CN101081194A - Radioactive medical solution synthesizer and the using method thereof - Google Patents
Radioactive medical solution synthesizer and the using method thereof Download PDFInfo
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- CN101081194A CN101081194A CNA2007101081504A CN200710108150A CN101081194A CN 101081194 A CN101081194 A CN 101081194A CN A2007101081504 A CNA2007101081504 A CN A2007101081504A CN 200710108150 A CN200710108150 A CN 200710108150A CN 101081194 A CN101081194 A CN 101081194A
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- A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
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Abstract
The invention provides an operation method of radioactive liquor synthesizer, which can keep the radiant quantity of radioactive liquor to operating crew at lower level and can effectively synthesize the radioactive liquor. The radioactive liquor synthesizer comprises target recovery ampoule (15) for holding target liquor containing radioactive isotope; reaction ampoule (16) for synthesizing radioactive liquor using target liquor; replace module (12) with pipe run (19), wherein the pipe run (19) is equipped with a first pipeline (discharge pipeline)(L4) for connecting target recovery ampoule (15) and reaction ampoule (16), intake pipeline (L5), recover pipeline (L6), connecting pipeline (L10) and a first versatile pipeline (L7); and fixing setting module (14) to disassembly the said replace module (12). The cleaning fluid is leaded into reaction ampoule (16) after discharging the radioactive liquor by the first pipeline. After completing cleaning in the reaction ampoule (16), the cleaning fluid is discharged from reaction ampoule (16).
Description
Technical field
The present invention relates to the using method and the radioactivity medicinal liquid synthesizer of radioactivity medicinal liquid synthesizer.
Background technology
People have developed a kind of nuclear medicine diagnostic method, its radioactivity medicinal liquid that will contain the chemical compound of useful radionuclide (RI) sign drops in the body, and adopt special-purpose device to take this mark compounds accumulative form of specific part in vivo, carry out the diagnosis of disease etc. thus.In this diagnostic method, with short radionuclide of life-span (for example, discharge nucleic as positron,
18F has 110 minutes half-life) sign
18F-FDG (fluorodeoxyglucose) etc. can be used as the radioactivity medicinal liquid and use.
The device of synthetic such radioactivity medicinal liquid for example has been disclosed in the patent documentation 1.This synthesizer has and will fixedly install the disposable module that module and a plurality of pipeline are fixed on the substrate and form.In this synthesizer, behind 1 end of synthesis, just disposable module is replaced by new module, in order to synthetic use next time.
At this, synthesizing in the radiological protection plate of radioactivity medicinal liquid only carried out 1 time in one day, in the next day that residual activity is fully reduced, opened the radiological protection plate, carried out the replacing of disposable module.
In recent years, required one day can carry out the synthetic of several to such synthesizer.But, after the synthesizing radioactive medicinal liquid, open the radiological protection plate immediately, the replacing of carrying out disposable module might make the level of residual activity higher, thus the suffered amount of radiation of operator raises.In addition, consider, preferably seek effective utilization of disposable module from the angle of environmental conservation and the synthetic cost of reduction.
Patent documentation 1: special table 2004-515330 communique
Summary of the invention
The present invention finishes in view of above-mentioned situation, purpose is to provide a kind of using method and radioactivity medicinal liquid synthesizer of radioactivity medicinal liquid synthesizer, it maintains lower level with the radioactivity medicinal liquid to operator's amount of radiation, can carry out the synthetic of radioactivity medicinal liquid simultaneously again effectively.
The present invention relates to a kind of using method of radioactivity medicinal liquid synthesizer, this radioactivity medicinal liquid synthesizer comprises: target solution accommodating container is used to take in and contains radioisotopic target solution; Reaction vessel uses target solution to carry out the synthetic of radioactivity medicinal liquid; Change module, it has piping installation, and this piping installation is equipped with the 1st pipeline that connects target solution accommodating container and reaction vessel on substrate; And fixedly install module, in mode that can the dismounting and change module and be provided with; It is characterized in that: import cleaning mixture in the reaction vessel after being discharged from by the 1st pipeline radiotropism medicinal liquid, after the washing in reaction vessel is finished, from reaction vessel, discharge cleaning mixture.In addition, after the washing of reaction vessel is finished, change module and need not change just and can utilize once more, to carry out the synthetic of radioactivity medicinal liquid.
