CN101119704A - 口腔护理除臭组合物 - Google Patents
口腔护理除臭组合物 Download PDFInfo
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- CN101119704A CN101119704A CNA2005800482272A CN200580048227A CN101119704A CN 101119704 A CN101119704 A CN 101119704A CN A2005800482272 A CNA2005800482272 A CN A2005800482272A CN 200580048227 A CN200580048227 A CN 200580048227A CN 101119704 A CN101119704 A CN 101119704A
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- yue
- volatile oil
- deodorizer
- oral cavity
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Abstract
麝香草酚、大茴香、小茴香和罗勒挥发油的大体上等比例的口腔除臭剂混合物，显示出在口腔护理中作为除臭剂控制大蒜气味的功效。
Description
前言
[0001]本发明涉及用于降低口臭的洁牙剂组合物。特别是，本发明包括加入有含麝香草酚、大茴香、小茴香、罗勒及杜松的挥发油的除臭剂(malodor agent)的洁牙剂。
[0002]在社会交往中许多人需要“明亮的”笑容、健康的牙齿和令人愉快的个人表现。遗憾的是，吃起来很好的有些食物沉积和/或转移一些化学成分进入口腔或血流中，伴随谈话和/或呼吸呼出臭气而影响其社会表现。这种臭气通常使人的社会表现大打折扣。对含有大蒜和洋葱的食物尤其要注意这一点，但关于除臭长期没有好效果。
概述
[0003]本发明提供口腔护理组合物。更详细的说，本发明为口腔除臭剂组合物，包含：
(a)约10％重量-约30％重量的麝香草酚挥发油；
(b)约10％重量-约30％重量的大茴香挥发油；
(c)约10％重量-约30％重量的小茴香挥发油；
(d)约10％重量-约30％重量的罗勒挥发油；和
(e)余量的(remainder)杜松挥发油，其中所述杜松挥发油占所述口腔混合物组合物的约10％重量-约30％重量。
[0004]一方面，以占口腔护理载体约0.3％重量-约2％重量存在于产品中提供这种口腔除臭剂，这种产品有漱口液、牙齿乳膏(dentalcream)或牙膏。另一方面，以糖锭或其它易携带形式例如薄荷剂、珠、糯米纸囊剂(wafer)、从小型轻便喷雾器(喷药瓶)应用到口腔的液体制剂、从小型轻便滴药瓶应用到口腔的液体制剂或柔软易折(pliable)片剂(″咀嚼片″(chewie))提供这种口腔除臭剂。
[0005]本发明也将口腔除臭剂混合进任何上述制剂的口腔护理载体中。
[0006]另一方面，本发明提供了一种通过将上述制剂应用到口腔抑制臭气的方法。
[0007]已经发现本发明组合物和方法具有优于本领域已知口腔护理组合物的优势。
[0008]应用中其它方面从下列提供的详述中来看是显而易见的。应理解虽然指出了本发明的实施方案，该详述和特定实例仅是为了描述的目的而非意图限制本发明的范围。
描述
[0009]下列定义及非限制性指示在全面把握本文所示本发明的说明书时必须予以考虑。本文所用标题(例如“前言”和“概述”)及副标题(例如“组合物”和“方法”)意图为仅仅说明本发明公开主题的普遍结构，而不是限制本发明公开或其任何方面。尤其是，“前言”中公开的主题可包括本发明范围内的技术方面，而不构成现有技术的叙述。“概述”中公开的主题并非详尽的或完全的公开发明的整个范围或其任何实施方案。本说明书部分中具有特定用途(例如为“活性物质”或“载体”成分)的物质的分类或讨论仅为方便起见，不应推断当其用于任何给定的组合物时该物质必须具有或仅具有与其文中分类一致的功能。
[0010]本文引用的任何参考文献并非认可那些参考为先有技术及与本文公开的专利性有任何关联。前言中引用的参考内容的任何讨论仅仅用于提供参考作者主张的概述，而不构成对这些参考精确内容的认可。说明书中描述部分引用的所有参考以其全部内容通过引用结合到本文中。
