CN2174707Y - Bead washer for radioimmunoassay and diagnosis - Google Patents
Bead washer for radioimmunoassay and diagnosis Download PDFInfo
- Publication number
- CN2174707Y CN2174707Y CN 93210055 CN93210055U CN2174707Y CN 2174707 Y CN2174707 Y CN 2174707Y CN 93210055 CN93210055 CN 93210055 CN 93210055 U CN93210055 U CN 93210055U CN 2174707 Y CN2174707 Y CN 2174707Y
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- reaction
- water
- reaction tray
- tray
- disk cover
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Abstract
The utility model relates to a bead washer used for washing and drying plastic beads of a hepatitis kit for radioimmunoassay and diagnosis. A response disk with a special-shaped hole at the center and a response disk cover are utilized to be matched with a special-shaped rotary middle shaft, or the inner side of the cover edge of the response disk cover is provided with three convex keys matched with semi-cylindrical notches at the outer side of the edge of the response disk. A baffle plate is arranged between the test tube openings of the response disk to prevent water from flowing between test tubes to cause the mutual pollution. Thus, the quality of measuring result can be guaranteed. A computer for controlling a motor and a water-filling electromagnetic valve is provided with a two-bit dial to set washing time and number, so the washing time and number can be regulated. Thereby, the convenient use is realized.
Description
The utility model belongs to a kind of and washs the device that drying is used for the solid phase carrier of radio-immunity detection of biological material with centrifugal treating, especially a kind of drying of washing is used for the bead wahser that hepatitis is put the plastic bead of exempting from Sickledex, and it comprises casing, computer, motor, water vat, reaction tray, reaction disk cover, pallet, solenoid valve, water injection pipe and drainpipe.
In radiommunoassay (RIA) technology, the most excellent, easy and simple to handle, highly sensitive with solid phase RIA (SPRIA), high specificity.Reach the level of 1ng/ml as hepatitis B surface antibody (HBsAg) detection sensitivity, be widely used in hospital clinical, the detection of anti-epidemic system and biomedicine experiment so hepatitis B detects medicine box.Plastic bead as solid phase carrier in detection washs and drying through needing behind the association reaction in the test tube of reaction tray, removes free radioactively labelled substance, just can send radioactivity seeker to detect.
The method of washing dry plastics pearl, general adopt water filling in the test tube of reaction tray, again water is absorbed, repeated multiple times, the available manual operations of a spot of detection, a large amount of detection then needs by instrument, external a kind of bead wahser of producing adopts above-mentioned principle design, therefore structure is comparatively complicated, need be with a vacuum pump to produce negative pressure, and the water in each test tube on the reaction tray is absorbed respectively.
Domestic production in 1988 and a kind of bead wahser of having put on market have been done significant improvement from principle, and it utilizes the centrifugal treating principle, reaction tray is designed to discoidal, test tube is arranged on its periphery, and the revolving reaction dish relies on the centrifugation of rotating to wash the dry plastics pearl.Such structure is comparatively simple, cost is lower.This bead wahser is made up of casing, computer, motor, water vat, reaction tray, reaction disk cover, pallet, electromagnetism, water injection pipe and drainpipe.Motor is installed on the base of casing, and pallet is connected with turning axle above motor.Reaction tray is placed on the pallet, and the pallet periphery has the semi-circular indentation that cooperates with reaction tray.The reaction disk cover covers on reaction tray, and there is the inlet opening at the center of reaction disk cover, also has three apertures on the capping, and three pillars on the reaction tray dish are carved and closed.The turning axle of motor passes the center of water vat cylinder bottom, the water vat accommodating tray, reaction tray and the reaction disk cover.Water injection pipe enters from water vat top, facing to the inlet opening of reaction tray, and the entering of water by solenoid control, the water vat bottom also has osculum, links to each other with drainpipe.Motor and solenoid valve are controlled by computer.Reaction tray is a disk that is shaped on test tube equidistant on periphery, and the inboard of test tube mouth and the outside all have recess, and inboard recess is equal with card.Open three semi-cylindrical recesses in the outer rim of reaction tray periphery, three recesses become triangle.The patent No. that can consult Patent Office of the People's Republic of China's bulletin on Dec 9th, 1992 is 92223332 utility application instructions, but this bead wahser is also deposited some problems on structure and clean result:
1, it is fixed on the reaction tray in order to make the reaction disk cover, do not produce relative displacement during rotation, to carve with reaction disk cover three holes only and close, on the card of reaction tray, designed three pillars, and the card of reaction tray is smooth, the central openings of reaction disk cover, water injects from the hole, so when water filling, because stopping and the surface tension of water of pillar is not easy in the even injecting tube of water.In order to guarantee that water injects each test tube, must increase water injection rate, make the water pipe face that overfills.Water is fled between adjacent test tube mutually like this, causes mutual pollution, influences the accuracy of testing result;
2, the material of its water vat is a rubber, and rubber adsorbs the radiomaterial that washs easily, and this will cause pollution;
3, its wash time and number of times are fixed, so usable range is restricted;
4, the solenoid valve of its controlled water flow is contained on the top cover, has increased the volume of bead wahser, makes one-piece construction compact inadequately.
