| CN111387218A (en) * | 2020-04-15 | 2020-07-10 | 石家庄正鸿生物科技有限公司 | Environment-friendly physical insecticide and preparation method thereof |
| CN112602730B (en) * | 2020-12-30 | 2021-08-17 | 彭氏(惠州)实业发展有限公司 | Mite-killing spray and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1448052A (en) * | 2002-04-04 | 2003-10-15 | 王正权 | Methyl-abamectin benzoate microemulsion and prep. thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1448052A (en) * | 2002-04-04 | 2003-10-15 | 王正权 | Methyl-abamectin benzoate microemulsion and prep. thereof |
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