CN101085050A - Heat-clearing and toxin-removing preparation medicine and preparation method thereof - Google Patents
Heat-clearing and toxin-removing preparation medicine and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a preparation medicament for clearing away heat and toxic material and its preparation method. The preparation medicament is a classic Chinese medicinal preparation, and mainly has effects in clearing away heat and toxic material; and can be used for treating wine-heat type common cold, fever, swollen sore throat, better taste and dry throat, chogh, yellow phlegm, brown urine, obstipation, supurative tonsillitis, acute pharyngitis, acute bronchitis, and simple pneumonia. Conventional preparation with effects in clearing away heat and toxic material has incomplete drug absorption, low bioavailability, and slow therapeutic effect. The invention conjugate Taraxacum mongolicum, Polygonum cuspidatum, dahurian patrinia and Barbat Skullcap; has good effects in clearing away heat and toxic material; and is an effective medicine in treating wine-heat type common cold, fever, swollen sore throat, better taste and dry throat, chogh, yellow phlegm, brown urine, obstipation, supurative tonsillitis, acute pharyngitis, acute bronchitis, and simple pneumonia. The preparation is effective in treating simple pneumonia; and has a total effective rate of 91.00% for treating acute tonsillitis, and 94% for acute pharyngitis.
Description
Technical field:
The present invention relates to a kind of heat-clearing and toxic substances removing, cure mainly anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, yellowish urine constipation; Suppurative tonsillitis, acute pharyngitis, acute bronchitis, the medicine ' Reyanning ' of simple pneumonia the invention still further relates to the preparation method of this medicine.
Technical background:
The antipyretic-detoxicant preparation medicine is a kind of classical Chinese patent medicine, mainly contains the effect of heat-clearing and toxic substances removing, is used for anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, yellowish urine constipation; Suppurative tonsillitis, acute pharyngitis, acute bronchitis, simple pneumonia.But traditional antipyretic-detoxicant preparation drug absorption is incomplete, and bioavailability is not high, slow curative effect.
Summary of the invention:
The object of the present invention is to provide a kind of bioavailability height, absorb fully the antipyretic-detoxicant preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of antipyretic-detoxicant preparation medicine:
To achieve these goals, the present invention takes following technical scheme:
The antipyretic-detoxicant preparation medicine, make that described Chinese medicine raw materials of effective components is formed and weight proportion is:
Herba Taraxaci 335-710 part Rhizoma Polygoni Cuspidati 335-710 part
Sonchus brachyotus DC. 335-710 part Herba Scutellariae Barbatae 167.5-355 part.
Above-mentioned antipyretic-detoxicant preparation medicine, make that described Chinese medicine raw materials of effective components is formed and the optimum weight proportioning is:
372 parts of 372 parts of Rhizoma Polygoni Cuspidati of Herba Taraxaci
186 parts of 372 portions of Herba Scutellariae Barbataes of Sonchus brachyotus DC..
The preparation method of above-mentioned antipyretic-detoxicant preparation medicine is as follows:
(1), get Herba Taraxaci, Rhizoma Polygoni Cuspidati, Sonchus brachyotus DC., Herba Scutellariae Barbatae four Chinese medicine and clean,
(2), decoct with water secondary, add the water of 10 times of amounts for the first time, decocted 2 hours,
(3), for the second time add the water of 7 times of amounts, decocted 1 hour,
(4), filter, merging filtrate, filtrate decompression is concentrated into 1000ml,
(5), add stevioside 15g,
(6), ethyl hydroxybenzoate 1.5g, packing is promptly.
The preparation method of above-mentioned antipyretic-detoxicant preparation medicine, its described preparation dosage form is capsule, tablet, granule, soft capsule or oral liquid.
The antipyretic-detoxicant preparation medicine is the treatment anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, yellowish urine constipation, suppurative tonsillitis, acute pharyngitis, acute bronchitis, effective good medicine of diseases such as simple pneumonia; Total effective rate to acute tonsillitis is 91.00%; Total effective rate to acute pharyngitis is 94%.
The specific embodiment:
This product is made up of Herba Taraxaci, Rhizoma Polygoni Cuspidati, Sonchus brachyotus DC., Herba Scutellariae Barbatae four Chinese medicine.Effect with heat-clearing and toxic substances removing.Be used for anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, yellowish urine constipation; Suppurative tonsillitis, acute pharyngitis, acute bronchitis, simple pneumonia.
Anemopyretic cold, suppurative tonsillitis, acute pharyngitis, acute bronchitis, simple pneumonias etc. all are common clinical frequently-occurring diseases.Suppurative tonsillitis is equivalent to the traditional Chinese medical science " acute throat trouble ", " throat moth ", and card belongs to hyperactivity of toxic heat, suppuration, the onset endogenous cause of ill is an eating and drinking too much at one meal, or the product of the hot frying of surfeit, form stomach internal organs intrinsic heat, the heresy of its affection due to external wind and heat, strongly fragrant and puzzled, fire-transformation becomes poison, pents up pharyngeal tonsils, causes meridians to block, due to the coagulation of QI-blood, putrefaction of blood and muscle.Said just as " a Ling Shu Miraculous Pivot or Divine Axis carbuncle piece of writing ": " battalion defends and delays among passages through which vital energy circulates, then blood tears and not all right; Not all right then defend gas from and obstructed, stop up hold back and go, so hot; Big heat is more than; Then meat corruption of intenseness of heat; Rottenness of muscle forming pus ".The acute pharyngitis traditional Chinese medical science is referred to as acute pharyngitis due to wind-heat, wind heat larynx, red larynx, is its cardinal symptom bitterly with red swelling of the pharynx, and often because of weather sharply changes, daily life is careless, lung is defended and is lost admittedly, and is that wind-heat evil toxin is invaded in an opponent's defence, directly attacks throat from mouth and nose, internal injury is fought mutually and is not gone in lung, causes laryngopharynx swelling and pain and is sore throat.Acute bronchitis belongs to the Chinese medicine wind-warm lung-heat " category.Chinese medicine thinks, primary disease be the pathogenic wind-warm pathogenic factor attack outward show heat, cough, one lung such as expectorant defends resembling of (stomach) intenseness of heat; Pathogenic wind-warm is attacked outward, accumulation of phlegm-heat in the interior, lung defend (stomach) have heat be primary disease basic pathogenesis; Control suitable wind and heat dispersing, the detoxifcation of reducing phlegm.As seen, anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, the yellowish urine constipation, suppurative tonsillitis, acute pharyngitis, acute bronchitis, simple pneumonia is all due to the heresy of pyretic toxicity, and cautiously grasping pathogenesis is worked as in its treatment, takes the method for treatment of heat-clearing and toxic substances removing.
The antipyretic-detoxicant preparation medicine is just according to this rule of treatment method of treatment and prescription is the treatment anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, yellowish urine constipation, suppurative tonsillitis, acute pharyngitis, acute bronchitis, effective good medicine of diseases such as simple pneumonia.
The experimental study of single medicine in the antipyretic-detoxicant preparation medicine
1, theory of Chinese medical science
Herba Taraxaci bitter in the mouth, sweet is cold in nature in the side, returns liver, stomach warp, and heat-clearing and toxic substances removing is arranged, and the effect of eliminating carbuncle eliminating stagnation is good at the treatment lung abscess, cold, fever, and cough, diseases such as laryngopharynx swelling and pain, promptly putting down in writing it as " Amplification on Materia Medica addendum " can " the heat-transformation poison, disappear and dislike swollen tuberculosis outstanding service is arranged.Detoxicating food-poisoning, gas loose to stagnate ", " the southern regions of the Yunnan Province book on Chinese herbal medicine " calls it can " detoxifcation "; " occupying the diet spectrum " with breath put down in writing its energy " lung heat clearing, sharp diaphragm reduces phlegm, the eliminating stagnation eliminating carbuncle, yin nourishing, removing heat from blood, benefit is smart "; " Shandong Chinese medicine " says its " for detoxifcation, antiinflammatory, antipyretic ", " Chinese herbal medicine is used in Shanghai always " Yan Qike " heat-clearing and toxic substances removing ... the heating that cures cold, tonsillitis, acute pharyngolaryngitis, acute bronchitis ", the effect that can play heat-clearing and toxic substances removing that we use; be to establish for main disease is so be monarch drug.
Rhizoma Polygoni Cuspidati bitter in the mouth, acid, cold nature is returned liver, gallbladder meridian, promoting blood circulation to remove blood stasis is arranged, dispelling wind and removing obstruction in the collateral, clearing away heat-damp and promoting diuresis, the merit of detoxifcation, " property of medicine opinion " Yan Qineng " it is irritated to control big heat, quenches the thirst; diuresis; press all pyretic toxicity ", " the southern regions of the Yunnan Province book on Chinese herbal medicine " put down in writing it and can " be attacked all toxic swellings, only have sore throat ", Rhizoma Polygoni Cuspidati cooperates monarch drug to strengthen the effect of heat-clearing and toxic substances removing in the side, is to be ministerial drug.Sonchus brachyotus DC. acrid in the mouth, hardship, cold nature is returned stomach, large intestine, Liver Channel, be longer than the effect of heat-clearing and toxic substances removing, evacuation of pus, arrogate to oneself the disease of controlling lung abscess, carbuncle, " not Lu " Yan Qike " removes carbuncle ", " property of medicine is cut usefulness " says that it can " detoxifcation of purging heat ", and " Fujian medicine will " calling it can " heat-clearing and toxic substances removing.Cure mainly pharyngolaryngitis ", that uses in the side helps the merit of monarch-minister drug heat-clearing and toxic substances removing with assistant, with being adjuvant drug.
Herba Scutellariae Barbatae acrid in the mouth, hardship, cold in nature, return lung, liver, kidney channel, merit is longer than heat-clearing and toxic substances removing, and the dissipating blood stasis hemostasis cures mainly the pyretic toxicity carbuncle, have sore throat, diseases such as lung abscess are promptly put down in writing its energy " antiinflammatory; dissipating blood stasis " as " Guangxi medicinal plants figure will ", and " Nanning City's medicine will " calls it can " subside a swelling pain relieving ", " Jiangxi medical herbs " Yan Qineng " heat-clearing and toxic substances removing; reducing swelling and alleviating pain " helps the function of monarch-minister drug heat-clearing and toxic substances removing with assistant in that side and Herba Scutellariae Barbatae are shared, and shared is adjuvant drug.
Make a general survey of this side, the cautiously grasping pathogenesis key cooperates with four Chinese medicine things such as Herba Taraxaci, Rhizoma Polygoni Cuspidati, Sonchus brachyotus DC., Herba Scutellariae Barbataes, medicine is concentrated one's efforts grand, and the effect that full side plays heat-clearing and toxic substances removing altogether is the treatment anemopyretic cold, heating, laryngopharynx swelling and pain, bitter taste in the mouth and dry throat, cough expectorant Huang, the yellowish urine constipation, suppurative tonsillitis, acute pharyngitis, acute bronchitis, effective good medicine of diseases such as simple pneumonia.
2, laboratory research
(Taraxasteroal C30H500), anti-gold-coloured staphylococci, suppresses Bacillus typhi, bacillus pyocyaneus to have the effect of resisting pathogenic microbes, Herba Taraxaci mainly to contain sterol through the experimentation Herba Taraxaci.The function heat-clearing and toxic substances removing, detumescence is loose long-pending; TM did has certain bacteriostasis to staphylococcus aureus, colibacillus, bacillus pyocyaneus, shigella flexneri, candida albicans, the TM did minimal bactericidal concentration is to the Ultrastructural influence experiment of staphylococcus aureus, the visible cell wall obviously thickens, the nucleoid coagulation is streak in the Cytoplasm, the texture that wherein has increases thick ditch like brain and returns, the cell modification that has, the internal structure stricture of vagina disorderly, the cell membrane walls that has is broken, Cytoplasm exposes, intensive electronic shell appears in the ribosome place, and is gathered into bulk.
Herba Scutellariae Barbatae has the bacteriostatic effect, Herba Scutellariae Barbatae mainly contains high mountain baicalin (scutllarein), golden Fructus Vitis viniferae ball Seedling, shigella flexneri, Bacillus typhi, bacillus pyocyaneus, escherichia coli, streptococcus pneumoniae and virus all there is inhibitory action, kinds of tumors there is therapeutical effect, the function heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.The dull and stereotyped trench method of 50% Herba Scutellariae Barbatae decoct has inhibitory action to staphylococcus aureus, shigella flexneri, Bacillus typhi, bacillus pyocyaneus, escherichia coli.
Rhizoma Polygoni Cuspidati has antimicrobial effect: Rhizoma Polygoni Cuspidati mainly contains Polydatin (Poaoaydatin, C20H22083H20), gold-coloured staphylococci, micrococcus catarrhalis, streptococcus, Staphylococcus albus, escherichia coli, bacillus pyocyaneus, herpesvirus, dust Ke Shi virus, adenovirus etc. all there is higher inhibitory action, the function clearing away heat-damp and promoting diuresis, the relieving constipation detoxifcation, removing blood stasis and activating blood flow; Rhizoma Polygoni Cuspidati decoct and polidatin have inhibitory action to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, escherichia coli etc. in vivo.Emodin and emodin monoglucoside have inhibitory action to staphylococcus aureus and streptococcus pneumoniae.Antiviral effect is arranged, cultivate with human embryo kidney (HEK) simple epithelium cell tissue of former generation, Rhizoma Polygoni Cuspidati decocting liquid all has inhibitory action to herpes simplex virus etc.
Sonchus brachyotus DC. mainly contains α-Gu Yunxi (gurjunence), and influenza virus is had obvious inhibitory action, and staphylococcus, streptococcus are had intensive killing action, function heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt;
The antipyretic-detoxicant preparation medicine is to the pathological influence of acute pharyngitis rat model pharyngeal
| Group | Number of animals (only) | Dosage (g/kg) | Histopathological examination result (only) | |||
| + | ++ | +++ | ||||
| The blank group | 10 | DW | 10 | 0 | 0 | 0 .. |
| The pharyngitis model group | 10 | DW | 1 | 1 | 3 | 5 |
| The Yinqiao detoxification group | 10 | 8.0 | 3 | 4 | 2 | 1 .. |
| The antipyretic-detoxicant preparation medicine is low | 10 | 7.0 | 2 | 5 | 2 | 1 . |
| In | 10 | 14.0 | 3 | 5 | 1 | 1 .. |
| High | 10 | 28.0 | 5 | 4 | 1 | 0 .. |
Through the Ridit check, relatively the basic, normal, high dosage group of antipyretic-detoxicant preparation medicine rat circumference of eyes tissue pathologies change is remarkable with the pharyngitis model group, shows that the antipyretic-detoxicant preparation medicine has therapeutical effect preferably to the rat acute pharyngitis as seen from the above table.
Antipyretic-detoxicant preparation medicine xylol causes the influence of scorching mice auricle swelling
Method; Get 50 of ICR cleaning level mices, male and female half and half, body weight 22.6 ± 1.8g is divided into 5 groups at random, is respectively model control group, YINQIAO JIEDU KELI group, the basic, normal, high dosage group of antipyretic-detoxicant preparation medicine.Every Mus according to the form below dosage gastric infusion, every day 1 time, continuous 3d, behind the last administration 30min, be coated with dimethylbenzene 0.1ml/ in the mouse right ear two sides and only cause inflammation, left ear is not coated with as normal control, put to death animal behind the Ih, beat with the 9mm card punch and to get the same position of left and right sides ear disk, weigh, be calculated as follows the swelling degree.
Swelling degree auris dextra sheet weight-left auricle heavily the results are shown in following table:
| Group | Number of animals (only) | Dosage (g/kg) | Swelling degree (mg) |
| Model control group | 10 | DW | 8.54±1.27 |
| The Yinqiao detoxification group | 10 | 11.6 | 7.01±1.40 . |
| The antipyretic-detoxicant preparation medicine is low | 10 | 10.00 | 7.35±1.21 . |
| In | 10 | 20.00 | 7.04±1.45 . |
| High | 10 | 40.00 | 5.79±1.35 .. |
Specific embodiment 1:
The present invention makes described Chinese medicine raw materials of effective components composition and weight proportion is:
Herba Taraxaci 372g Rhizoma Polygoni Cuspidati 372g
Sonchus brachyotus DC. 372g Herba Scutellariae Barbatae 186g;
Specific embodiment 2:
The present invention makes described Chinese medicine raw materials of effective components composition and weight proportion is:
Herba Taraxaci 335g Rhizoma Polygoni Cuspidati 335g
Sonchus brachyotus DC. 335g Herba Scutellariae Barbatae 167.5g;
The preparation method of the specific embodiment of the invention 1,2 is as follows:
1, getting Herba Taraxaci, Rhizoma Polygoni Cuspidati, Sonchus brachyotus DC., Herba Scutellariae Barbatae four Chinese medicine cleans.