[0011]本发明实施方案指示的描述及特定实施例仅作为描述性目的而并非限制本发明的范围。另外，具有所述特征的多个实施方案的详述不排斥具有其它特征的其他实施方案，或将现有技术特征进行不同组合的其他实施方案。除非另有说明，特定实施例用来描述如何制备和使用该组合物及本发明方法，而并非代表本发明的给定实施方案已经制备或试验或者尚未制备或试验。
[0012]文中所用“优选”及“优选的”，指本发明在特定条件下具有特定优势的实施方案。但是在相同或其它条件下也可优选其它实施方案。此外，详述的一个或多个优选的实施方案不意味着不使用其它实施方案，而且不意味着排斥其它本发明范围内的实施方案。
[0013]本为所用“包括”及其类似表述，指非限制性的，这就是说所列范围内的项目的描述不排除本发明物质、组合物、设备及方法中有用的其它类似项目。
[0014]本文所用术语“约”，当用在本发明组合物或方法上的参数的值时指计算或测量的值允许稍许不精确而不显著影响组合物或方法的化学或物理特征。如果为某些原因由“约”所导致的不确定性用该普通的词义在本领域无法理解时，则文中所用“约”指可能在该值的上下5％的范围内变化。
[0015]除非另有说明，文中涉及的所有组成百分数为总组合物的重量百分数。
组合物
[0016]本发明提供一种含有除臭剂(除臭口腔护理)组合物的口腔护理组合物及给予或应用或使用到人或其他动物受试者的方法。总之，用包含麝香草酚、大茴香、小茴香、罗勒及杜松挥发油的除臭混合物制备口腔护理组合物及除臭剂组合物。
[0017]本文所用“口腔护理组合物”为适于给予或应用到人或动物受试者口腔而提高受试者的健康、卫生或形象的任何组合物，优选提供如下优点：预防或治疗牙、龈、粘膜或口腔其它坚硬或柔软组织的疾病或紊乱，预防或治疗全身疾病或紊乱，提供感官上、装饰或美容上的益处，及上述益处的组合。在多个实施方案中，口腔护理组合物不用于吞服，而需要在口腔中维持足够时间以发挥所需作用。在其他易携带的实施方案中(例如糖锭、薄荷剂、珠、糯米纸囊剂、从小型易携带喷雾器喷雾应用于口腔的液体制剂、从小型易携带药瓶滴加应用到口腔的液体制剂及柔软易折片剂)，口腔护理组合物用于吞服，任选在口腔中停留足够时间而发挥所需作用后吞服。优选的，本发明中使用的特定物质及组合物为相应的药学上或美容上可接受的，临床有效的和/或临床上显效的(efficacious)。本文所用“药学上可接受的”或“美容上可接受的”，“临床上有效的”和/或“1临床上显效的”组分是指适于人和/或动物使用且以适当量(临床上有效量)提供而显示所需的治疗上、预防上、感官上、装饰或美容上的益处，且具有适当的益处/危险比例而没有过度的有害副作用(例如毒性、刺激、及过敏反应)。
口腔可接受的载体
[0018]本发明提供包含于产品中的口腔可接受载体的组合物，产品例如漱口液、牙膏、牙齿乳膏或易携带剂型例如但不限于糖锭、薄荷剂、珠、糯米纸囊剂、从小型轻便喷雾器(喷药瓶)应用到口腔的液体制剂、从小型轻便滴药瓶应用到口腔的液体制剂或柔软易折片剂(″咀嚼片″)。文中所用“口腔可接受载体”指与含有麝香草酚、大茴香、小茴香、罗勒及杜松挥发油混合而安全用于本发明组合物中的物质或物质的组合，具有显著效果且具有适当的益处/危险比例。优选的载体基本不影响混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油的效力。
[0019]适于载体中使用的物质包括粘合剂、表面活性剂、起泡调节剂、研磨剂、pH调节剂、润湿剂、口感剂(mouth feel agents)、增甜剂、芳香剂、着色剂及其组合。应理解上述分类的物质的一般性质可不同，可能有一些共同性质及任何给定的物质可用作这种分类物质中两种或多种的多重目的物质。优选的，这种载体物质的选择应相容于相混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油与组合物中其他成分。
[0020]口感剂包括使用这种组合物期间赋予所需结构或其它感觉的物质。这种药剂包括分散的芳香剂和增甜剂。