In addition, the present invention relates to a kind of radioactivity medicinal liquid synthesizer, it comprises: target solution accommodating container is used to take in and contains radioisotopic target solution; Reaction vessel uses target solution to carry out the synthetic of radioactivity medicinal liquid; Change module, it has piping installation, and this piping installation is equipped with the 1st pipeline that connects target solution accommodating container and reaction vessel on substrate; And fixedly install module, in mode that can the dismounting and change module and be provided with; It is characterized in that: import cleaning mixture in the reaction vessel after being discharged from by the 1st pipeline radiotropism medicinal liquid, after washing in reaction vessel is finished, from reaction vessel, discharge cleaning mixture, change module and need not change just and can utilize once more, to supply with next time synthetic.
In this method and device, in reaction vessel, import cleaning mixture by the 1st pipeline, just can wash the 1st pipeline and reaction vessel thus, thereby can use the replacing module repeatedly, can seek the reduction of synthetic cost, aspect cost, can carry out the synthetic of radioactivity medicinal liquid effectively.In addition, in particularly can the wash residual radioactive level high reaction vessel, so can under the low state of residual activity level, be used for next synthetic reagent and change and change the replacing of module, thereby the amount of radiation to operator can be maintained lower level.In addition, owing to need not wait until that just can to transfer to next time when the residual activity level is fully low synthetic, so at synthesizing radioactive medicinal liquid effectively aspect the time.
The present invention is preferably: import cleaning mixture in the target solution accommodating container after target solution is discharged from, import cleaning mixture by the 1st pipeline to reaction vessel from target solution accommodating container again.So, both can wash target solution accommodating container, simultaneously also can wash the 1st pipeline from cardinal extremity, thereby can improve repeatedly to use and change module and the quality of synthetic radioactivity medicinal liquid, be suppressed at lower level by amount of radiation in the time of replacing can also being used for next synthetic reagent simultaneously and changing module.
The present invention is preferably: piping installation has and is used for discharging synthetic radioactivity medicinal liquid and being installed in the 2nd pipeline on the substrate from reaction vessel; Discharge from the cleaning mixture of reaction vessel is undertaken by the 2nd pipeline.So, both can wash the 2nd pipeline, and also can improve repeatedly and to use the quality of changing the synthetic radioactivity medicinal liquid of module institute, can also effectively utilize the 2nd pipeline complicated with the inhibition pipe arrangement simultaneously.
The present invention is preferably: boiling washing liquid in reaction vessel.So, can improve the interior clean result of reaction vessel.
According to the present invention, a kind of using method and radioactivity medicinal liquid synthesizer of radioactivity medicinal liquid synthesizer can be provided, it maintains lower level with the radioactivity medicinal liquid to operator's amount of radiation, can carry out the synthetic of radioactivity medicinal liquid simultaneously again effectively.
Description of drawings
Fig. 1 is the axonometric chart of formation of the radioactivity medicinal liquid synthesizer of expression the present embodiment.
Fig. 2 is the front view of formation of the replacing module that synthesizer had of presentation graphs 1.
Fig. 3 represents is in changing module, constitute the 1st pipeline and the pipeline by target water and constitute the 2nd pipeline and by the pipeline of synthetic radioactivity medicinal liquid.
Symbol description:
10 radioactivity medicinal liquid synthesizers
12 change module
14 fixedly install module
15 targets reclaim bottle
16 reaction bottles
18 plates
19 piping installations
32 main parts
34 portions
The L1-L17 pipeline
The specific embodiment
Describe with regard to embodiment of the present invention with reference to the accompanying drawings.In addition, in the following description, same parts is used identical symbol, and the repetitive description thereof will be omitted at this.In addition, in the present embodiment, just synthetic
18F-FDG (fluorodeoxyglucose) describes as the situation of radioactivity medicinal liquid.
Fig. 1 is the axonometric chart of formation of the radioactivity medicinal liquid synthesizer of expression the present embodiment.In addition, Fig. 2 is the front view of formation of the replacing module that synthesizer had of presentation graphs 1.As Fig. 1 and shown in Figure 2, synthesizer 10 has the module of replacing 12 and fixedly installs module 14.
Changing module 12 has: target reclaims bottle (target solution accommodating container) 15; Reaction bottle (reaction vessel) 16; Be used to flow through fluidic piping installation 19, this piping installation 19 is located many pipeline L1-L15 and be supported on the plate (substrate) 18.Many pipeline L1-L15 are formed by silicone pipe etc.
The terminal part of this discharge pipe L4 is connected the centre that imports pipeline L5, wherein imports pipeline L5 and is used to import potassium carbonate (K
2CO
3) solution and kryptofix 222 (K222: solution amino-polyether).The base end part of this importing pipeline L5 with taking in K
2CO
3The 1st reagent bottle V1 of solution and K222 solution connects, the terminal part that imports pipeline L5 be used to catch
18One end of the ionic anion exchange resin box 20 of F connects.And the other end of this anion exchange resin box 20 be used for reclaiming
18The recovery line L6 of the target water after the F ion is hunted down connects.In addition, this anion exchange resin box 20 is whenever just changed for synthetic 1 time, owing to be not included in the replacing module 12 of the present embodiment, so with dashed lines is represented among the figure.But if the formation that can use repeatedly with cleaning mixture washing described later, then anion exchange resin box 20 also can be included in and change in the module 12.
The 1st multipurpose pipeline L7 is connected by connecting line L10 with recovery line L6.And, connecting the importing pipeline L11 that is used to import acetonitrile in the centre of this connecting line L10.In addition, the acetonitrile that imports from the 2nd reagent bottle V2 by this importing pipeline L11 is used to make the flow of solution in the pipeline.
In addition, on the 1st multipurpose pipeline L7, between the junction point of the branch point of the 2nd multipurpose pipeline L8 and connecting line L10, connecting importing pipeline L12, be used for importing at the dissolved mannose triflate of acetonitrile (mannose triflate) from the 3rd reagent bottle V3.
In addition, the centre from the 2nd multipurpose pipeline L8 branches out tapping line L15, is used to discharge synthetic radioactivity medicinal liquid.And in the centre of this tapping line L15, connecting water and importing pipeline L13, be used for importing in the reaction bottle 16 with in reaction bottle 16, discharging the employed water of radioactivity medicinal liquid.The base end part that water imports pipeline L13 is connected with the 4th reagent bottle V4 that is for example storing 5cc left and right sides water.And, connecting importing pipeline L14 in the centre of this water importing pipeline L13, be used for importing sodium hydroxide solution to be hydrolyzed from the 5th reagent bottle V5.
Moreover, at the upstream side of the 1st reagent bottle V1, be provided with cleaning mixture bottle V6, wherein storing as the water about the 21cc of cleaning mixture.And the 1st reagent bottle V1 and cleaning mixture bottle V6 adopt cleaning mixture to import pipeline L17 to be connected with control valve.
The plate 18 of piping installation is for example formed orthogonal tabular by resin materials such as polypropylene, by a plurality of claws 26 many above-mentioned pipeline L1-L15 are located and be supported on preposition.In the precalculated position of this plate 18, and piston described later 28 between, be provided with and be used to press the backboard 13 of pipeline L1-L15 of collapsing.
Fixedly installing module 14 is members that profile is roughly cubic, has main part 32 and door portion 34.At the front surface of main part 32, be provided with installation portion 36, be used to install the plate 18 of changing module 12.In addition, at the upper surface of main part 32, be provided with reception hole 38 and reclaim bottle 15 to take in target.Moreover, at the upper surface of the end difference 32a of main part 32, be provided with reception hole 40 to take in reaction bottle 16.Around this reception hole 40, be provided with the not shown heater that is used for reacting by heating bottle 16.
Moreover this main part 32 is provided with not shown incorporating section, and it is being taken in from the 1st to the 5th above-mentioned reagent bottle V1-V5 and cleaning mixture bottle V6 in the mode that can dismantle.
In such radioactivity medicinal liquid synthesizer 10, on tapping line L15, connecting the treating column 50 that is used for refining radioactivity medicinal liquid.And the product supply pipeline L16 that is used to supply with refining medicinal liquid extends to not shown product bottle from this treating column 50.In addition, the shielding material for the treatment of column 50 conductively-closed lonizing radiation covers.