2, decoct with water secondary, add the water of 10 times of amounts for the first time, decocted 2 hours,
3, add the water of 7 times of amounts for the second time, decocted 1 hour,
4, filter, merging filtrate, filtrate decompression is concentrated into 1000ml,
5, add stevioside 15g,
6, ethyl hydroxybenzoate 1.5g, packing promptly.
Sum up with antipyretic-detoxicant preparation Drug therapy of the present invention acute upper respiratory tract infection 320 examples, the treatment group is used the antipyretic-detoxicant preparation medicine, and (Hu'nan Sanjiu Nankai Pharmaceutical Co., Ltd. produces, lot number: 20020116), every bag 16g (being equivalent to crude drug 13g), each 2 bags, boiled water is taken after mixing it with water, every day 3 times.Matched group use Yinqiao detoxification mixture (Chinese medicine limited company in Qingdao produces, lot number: 20011026), every bag 15g, each 2 bags, boiled water is taken after mixing it with water, every day 3 times.The course of treatment: common cold 3 days, acute pharyngitis 5 days, acute tonsillitis 7 days, all observe 1 course of treatment, in the observation process, do not use the medicine of other treatment acute upper respiratory tract infection, truly have the state of an illness need and use other, in the curative effect statistics, handle by invalid case at this clinical observation disease medicine person.
320 examples are organized in treatment, recovery from illness 117, and produce effects 102, effective 73, invalid 28, total effective rate 91.25%; Matched group 120, recovery from illness 30, produce effects 42, effective 34, invalid 14, total effective rate 88.33%; Compare with matched group (Ridit analyzes, u=2.176), and P＜0.05.Two groups of common cold therapeutic outcomes relatively, treatment group 120, recovery from illness 40, produce effects 41, effective 26, invalid 13, total effective rate 89.17%;
Matched group 40, recovery from illness 10, produce effects 14, effective 11, invalid 5, total effective rate 87.50%.Compare with matched group (Ridit analyzes, u=0.982), and P＞0.05.Two groups of acute tonsillitis therapeutic outcomes relatively, recovery from illness 36, produce effects 33, effective 22, invalid 9, total effective rate 91.00%.Matched group 40, recovery from illness 10, produce effects 12, effective 13, invalid 5, total effective rate 87.50%.Compare with matched group (Ridit analyzes, u=1.516), and P＞0.05.Two groups of acute pharyngitis therapeutic outcomes relatively, treatment group 100, recovery from illness 40, produce effects 26, effective 28, invalid 6, total effective rate 94.00%; Matched group 40, recovery from illness 10, produce effects 14, effective 11, invalid 5, total effective rate 87.50%.Compare with matched group (Ridit analyzes, u=1.421), and P＞0.05.Two groups bring down a fever and the pharyngalgia extinction time relatively, 236 examples of generating heat, treatment group heating extinction time (day) mean standard deviation is 1.49 ± 1.17 (P＜0.05), matched group 89 examples, the extinction time that generates heat (my god) mean standard deviation is 1.85 ± 1.25; Pharyngalgia 193 examples, treatment group heating extinction time (my god) mean standard deviation is 1.78 ± 1.46 (P＜0.01), matched group 60 examples, the pharyngalgia extinction time (my god) mean standard deviation is 2.18 ± 1.59.
Example: two groups of acute tonsillitis therapeutic outcomes and curative effect are relatively
| Group treatment group | n 100 | Recovery from illness 36 | Produce effects 33 | Effective 22 | Invalid 9 | Total effective rate % 91.00 |
| Matched group | 40 | 10 | 12 | 13 | 5 | 87.50 |
Annotate: compare with matched group (Ridit analyzes, U=1.516,
*P＞0.05
Example: two groups of acute pharyngitis therapeutic outcomes and curative effect are relatively
| Group treatment group | n 100 | Recovery from illness 40 | Produce effects 26 | Effective 28 | Invalid 6 | Total effective rate % 94.00 |
| Matched group | 40 | 10 | 14 | 11 | 5 | 87.50 |
Annotate: relatively (Ridit analyzes, U=1.421, * P＞0.05 with matched group.
Claims (4)
1, antipyretic-detoxicant preparation medicine is characterized in that making that described Chinese medicine raw materials of effective components is formed and weight proportion is:
Herba Taraxaci 335-710g Rhizoma Polygoni Cuspidati 335-710g
Sonchus brachyotus DC. 335-710g Herba Scutellariae Barbatae 167.5-355g.
2, antipyretic-detoxicant preparation medicine according to claim 1 is characterized in that: making described Chinese medicine raw materials of effective components composition and optimum weight proportioning thereof is:
Herba Taraxaci 372g Rhizoma Polygoni Cuspidati 372g
Sonchus brachyotus DC. 372g Herba Scutellariae Barbatae 186g.
3, the preparation method of antipyretic-detoxicant preparation medicine according to claim 1 and 2 is characterized in that:
(1), get Herba Taraxaci, Rhizoma Polygoni Cuspidati, Sonchus brachyotus DC., Herba Scutellariae Barbatae four Chinese medicine and clean,
(2), decoct with water secondary, add the water of 10 times of amounts for the first time, decocted 2 hours,
(3), for the second time add the water of 7 times of amounts, decocted 1 hour,
(4), filter, merging filtrate, filtrate decompression is concentrated into 1000ml,
(5), add stevioside 15g,
(6), ethyl hydroxybenzoate 1.5g, packing is promptly.
4, the preparation method of antipyretic-detoxicant preparation medicine according to claim 3 is characterized in that: described preparation dosage form is capsule, tablet, granule, soft capsule or oral liquid.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626511A (en) * | 2012-03-31 | 2012-08-08 | 韩萍 | Drug composition used for relieving cough and eliminating phlegm |
| CN103535828A (en) * | 2013-10-23 | 2014-01-29 | 南通惠然生物科技有限公司 | Heat clearing drink formula |
| CN105687535A (en) * | 2016-03-10 | 2016-06-22 | 广西大学 | Film-coated tablets and preparation method thereof |
| CN106620449A (en) * | 2016-12-26 | 2017-05-10 | 陈福生 | Cough-relieving medicine with special effects |
| CN111084836A (en) * | 2019-12-17 | 2020-05-01 | 清华德人西安幸福制药有限公司 | Application of combination of thermionic acid and antibiotics in intervention of antibacterial action against pathogenic bacteria |
| WO2024040799A1 (en) * | 2022-08-24 | 2024-02-29 | 清华德人西安幸福制药有限公司 | Use of reyanning in preparation of drug for treating sars-cov-2 asymptomatic or mild infection in children or adolescents |
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2007
- 2007-07-03 CN CN 200710018187 patent/CN101085050A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626511A (en) * | 2012-03-31 | 2012-08-08 | 韩萍 | Drug composition used for relieving cough and eliminating phlegm |
| CN103535828A (en) * | 2013-10-23 | 2014-01-29 | 南通惠然生物科技有限公司 | Heat clearing drink formula |
| CN105687535A (en) * | 2016-03-10 | 2016-06-22 | 广西大学 | Film-coated tablets and preparation method thereof |
| CN106620449A (en) * | 2016-12-26 | 2017-05-10 | 陈福生 | Cough-relieving medicine with special effects |
| CN111084836A (en) * | 2019-12-17 | 2020-05-01 | 清华德人西安幸福制药有限公司 | Application of combination of thermionic acid and antibiotics in intervention of antibacterial action against pathogenic bacteria |
| CN111084836B (en) * | 2019-12-17 | 2021-12-10 | 清华德人西安幸福制药有限公司 | Application of combination of thermionic acid and antibiotics in intervention of antibacterial action against pathogenic bacteria |
| WO2024040799A1 (en) * | 2022-08-24 | 2024-02-29 | 清华德人西安幸福制药有限公司 | Use of reyanning in preparation of drug for treating sars-cov-2 asymptomatic or mild infection in children or adolescents |
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Open date: 20071212 |