[0021]适于本文使用的芳香剂包括可切实改善组合物味道的任何物质或物质的混合物。可使用任何口服可接受的天然或合成芳香剂，例如芳香油脂、芳香醛、酯、醇、类似物质及其组合。芳香剂包括香草醛、鼠尾草(sage)、马郁兰、欧芹油、薄荷剂油、桂皮油、冬青油(水杨酸甲酯)、薄荷剂油、丁香油、桂花油、大茴香油、桉树油、柑桔油、及包括得自柠檬、橙子、酸柚、葡萄柚、杏、香蕉、葡萄、苹果、草莓、樱桃、菠萝等的挥发油，豆类或坚果类衍生的香料例如咖啡、可可、可乐、花生、杏仁等，吸附的和包囊的芳香剂，及其混合物。本文中芳香剂也包括提供香味和/或其它口感效果包括冷却或加温效果的成分。这些成分包括薄荷剂醇、醋酸薄荷剂酯、乳酸薄荷剂酯、樟脑、桉树油、桉油精、茴香烯、丁香酚、肉桂(cassia)、oxanone、α-紫罗兰酮、丙烯基guaiethol、麝香草酚、沉香醇、苯甲醛、桂皮醛、N-乙基-对甲基-3-酰胺、N，2，3-三甲基-2-异丙基丁酰胺、3-1-甲氧基丙基-1，2-二醇、桂皮醛甘油缩醛(CGA)、达美酮(methone)甘油缩醛(MGA)，及其混合物。任选一种或多种芳香剂为总量的约0.01％-约5％，在多种实施方案中任选约0.05％-约2％，约0.1％-约2.5％，及约0.1％-约0.5％。
[0022]适于本文使用的增甜剂包括口腔用可接受的天然或合成的、有营养的或无营养的增甜剂。这种增甜剂包括葡萄糖、聚葡萄糖、蔗糖、麦芽糖、糊精、无水转化糖、甘露糖、木糖、核糖、果糖、果糖(levulose)、半乳糖、玉米糖浆(包括高级果糖玉米糖浆及玉米糖浆固体)、部分水解淀粉、氢化淀粉水解产物、山梨醇、甘露醇、木糖醇、麦芽糖醇、异麦芽糖(isomalt)、阿司帕坦、neotame、糖精及其盐，三氯半乳蔗糖、基于二肽的强效增甜剂、环己烷氨基磺酸酯(cyclamates)、双氢查尔酮，及其混合物。存在的一种或多种增甜剂的量依赖于选择的特定增甜剂，但典型的含量为总量的约0.005％-约5％，任选约0.01％-约1％。
[0023]适于本文使用的着色剂包括色素、染料、传递特殊光泽或反射性的色淀和试剂例如珠光剂。在多种实施方案中，着色剂可包被在牙齿表面而提供白色或浅色涂层，作为定位指示剂作用在与组合物有效接触的牙齿表面，和/或修饰组合物外观尤其是颜色和/或不透明性从而增加对消费者的吸引力。可使用任何口腔用可接受的着色剂，包括FD&C染料和色素、滑石、云母、碳酸镁、碳酸钙、硅酸镁、硅酸镁铝、二氧化硅、二氧化钛、氧化锌，红色、黄色、棕色及黑色氧化铁，氰亚铁酸铁铵、锰紫、群青、二氧化钛化云母(titaniated mica)、氯氧化铋，及其混合物。任选一种或多种着色剂为总量的约0.001％-约20％，例如约0.01％-约10％或约0.1％-约5％。
活性物质
[0024]在一个优选的实施方案中，以挥发油混合物形式提供口腔除臭剂混合物组合物。这种混合物包含：
(a)约10％重量-约30％重量(优选20％重量)的麝香草酚挥发油；
(b)约10％重量-约30％重量(优选20％重量)的大茴香挥发油；
(c)约10％重量-约30％重量(优选20％重量)的小茴香挥发油；
(d)约10％重量-约30％重量(优选20％重量)的罗勒挥发油；和
(e)约10％重量-约30％重量(优选20％重量)的杜松挥发油。
在一个实施方案中，该混合物包含余量的杜松挥发油，其中所述杜松挥发油占所述口腔混合物组合物的约10％重量-约30％重量(优选20％重量)。在一个实施方案中，本发明提供一种基本上由载体及混合物组成的组合物，而混合物基本上由以上述浓度混合的麝香草酚挥发油、大茴香挥发油、小茴香挥发油、罗勒挥发油及杜松挥发油组成。在多种实施方案中，这种基本由混合物组成的组合物不含有显著水平的其他挥发油。
[0025]在这种情况下，人体实验中惊人的结果(参见实施例)显示特定的麝香草酚、大茴香、小茴香、罗勒及杜松的挥发油的混合物对于降低蒜臭气中具特殊效力。这种惊人的发现克服了传统上控制复杂并影响全身的蒜臭气及洋葱臭气中的困难。常规上使用例如叶绿酸铜和欧芹籽油的活性物质控制蒜臭气。但是麝香草酚、大茴香、小茴香、罗勒及杜松的挥发油的等量混合物实施方案惊人的显示出减少近80％的蒜臭气。
[0026]在一个实施方案中，麝香草酚、大茴香、小茴香和罗勒挥发油各自独立占组合物的约15％重量-约25％重量。在一个实施方案中，在口腔护理组合物中麝香草酚、大茴香、小茴香和罗勒挥发油各自独立占除臭剂的约20％重量。