The purpose of this utility model provides a kind of reaction tray and can avoid water to flee mutually, selects for use to be not easy to adsorb radioactive material water vat, and wash time and number of times are adjustable, the bead wahser of compact conformation.
To achieve these goals, the technical scheme that the utility model is taked is: discoid on the capping of reaction disk cover, the web that makes progress with down to the lid limit not on a vertical plane, the lid limit is at the edge, web is within the lid limit.Drive water and hole into along web in dish, water injection pipe is above the hole, and water is gone into along marginal not under the reaction tray slow rotation, is easy to flow into test tube.Computer adopts two dials that wash time and washing times can be set, and in conjunction with the program that deposits in, makes wash time and washing times adjustable.Water vat adopts the stainless steel structure that is difficult for the absorption radiomaterial and is convenient to wash, solenoid valve places in the casing, make complete machine structure comparatively compact, establish the technical scheme that three pillars cooperate with the reaction disk cover for fear of adopting on the reaction card, the utility model adopts two new technical schemes respectively:
1, all has a profile hole at the center of reaction tray and reaction disk cover, carve mutually with the special-shaped axis of pallet upper end and close.
2, in the inboard on reaction disk cover lid limit three protruding keys are set, carve mutually with three half-cylindrical recesses on the reaction tray edge and close.
For fleeing of more effective anti-sealing, also use following technical scheme: make the card of reaction tray have the gradient, disk center's height is low around the dish.Or on the card of reaction tray, between every two adjacent test tube mouths, be provided with and prevent the baffle plate that water is fled mutually.Or make the outside recess on the test tube mouth on the reaction tray periphery be lower than inboard recess.
After the utility model has adopted technique scheme, compared with prior art, have following good effect:
1, makes the water that injects reaction tray flow into test tube glibly, avoid fleeing mutually of water between test tube preferably, therefore avoid mutual pollution, reduce the error of testing result;
2, water vat adopts stainless structure, reduces the contamination of radioactive material confrontation instrument, helps environmental protection and detects quality;
3, computer control employing wash time and washing times are adjustable, bring many convenience to using instrument, enlarge usable range;
4, the solenoid valve slave is moved on to outward in the machine, make instrument very compact, bring convenience for packing, transportation and use.
Description of drawings:
Fig. 1 is the bead wahser structural representation.
Fig. 2 is reaction disk cover configuration diagram
Fig. 3 is the reaction tray configuration diagram
Fig. 4 is the computer block diagram
Among Fig. 11 be casing, 2 for computer, 3 for base, 4 for motor, 5 for the stainless steel cylinder, 6 for reaction tray, 7 for the reaction disk cover, 8 for special-shaped axis, 9 for water injection pipe, 10 for pallet, 11 for solenoid valve, 12 for drainpipe.
Among Fig. 2,13 for inlet opening, 17 are profile hole for protruding key, 16 for cover limit, 14 for web, 15.
Among Fig. 3,18 is that test tube mouth, 19 is that test tube mouth inboard recess, 20 is that test tube mouth outside recess, 21 is that half-cylindrical recess, 22 is that baffle plate, 23 is that profile hole, 24 is a test tube.
