CN101810675A - Medicament for treating pharyngitis - Google Patents
Medicament for treating pharyngitis Download PDFInfo
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- CN101810675A CN101810675A CN201010171142A CN201010171142A CN101810675A CN 101810675 A CN101810675 A CN 101810675A CN 201010171142 A CN201010171142 A CN 201010171142A CN 201010171142 A CN201010171142 A CN 201010171142A CN 101810675 A CN101810675 A CN 101810675A
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Abstract
The invention relates to a medicament for treating pharyngitis, which is prepared from the following medicaments in part by weight: 1 to 3 parts of dregea sinensis, 1 to 2 parts of baical skullcap root, 1 to 2 parts of common alstonia leaf and 0.5 to 1 part of liquoric root. The medicament has reasonable compatibility, acute toxicity tests prove that the medicament has no toxic response, safe and reliable curative effects, good formulations and mouthfeel, and effects of improving local curative effect because of buccal administration, clearing heat and detoxifying, relieving sore throat and downbearing counterflow, and relieving cough and reducing sputum. The clinical curative effect observation and acute toxicity research prove that the medicament has the advantages of no toxic or side responses, and safe and reliable curative effects and is suitable for preventing and treating diseases such as acute and chronic pharyngitis, stomatitis, gingivitis, toothache due to wind-fire evil and allergic cough.
Description
Technical field
The invention provides a kind of preparation technology who is used for the treatment of pharmaceutical formulation and this medicine thereof of acute and chronic pharyngitis, stomatitis.
Background technology
Acute/chronic pharyngitis, stomatitis, gingivitis, acute toothache, anaphylaxis cough illness are clinical common and multiple diseases.Though this class disease is not a serious disease, brings very big misery to the patient, and often is the topical manifestations of general disease or is the prodrome of acute infectious disease and paathogenic factor that therefore, effectively treatment, prevention can be contained its generation relevant and seriously disease.At present, for this class treatment of diseases, all develop the medicine and the buccal tablet of the treatment prevention of having gone on the market many both at home and abroad, as JINSANGZIHOUBAO, watermelon crystal buccal tablet, Cydiodine buccal tablet, four seasons throat lozenge, Herba Pileae Scriptae Tabellae, Fructus Phyllanthi buccal tablet etc., what have also has certain therapeutic effect, but there is safe and reliable relatively poor problem in the prescription that has, and what have also has than big toxic and side effects, the DeGrain that has.
Summary of the invention
The objective of the invention is to propose a kind of heat-clearing and toxic substances removing, the sore-throat relieving sending down the abnormal ascending QI is the medicine of main medicinal ingredient treatment pharyngitis with Dai Nationality's medicine.
The medicine of this treatment pharyngitis that the present invention proposes, make by the medical material of following weight parts:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Radix Scutellariae 1-2, Folium Alstoniae Scholaris 1-2, Radix Glycyrrhizae 0.5-1.
In the above-mentioned prescription, cold in nature, the bitter in the mouth of Radix Ilicis Asprellae (produced by Dai nationality) is gone into fire, wind tower, has heat-clearing and toxic substances removing, and the merit of relieving sore throat and pain is principal agent; Radix Scutellariae, Folium Alstoniae Scholaris is cold in nature, bitter in the mouth, inlet air, fire, water tower have heat-clearing and toxic substances removing, relieving cough and resolving phlegm, the function of smooth throat to stop cough helps principal agent to heighten the effect of a treatment, and is adjuvant; The existing heat-clearing and toxic substances removing of Radix Glycyrrhizae, the merit of relieving cough and resolving phlegm, can suppress again the bitter cold of Radix Ilicis Asprellae (produced by Dai nationality), Radix Scutellariae, Folium Alstoniae Scholaris property, can also coordinating the actions of various ingredients in a prescription, make it heat-clearing and toxic substances removing and cold, amount to heat-clearing and toxic substances removing, smooth throat to stop cough, the purpose of lowering the adverse-rising QI to resolve phlegm.
On the basis of above-mentioned prescription, can add Caulis seu Radix Derridis eriocarpae according to the state of an illness is required, this property of medicine cold, it is sweet to distinguish the flavor of, inlet air, fire, water tower.Have heat-clearing and toxic substances removing, moistening the lung and resolving phlegm, the merit of reducing swelling and alleviating pain is longer than the treatment dryness of the lung deficiency of YIN, cough spitting of blood or dry cough without phlegm, the disease that chronic cough is not healed.
On the basis of above-mentioned two prescriptions, also can add Herba Scopariae according to disease, this property of medicine cold, it is sweet to distinguish the flavor of, entry, Feng Ta have heat-clearing and toxic substances removing, the merit of preventing phlegm from forming and stopping coughing, speciality is in relieving cough and resolving phlegm, for cough with copious phlegm, chronic cough more the person be first-selection, therefore, add Herba Scopariae, can strengthen the power of our relieving cough and resolving phlegm.
The present invention is based on the theoretical Therapeutic Principle of the doctor of Dai Nationality detoxifcation in the Chinese medicine, has carried out plus-minus and science compatibility under the doctor of Dai Nationality detoxifcation theoretical direction, in conjunction with the modern pharmaceutical technology powder is developed into buccal tablet.The integrally-regulated characteristics that combine with topical therapeutic of the doctor of the Dai Nationality have been demonstrated fully.Make it both have a Dai Nationality doctor traditional characteristics, modern preparation characteristic is arranged again.Medicine compatibility provided by the invention is reasonable, anxious malicious evidence non-toxic reaction, and curative effect is safe and reliable, the dosage form good mouthfeel, it is tasty and refreshing that taste is fresh and sweet, and buccal has strengthened local curative effect, and cost is low, old young taking convenience has heat-clearing and toxic substances removing, the function of sore-throat relieving sending down the abnormal ascending QI, relieving cough and resolving phlegm.
Studies have shown that through clinical observation on the therapeutic effect and anxious poison do not find toxicity, curative effect is safe and reliable, be applicable to control acute/chronic pharyngitis, stomatitis, gingivitis, acute toothache, anaphylaxis cough with asthma disease, have the good development prospect and the market competitiveness.
Warp has carried out the clinical observation of taking to 102 acute pharyngitises, produce effects 67 examples, effective 26 examples, invalid 9 examples, and total effective rate is 91.1%; 108 examples of coughing, produce effects 86 examples, effective 12 examples, invalid 10 examples, total effective rate is 90.7%.
The specific embodiment
Embodiment 1, a kind of medicine for the treatment of pharyngitis, make by following raw medicaments in portion by weight:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Radix Scutellariae 1-2, Folium Alstoniae Scholaris 1-2, Radix Glycyrrhizae 0.5-1.
Step of preparation process is as follows: get Radix Ilicis Asprellae (produced by Dai nationality), Folium Alstoniae Scholaris, Radix Scutellariae and Radix Glycyrrhizae by prescription, extract at twice, the decocting that at every turn is incorporated in 10 times of amounts of medical material boils, and picks up counting with the medicinal liquid boiling, extracts 1.5 hours at every turn.Incline and decoction liquor, merge, filter, when gained filtrate is concentrated into relative density 1.3, with adjuvants such as extractum and non-dairy creamer, stevioside, silicon dioxide, Mentholum, magnesium stearate, press the mixed of extract powder weight respectively, be statically placed in more than the hermetic container 2h, treat that Mentholum volatilizees fully and tabletting behind other material mixing, film coating, aluminum-plastic packaged, 12/plate of specification, promptly.
Embodiment 2, a kind of medicine for the treatment of pharyngitis, make by following raw medicaments in portion by weight:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Folium Alstoniae Scholaris 1-2, Radix Scutellariae 1-2, Caulis seu Radix Derridis eriocarpae 1-3, Radix Glycyrrhizae 0.5-1.
Step of preparation process is as follows: get Radix Ilicis Asprellae (produced by Dai nationality), Folium Alstoniae Scholaris, Radix Scutellariae, Caulis seu Radix Derridis eriocarpae and Radix Glycyrrhizae by prescription, extract at twice, the decocting that at every turn is incorporated in 10 times of amounts of medical material boils, and picks up counting with the medicinal liquid boiling, extracts 1.5 hours at every turn.Incline and decoction liquor, merge, filter, when gained filtrate is concentrated into relative density 1.3, with adjuvants such as extractum and non-dairy creamer, stevioside, silicon dioxide, Mentholum, magnesium stearate, press the mixed of extract powder weight respectively, be statically placed in more than the hermetic container 2h, treat that Mentholum volatilizees fully and tabletting behind other material mixing, film coating, aluminum-plastic packaged, 12/plate of specification, promptly.
Embodiment 3, a kind of medicine for the treatment of pharyngitis, make by following raw medicaments in portion by weight:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Radix Scutellariae 1-2, Folium Alstoniae Scholaris 1-2, Caulis seu Radix Derridis eriocarpae 1-3, Herba Scopariae 1-3, Radix Glycyrrhizae 0.5-1.
Step of preparation process is as follows: get Radix Ilicis Asprellae (produced by Dai nationality), Radix Scutellariae, Folium Alstoniae Scholaris, Caulis seu Radix Derridis eriocarpae, Herba Scopariae and Radix Glycyrrhizae by prescription, extract at twice, the decocting that at every turn is incorporated in 10 times of amounts of medical material boils, and picks up counting with the medicinal liquid boiling, extracts 1.5 hours at every turn.Incline and decoction liquor, merge, filter, when gained filtrate is concentrated into relative density 1.3, with adjuvants such as extractum and non-dairy creamer, stevioside, silicon dioxide, Mentholum, magnesium stearate, press the mixed of extract powder weight respectively, be statically placed in more than the hermetic container 2h, treat that Mentholum volatilizees fully and tabletting behind other material mixing, film coating, aluminum-plastic packaged, 12/plate of specification, promptly.
The medicine that above-mentioned three embodiment of foundation make confirms that by acute toxicity test curative effect is safe and reliable, and result of the test is as follows:
One, experiment purpose: the acute toxic reaction of observing the mice oral drugs;
Experiment material: (1) this medicine provides (2) animal by doctor hospital of state, Xishuangbanna Dai Nationality: 30 of Kunming mouses, and 20 ± 2g, male and female half and half are provided by Chinese Academy of Sciences Kunming animal.The quality certification number: No. the 9712nd, the real moving card in Yunnan.
Experimental technique: get this product 1.97 crude drug g/ sheets, consumption is made into the medicinal liquid of 1.18 crude drug g/ml and uses for experiment with distilled water; 1, LD
50Measure: get 10 of healthy mices, once irritate stomach through giving 1.18 crude drug g/ml (Cmax), 0.8ml/20g (maximum volume) observes mice toxic reaction and death condition, and the result does not see dead mouse and toxic reaction.
The mensuration of maximum tolerated dose: get 20 of healthy mices, male and female half and half divided 3 filling stomaches to give mice through giving this product medicine 0.8ml/20g of 1.18 crude drug g/ml in one day, and the accumulative total dosage reaches 141.6g crude drug/Kg, observed 7, the result does not see that dead and other toxic reactions appear in mice.20 all healthy survivals of mice.
Experimental result: this product is to mice LD
50Can't obtain, maximum tolerated dose is not less than and is 141.6g/Kg, proves that the oral safety of this product is higher.
Two, this medicine bacteriostatic test is good, and the result is as follows:
Experiment material: (1) this medicine is provided by doctor hospital of state, Xishuangbanna Dai Nationality: (2) strain: staphylococcus aureus (26001), streptococcus pneumoniae (31001), Jia Xingrongxuexinglianqiujun (32205), beta hemolytic streptococcus (32210), Escherichia coli (055) provides by Beijing biological products assay institute, and unming Medical College's microbiology and immunology teaching and research room preserve; (3) culture medium: Nutrient agar, nutrient broth, calf serum are provided by Shanghai Vaccine and Serum Institute, and fresh sheep blood is provided by animal section of unming Medical College.
Experimental technique and result:
1, method; (1) preparation of medicine: it is standby that 10 in tablet is added physiological saline solution soaked overnight dissolving back, and every ml soaking medicated liquid is a crude drug in whole concentration, and its crude drug content is 1.97 crude drug g/ml.(2) preparation of strain: respectively with above-mentioned bacterial classification inoculation in serum broth pipe and meat soup pipe 37 ℃ cultivate after 18 hours with McFar LandShi turbidity standard pipe than turbid be that the antibacterial liquid of 300,000,000/ml is standby.(3) adopt tube dilution method, after adding aseptic culture fluid, medicine stock solution and test organisms liquid are operated by each dilution factor, after 37 ℃ of cultivations in 18 hours, each managed liquid transferred species blood plate after 18 hours, observed result, and this product is respectively the MIC of each bacterium: staphylococcus aureus 0.015g/ml, streptococcus pneumoniae 0.123g/ml, Jia Xingrongxuexinglianqiujun 0.0615g/ml, beta hemolytic streptococcus 0.123g/ml, Escherichia coli 0.492g/ml.Fungistatic effect is in various degree all arranged.
Claims (6)
1. medicine for the treatment of pharyngitis is characterized in that being made by the medical material of following weight parts:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Radix Scutellariae 1-2, Folium Alstoniae Scholaris 1-2, Radix Glycyrrhizae 0.5-1.
2. a kind of preparation technology who treats the medicine of pharyngitis according to claim 1 is characterized in that step is as follows:
Get Radix Ilicis Asprellae (produced by Dai nationality), Folium Alstoniae Scholaris, Radix Scutellariae and Radix Glycyrrhizae, adding decocting in water carries twice, the decocting that at every turn is incorporated in 10 times of amounts of medical material boils, pick up counting with the medicinal liquid boiling, extracted 1.5 hours at every turn, inclining decoction liquor, merge, filter, gained filtrate is concentrated into relative density 1.3, gets extractum, pulverize, with extract powder and pharmaceutic adjuvant non-dairy creamer, stevioside, silicon dioxide, Mentholum and magnesium stearate are pressed the mixed of extract powder weight respectively, are statically placed in hermetic container 2h at least, treat that Mentholum volatilizees fully and tabletting behind other material mixing, film coating, 12/plate of aluminum-plastic packaged one-tenth specification, promptly.
3. medicine for the treatment of pharyngitis is characterized in that being made by the medical material of following weight parts:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Folium Alstoniae Scholaris 1-2, Radix Scutellariae 1-2, Caulis seu Radix Derridis eriocarpae 1-3, Radix Glycyrrhizae 0.5-1.
4. a kind of preparation technology who treats the medicine of pharyngitis according to claim 3 is characterized in that step is as follows:
Get Radix Ilicis Asprellae (produced by Dai nationality), Folium Alstoniae Scholaris, Radix Scutellariae, Caulis seu Radix Derridis eriocarpae and Radix Glycyrrhizae, add decocting in water and carry twice, the decocting that at every turn is incorporated in 10 times of amounts of medical material boils, and picks up counting with the medicinal liquid boiling, extracts 1.5 hours at every turn.Inclining decoction liquor, merges, and filters, gained filtrate is concentrated into relative density 1.3, extractum, pulverize, with extract powder and pharmaceutic adjuvant non-dairy creamer, stevioside, silicon dioxide, Mentholum, magnesium stearate, press the mixed of extract powder weight respectively, be statically placed in hermetic container 2h at least, treat Mentholum volatilization tabletting fully and behind other material mixing, film coating, 12/plate of aluminum-plastic packaged one-tenth specification, promptly.
5. medicine for the treatment of pharyngitis is characterized in that being made by the medical material of following weight parts:
Radix Ilicis Asprellae (produced by Dai nationality) 1-3, Radix Scutellariae 1-2, Folium Alstoniae Scholaris 1-2, Caulis seu Radix Derridis eriocarpae 1-3, Herba Scopariae 1-3, Radix Glycyrrhizae 0.5-1.
6. a kind of preparation technology who treats the medicine of pharyngitis according to claim 5 is characterized in that step is as follows:
Get Radix Ilicis Asprellae (produced by Dai nationality), Radix Scutellariae, Folium Alstoniae Scholaris, Caulis seu Radix Derridis eriocarpae, Herba Scopariae and Radix Glycyrrhizae, add decocting in water and carry twice, the decocting that at every turn is incorporated in 10 times of amounts of medical material boils, and picks up counting with the medicinal liquid boiling, extracts 1.5 hours at every turn.Inclining decoction liquor, merges, and filters, gained filtrate is concentrated into relative density 1.3, get extractum, pulverize, extract powder and pharmaceutic adjuvant non-dairy creamer, stevioside, silicon dioxide, Mentholum and magnesium stearate, press the mixed of extract powder weight respectively, be statically placed in more than the hermetic container 2h, treat Mentholum volatilization tabletting fully and behind other material mixing, film coating, 12/plate of aluminum-plastic packaged one-tenth specification, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010171142A CN101810675A (en) | 2010-05-13 | 2010-05-13 | Medicament for treating pharyngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010171142A CN101810675A (en) | 2010-05-13 | 2010-05-13 | Medicament for treating pharyngitis |
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| Publication Number | Publication Date |
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| CN101810675A true CN101810675A (en) | 2010-08-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010171142A Pending CN101810675A (en) | 2010-05-13 | 2010-05-13 | Medicament for treating pharyngitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230464A (en) * | 2013-05-06 | 2013-08-07 | 西双版纳傣族自治州民族医药研究所 | Dai medical mixture for treating cough |
| CN103990061A (en) * | 2014-04-21 | 2014-08-20 | 史家举 | Traditional Chinese medicine composition for treating cough with lung heat |
-
2010
- 2010-05-13 CN CN201010171142A patent/CN101810675A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230464A (en) * | 2013-05-06 | 2013-08-07 | 西双版纳傣族自治州民族医药研究所 | Dai medical mixture for treating cough |
| CN103230464B (en) * | 2013-05-06 | 2014-11-05 | 西双版纳傣族自治州民族医药研究所 | Dai medical mixture for treating cough |
| CN103990061A (en) * | 2014-04-21 | 2014-08-20 | 史家举 | Traditional Chinese medicine composition for treating cough with lung heat |
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Application publication date: 20100825 |