[0027]在一个实施方案中，以占口腔护理载体中口腔护理组合物约0.3％重量-约2％重量提供这种口腔除臭剂。在一个实施方案中，这种口腔护理载体和口腔除臭剂混合物为牙膏。在另一个实施方案中，这种口腔护理载体和口腔除臭剂混合物为牙齿乳膏。在又一个实施方案中，这种口腔护理载体和口腔除臭剂混合物为漱口液。在另一个实施方案中，这种口腔护理载体和口腔除臭剂混合物为糖锭，其中在一个实施方案中这种口腔护理载体和口腔除臭剂混合物灌注到包壳(shell)中或胶囊中。在另一个实施方案中，这种口腔护理载体和口腔除臭剂混合为干燥为糖锭的口服糊剂。该糖锭在口腔中与唾液中水分接触溶解到口腔护理载体中。同时应明确的是，也可使用类似灌注和/或混合步骤制备其他易携带形式的实施方案中，例如但不限于薄荷剂、珠、糯米纸囊剂、从小型轻便喷雾器(喷药瓶)应用到口腔的液体制剂、从小型轻便滴药瓶应用到口腔的液体制剂或柔软易折片剂(″咀嚼片″)。
[0028]除文中详述的除臭(臭气)剂外，本发明组合物任选包含其他活性物质，可以任何漱口液、牙齿乳膏、牙膏或糖锭(以及如本文先前的其他易携带形式实施方案中所述的)制剂用于预防或治疗口腔中坚硬或柔软组织的疾病或紊乱，预防或治疗生理上紊乱或疾病，或提供美容上益处。在多种实施方案中，该活性物质为可用于治疗或预防非为口腔疾病的全身或局部疾病的“全身性活性物质”。在多种实施方案中，该活性物质为可用于治疗或预防口腔内(例如牙、龈或口腔其他坚硬或柔软组织)的疾病或提供美容上益处的“口腔护理活性物质”。适于本文使用的口腔护理活性物质包括增白剂、防龋剂、牙石抑制剂(tartar control agents)、防牙斑剂、牙周病活性物质、研磨剂、呼吸清新剂、牙齿脱敏剂、催唾剂(salivary stimulants)，及其组合物。应理解上述分类的物质的一般性质可不同，可能有一些共同性质及任何给定的物质可用作这种分类物质中两种或多种的多重目的物质且任选这种活性物质不影响文中上述混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油除臭剂的效力。
[0029]本发明组合物中适用的活性物质以安全的且有效的量存在。活性物质的“安全且有效”及“临床上有效”量为给药后具有人或低级受试动物所需治疗或预防效果的有效量，且以本发明方法使用时具有适当的益处/危险比例而没有过度的有害副作用(例如毒性、刺激、及过敏反应)。该活性物质的这种特定的安全及有效(“临床上有效”)量据多种因素例如治疗的特定疾病、受试者身体状况、联合治疗(如果具有)的性质、使用的特定活性物质、特定的剂型、采用的载体及所需给药方案而变化。
[0030]本发明组合物进一步包含任选的研磨剂，按配方制备从而不影响文中上述混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油除臭剂的效力。在多个实施方案中，适用的另外的任选研磨剂例如抛光剂。可适用任何口服可接受的研磨剂，但是应选择研磨剂的类型、细度(粒径)及量使在正常使用组合物时不过分刮擦牙釉质。适当的任选研磨剂包括二氧化硅，例如沉淀形式的二氧化硅，或与铝、不溶性磷酸盐、碳酸钙及其混合物混合形式的二氧化硅。研磨剂适用的不溶性磷酸盐为正磷酸盐、聚偏磷酸盐及焦磷酸盐。描述性实例为磷酸氢钙二水合物、焦磷酸钙、焦磷酸钙、磷酸三钙、聚偏磷酸钙及不溶性聚偏磷酸钠。
[0031]本发明组合物任选包含牙石抑制剂(防牙垢剂)，按配方制备从而不影响文中上述混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油除臭剂的效力。适于本文使用的牙石抑制剂包括这些药物任何的盐，例如其碱金属盐及铵盐、磷酸盐及多磷酸盐(例如焦磷酸盐)、聚氨基丙磺酸(AMPS)、聚烯烃磺酸酯(polyolefin sulfonates)、聚烯烃磷酸酯，二磷酸酯例如氮杂环烷基-2，2-二磷酸酯(例如氮杂环庚烷-2，2-二磷)、N-甲基氮杂环戊烷-2，3-二磷酸、乙烷-1-羟基-1，1-二磷酸(EHDP)及乙烷-1-氨基-1，1-二磷酸酯、膦酸基烷基甲酸等。适用的无机磷酸盐及多聚磷酸盐包括磷酸二氢钠、磷酸氢二钠和磷酸钠，三聚磷酸钠、四聚磷酸盐，焦磷酸一钠、二钠、三钠和四钠，三偏磷酸钠、六偏磷酸钠及其混合物。
[0032]本发明组合物任选包含氟离子源，按配方制备从而不影响文中上述混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油除臭剂的效力，且适于用作例如防龋剂。可使用任何口服可接受的微粒型氟离子源，包括氟化钾、氟化钠及氟化铵和一氟磷酸盐(monofluorophosphates)、氟化亚锡、氟化铟、氟化胺例如奥拉氟(N′-十八烷基三亚甲基二胺-N，N，N′-三(2-乙醇)-二氢氟化物)，及其混合物。一种或多种氟离子源任选以提供临床上有效量的可溶性氟离子的量存在于口腔护理组合物中。
[0033]本发明组合物任选包含催唾剂，按配方制备从而不影响文中上述混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油除臭剂的效力，且适用于例如改善口干燥。可使用任何口服可接受的催唾剂，包括但不限于食品酸味剂例如柠檬酸、乳酸、苹果酸、琥珀酸、抗坏血酸、脂肪酸、富马酸及酒石酸，及其混合物。一种或多种催唾剂任选以有效刺激唾液的有效总量存在。
[0034]本发明组合物任选包含营养物质，按配方制备从而不影响文中上述混合的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油除臭剂的效力。适当的营养物质包括维生素、矿物质、氨基酸及其混合物。维生素包括维生素C和维生素D、硫胺素、核黄素、泛酸钙、烟酸、叶酸、尼克酰胺、吡多辛、氰钴铵、对氨基苯甲酸、生物类黄酮及其混合物。营养添加剂(Nutritional supplements)包括氨基酸(例如L-色氨酸、L-赖氨酸、甲硫氨酸、苏氨酸、左卡尼汀和L-卡尼丁)，，抗脂肪剂(例如胆碱、肌醇、甜菜碱和亚麻酸)，及其混合物。
制备方法
[0035]根据多种方法制备前述本发明的组合物，这些方法包括混合上述的麝香草酚、大茴香、小茴香、罗勒及杜松挥发油从而制得除臭剂。然后将除臭剂混合进口腔护理载体得到制剂例如漱口液、牙膏、牙齿乳膏或糖锭(或混合进如本文前面所述实施方案中另一种易携带形式而使除臭剂与口腔载体混合而提供易携带剂型例如但不限于糖锭、薄荷剂、珠、糯米纸囊剂、含有喷雾应用于口腔的液体制剂的小型易携带喷雾器、含有滴加应用到口腔的液体制剂的小型易携带药瓶或柔软易折咀嚼片剂)，通过本领域技术人员熟练的常规方法制备这些制剂。
[0036]在一个可选择的实施方案中，将麝香草酚、大茴香、小茴香、罗勒及杜松挥发油单独混合进口腔护理载体从而制得制剂例如漱口液、牙膏、牙齿乳膏或糖锭(或混合进如本文前面所述实施方案中另一种易携带形式从而实际上使除臭剂与口腔载体混合而提供易携带剂型例如但不限于糖锭、薄荷剂、珠、糯米纸囊剂、含有喷雾应用于口腔的液体制剂的小型易携带喷雾器、含有滴加应用到口腔的液体制剂的小型易携带药瓶或柔软易折咀嚼片剂)，这些制剂具有如前所述有效的除臭剂。正如本领域技术人员理解得，在此可选择实施方案方法中实际上混合了除臭剂，即使并未预先混合麝香草酚、大茴香、小茴香、罗勒及杜松挥发油成为单独制剂。
使用方法
[0037]本发明提供了使用本发明组合物清洗牙齿表面得方法。文中所用牙(″tooth″)或″牙齿″指天然牙齿、假牙、齿板、填充物(fillings)、帽(caps)、冠(crowns)、齿桥、牙植入物等，及其他长期或暂时固定于口腔内假牙的任何坚硬表面。
[0038]相应的，本发明提供清洗牙齿表面的方法，包括在表面上应用安全且有效量的洁牙剂(例如但不限于牙膏或牙齿乳膏)或漱口液，其中洁牙剂或漱口液含有有效(临床上有效)量的除臭剂，然后用牙刷在牙齿表面搅动洁牙剂或通过强力漱口搅动漱口液。本文所用“应用”指将洁牙剂或漱口液与牙齿表面接触的任何方法。在多个实施方案中，这些方法包括通过涂抹及刷牙方法直接应用组合物。在多个实施方案中，应用组合物包括使用装置帮助维持组合物与牙齿表面接触足够时间而完成清洗。
[0039]本发明也提供了使用本发明组合物抑制臭气的方法，包括(a)摄取口腔安全且有效量的制备的文中所述除臭剂剂型混合物，例如但不限于糖锭、薄荷剂、珠、糯米纸囊剂、含有喷雾应用于口腔的液体制剂的小型易携带喷雾器、含有滴加应用到口腔的液体制剂的小型易携带药瓶及柔软易折“咀嚼”片剂，(b)任选在口腔内保留该剂型一段时间，及(c)吞服下该制剂。
[0040]在各种实施方案中优选受试者在洁牙剂和/或漱口液口腔护理组合物与牙齿表面接触时不进任何食物。如有需要，可通过采用标准口腔卫生步骤例如刷牙或用水清洗除去这种口腔护理组合物。可重复此步骤数次直至获得需要的清洁效果。
[0041]在多个实施方案中，本发明组合物也用于治疗或预防口腔疾病，包括预防牙洞(cavity)、增白、预防或减轻牙斑、防牙石、预防或减轻敏感度、预防或减轻呼吸口臭及预防色素斑。本发明组合物也用于治疗或预防全身疾病，例如通过降低发生全身疾病的风险，例如心血管疾病、中风、糖尿病、严重呼吸道感染、早产儿和低体重出生儿(包括与产后神经/发育功能的机能障碍有关的风险)，及与提高死亡率的风险而改善全身健康状况。这些方法包括在2003年11月6日公开的Doyle等的美国专利公开2003/0206874，中公开的方法。
[0042]通过下列非限制性实施例进一步描述本发明。
实施例1
[0043]用来控制大蒜的各种天然提取物的体外筛选如下进行：在密闭容器中用待测提取物处理大蒜-唾液混合物至少8小时(过夜)，对气相色谱进行设置使其适于大蒜检测并用其分析容器顶部空间的气体。以1∶1比例制备大蒜-唾液混合物，即一份全唾液与一份1％重量的大蒜水提取物。用待测提取物处理大蒜-唾液混合物并在37℃下孵育过夜。表1显示了研究结果。
表1
| 活性物质 | 总大蒜臭味(ppb) | 大蒜臭味降低百分率 |
| 阴性对照(水处理) | 1800 | N/A |
| 大茴香(Anise star) | 90.1 | 95.0 |
| 罗勒 | 90.7 | 95.0 |
| 莳萝籽 | 90.1 | 95.0 |
| 甜小茴香 | 91.2 | 94.9 |
| 杜松 | 91.1 | 94.9 |
| 欧芹 | 90.5 | 95.0 |
| 迷迭香 | 88.9 | 95.0 |
| 鼠尾草 | 85.9 | 95.2 |
| 樟脑 | 81.0 | 95.5 |
| 桂皮 | 84.9 | 95.3 |
| 丁香 | 78.6 | 95.6 |
| 橙花(Neroli) | 91.0 | 94.9 |
| 松树 | 91.6 | 94.9 |
| 百里香 | 90.8 | 95.0 |
| 藏红花 | 95.7 | 94.7 |
| 香茅 | 87.3 | 95.1 |
| 亚麻籽 | 1026 | 43.2 |
| 霍霍巴 | 1188 | 34.1 |
| 棉籽 | 1452 | 19.3 |
[0044]如表1所示，当在实验中使用小于0.13％重量水平时，大茴香(anise star)、罗勒、莳萝籽、甜小茴香、杜松、香茅、欧芹、迷迭香、鼠尾草、樟脑、桂皮、丁香、橙花、松树、藏红花、和百里香提取物均显示显著的降低大蒜臭气的效力。
实施例2
[0045]使用实施例1的技术，将实施例1中性能最好的除臭活性物质组合起来进行测试以验证联用的协同效应。根据相同技术也试验了对照的常规大蒜臭气口腔护理活性物质混合物。麝香草酚、大茴香、小茴香、罗勒和杜松挥发油这5种活性物质当以1∶1∶1∶1∶1(除臭活性物质试验制剂中各占20％)组合使用时显示出所有组合中最有效的累加和/或协同效果。以1∶1∶1∶1∶1比例混合的麝香草酚、大茴香、小茴香、罗勒和杜松挥发油的混合物的定量的降低大蒜臭气效力表明在试验顶部空间中大蒜臭气组分下降了78％。对照(常规降低大蒜臭气活性物质混合物)的定量的降低大蒜臭气效力表明在试验顶部空间中大蒜臭气组分下降了53％。结果表明了以1∶1∶1∶1∶1比例混合的麝香草酚、大茴香、小茴香、罗勒和杜松挥发油的混合物的惊人的功效。
[0046]本文所述实施例和其他实施方案均为示例性的，并且不能将其限于描述组合物的全部范围和本发明的方法。在本发明范围内可进行特定实施方案、材料、组合物与方法的等同变化、修改和改变且结果基本类似。
Claims (21)
1.一种口腔除臭剂混合物组合物，包含：
(a)约10％重量-约30％重量的麝香草酚挥发油；
(b)约10％重量-约30％重量的大茴香挥发油；
(c)约10％重量-约30％重量的小茴香挥发油；
(d)约10％重量-约30％重量的罗勒挥发油；和
(e)约10％重量-约30％重量的杜松挥发油。
2.权利要求1的组合物，其中所述麝香草酚、大茴香、小茴香和罗勒挥发油各自独立占所述组合物的约15％重量-约25％重量。
3.权利要求1的组合物，其中所述麝香草酚、大茴香、小茴香和罗勒挥发油各自独立占所述组合物的约20％重量。
4.一种口腔护理组合物，包含：
(a)一种口腔护理载体，和
(b)分散在所述口腔护理载体中的约0.3％重量-约2％重量的口腔除臭剂，所述除臭剂包含挥发油，各挥发油在所述除臭剂中的比例为：
(1)约10％重量-约30％重量的麝香草酚挥发油；
(2)约10％重量-约30％重量的大茴香挥发油；
(3)约10％重量-约30％重量的小茴香挥发油；
(4)约10％重量-约30％重量的罗勒挥发油；和
(5)余量的杜松挥发油，其中所述杜松挥发油占所述除臭剂的约10％重量-约30％重量。
5.权利要求4的组合物，其中所述口腔护理载体为用于牙膏的口腔护理载体。
6.权利要求4的组合物，其中所述口腔护理载体为用于牙齿乳膏的口腔护理载体。
7.一种用于制造减少大蒜臭气的口腔除臭制剂的方法，包括：
(a)混合麝香草酚、大茴香、小茴香、罗勒及杜松挥发油以构成具有下列组分的除臭剂：
(1)约10％重量-约30％重量的麝香草酚挥发油；
(2)约10％重量-约30％重量的大茴香挥发油；
(3)约10％重量-约30％重量的小茴香挥发油；
(4)约10％重量-约30％重量的罗勒挥发油；和
(5)余量的杜松挥发油，其中所述杜松挥发油占所述口腔混合物组合物的约10％重量-约30％重量；及
(b)以口腔用有效比例混合所述除臭剂与口腔护理载体。
8.根据权利要求7的方法制备的口腔除臭剂。
9.权利要求7的方法，其中以所述口腔用有效比例混合所述口腔护理载体与所述除臭剂从而提供牙膏。
10.通过权利要求9的方法制备的牙膏。
11.权利要求7的方法，其中以所述口腔用有效比例混合所述口腔护理载体与所述除臭剂从而提供牙齿乳膏。
12.通过权利要求11的方法制备的牙齿乳膏。
13.权利要求7的方法，其中以所述口腔用有效比例混合所述口腔护理载体与所述除臭剂从而提供易携带的剂型，所述易携带剂型选自糖锭、薄荷剂、珠、糯米纸囊剂、从小型易携带喷雾器喷雾应用于口腔的液体制剂、从小型易携带药瓶滴加应用到口腔的液体制剂及柔软易折片剂。
14.通过权利要求13的方法制备的易携带剂型，所述易携带剂型选自糖锭、薄荷剂、珠、糯米纸囊剂、喷雾应用于口腔的液体制剂中含有所述混合物的小型易携带喷雾器、滴加应用到口腔的液体制剂中含有所述混合物的小型易携带药瓶及柔软易折片剂。
15.权利要求7的方法，其中以所述口腔用有效比例混合所述口腔护理载体与所述除臭剂从而提供漱口液。
16.通过权利要求15的方法制备的漱口液。
17.一种抑制口臭的方法，所述方法包括：将具有口腔用有效量的分散的除臭剂的口腔护理载体应用到口腔中，所述除臭剂包含挥发油，各挥发油在所述除臭剂中的比例为：
(1)约10％重量-约30％重量的麝香草酚挥发油；
(2)约10％重量-约30％重量的大茴香挥发油；
(3)约10％重量-约30％重量的小茴香挥发油；
(4)约10％重量-约30％重量的罗勒挥发油；和
(5)余量的杜松挥发油，其中所述杜松挥发油占所述除臭剂的约10％重量-约30％重量。
18.权利要求17的方法，其中所述口腔护理载体及所述分散的除臭剂包含于牙膏中。
19.权利要求17的方法，其中所述口腔护理载体及所述分散的除臭剂包含于牙齿乳膏中。
20.权利要求17的方法，其中混合物中的所述口腔护理载体及所述除臭剂包含于易携带剂型中，该剂型选自糖锭、薄荷剂、珠、糯米纸囊剂、喷雾应用于口腔的液体制剂中含有所述混合物的小型易携带喷雾器、滴加应用到口腔的液体制剂中含有所述混合物的小型易携带药瓶及柔软易折片剂。
21.权利要求17的方法，其中所述口腔护理载体及所述分散的除臭剂包含于漱口液中。
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| US11/020,009 US7297327B2 (en) | 2004-12-21 | 2004-12-21 | Oral care malodor composition |
| US11/020,009 | 2004-12-21 | ||
| PCT/US2005/042162 WO2006068752A1 (en) | 2004-12-21 | 2005-11-18 | Oral care malodor composition |
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| EP (1) | EP1830799A1 (zh) |
| CN (1) | CN101119704B (zh) |
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| WO (1) | WO2006068752A1 (zh) |
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| CN102178614A (zh) * | 2011-04-07 | 2011-09-14 | 杭州皎洁口腔保健用品有限公司 | 一种复方中草药牙膏及其制备方法 |
| CN102793885A (zh) * | 2012-09-06 | 2012-11-28 | 苏州谷力生物科技有限公司 | 一种具有清新口腔作用的植物提取物 |
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| WO2010134903A1 (en) * | 2009-05-18 | 2010-11-25 | Colgate-Palmolive Company | Oral composition |
| AU2009354829B2 (en) | 2009-10-26 | 2013-03-07 | Colgate-Palmolive Company | Oral composition for treating oral malodor |
| TWI435733B (zh) | 2010-01-29 | 2014-05-01 | Colgate Palmolive Co | 用於口臭控制之口腔保健調配物 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178614A (zh) * | 2011-04-07 | 2011-09-14 | 杭州皎洁口腔保健用品有限公司 | 一种复方中草药牙膏及其制备方法 |
| CN102793885A (zh) * | 2012-09-06 | 2012-11-28 | 苏州谷力生物科技有限公司 | 一种具有清新口腔作用的植物提取物 |
Also Published As
| Publication number | Publication date |
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| AR052345A1 (es) | 2007-03-14 |
| TWI389705B (zh) | 2013-03-21 |
| CA2592050C (en) | 2014-01-14 |
| AU2005319562A1 (en) | 2006-06-29 |
| RU2007127855A (ru) | 2009-01-27 |
| WO2006068752A1 (en) | 2006-06-29 |
| BRPI0519389A2 (pt) | 2009-01-27 |
| EP1830799A1 (en) | 2007-09-12 |
| MX2007007628A (es) | 2007-08-03 |
| US20060134023A1 (en) | 2006-06-22 |
| US7297327B2 (en) | 2007-11-20 |
| TW200637601A (en) | 2006-11-01 |
| RU2392924C2 (ru) | 2010-06-27 |
| ZA200706040B (en) | 2009-01-28 |
| MY138305A (en) | 2009-05-29 |
| AU2005319562B2 (en) | 2011-07-21 |
| CN101119704B (zh) | 2011-08-17 |
| CA2592050A1 (en) | 2006-06-29 |
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