Among Fig. 4,25 for single-chip microcomputer, 26 for latch, 27 for memory under program, 28 for the peripheral expansion chip, 29 for gate circuit, 30 be two dials, 31 for LED show, 11 for solenoid valve, 4 for motor, 32 for hummer, 33 for relay, 34 and 35 for solid-state relay, 36 for optocoupler, 37 be power supply.
In conjunction with the accompanying drawings the technical solution of the utility model is further described:
The utility model is made up of casing 1, computer 2, motor 4, stainless steel cylinder 5, reaction tray 6, reaction disk cover 7, pallet 10, solenoid valve 11, water injection pipe 9 and drainpipe 12.Motor 4 is installed on the chassis base 3.Pallet 10 is connected with its turning axle above motor 4.Reaction tray 6 is placed on the pallet 10.Reaction disk cover 7 covers on reaction tray 6.The turning axle of motor 4 passes the cylinder bottom center of stainless steel cylinder 5.Stainless steel cylinder 5 accommodating trays 10, reaction tray 6 and reaction tray 7.Water injection pipe 9 enters from the top of stainless cylinder 5, and facing to the inlet opening 16 of reaction on the disk cover 7, water injects at the reaction tray lower edge web that slowly runs, and the injection of water is by solenoid valve 11 controls.Also having freeing port on the cylinder bottom of stainless steel cylinder 5 links to each other with drainpipe 12.
Discoid on the capping of reaction disk cover 7.Web 14 that makes progress and downward lid limit 13 be not on a vertical plane, and lid limit 13 is at the edge, and web 14 is within lid limit 13.Drive water hole 16 into along web in dish, inlet opening 16 is corresponding with the test tube mouth 18 on the reaction tray 6.Make the unobstructed inflow test tube of water like this.
Establish pillar and stop current through part for fear of current on the reaction tray card, adopted two technical measures respectively:
1, the center on reaction tray 6 and reaction disk cover 7 has a profile hole 23 and 17, carves mutually with the special-shaped axis 8 of pallet 10 upper ends and closes.
2, cover 7 inboard, lid limit in reaction three protruding keys 15 are set, protruding key 15 is carved mutually with three half-cylindrical recesses 21 on reaction tray 6 edges and is closed.
Flee between test tube for more effective anti-sealing, adopt following technical measures, make the card of reaction tray 6 have the gradient, the height of center of dish, low all around, or on the card of reaction tray 6, between every two adjacent test tube mouths, baffle plate 22 is set in case water is fled mutually; Or make the outside recess 20 on the test tube mouth on reaction tray 6 peripheries be lower than inboard recess 19, overflow in dish from test tube with waterproof.
Computer by single-chip microcomputer 25, latch 26, memory under program 27, peripheral expansion chip 28, gate circuit 29, two dials 30, LED show 31, solenoid valve 11, motor 4, hummer 32, relay 33, solid- state relay 34 and 35, optocoupler 36 and power supply 37 form.By two dials wash time and washing times n are set, LED show 37 display orders (n, n-1 ... 0 successively decreases successively).Water inlet is by solenoid valve 11 controls.Washing and drying are by motor 4 controls.Solenoid valve 11 and motor 4 are by solid- state relay 34 and 35 control break-makes.The commutation of motor 4 realizes by relay 33.Electricity sheet machine 25 is by optocoupler 36 control hummer 32 and relays 33.Whole device is undertaken by the procedure order that is stored in memory under program 27 under the CPU of single-chip microcomputer 25 management and control.After program finishes, show that by hummer 32 and LED 31 carry out sound and light alarm.
Claims (5)
1, a kind of putting exempted from the diagnostic detection bead wahser, by casing, computer, motor, water vat, reaction tray, the reaction disk cover, pallet, solenoid valve, water injection pipe and drainpipe are formed, motor is installed on the base of casing, pallet is connected with turning axle above motor, reaction tray is placed on the pallet, the reaction disk cover covers on reaction tray, the turning axle of motor passes the center of water vat cylinder bottom, the water vat accommodating tray, reaction tray and reaction disk cover, water injection pipe enters the inlet opening facing to the reaction disk cover from the water vat top, the water vat bottom also has osculum, link to each other with drainpipe, the equidistant test tube that is shaped on the periphery of reaction tray, the inboard of test tube mouth and the outside all have recess, inboard recess is equal with card, the center that it is characterized in that described reaction tray and reaction disk cover all has a profile hole, carve mutually with the special-shaped axis of pallet upper end and to close, discoid on the capping of reaction disk cover, web upwards with down to the lid limit not on a vertical plane, the lid limit is at the edge, web is within the lid limit, in dish, drive the hole of water into along web, water injection pipe is above the hole, wash time can be set in described computer employing and washing times makes its two adjustable dials, described water vat adopts the stainless steel structure that is difficult for the absorption radiomaterial and is convenient to clean, and described solenoid valve places in the casing.