At this, the oblique line of the present embodiment in Fig. 3 is represented, constitutes the 1st pipeline of the present invention by the part of a part, connecting line L10 and the 1st multipurpose pipeline L7 of discharge pipe L4, a part that imports pipeline L5, recovery line L6.In addition, when anion exchange resin box 20 was also contained in the replacing module 12, the 1st pipeline that is constituted was also included anion exchange resin box 20.In addition, as the blacking part among Fig. 3 is represented, constitute the 2nd pipeline of the present invention by a part and the tapping line L15 of the 2nd multipurpose pipeline L8.Moreover a part that is imported pipeline L17, the 1st reagent bottle V1 and importing pipeline L5 by cleaning mixture bottle V6, cleaning mixture constitutes the cleaning mixture introducing mechanism.
Secondly, the synthetic method that with regard to the using method of above-mentioned radioactivity medicinal liquid synthesizer 10, also comprises the radioactivity medicinal liquid describes interior.
Synthetic
18Under the situation of F-FDG as the radioactivity medicinal liquid, at first, new replacing module 19 be installed in fixedly install on the module 14, and with anion exchange resin box 20 with import pipeline L5 and be connected with recovery line L6.Secondly, install the from the 1st to the 5th reagent bottle V1-V5 and cleaning mixture bottle V6.Moreover, will contain
18F ion (radioactive fluorine) for example target water about 2cc is recovered in the target recovery bottle 15 by recovery line L1, and wherein, target water is to be radiated at H with the high energy proton that not shown cyclotron quickens
2 18On the O, generate by nuclear reaction then.At this moment, when by vacuum pipeline L2 evacuation, then in target reclaims bottle 15, import target water easily, and be enclosed in easily in the target recovery bottle 15, thereby be preferred.
Secondly, by gas introduction tube line L3 with N
2Conductance is gone into target and is reclaimed in the bottle 15, all discharges target water by discharge pipe L4.At this moment, by closing open and close valve 13-1,13-4, and open open and close valve 13-2,13-3, make target water pass to anion exchange resin box 20, to catch
18The F ion.Then, reclaim remaining target water by recovery line L6.
Then make solution of potassium carbonate by importing pipeline L5, pass to anion exchange resin box 20, stripping from the 1st reagent bottle V1
18Import behind the F ion in the reaction bottle 16.Meanwhile, kryptofix solution is imported in the reaction bottle 16 from the 1st reagent bottle V1.At this moment, close open and close valve 13-2,13-3,13-5,13-6,13-7, open open and close valve 13-1,13-4,13-12.Under this state, in reaction bottle 16, take in the raw material about 0.9cc.
Then pass through vacuum pipeline L9 to evacuation in the reaction bottle 16, adopt not shown heater reacting by heating bottle 16 simultaneously, make thus
18F ion, solution of potassium carbonate and kryptofix solution evaporation are also done admittedly, thereby remove moisture.
Then, the mannose triflate that is dissolved in the acetonitrile is imported in the reaction bottle 16 from the 3rd reagent bottle V3 by importing pipeline L12 and the 1st multipurpose pipeline L7.At this moment, close open and close valve 13-4,13-5,13-7, open open and close valve 13-12.Then, under the state of sealed reaction bottle 16, by not shown heater, heating is 5 minutes under 100 ℃ design temperature.Carry out the fluorination treatment of mannose triflate thus.Under this state, in reaction bottle 16, take in the raw material about 1.3cc.
Secondly, to evacuation in the reaction bottle 16, by with not shown heater reacting by heating bottle 16, make inner liquid boiling simultaneously, remove harmful acetonitrile thus by vacuum pipeline L9.At this moment, the design temperature of not shown heater is about 80 ℃.
Then, the sodium hydroxide about 4cc is imported in the reaction bottle 16 from the 5th reagent bottle V5 by importing pipeline L14.At this moment, close open and close valve 13-8,13-10,13-11, open open and close valve 13-9,13-13.Then, the design temperature of not shown heater is set at 100 ℃, and under sealing state heating to be hydrolyzed.At this moment, preferably close open and close valve 13-7,13-9,13-10,13-11, open open and close valve 13-8,13-13 simultaneously, by the 1st multipurpose pipeline L7 and the 2nd multipurpose pipeline L8, with N
2Conductance goes into to react in the bottle 16, handles to carry out bubbling.So, inner liquid is stirred, thereby has promoted the carrying out of hydrolysis.Like this, in reaction bottle 16, just synthesize
18F-FDG.
Then, by the 1st multipurpose pipeline L7 with N
2Conductance goes into to react in the bottle 16, discharges by the 2nd multipurpose pipeline L8 and tapping line L15
18F-FDG.At this moment, close open and close valve 13-4,13-5,13-6,13-8,13-9,13-10, open open and close valve 13-7,13-11,13-12,13-13.Then, remove impurity by treating column 50, taking-up is purified
18F-FDG, L16 is supplied to the product bottle by the product supply pipeline.
, by water import pipeline L13, from the 4th reagent bottle V4 water about importing 5cc in reaction bottle 16 thereafter.At this moment, close open and close valve 13-8,13-9,13-11, open open and close valve 13-10,13-13.Then, by the 1st multipurpose pipeline L7 with N
2Conductance goes into to react in the bottle 16, by the 2nd multipurpose pipeline L8 and tapping line L15, with residual in the reaction bottle 16
18F-FDG discharges with the water of importing.At this moment, close open and close valve 13-4,13-5,13-6,13-8,13-9,13-10, open open and close valve 13-7,13-11,13-12,13-13.Then, remove impurity by treating column 50, taking-up is purified
18F-FDG, L16 is supplied to the product bottle by the product supply pipeline.
Undertaken by above-mentioned radioactivity medicinal liquid synthesizer 10
18Synthesizing in not shown radiological protection plate (hot material operation room) of F-FDG carried out.In addition, behind 1 time end of synthesis, change the washing of module 12.
In the washing of changing module 12, need not open not shown radiological protection plate, just be arranged under the state that fixedly installs on the module 14, import pipeline L17, from the cleaning mixture of cleaning mixture bottle V6 to about the 1st reagent bottle V1 importing 7cc by cleaning mixture in replacing module 12.Then, by importing pipeline L5 and discharge pipe L4, reclaim bottle 15 from the 1st reagent bottle V1 to target and import cleaning mixture.At this moment, open open and close valve 13-1,13-2, close open and close valve 13-3,13-4.As cleaning mixture, beyond dewatering, can also use acetonitrile, organic solvent etc.
Secondly, by gas introduction tube line L3, with N
2Conductance is gone into target and is reclaimed in the bottle 15, all discharges cleaning mixture by discharge pipe L4.At this moment, by closing open and close valve 13-1,13-3,13-5,13-6,13-7, and open open and close valve 13-2,13-4,13-12, washings just are imported into reaction vessel 16.
Then by the 1st multipurpose pipeline L7, with N
2Conductance goes into to react in the bottle 16, and for example the bubbling that cleaning mixture was carried out about 1 minute is handled.Then, discharge cleaning mixture by the 2nd multipurpose pipeline L8 and tapping line L15.At this moment, close open and close valve 13-4,13-5,13-6,13-8,13-9,13-10, open open and close valve 13-7,13-11,13-12,13-13.
Secondly, carry out repeatedly and above-mentioned same operation, amount to 3 times, wash changing module 12.Special in the 3rd time washing, the cleaning mixture in the reaction bottle 16 was heated 10 minutes down at 130 ℃, with boiling washing liquid.Then, after 3 washings finish, will react bottle 16 and be warming up to 80 ℃, simultaneously by the 1st multipurpose pipeline L7, with N
2Conductance goes into to react in the bottle 16, to discharge pipe L4, import pipeline L5, recovery line L6, connecting line L10 and the 1st multipurpose pipeline L7, target and reclaim bottle 15 and carry out that nitrogen cleans and make its drying about 10 minutes.Moreover, by the 1st multipurpose pipeline L7, with N
2Conductance goes into to react in the bottle 16, the 2nd multipurpose pipeline L8 and tapping line L15 is carried out nitrogen cleans and make its drying about 10 minutes.
After above-mentioned washing and dry the end, open not shown radiological protection plate, anion exchange resin box 20 is replaced by new, be replaced by reagent bottle V1-V5 and cleaning mixture bottle V6 new simultaneously.In addition, if can use anion exchange resin box 20 repeatedly, then there is no need to change anion exchange resin box 20 by above-mentioned washing.
Secondly, after above-mentioned synthetic next time setting is finished, close not shown radiological protection plate, carry out once more
18F-FDG's is synthetic.And carrying out pre-determined number (for example about 3 times)
18After the washing of the synthetic and replacing module 12 of F-FDG, change the replacing of module 12.
When changing the replacing of module 12, open not shown radiological protection plate, and the door portion 34 that opens radioactivity medicinal liquid synthesizer 10, take off replacing module 12 that finished using, after the washing from the main part 32 that fixedly installs module 14, and it is replaced by new.
As above describe in detail, the using method of the radioactivity medicinal liquid synthesizer 10 of the present embodiment is by discharge pipe L4, importing pipeline L5, recovery line L6, connecting line L10 and the 1st multipurpose pipeline L7, in reaction bottle 16, import cleaning mixture, just can wash these pipelines and reaction bottle 16 thus, thereby can use repeatedly and change module 12, thereby can seek the reduction of synthetic cost, aspect cost, can carry out the synthetic of radioactivity medicinal liquid effectively.In addition, in particularly can the wash residual radioactive level high reaction bottle 12, so can under the low state of residual activity level, be used for next synthetic reagent and change and change the replacing of module 12, thereby the amount of radiation to operator can be maintained lower level.In addition, owing to need not wait until that just can to transfer to next time when the residual activity level is fully low synthetic, so at effective synthesizing radioactive medicinal liquid aspect the time.
Especially, because the target after target water is discharged from reclaims and imports cleaning mixture in the bottle 15, and by discharge pipe L4, import pipeline L5, recovery line L6, connecting line L10, and the 1st multipurpose pipeline L7, reclaim bottle 15 from target and import cleaning mixture to reaction bottle 16, thereby also can wash target and reclaim bottle 15, simultaneously can be from the cardinal extremity of discharge pipe L4, the pipeline that washing makes target water be able to pass through, use the quality of changing 12 synthetic radioactivity medicinal liquids of module so can improve repeatedly, be suppressed at lower level by amount of radiation in the time of replacing can also being used for next synthetic reagent simultaneously and changing module 12.
In addition, the discharge of cleaning mixture that comes autoreaction bottle 16 is owing to undertaken by the 2nd multipurpose pipeline L8 and tapping line L15, thereby also can wash these lines, can improve to use repeatedly and change module 12 and the quality of synthetic radioactivity medicinal liquid, simultaneously these the 2nd multipurposes pipeline L8 and tapping line L15 can be effectively utilized, thereby the complicated of pipe arrangement can be suppressed.
In addition, owing to boiling washing liquid in reaction bottle 16, thereby can improve the clean result of reacting in the bottle 16, and then implement the bubbling processing, can further improve clean result.
In addition, the present invention is not limited to above-mentioned embodiment, but various variations can be arranged.For example, in above-mentioned embodiment, import pipeline L17 by cleaning mixture and once in the 1st reagent bottle V1, import cleaning mixture, in reclaiming bottle 15, target imports cleaning mixture then, but also can directly connect cleaning mixture bottle V6 and target and reclaim bottle 15, thereby import pipeline L17 by cleaning mixture, in target reclaims bottle 15, directly import cleaning mixture.In the case, import pipeline L17 by cleaning mixture and constitute cleaning mixture introducing mechanism of the present invention.
In addition, under the situation of the pollution in discharge pipe L4 that does not worry target recovery bottle 15 and formation the 1st pipeline and importing pipeline L5, import pipeline L17 at discharge pipe L4 with the middle cleaning mixture that is connected that imports pipeline L5, also can import cleaning mixture to reaction bottle 16 from cleaning mixture bottle V6.In the case, import pipeline L17 by cleaning mixture and constitute cleaning mixture introducing mechanism of the present invention.But preferred connect cleaning mixture at the upstream side of discharge pipe L4 as much as possible and import pipeline L17.
In addition, in the above-described embodiment, change module 12 and comprise that target reclaims bottle 15 and reaction bottle 16, also can be not included in and change in the module, fixedly install in the module but be included in the formation that does not need to change but target reclaims bottle 15 and reaction bottle 16.In the case, change module 12 and be made of piping installation 19 for flowing through fluid, this piping installation 19 is located many pipeline L1-L15 and be supported on the plate 18.
In addition, in the above-described embodiment, just synthetic
18F-FDG is illustrated as the situation of radioactivity medicinal liquid, but also can synthesize other radioactivity medicinal liquid.
Claims (6)
1. the using method of a radioactivity medicinal liquid synthesizer, this radioactivity medicinal liquid synthesizer comprises: target solution accommodating container is used to take in and contains radioisotopic target solution; Reaction vessel uses described target solution to carry out the synthetic of radioactivity medicinal liquid; Change module, it has piping installation, and this piping installation is equipped with the 1st pipeline that connects described target solution accommodating container and described reaction vessel on substrate; And fixedly install module, be provided with in the mode that can dismantle described replacing module; It is characterized in that:
By importing cleaning mixture in the described reaction vessel of the 1st pipeline after described radioactivity medicinal liquid is discharged from, after the washing in described reaction vessel is finished, from described reaction vessel, discharge cleaning mixture.
2. the using method of radioactivity medicinal liquid synthesizer according to claim 1, it is characterized in that: import cleaning mixture in the described target solution accommodating container after described target solution is discharged from, import cleaning mixture by described the 1st pipeline to described reaction vessel from described target solution accommodating container again.
3. the using method of radioactivity medicinal liquid synthesizer according to claim 1 and 2 is characterized in that: described piping installation has and is used for discharging synthetic radioactivity medicinal liquid and being installed in the 2nd pipeline on the described substrate from described reaction vessel;
Discharge from the cleaning mixture of described reaction vessel is undertaken by described the 2nd pipeline.
4. according to the using method of each described radioactivity medicinal liquid synthesizer of claim 1～3, it is characterized in that: boiling washing liquid in described reaction vessel.
5. the using method of the described radioactivity medicinal liquid of each of claim 1～4 synthesizer is characterized in that: after the washing of described reaction vessel was finished, described replacing module need not be changed just and utilize once more, to carry out the synthetic of radioactivity medicinal liquid.
6. radioactivity medicinal liquid synthesizer, it comprises: target solution accommodating container is used to take in and contains radioisotopic target solution; Reaction vessel uses described target solution to carry out the synthetic of radioactivity medicinal liquid; Change module, it has piping installation, and this piping installation is equipped with the 1st pipeline that connects described target solution accommodating container and described reaction vessel on substrate; And fixedly install module, be provided with in the mode that can dismantle described replacing module; It is characterized in that:
By importing cleaning mixture in the described reaction vessel of described the 1st pipeline after described radioactivity medicinal liquid is discharged from, after washing in described reaction vessel is finished, discharge cleaning mixture from described reaction vessel, described replacing module need not be changed just once more and utilize, to supply with next time synthetic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006150397A JP4926546B2 (en) | 2006-05-30 | 2006-05-30 | Method of using radiochemical solution synthesizer and radiochemical solution synthesizer |
| JP150397/2006 | 2006-05-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101081194A true CN101081194A (en) | 2007-12-05 |
| CN101081194B CN101081194B (en) | 2012-10-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007101081504A Active CN101081194B (en) | 2006-05-30 | 2007-05-30 | Radioactive medical solution synthesizer and the using method thereof |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP4926546B2 (en) |
| KR (1) | KR100835591B1 (en) |
| CN (1) | CN101081194B (en) |
| HK (1) | HK1111078A1 (en) |
| TW (1) | TW200744565A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430133A (en) * | 2011-12-02 | 2012-05-02 | 无锡江原安迪科分子核医学研究发展有限公司 | Radioactive medicine synthesis module capable of being repeatedly used in same day |
| CN103301484A (en) * | 2012-03-13 | 2013-09-18 | 住友重机械工业株式会社 | Cassette for radioactive isotope handling apparatus, radioactive isotope handling apparatus, and radioactive isotope handling system |
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| JP3008329B2 (en) * | 1995-01-26 | 2000-02-14 | 信彦 中澤 | Prefilled kit for preparation of radioisotope labeling reagents |
| EP1216715A1 (en) * | 2000-12-22 | 2002-06-26 | Ion Beam Applications S.A. | Synthesing device von radiopharmaceuticals |
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2006
- 2006-05-30 JP JP2006150397A patent/JP4926546B2/en active Active
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2007
- 2007-04-18 TW TW096113640A patent/TW200744565A/en unknown
- 2007-05-29 KR KR1020070051818A patent/KR100835591B1/en active IP Right Grant
- 2007-05-30 CN CN2007101081504A patent/CN101081194B/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2007319254A (en) | 2007-12-13 |
| KR100835591B1 (en) | 2008-06-09 |
| CN101081194B (en) | 2012-10-03 |
| TWI339575B (en) | 2011-04-01 |
| KR20070115664A (en) | 2007-12-06 |
| TW200744565A (en) | 2007-12-16 |
| HK1111078A1 (en) | 2008-08-01 |
| JP4926546B2 (en) | 2012-05-09 |
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