CN101095440A - Slimming function of kutin tea and method for manufacturing kutin tea micro-pill - Google Patents

Slimming function of kutin tea and method for manufacturing kutin tea micro-pill Download PDF

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CN101095440A
CN101095440A CNA2006100522505A CN200610052250A CN101095440A CN 101095440 A CN101095440 A CN 101095440A CN A2006100522505 A CNA2006100522505 A CN A2006100522505A CN 200610052250 A CN200610052250 A CN 200610052250A CN 101095440 A CN101095440 A CN 101095440A
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bitter leaves
holly leaf
preparation
leaves tea
broadleaf holly
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CN101095440B (en
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范敏华
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Hainan Poly Pharm Co ltd
Zhejiang Poly Pharmaceutical Co ltd
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Abstract

The invention belongs to health-care foodstuff application field, especially relates to the fat-reduction effect of broadleaf holly leaf and a method for preparing broadleaf holly leaf micro-pills. The invention proposes a new application of broadleaf holly leaf for fat reduction, and provides a large amount of scientific data to prove the function. Said method comprises following steps: cutting broadleaf holly leaf, putting it into ethanol for extracting through refluxing for two times or extracting with water for 2 times, combining extraction liquid and condensing, adding adhesives into ethanol, stirring evenly, adding extraction liquid and talcum powder, stirring evenly, sifting and feeding it to fluidized bed, feeding it into pill and packing, controlling air temperature and material temperature, drying and getting broadleaf holly leaf micro-pill.

Description

The antiobesity action of bitter leaves tea and a kind of preparation method of broadleaf holly leaf pellets
Technical field
The invention belongs to the health food application, particularly relate to the preparation method of antiobesity action and a kind of broadleaf holly leaf pellets of bitter leaves tea.
Background technology
Bitter leaves tea is the plant medicinal herb tea that a kind of quilt is extensively drunk, and enters into market gradually from the earliest among the people drinking, and is now accepted by consumers in general and likes.Bitter leaves tea is otherwise known as in the document " highland Lu " in ancient times, appears at " paulownia monarch record " that the Eastern Han Dynasty becomes book the earliest, and Tang Yiqian is called " melon Lu " or " highland Lu ", and Song Yihou renames as " bitter taro " gradually, is abbreviated as " bitter leaves " afterwards.Tang's (Christian era 618～907) supplement to the Herbal was once put down in writing: " highland Lu, leaf bitter, flat do that drink quenches the thirst, eliminating phlegm, sit up, Li Shui, make eye bright.Go out South Sea Zhu Shan, and big, southern people gets and is used as tender tea leaves leaf like tender tea leaves ... food makes us thin for a long time, removes people's fat." " Chinese medicine voluminous dictionary " go up the record bitter leaves tea wind-heat of loosing, the refresh oneself, relieving thirst and restlessness can be controlled headache, dentalgia, hot eyes, pyreticosis polydipsia, cerumen ear, dysentery.
Bitter leaves tea source is complicated, " China's book on Chinese herbal medicine " goes up record: certified products bitter leaves tea should derive from the tender leaf of holly plant Chinese holly, Cortex Ilicis Rotundae and Ilex kudincha C. J. Tseng, but the bitter leaves tea that some other plant origin is also arranged, native tea described in " Xinhua book on Chinese herbal medicine outline " is promptly risen the tender leaf of the red bud wood of yellow section plant; Sichuan bitter leaves tea in " Sichuan Chinese medicine standard ", promptly oleaceae plant always obstructs the leaf of glossy privet, sturdy glossy privet or beautiful leaf glossy privet; Ligustrum groffiae Merr of collecting in " Guangxi medicinal plant register " derives from the branches and leaves of the little wax of oleaceae plant light leaf; Big hilllock tea in " national Chinese herbal medicine compilation " derives from the heartwood of comfrey Obovate Acuminate Ehretia; Terrible lantern in " the sward property of medicine be equipped with want ", promptly the Verenaceae plant cauline leaf different name of spending lantern in vain all is called bitter leaves tea.
Along with reform and opening-up, people's living standard progressively improves, living condition is improved day by day, the change of dietary structure and life style makes obese people more and more, the increase of following simultaneously that also has hyperlipidemia and pathogenesis of fatty liver rate, have data to show that the obesity patient has 1,200,000,000 at present at least in the world, China has surpassed 7,000 ten thousand people (not comprising children), and obesity has become the formidable enemy of harm humans health.Domestic and international most of slimming medicines are appetite inhibitor, diuretics, cathartic etc. all at present, and the mode of passing through diarrhoea that has is discharged moisture in the human body and protein, causes the illusion that loses weight, and fail to touch the basic of obesity; Have pass through to go on a diet reaches the purpose of fat-reducing, promptly to reduce the take the photograph people of human body to fat, carbohydrate, relies on the consumption of human body self fat to come makeup energy; The slimming medicine that has adds appetite inhibitor such as fenfluramine etc., makes human body be in starvation after taking, and has reduced the mobility of body each side, in case and drug withdrawal, body weight quicks rebound.More than these weight reduction with drugs in various degree side effect is all arranged, take for a long time also and can cause damage function of human body.Bitter leaves tea as integration of drinking and medicinal herbs is widely used in various places, China south, because it has certain effect for obesity, hyperlipemia, hypertension, geomantic omen edema etc. and has no side effect, be loved by the people, be described as " slim tea ", " beauty treatment tea ", " life-prolonging tea " and in long-term use among the people.And the obesity that the traditional Chinese medical science is thought mostly is actual situation and holds concurrently mutually, belongs to spleen emptiness and wet sputum type, stomach energy damp-obstruction type.That the bitter leaves tea set has is clearing heat and detoxicating, the greasy effect such as stagnant that disappears of dispelling; The health nutrient that bitter leaves tea includes, medical substance reach kind more than 250, and wherein flavonoid component is high, be tealeaves 1.6-14.7 doubly, thereby have obvious reducing blood lipid, hypoglycemic, antithrombotic, physiological activity such as anti-oxidant.
The application of present domestic bitter leaves tea is also many, a lot of all is to inquire into for the convenience that the bitter leaves tea-drinking is used, simultaneously more be application extension with bitter leaves tea to deep processing for food, or be made into the food of certain health-care effect with other medicative drug matching of multi-flavor.
Publication number is a kind of natural Kudingcha beverage of Chinese patent of CN1168244A and preparation method thereof, and it is that the tea beverage of primary raw material is prepared that this patent is directed to bitter leaves tea, has added compositions such as green tea, honey.
Publication number is the Chinese patent bitter leaves tea of CN1088395A, has pointed out that with bitter leaves tea be primary raw material, and interpolation gynostemma pentaphylla, Momordica grosvenori, Jasmine, sweet osmanthus etc. are prepared and make tea beverage.
Publication number is the Chinese patent compounded " kuding " tea series beverage of CN1098859A, has pointed out that with bitter leaves tea be primary raw material, adds gynostemma pentaphylla, top grade green tea etc. equally, is prepared into a bag bubble, oral liquid and beverage.
Publication number is the Chinese patent bitter leaves tea cream of CN1481698A, is serve as finally to prepare purpose with the bitter leaves tea that concentrates.
Publication number is Chinese patent fully natural green refined lectuce tea capsule and the processing technology of CN1695472A, has pointed out that with bitter leaves tea be primary raw material, adds green tea etc., is prepared into the tea in bag essence after concentrating.
Publication number is the prescription and the manufacturing process of the Chinese patent Ilex kudingcha series health food of CN1119076A, is the bitter leaves tea and different Chinese medicine medicinal material compatibilities that extracts after concentrating to soak, and is made into oral liquid formulation and particle formulation and is final preparation purpose.
Summary of the invention
The objective of the invention is to be clearly to propose a kind of new purposes of bitter leaves tea, main is the single antiobesity action with bitter leaves tea that is applied to field of health care food, and a large amount of scientific experiment data are provided simultaneously, and instruction book has the effect that reduces blood fat, fat-reducing with bitter leaves tea.
Another object of the present invention also is to provide a kind of preparation method who can be used for the bitter leaves tea formulation of lowering blood-fat and reducing weight.
For better understanding essence of the present invention, with pharmacodynamics and result lipopenicillinase, the antiobesity action that bitter leaves tea list is used is described below:
Experiment one:
1 experiment material
1.1 medicine and reagent
(1) general flavone group (alcohol extract micro pill capsule): it is an amount of to get the alcohol extract micro pill capsule, is made into the 0.2g/ml soup 200ml of (containing the crude drug amount) with distilled water.
(2) decocting liquid group (water extract micro pill capsule): it is an amount of to get the water extract micro pill capsule, is made into the 1g/ml soup 200ml of (containing the crude drug amount) with distilled water.
(3) positive control drug: Bei Shi fat-reducing sheet (hydrochloric acid phenol fluorine Lamine sheet Tablet Fenfluranmine Hydrochloride TFH) Guangzhou pharmacy seven factories, 0003325 specification: every contains phenol fluorine Lamine 20mg, and clinical dosage is each 1, every day 3 times; Preparation: get the TFH sheet, be made into the solution of 0.5mg/mL with distilled water.
1.2 animal
Kunming mouse, body weight 18-22g, male and female half and half are provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center, and the quality certification number is No. the 12nd, the real moving pipe in river, and the qualified back of all quarantining is standby.
2 methods and result
2.1 the preparation of fat animal model
Add each 10g of milk powder lard in every 100g basal feed, 1 in egg, cleum jecoris piscis concentratum an amount of (every gram contains vitamin A 9000 units, calciferol 3000 units), formulated voluntarily, divide 2 supplies every day, press about 20g mouse 6g every day continuous 6 weeks.
2.2 modeling and grouping
110 mouse are divided into 11 groups at random by body weight: blank group, fat model group, positive controls, general flavone high dose group, general flavone low dose group, general flavone high dose prevention group, general flavone low dosage prevention group, decocting liquid high dose group, decocting liquid low dose group, decocting liquid high dose prevention group, decocting liquid low dosage prevention group, promptly be divided into prevention part experiment with and the experiment of treatment part use, every group 10, blank group unit feeds and normal diet from start to finish; All the other each groups give nutritional feed to experiment and finish, and give nutritional feed after 2 weeks, make it cause simple property alimentary obesity model; Decocting liquid high dose prevention group, decocting liquid low dosage prevention group, general flavone high dose prevention group, the limit modeling limit administration of general flavone low dosage prevention group; Decocting liquid high dose group, decocting liquid low dose group, general flavone high dose group, general flavone low dose group, positive controls begin administration and continue to feed and nutrient fodder after modeling 2 week success.
2.3 administration time and method
Adopt not isoconcentration administration of isometric(al), irritate stomach volumetric water decocting liquid high dose group (25ml/kg), decocting liquid high dose prevention group (25ml/kg), decocting liquid low dose group (12.5ml/kg), decocting liquid low dosage prevention group (12.5ml/kg), general flavone high dose group (10g/kg), general flavone high dose prevention group (10g/kg), general flavone low dose group (5g/kg), general flavone low dosage prevention group (5g/kg), the Bei Shi sheet (6mg/kg) of losing weight, irritate stomach every day once, continuously 4-6 week, weigh weekly 1 time.
2.4 evaluation index
2.4.1 the mensuration of body weight and lipschitz exponent (Lee ' s index)
In experimentation, be that the electronic balance of 0.1g regularly claims body weight 1 time by the special messenger with precision weekly, experimental session is observed the mouse diet situation of every day at any time, and cerebration and ight soil are done rare degree.Before the execution, under anesthesia, accurately measure the length (body long) of mouse, calculate lipschitz exponent as follows from nose to anus:
Lipschitz exponent=[body weight (g) * 103] 1/3/ body long (cm)
2.4.2 the mensuration of fat weight around uterus and the testis
Measure the long back of body and put to death mouse.With in the abdominal cavity, around the kidney, abdominal cavity fat all takes off, and claims its weight in wet base.
Experimental result sees Table 1-table 3
Table 1 mouse growth body weight index determining value (x ± s)
Numbering Group Animal (only) Experiment is body weight (g) just Body weight (g) after two weeks Experiment end-body heavy (g)
1 Fat model group 10 18.93±1.31 29.51±1.51 38.23±2.42
2 The blank group 10 19.28±0.99 25.51±3.22 35.93±6.00
3 Positive controls 10 18.60±0.92 28.91±3.07 29.66±3.61*
4 The general flavone low dose group 10 18.05±1.46 26.94±4.04 30.31±4.40*
5 General flavone low dosage prevention group 10 18.38±0.9 29.63±1.48 34.23±9.32
6 The general flavone high dose group 10 19.41±3.59 30.37±4.03 27.94±3.19**
7 General flavone high dose prevention group 9 18.42±1.36 27.09±2.81 28.88±6.57*
8 Decocting liquid low dose group 10 18.20±0.85 29.82±4.62 28.09±4.27**
9 Decocting liquid low dosage prevention group 8 18.28±0.92 24.73±3.64 28.31±3.90**
10 Decocting liquid high dose group 9 18.01±0.88 30.87±3.15 37.29±2.34
11 Decocting liquid high dose prevention group 8 18.33±0.82 36.70±3.04 32.06±7.58
Compare with model control group: * * p＜0.01 * p＜0.01
Table 2 mouse lipschitz exponent (Lee ' s) measured value (x ± s)
Numbering Group Animal (only) Lipschitz exponent
1 Fat model group 10 347.11±9.06
2 The blank group 10 345.43±7.97
3 Positive controls 10 320.42±9.45*
4 The general flavone low dose group 10 322.40±1.17*
5 General flavone low dosage prevention group 10 319.22±3.14*
6 The general flavone high dose group 10 311.84±6.14**
7 General flavone high dose prevention group 9 310.77±3.56**
8 Decocting liquid low dose group 10 315.23±6.54*
9 Decocting liquid low dosage prevention group 8 310.94±3.58**
10 Decocting liquid high dose group 9 339.23±10.04
11 Decocting liquid high dose prevention group 8 331.18±6.87
Compare with model control group: * * p＜0.01 * p＜0.01
Table 3 mouse body fat weight in wet base index determining value (x ± s)
Numbering Group Animal (only) Body fat weight in wet base
1 Fat model group 10 1.301±0.59
2 The blank group 10 0.846±0.29
3 Positive controls 10 0.698±0.23*
4 The general flavone low dose group 10 0.536±0.31**
5 General flavone low dosage prevention group 10 0.579±0.23**
6 The general flavone high dose group 10 0.431±0.29**
7 General flavone high dose prevention group 9 0.382±0.12**
8 Decocting liquid low dose group 10 0.721±0.53*
9 Decocting liquid low dosage prevention group 8 0.459±0.32
10 Decocting liquid high dose group 9 0.499±0.24**
11 Decocting liquid high dose prevention group 8 0.701±0.39*
Compare with model control group: * * p＜0.01 * p＜0.01
3. result and discussion:
This experiment is by giving the Animal nutrition forage, cause owing to exogenous lipid is taken the photograph the too much body weight of people and increased and form the alimentary obesity model, prove through experimental study: the total flavone part of bitter leaves tea and decocting liquid position all have comparatively significantly antiobesity action, after the medication, the growth figure such as the lipschitz exponent (IC) of reflection body obese degree, body fat weight in wet base (adipose tissue) etc. all has obvious decline, alimentary obesity mouse body weight is subjected to obvious inhibition, every index that is adopted and model group relatively have conspicuousness or utmost point significant difference (P＜0.05 or P＜0.01), show that it has curative effect preferably, and in antiobesity action, no obvious adverse reaction takes place.Can think: bitter leaves tea (alcohol extracting or water extract) has prevention to high fat trophism induced mice obesity; To forming fat mouse therapeutic action is arranged; With positive controls comparison bitter leaves tea to obesity control do not have apocleisis, diarrhoea, attenuating body weight and reduce the performance of muscle power; Its fat-reducing effect to mouse is roughly suitable with the Bei Shi fat-reducing sheet of using clinically at present, and dosage does not have significant difference between each group of general flavone, and general flavone high dose, general flavone high dose prevention group are then better than Bei Shi fat-reducing sheet, and than safety.
Experiment two:
1 experiment material and method
1.1 experimental drug: the micro pill capsule of (1) bitter leaves tea alcohol extracting preparation, every contains 0.3g crude drug amount; (2) cholesterol powder, the packing of Guangzhou chemical reagent branch company; (3) clofibrate, the 125mg/ sheet, Guangzhou the 4th pharmaceutical factory produces.
1.2 animal used as test: the big ear rabbit of Japan is provided by Zhejiang College Of Traditional Chinese Medicine laboratory animal room, and adaptability is fed after 1 month standby.
1.3 experiment grouping: get 19 of the big ear rabbits of body weight 1898 ± 228g bull Japan, be divided at random: (1) high fat control group: 7 of animals, every cholesterol powder 0.5g/d feeds; (2) bitter leaves tea group: 7 of animals, every cholesterol powder 0.5g/d adds broadleaf holly leaf pellets capsule 2.0g/d simultaneously and feeds; (3) clofibrate group: 5 of animals, every cholesterol powder 0.5g/d, the nursing next day of adding clofibrate 0.125g/d (proportionately people's consumption conversion) simultaneously, said medicine is all in a small amount of feed of tripping in morning every day, treating that medicine has been eaten adds with normal diet, forage fed to appetite animal, fully takes the photograph the people to guarantee medicine.
1.4 hematology detects: the total fat of (1) blood (TL), T-CHOL (TC), beta lipoprotein (β-LP), triglycerides (TG).1 the end of month, 2 the end of month, 3 the end of month are finished by the people of specialized staff inspection teachers training school of clinical laboratory before high fat nursing, after the experiment.(2) lipid peroxide (LPO).1 the end of month, 2 the end of month are finished by the appropriate sour colorimetric method of sulfo-crust pyrene by my institute's control laboratory after experiment, and medicine box is provided by clinical examination reagent development centre, Sichuan Province.
1.5 pathologic finding: in experiment back 3 the end of month femoral artery sacrificed by exsanguination animal, core, brain, kidney, the inspection of liver routine pathology, understand atherosclerotic and other pathomorphisms and change.Other rounds the bar sustainer and vertically cuts off back row the Sudan VI dyeing, measures the atherosclerotic plaque area to duplicate a paper method, calculates pathology area and whole piece sustainer area percentage.
2 experimental results
2.1 bitter leaves tea group is to the influence of blood TL, TC, β-LP, TG: TL, TC, β-LP, TG four indices indifference (P＞0.05) before the experiment of 3 treated animals.1 the end of month of experiment back, 2 the end of month, 3 the end of month TL, TC bitter leaves tea group and all higher fat group of clofibrate group reduce (P＜0.05), 2 the end of month bitter leaves tea group the also higher fat group of β-LP low (P＜0.05), the also higher fat control group of the every index of all the other blood fat is low, but not statistically significant (P＞0.05).
Bitter leaves tea group and clofibrate group are not seen variant (P＞0.05) to the influence of These parameters, see Table 1.
3 groups of 4 blood lipids index of table 1 and aortosclerosis analytical table
The PROJECT TIME group Before total fat (mg/dl) experiment, 3 the end of month of 2 the end of month, 1 the end of month Before T-CHOL (mg/dl) experiment, 3 the end of month of 2 the end of month, 1 the end of month Before beta lipoprotein (mg/dl) experiment, 3 the end of month of 2 the end of month, 1 the end of month Before triglycerides (mg/dl) experiment, 3 the end of month of 2 the end of month, 1 the end of month A sclerosis area integral percentage
High fat group (1) 348.57±96.86 48.57±23.40 175.93±70.97 106.21±31.96 53.97±27.17
1140.7±218.34 587.14±209.02 445.57±154.47 109.86±23.73
1807.14±493.65 897.42±244.08 428.14±72.38 165.29±121.1
1808.43±159.42 1106.57±125.31 566.29±31.50 107.29±61.52
Medicine group (2) 338.29±129.59 52.86±17.04 173.5±91.44 104.46±27.30 11.08±11.71
808±311.20 269.29±170.95 418.29±135.94 96.71±12.26
835.71±459.34 425.29±333.93 274.86±168.84 102.71±13.83
1300±595.62 704.29±446.59 472±132.31 73.57±20.71
Clofibrate group (3) 365.6±125.13 40±15.81 170.6±76.57 121.20±24.10 31.11±35.23
710±354.26 264.2±212.87 317.2±154.15 96.8±3.7
960±634.82 465.8±421.18 288±146.03 155.4±93.32
1153.2±658.04 662.8±470.78 417±210.34 69±7.68
P1.2 ＞0.05 ＜0.05 ＞0.05 ＜0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＜0.001
P1.3 ＜0.05 ＜0.05 ＜0.05 ＜0.05 ＜0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05
P2.3 ＞0.05 ＜0.05 ＞0.05 ＜0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05
＜0.05 ＜0.05 ＜0.05 ＜0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05
＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05
＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05
3 results and discussion
This research adopt the big ear rabbit of Japan to set up hyperlipemia model and observe bitter leaves tea and clofibrate to the influence of indexs such as blood fat, LPO, atherosclerotic area.Found that: bitter leaves tea all has the reduction effect to serum T L, TC and the LPO of experimental high fat animal model; To in the percentage of the shared sustainer area of animal used as test atherosclerosis of aorta patch, bitter leaves tea group also is starkly lower than control group.The result shows: the bitter leaves tea set has the blood fat of reduction, antiatherogenic effect.
On regard to single effect and carried out the description of science data with broadleaf holly leaf pellets capsule reduction blood fat, fat-reducing, the preparation method to the micropill of the broadleaf holly leaf pellets capsule that can be used for lowering blood-fat and reducing weight is described below:
Get a certain amount of bitter leaves tea raw material, chopping is inserted in the alcoholic solution refluxing extraction 2 times or is extracted 2 times with decocting, merges extract and concentrates; Taking adhesive adds in a certain amount of alcoholic solution, stirs, and adds to extract concentrate, talcum powder, goes up fluid bed after the solution that stirs sieves, to the medicine-feeding of ball core, and dressing, control air intake temperature, material temperature.Drying is finished and is promptly got broadleaf holly leaf pellets behind the dressing.
In order to reach this purpose of the present invention, the present invention has adopted following technical scheme:
A kind of broadleaf holly leaf pellets, form by Folum Ilicis extract and the blank pill heart, adhesive, contain Folum Ilicis extract in every and account for 10%～80% of micropill gross weight, medicinal fine pellet core accounts for 15%～60% of micropill gross weight, 5%～30% of binder constitutes micropill gross weight.
Folum Ilicis extract can be ethanol extract or decocting liquid.
As preferably, contain Folum Ilicis extract in every and account for 20%～60% of micropill gross weight, medicinal fine pellet core accounts for 30～55% of micropill gross weight, 5%～30% of binder constitutes micropill gross weight.
Medicinal fine pellet core is selected from the microcrystalline cellulose ball heart, the sucrose ball heart, or both mixtures.
As preferably, adhesive is selected from one or more in PVP, sodium carboxymethylcellulose, sodium carboxymethyl starch, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, the microcrystalline cellulose.
As preferably, coating material is selected from acrylic resin, methylcellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl cellulose, titanium dioxide, gelatin, polyethylene glycol, glycerine, the mixture of one or more in the isopropyl alcohol.
The preparation method of aforesaid broadleaf holly leaf pellets comprises the steps:
(1), the adhesive of 5～30% percentage by weights is dissolved in the ethanolic solution, be prepared into the granulation liquid of alcoholic solution;
(2), the Folum Ilicis extract of 10%～80% percentage by weight is added in the above-mentioned granulation liquid, and constantly stir and make it become even suspension, add talcum powder, stir and sieve;
(3), the fine pellet core with 15%～60% percentage by weight places fluidised bed granulator;
(4), use suspension to sparge on the material that places fluid bed, carry out fluid bed system micropill;
(5), after system micropill drying is finished, screening gained micropill;
(6), micropill is placed dressing on the fluid bed;
(7), drying is finished promptly.
As preferably, the nozzle entrance air themperature of spraying is 30～50 ℃ in step (4), and atomizing pressure is 0.1～0.5 megapascal (MPa), and the speed of peristaltic pump is 2～30rpm.
As preferably, in the drying steps of step (5), baking temperature is 40～60 ℃, and be 60～120 minutes drying time.
As preferably, in step (5) screening step, select 16～30 mesh sieves for use.
As preferably, the micropill that drying is finished carries out dressing, and the air intake temperature control is at 30-50 ℃, and the material temperature control is at 25-45 ℃.
As preferably, fluid bed is provided with powder recovering device.
The technique effect of broadleaf holly leaf pellets capsule of the present invention is as follows:
1, effective bonding functions of lowering blood-fat and reducing weight of bitter leaves tea;
2, effectively guarantee not the losing of all active ingredients of bitter leaves tea;
3, big at the intestines and stomach distribution area, the bioavilability height;
4, effectively cover the disagreeable taste of Folum Ilicis extract, be suitable for the high consumer of any obesity or blood fat.
5, by the preparation of broadleaf holly leaf pellets, deep processing prepares all oral formulations commonly used such as capsule, tablet, powder, granule again.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, but the present invention is not limited by embodiment.
Embodiment 1:
The preparation of broadleaf holly leaf pellets of the present invention:
1, get 1 kilogram of bitter leaves tea raw material, chopping, 70% ethanol 3000ml refluxing extraction 1h filters, residue adds the 3000m170% alcohol reflux again and extracts 1h, filters, and merging filtrate reclaims ethanol to there not being the alcohol flavor, ethyl acetate repeatedly extracts, and reclaims and fling to ethyl acetate, and it is standby to get Folum Ilicis extract;
2, prepare broadleaf holly leaf pellets in following ratio:
100g (gives birth to
Folum Ilicis extract
Medicine content)
PVP 9.2g
Medicinal fine pellet core (50 order) 76.7g
Talcum powder 10g
Get the PVP of 9.2 grams,, make the PVP ethanolic solution as adhesive with the dissolving of 320ml ethanol.The Folum Ilicis extract of recipe quantity is added in the above-mentioned adhesive, and constantly stirring makes it become even suspension; Add talcum powder and cross 200 mesh sieves;
The medicinal fine pellet core that takes by weighing recipe quantity places the spray of fluid bed side, and preheating is after 5 minutes, and the side spray loads medicine, and the nozzle entrance air themperature of spraying is 40 ℃, and atomizing pressure is 0.3 megapascal (MPa), and the speed of peristaltic pump is 7rpm.Until the whole loadeds of even suspension; Sieve is got 30 order micropills, places fluid bed top spray, 50 ℃ of dryings 1 hour.
3, get the micropill that the 100g drying is finished, place fluid bed, carry out dressing with Eudragit E 100 ethanolic solutions of 4-5%, the air intake temperature control is about 45 ℃, and the material temperature control is about 32 ℃.
4, drying is finished promptly.
Embodiment 2:
The preparation of broadleaf holly leaf pellets of the present invention:
1, get 1 kilogram of bitter leaves tea raw material, chopping, 10 times of water gagings soaked 20 minutes, decocted 1 hour, filtered, and residue adds 8 times of water gagings again and decocted 45 minutes, filters, and merges filtrate twice, concentrates to such an extent that Folum Ilicis extract is standby;
2, prepare broadleaf holly leaf pellets in following ratio:
200g (gives birth to
Folum Ilicis extract
Medicine content)
PVP 18.4g
Medicinal fine pellet core (40 order) 153.4g
Talcum powder 20g
Get the PVP of 18.4 grams,, make the PVP ethanolic solution as adhesive with the dissolving of 640ml ethanol.The Folum Ilicis extract of recipe quantity is added in the above-mentioned adhesive, and constantly stirring makes it become even suspension; Add talcum powder and cross 300 mesh sieves;
The medicinal fine pellet core that takes by weighing recipe quantity places the spray of fluid bed side, and preheating is after 5 minutes, and the side spray loads medicine, and the nozzle entrance air themperature of spraying is 30 ℃, and atomizing pressure is 0.5 megapascal (MPa), and the speed of peristaltic pump is 30rpm.Until the whole loadeds of even suspension; Sieve is got 16 order micropills, places fluid bed top spray, 50 ℃ of dryings 1 hour.
3, get the micropill that the 200g drying is finished, place fluid bed, carry out dressing with the acrylic resin RL100 ethanolic solution of 4-5%, the air intake temperature control is about 50 ℃, and the material temperature control is about 30 ℃.
4, drying is finished promptly.
Embodiment 3:
The preparation of broadleaf holly leaf pellets capsule of the present invention:
1, get 1 kilogram of bitter leaves tea raw material, chopping, 10 times of water gagings soaked 20 minutes, decocted 1 hour, filtered, and residue adds 8 times of water gagings again and decocted 45 minutes, filters, and merges filtrate twice, concentrates to such an extent that Folum Ilicis extract is standby;
2, prepare broadleaf holly leaf pellets in following ratio:
50g (crude drug
Folum Ilicis extract
Content)
Hydroxypropyl methylcellulose (4000cp) 10g
Medicinal fine pellet core (60 order) 40g
Talcum powder 5g
Get the hydroxypropyl methylcellulose of 10 grams,, make the hydroxypropyl methylcellulose ethanolic solution as adhesive with the dissolving of 350ml ethanol.The Folum Ilicis extract of recipe quantity is added in the above-mentioned adhesive, and constantly stirring makes it become even suspension; Add talcum powder and cross 350 mesh sieves;
The medicinal fine pellet core that takes by weighing recipe quantity places the spray of fluid bed side, and preheating is after 5 minutes, and the side spray loads medicine, and the nozzle entrance air themperature of spraying is 50 ℃, and atomizing pressure is 0.1 megapascal (MPa), and the speed of peristaltic pump is 20rpm.Until the whole loadeds of even suspension; Sieve is got 30 order micropills, places fluid bed top spray, 50 ℃ of dryings 1 hour.
3, get the micropill that the 50g drying is finished, place fluid bed, carry out dressing with the acrylic resin RS100 ethanolic solution of 4-5%, the air intake temperature control is about 40 ℃, and the material temperature control is about 35 ℃.
4, the micropill for preparing is filled in a capsule promptly gets the broadleaf holly leaf pellets capsule.

Claims (15)

1, bitter leaves tea alcohol extract and decocting liquid field of health care food antiobesity action.
2, a kind of preparation method who can be used for the broadleaf holly leaf pellets of lowering blood-fat and reducing weight.
3, the preparation method of the antiobesity action of bitter leaves tea according to claim 1 and a kind of broadleaf holly leaf pellets is characterized in that Folum Ilicis extract can be the concentrate of alcohol extract or the concentrate that extracts with decocting.
4, the preparation method of the antiobesity action of bitter leaves tea according to claim 1 and a kind of broadleaf holly leaf pellets, the pharmacodynamics data verification that it is characterized in that providing a large amount of the antiobesity action of bitter leaves tea.
5, the preparation method of the antiobesity action of bitter leaves tea according to claim 2 and a kind of broadleaf holly leaf pellets is characterized in that the preparation of broadleaf holly leaf pellets is operated as follows:
Get a certain amount of bitter leaves tea raw material, chopping is inserted in the alcoholic solution refluxing extraction 2 times or is extracted 2 times with decocting, merges extract and concentrates; Taking adhesive adds in a certain amount of alcoholic solution, stirs, and adds to extract concentrate, talcum powder, goes up fluid bed after the solution that stirs sieves, to the medicine-feeding of ball core, and dressing, control air intake temperature, material temperature.Drying is finished promptly behind the dressing.
6, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets is characterized in that Folum Ilicis extract accounts for 10%～80% of micropill gross weight.
7, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets is characterized in that medicinal fine pellet core accounts for 15～60% of micropill gross weight.
8, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets is characterized in that 5%～30% of binder constitutes micropill gross weight.
9, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets, the nozzle entrance air themperature that it is characterized in that spraying when fine pellet core added medicine to is 30～50 ℃, atomizing pressure is 0.1～0.5 megapascal (MPa), and the speed of peristaltic pump is 2～30rpm.
10, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets, when it is characterized in that micropill carries out dressing, the air intake temperature control is at 30-50 ℃, and the material temperature control is at 25-45 ℃.
11, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets, when it is characterized in that micropill carried out drying, baking temperature is 40～60 ℃, be 60～120 minutes drying time.
12, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets, it is characterized in that coating material is selected from acrylic resin, methylcellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl cellulose, titanium dioxide, gelatin, polyethylene glycol, glycerine, the mixture of one or more in the isopropyl alcohol.
13, the preparation method of the antiobesity action of bitter leaves tea according to claim 5 and a kind of broadleaf holly leaf pellets is characterized in that can preparing capsule, tablet, powder, granule etc. to the reprocessing of micropill.
14, the preparation method of the antiobesity action of bitter leaves tea according to claim 7 and a kind of broadleaf holly leaf pellets is characterized in that medicinal fine pellet core is selected from the microcrystalline cellulose ball heart, the sucrose ball heart, or both mixtures.
15, the preparation method of the antiobesity action of bitter leaves tea according to claim 8 and a kind of broadleaf holly leaf pellets is characterized in that adhesive is selected from one or more in PVP, sodium carboxymethylcellulose, sodium carboxymethyl starch, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, the microcrystalline cellulose.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579567A (en) * 2012-04-10 2012-07-18 广西壮族自治区中医药研究院 Medicine for treating diabetes and preparation method thereof
CN115067409A (en) * 2022-05-25 2022-09-20 贵州泰和现代生态农业科技有限公司 Application of lobular broadleaf holly leaf instant powder in preparation of lipid-lowering health-care food

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1466910A (en) * 2003-04-23 2004-01-14 冯文静 Bitter leaves tea series beverage and method for making same
CN100475194C (en) * 2004-01-13 2009-04-08 贵州益佰制药股份有限公司 Micropill of traditional Chinese medicine and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579567A (en) * 2012-04-10 2012-07-18 广西壮族自治区中医药研究院 Medicine for treating diabetes and preparation method thereof
CN115067409A (en) * 2022-05-25 2022-09-20 贵州泰和现代生态农业科技有限公司 Application of lobular broadleaf holly leaf instant powder in preparation of lipid-lowering health-care food

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