2, bead wahser according to claim 1 is characterized in that the card of described reaction tray has the gradient, height of center, low all around.
3, bead wahser according to claim 1 and 2 is characterized in that on the card of described reaction tray, is provided with between every two adjacent test tube mouths and prevents the baffle plate that water is fled mutually.
4, a kind of putting exempted from the diagnostic detection bead wahser, by casing, computer, motor, water vat, reaction tray, the reaction disk cover, pallet, solenoid valve, water injection pipe and drainpipe are formed, motor is installed on the base of casing, pallet is connected with turning axle above motor, reaction tray is placed on the pallet, the reaction disk cover covers on reaction tray, the turning axle of motor passes water vat cylinder bottom portion center, the water vat accommodating tray, reaction tray and reaction disk cover, water injection pipe enters from the water vat top, inlet opening facing to reaction tray, the injection of water is by solenoid control, the water vat bottom also has osculum, link to each other with drainpipe, motor and solenoid valve are controlled by computer, reaction tray is the disk that is shaped on test tube equidistant on periphery, the inboard of test tube mouth and the outside all have recess, inboard recess is equal with card, open three semi-cylindrical recesses in the outer rim of reaction tray periphery, three recesses become triangle, it is characterized in that on the capping of described reaction disk cover discoid, cover under the limit to edge at lid, web is upwards within the lid limit, open some inlet openings along web in dish, water injection pipe is provided with three protruding keys in the inboard on lid limit above the hole, carve with three half-cylindrical recesses on the reaction tray edge and to close, wash time can be set in described computer employing and washing times makes its two adjustable dials, and described water vat adopts the stainless steel structure that is difficult for the absorption radiomaterial and is convenient to clean, and described solenoid valve places in the casing.
5, bead wahser according to claim 4 is characterized in that the outside recess on the test tube mouth on the described reaction tray periphery is lower than inboard recess.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93210055 CN2174707Y (en) | 1993-04-19 | 1993-04-19 | Bead washer for radioimmunoassay and diagnosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93210055 CN2174707Y (en) | 1993-04-19 | 1993-04-19 | Bead washer for radioimmunoassay and diagnosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2174707Y true CN2174707Y (en) | 1994-08-17 |
Family
ID=33792067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93210055 Expired - Fee Related CN2174707Y (en) | 1993-04-19 | 1993-04-19 | Bead washer for radioimmunoassay and diagnosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2174707Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102500587A (en) * | 2011-10-27 | 2012-06-20 | 北京北方生物技术研究所 | Cleaning machine for automatically cleaning coat bead or pipes for immunization radiation analysis |
| CN101081194B (en) * | 2006-05-30 | 2012-10-03 | 住友重机械工业株式会社 | Radioactive medical solution synthesizer and the using method thereof |
| CN113102367A (en) * | 2021-04-08 | 2021-07-13 | 中南大学湘雅医院 | Cross infection prevention bronchoscope cleaning device |
-
1993
- 1993-04-19 CN CN 93210055 patent/CN2174707Y/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101081194B (en) * | 2006-05-30 | 2012-10-03 | 住友重机械工业株式会社 | Radioactive medical solution synthesizer and the using method thereof |
| CN102500587A (en) * | 2011-10-27 | 2012-06-20 | 北京北方生物技术研究所 | Cleaning machine for automatically cleaning coat bead or pipes for immunization radiation analysis |
| CN113102367A (en) * | 2021-04-08 | 2021-07-13 | 中南大学湘雅医院 | Cross infection prevention bronchoscope cleaning device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |