CN113490514A - Replaceable module for a radioisotope operating system and radioisotope operating system - Google Patents

Replaceable module for a radioisotope operating system and radioisotope operating system Download PDF

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Publication number
CN113490514A
CN113490514A CN201980079355.5A CN201980079355A CN113490514A CN 113490514 A CN113490514 A CN 113490514A CN 201980079355 A CN201980079355 A CN 201980079355A CN 113490514 A CN113490514 A CN 113490514A
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CN
China
Prior art keywords
radioisotope
operating system
tube
replaceable module
module
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Pending
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CN201980079355.5A
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Chinese (zh)
Inventor
刘学文
徐超
虞善友
岳正江
李新平
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Mitro Biotech Co ltd
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Mitro Biotech Co ltd
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Publication date
Priority claimed from CN201811465285.0A external-priority patent/CN111261309A/en
Priority claimed from CN201811465289.9A external-priority patent/CN111257921A/en
Application filed by Mitro Biotech Co ltd filed Critical Mitro Biotech Co ltd
Priority claimed from PCT/CN2019/122428 external-priority patent/WO2020114353A1/en
Publication of CN113490514A publication Critical patent/CN113490514A/en
Pending legal-status Critical Current

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Abstract

A replaceable module (200) for a radioisotope operating system (10) and a radioisotope operating system (10), wherein the replaceable module (200) for a radioisotope operating system (10) comprises: a base (210); a holding portion (211), the holding portion (211) being provided on the base (210), the holding portion (211) protruding out of a surface of the base (210); and a medium transfer part (220) including a tube (221), the medium transfer part (220) being mounted on the base (210) through the holding part (211); wherein the holding portion (211) further comprises: a slot (2112), the slot (2112) configured to secure the tube (221); a receiving cavity (2113), the receiving cavity (2113) being configured to receive a pressing portion (C), and the tube (211) passing through the receiving cavity (2113).

Description

Replaceable module for a radioisotope operating system and radioisotope operating system
Cross Reference to Related Applications
The present application is based on and claims priority from chinese patent applications with application numbers 201811465285.0 and 201822012495.6 filed on 3.12.2018 and chinese patent applications with application numbers 201811465289.9 and 201822012958.9 filed on 3.12.2018, the entire contents of which are incorporated herein by reference.
Technical Field
The present invention relates to the field of radioisotope operation, and in particular, to a replaceable module for a radioisotope operating system and a radioisotope operating system having the replaceable module.
Background
Molecular imaging is a science that uses imaging means, and is generally used to display specific molecules at the tissue level, cellular level, and subcellular level, reflect changes in the molecular level in a living body state, and qualitatively and quantitatively study biological behaviors in the aspect of imaging. The most commonly used molecular imaging techniques at present include nuclear medicine imaging techniques, of which molecular imaging studies of PET are the most active. Positron Emission Tomography (PET) is a medical imaging technique that observes the metabolic activity of an organ after injection of a radioactive tracer in which the biological properties of the tracer are known. In a hospital such as, for example, in order to carry out examinations such as PET, it is often necessary to perform operations such as purification, synthesis and the like of a radioisotope to obtain a radioisotope-labeled compound to be used, and these operations are generally carried out in the hospital, and therefore, it is required that an apparatus for carrying out radioisotope operations has high versatility and that a plurality of different operations can be carried out on the same apparatus. In addition, in the use process of the existing equipment for carrying out radioisotope operation, because residual radioactivity exists in the pipeline, the pipeline can be used for subsequent operation after being cleaned usually, and the cleaning process usually consumes time and labor, is complex to operate and is difficult to ensure the cleaning effect.
Disclosure of Invention
In order to solve the above technical problem, an aspect of the present invention provides a replaceable module for a radioisotope operating system, the replaceable module for a radioisotope operating system including, according to an embodiment of the present invention: a base; a holding portion provided on the base, the holding portion protruding from a surface of the base; and a medium transfer part including a tube, the medium transfer part being mounted on the base through the holding part; wherein the holding portion further comprises: a clamp slot configured to be adapted to secure the tube; a receiving cavity configured to receive the pressing part, and through which the tube passes. According to the embodiment of the invention, after the radioactive isotope operation is carried out by adopting the replaceable module consisting of the base and the medium transmission part, the replacement can be directly carried out, the pipeline does not need to be cleaned, and the radioactive residue is not caused. In addition, according to the embodiment of the present invention, by providing the accommodating chamber adapted to accommodate the pressing portion, it is possible to effectively deform the tube by receiving the pressing force from the pressing portion during the operation of the radioisotope and to prevent the pressing portion from being displaced, thereby controlling the flow path in the tube, for example, opening or closing the tube, i.e., the pressing portion and the accommodating chamber may constitute a valve for opening and closing the tube passing through the accommodating chamber, and the reliable function of the valve may be ensured. In addition, according to an embodiment of the present invention, the holding part includes a catching groove adapted to fix the tube, and thus, it is possible to ensure that the tube does not significantly move during the radioisotope operation, particularly when the tube is pressed by the pressing part, and to improve the efficiency of closing the flow path when the pressing part presses the tube, and thus, the reliability of the apparatus can be further improved.
According to an embodiment of the present invention, the replaceable module for a radioisotope operating system as described above may further comprise at least one of the following additional features:
according to an embodiment of the present invention, further comprising: the boss is arranged in the accommodating cavity, and the boss protrudes out of the plane of the bottom of the accommodating cavity.
According to the embodiment of the invention, by adopting the boss, the efficiency of closing the flow path when the pressing part presses the pipe can be further improved, and the pipe can be effectively prevented from obviously moving when the pipe is pressed by the pressing part.
According to an embodiment of the invention, the boss is configured to extend in a direction non-parallel to the tube. Preferably, according to an embodiment of the present invention, the boss is configured to extend in a direction perpendicular to the pipe. Therefore, the boss and the flow path form a certain included angle to extrude the pipe, and the effect of closing the flow path is improved.
According to the embodiment of the invention, the surface of the boss, which is in contact with the pipe, is a plane or a circular arc surface. Therefore, when the boss extrudes the pipe, the boss can uniformly provide pressure for the pipe, so that the insufficient closing of the pipe under uneven stress can be avoided.
According to an embodiment of the invention, the base is a flat plate.
According to an embodiment of the invention, the distance of the opening of the clamping groove does not exceed the outer diameter of the tube.
According to an embodiment of the invention, the base comprises: a protrusion on which the slot and the receiving cavity are disposed.
According to an embodiment of the present invention, an outer contour of the protrusion is circular, the receiving cavity is circular, and two of the locking grooves are disposed on the protrusion in a diametrically opposite manner.
According to the embodiment of the invention, the device comprises a plurality of protruding parts, and the protruding parts are distributed transversely in two rows. This makes it possible to easily control the plurality of parallel flow paths.
According to an embodiment of the present invention, the card slot includes: a closing-in part, wherein the closing-in distance of the closing-in part does not exceed the outer diameter of the tube; an enlarged portion, said enlarged portion being enlarged a distance no less than an outer diameter of said tube.
According to an embodiment of the invention, the constriction distance of the constriction is smaller than the outer diameter of the tube and the enlargement distance of the enlargement is larger than the outer diameter of the tube.
According to an embodiment of the present invention, further comprising: a guide portion disposed on the base in the form of a groove having a concave distance less than the outer diameter of the tube.
According to the embodiment of the invention, the groove is communicated with the clamping groove and the accommodating cavity.
According to an embodiment of the present invention, further comprising: the auxiliary positioning part is arranged on the base in a protruding mode; a receiving groove provided on the protrusion and adapted to pass the pipe therethrough and guide the pipe.
According to an embodiment of the present invention, the pilot portion is detachably or movably provided on the base.
According to the embodiment of the invention, the groove is communicated with the accommodating groove.
According to the embodiment of the invention, the extending direction of the accommodating groove is arc-shaped.
According to an embodiment of the invention, the height of the protrusion does not exceed the protrusion.
According to an embodiment of the invention, said receiving groove is adapted to guide said tube at right angles.
According to an embodiment of the present invention, further comprising: a container, wherein the medium transfer part includes a connection part connected with the container, the connection part including: a housing in threaded connection with the container; the rubber plug is arranged in the shell and is provided with at least one through hole, and the shell compresses the rubber plug to form a seal between the wall of the container and the shell; and the connecting pipe penetrates through the through hole and the shell, and the connecting pipe is connected with the rubber plug in a sealing manner through rubber.
According to an embodiment of the present invention, further comprising: an exhaust gas treatment device, the exhaust gas treatment device comprising: an inlet and an outlet; an exhaust treatment device housing communicating the inlet and the outlet; at least two different fillers disposed within the exhaust treatment device housing.
According to an embodiment of the present invention, the exhaust gas treatment device housing is configured in the form of a column tube, and the inlet and the outlet are provided at both ends of the column tube, wherein the exhaust gas treatment device further comprises: the screen plate is arranged in the column tube, a plurality of accommodating spaces are limited in the column tube, at least two different fillers are respectively arranged in at least one of the accommodating spaces, the screen plate is flat, through holes are formed in the plate surface of the screen plate, and the appearance of the screen plate is matched with the cross section of the inner wall of the column tube. According to an embodiment of the invention, the at least two substances comprise a fibrous material, an acid-removing substance and an adsorbing substance.
According to an embodiment of the present invention, the fibrous material, the acid removing substance, and the adsorbing substance are disposed in this order in a direction from the inlet to the outlet.
According to an embodiment of the invention, the fibrous material is cotton; the acid removing substance is an alkaline substance; and/or the adsorbent material is activated carbon.
According to the embodiment of the invention, the moisture content of the cotton is 5-10 wt%; the alkaline substance is cotton containing soda lime, and the soda lime is porous granular soda lime; and/or the aperture of the activated carbon is 10-500 angstrom meters. According to an embodiment of the present invention, further comprising: and a purification device, both ends of which are respectively connected with the pipes and formed in the flow path.
In a second aspect of the invention, a radioisotope manipulation system is provided. According to an embodiment of the present invention, the radioisotope handling system includes: fixedly arranging a module; and a replaceable module for a radioisotope operating system as claimed in any one of the preceding claims, wherein the securement module comprises: a body portion configured to mount the replaceable module; and a pressing portion configured to be movably accommodated in the accommodation chamber. As described above, according to the embodiments of the present invention, after the radioisotope operation is performed using the replaceable module including the base and the medium transferring portion, the replacement can be performed directly without cleaning the pipeline and without causing radioactive residues. In addition, according to the embodiment of the present invention, by providing the accommodating chamber adapted to accommodate the pressing portion, it is possible to effectively deform the tube by receiving the pressing force from the pressing portion during the radioisotope operation, thereby controlling the flow path in the tube, for example, opening or closing the tube, i.e., the pressing portion and the accommodating chamber may constitute a valve for opening and closing the tube passing through the accommodating chamber, and the reliable function of the valve may be ensured. In addition, according to an embodiment of the present invention, the holding part includes a catching groove adapted to fix the tube, and thus, it is possible to ensure that the tube does not significantly move during the radioisotope operation, particularly when the tube is pressed by the pressing part, and to improve the efficiency of closing the flow path when the pressing part presses the tube, and thus, the reliability of the apparatus can be further improved.
According to an embodiment of the present invention, the radioisotope manipulation system as described above may further comprise at least one of the following additional features:
according to an embodiment of the invention, the securing module further comprises: the door leaf part is pivotally connected with the main body part, and the pressing part is arranged on the door leaf part. According to an embodiment of the present invention, further comprising: an accommodating portion detachably provided on the main body portion, the accommodating portion being configured to accommodate the container, the exhaust gas treatment device, and the purification device; and a medium control section including: a drive assembly; a rotor driven in rotation by the drive assembly; a pressing element arranged on the rotor and suitable for rotating with the rotor and moving relative to the rotor; a housing surrounding the rotor, at least a portion of the drive assembly being disposed inside the body portion, the rotor, the compression member and the housing being disposed at a front surface of the body portion, at least a portion of the tube being disposed between the compression member and the housing, the compression member being configured and adapted to compress and release the tube by movement so as to convey fluid within the tube.
According to an embodiment of the present invention, further comprising: a reaction vessel disposed in the replaceable module and configured for radioisotope operation; an exhaust gas pipe connected to the reaction vessel; and an exhaust gas channel which is provided in the stationary module and is connected to the exhaust gas pipe and the exhaust gas treatment device, respectively.
According to an embodiment of the present invention, further comprising: and the vacuum pump is arranged in the fixed module.
Those skilled in the art will appreciate that the features and advantages described above with respect to the replaceable module for use proximate to a radioisotope operating system are equally applicable to that radioisotope operating system.
Thus, according to an embodiment of the present invention, there is provided a replaceable module for a radioisotope operating system, including a base and a medium transfer portion mounted on the base by a holding portion provided on the base, the medium transfer portion forming a flow path through which a fluid flows and including a tube, the holding portion including a catching groove that catches the tube and a housing chamber through which the tube passes, the housing chamber constituting a portion that opens and closes a valve of the tube passing through the housing chamber. The replaceable module formed by the base and the medium transmission part can be replaced after one-time radioactive isotope operation is completed, a pipeline does not need to be cleaned, radioactive residues cannot be caused, and the reliable function of the valve can be guaranteed by the accommodating cavity.
Preferably, the base is a flat plate, the holding portion is configured as a protruding portion on the flat plate, the engaging groove and the receiving cavity are disposed on the protruding portion, the engaging groove is closed and prevents the tube from being accidentally detached from the base, the engaging groove includes a closing portion and an expanding portion connected to the closing portion, the closing portion has a closing distance smaller than or equal to the outer diameter of the tube, and the expanding portion has an expanding distance larger than the outer diameter of the tube.
Further, a guide portion is arranged on the base, the guide portion is configured as a groove on the flat plate, the groove has a concave distance smaller than the outer diameter of the pipe and at least partially extends through the protruding portion and is communicated with the clamping groove and the accommodating cavity, and the guide portion guides the medium transmission portion.
Furthermore, the base is provided with an auxiliary positioning part at the bending part of the pipe, the auxiliary positioning part is a protrusion on the flat plate, the protrusion is provided with a containing groove through which the pipe extends, the groove extends through the protrusion and is communicated with the containing groove, the containing groove is arc-shaped in the extending direction of the pipe, and the pipe is guided and positioned in the arc-shaped containing groove.
Preferably, the replaceable module further comprises a container, the medium transmission part comprises a connecting part connected with the container, the connecting part comprises a shell, a rubber plug arranged in the shell and provided with at least one through hole, and a connecting pipe penetrating through the through hole and the shell, the shell is in threaded connection with the container, the rubber plug and the connecting pipe are in sealing connection through the rubber, and the shell presses the rubber plug to form a seal between the wall of the container and the shell.
Preferably, the replaceable module comprises an exhaust gas treatment device through which exhaust gas generated by the radioisotope operating system is exhausted, the exhaust gas treatment device comprising a housing, at least two different fillers disposed in the housing, and at least one screen, the at least two different fillers being separated by the screen.
Preferably, the replaceable module includes a purification device, both ends of which are connected to the pipes, respectively, and are formed in the flow path, and the purification device includes a housing and a packing disposed in the housing.
Furthermore, according to an embodiment of the present invention, there is provided a radioisotope operating system including a replaceable module as claimed in any one of the preceding claims and a fixed module, the fixed module including a body portion for mounting the replaceable module and a pressing portion forming with the receiving cavity a valve for opening and closing a tube passing through the receiving cavity. The accommodating cavity can limit the pressing part to prevent the relative position deviation of the pressing part and the base when the pipe is pressed.
Preferably, the fixing module further includes a door leaf portion pivotally connected to the main body portion, the pressing portion is disposed on the door leaf portion, when the door leaf portion is closed, the pressing portion can enter the accommodating cavity to press the pipe, a boss is disposed at the bottom of the accommodating cavity, and the boss and the pressing portion are matched to reliably press the pipe. The contact surface of the boss and the pipe can be a plane, an arc surface and the like; the boss may not be provided.
Preferably, the fixing module includes a housing for housing the container, the exhaust gas treatment device, and the purification device, and a medium control unit, the housing is detachably connected to the main body, the medium control unit includes a driving assembly, a rotor driven by the driving assembly to rotate, a pressing member disposed on the rotor to rotate together with the rotor and capable of moving relative to the rotor, and a cover surrounding the rotor and the roller, the driving assembly is at least partially disposed inside the main body, the rotor, the pressing member, and the cover are disposed on a front surface of the main body, the pipe is at least partially disposed between the pressing member and the cover, and the pressing member moves to press the pipe to transfer the fluid in the pipe by pressing and releasing force. The radioisotope operating system provided by the embodiment of the invention has high universality, the replaceable module can be replaced after one-time radioisotope operation is finished, a pipeline does not need to be cleaned, and radioactive residues are not caused.
In addition, the radioactive isotope operation system solves the problems of corrosion of acid gas and radioactive volatile matters discharged in the operation process of metallic nuclide purification, labeling synthesis and other processes to equipment and environmental pollution, and the waste gas treatment device has the advantages of simple structure, low cost, repeated use, convenient replacement and capability of being used for other products.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic view of a radioisotope operating system in accordance with an embodiment of the invention;
FIG. 2 is a schematic diagram of a media transport and receptacle connection configuration of a replaceable module according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a base structure of a replaceable module according to one embodiment of the invention;
FIG. 4 is an enlarged partial view of a base structure of a replaceable module according to one embodiment of the present invention;
FIG. 5 is a schematic diagram of a replaceable module exhaust treatment device according to one embodiment of the present disclosure;
fig. 6 is a schematic structural view of a second accommodating portion of the fixing module according to an embodiment of the invention;
FIG. 7 is a schematic view of a fastening device for fastening a door leaf of a module according to an embodiment of the present invention;
FIG. 8 is a schematic view of another orientation of a fastening device for fastening a door leaf portion of a module according to one embodiment of the present invention;
FIG. 9 is a schematic structural diagram of a media control portion of a mounting module according to one embodiment of the invention;
FIG. 10 is a schematic diagram of the operation of a control module according to one embodiment of the present invention;
FIG. 11 shows an embodiment of the present invention89A schematic diagram of a Zr (zirconium oxalate) purification system;
FIG. 12 is a schematic diagram of an embodiment in accordance with the invention89A schematic diagram of a Zr (zirconium chloride hydrochloride) purification system;
FIG. 13 is a schematic diagram of an embodiment in accordance with the invention64Schematic diagram of a Cu (copper chloride hydrochloride) purification system;
FIG. 14 is a schematic diagram of an embodiment in accordance with the invention64Schematic diagram of Cu (neutral copper chloride) purification system;
FIG. 15 shows an embodiment of the present invention68Schematic diagram of Ga (gallium chloride hydrochloride) purification system;
FIG. 16 is a view showing another embodiment of the present invention89A schematic diagram of a Zr (zirconium chloride hydrochloride) purification system;
FIG. 17 is a schematic diagram of an embodiment in accordance with the invention89Schematic diagram of a synthetic system of DFO modified monoclonal antibody marked by Zr (zirconium oxalate); and
FIG. 18 shows an embodiment of the present invention68Schematic diagram of synthesis system of Ga (gallium chloride hydrochloride) labeled DOTA modified small molecule peptide.
It should be noted that, for the convenience of illustration and the prevention of mutual interference between the structures, not all parts of the product are shown in the drawings, for example, the tube mounted on the base 210 and overlapping the base 210 in fig. 1 is not shown, and the tube in some of the drawings (only the lines are used instead) may be the tube described with reference to the outer tube e in fig. 2, or may be a tube of different diameter and wall thickness connected to the outer tube e.
Detailed Description
The following describes embodiments of the present invention in detail. The following examples are illustrative only and are not to be construed as limiting the invention.
Referring to fig. 1, the present invention contemplates a replaceable module 200 that may be applied to a radioisotope operating system 10 and a radioisotope operating system 10 that includes the replaceable module 200, in accordance with embodiments of the present invention. For convenience of understanding, hereinafter, the structure of the radioisotope operating system 10 will be first briefly described, and in describing the radioisotope operating system 10, the main components included in the radioisotope operating system 10, such as the replaceable module 200, the stationary module 100, and the exhaust gas processing device 250, etc., will be described.
Referring to fig. 1, a radioisotope operating system 10 in accordance with the present embodiment of the invention includes a setup module 100 and a replaceable module 200. The replaceable module 200 is a disposal cassette for a particular radioisotope operation (e.g., purification or tag synthesis of a radioisotope), and includes a base 210, a media transport 220, and a container 230. The medium transferring part 220 is mounted on the base 210 to form a fixed shape or position, and the base 210 may be a rectangular or substantially rectangular flat plate. According to the embodiment of the present invention, the base 210 may be formed of a photosensitive resin, whereby the curing degree of the base 210 may be improved to reduce deformation during use, and in addition, the photosensitive resin has less swelling to ensure the accuracy of the base 210. Of course, other materials may be selected by one skilled in the art depending on the application scenario. In addition, for convenience of description, in this document, unless otherwise specified, the extending direction corresponding to the long side of the base will be defined as the lateral direction, and the extending direction corresponding to the short side of the base will be defined as the longitudinal direction.
According to an embodiment of the present invention, the container 230(R0-R14) for accommodating various media or providing an accommodating space during the operation of the radioisotope manipulation system 10 may be a reagent bottle having various reagents required for performing radioisotope manipulations pre-filled therein, having a predetermined capacity, for example, about 5ml, 10 ml; or empty waste bottles, product bottles, target water bottles, and the like. Those skilled in the art will appreciate that the material of the container 230 may be selected by those skilled in the art according to the type of medium or the purpose of use of the container 230, for example, the container 230 may be a glass bottle, a plastic bottle, or other materials. According to an embodiment of the present invention, the container 230 may be a cylindrical glass bottle. In addition, depending on the type of operation or application scenario, a different number of containers 230 may be provided, each container 230 may have a different capacity, and further the containers 230 may have a flat bottom, a rounded bottom, a tapered bottom, or a weight-shaped bottom to improve responsiveness.
Referring now to fig. 1-4, in a detailed description of the replaceable module 200, according to an embodiment of the present invention, there is provided a replaceable module 200 for a radioisotope operating system 10, the replaceable module 200 comprising: a base 210, a holding part 211, and a medium transferring part 220, wherein the holding part 211 is provided on the base 210, and the holding part 211 protrudes from the surface of the base 210, the medium transferring part 220 includes a tube 221, and the medium transferring part 220 can be mounted on the base 210 through the holding part 211. According to an embodiment of the present invention, the holding part 211 may further include: a catching groove 2112 and a receiving chamber 2113, the catching groove 2112 being configured to fix the tube 221, the receiving chamber 2113 being configured to receive a pressing portion C provided on the fixing module 100, and the tube 221 passing through the receiving chamber 2113. Thus, according to the embodiment of the present invention, by providing the accommodating chamber 2113 adapted to accommodate the pressing portion C, it is possible to effectively deform the tube 221 by receiving the pressure from the pressing portion C during the radioisotope operation, thereby controlling the flow path in the tube 211, for example, opening or closing the tube, i.e., the pressing portion C may constitute a valve together with the accommodating chamber 2113 for opening and closing the tube 221 passing through the accommodating chamber 2113, and the reliable function of the valve may be ensured. In addition, according to the embodiment of the present invention, the holding portion 211 includes the notch 2112, and the notch 2112 is adapted to fix the tube 221, so that it is possible to ensure that the tube 221 does not move significantly during the radioisotope operation, particularly when the tube 221 is pressed by the pressing portion C, and to improve the efficiency of closing the flow path when the tube 221 is pressed by the pressing portion C, and therefore, the reliability of the apparatus can be further improved.
According to an embodiment of the present invention, it can be understood by those skilled in the art that the card slot 2112 and the accommodating portion 2113 may be separately provided or may be integrated. In addition, according to an embodiment of the present invention, the medium transferring part 220 may provide a flow path for fluid to flow therethrough, and include a plurality of pipes 221 and joints 222 for communicating the plurality of pipes 221 in a predetermined position or relationship, and each joint 222 may communicate one end of 2 or more pipes 221 with each other. According to an embodiment of the present invention, the tube 221 may be formed of silicone tube or platinum tube (i.e., a layer of teflon material is attached to the inner wall of the silicone tube), so that the tube 221 has good flexibility, is suitable for responding to the pressure of the pressing portion C, and can rapidly recover its shape after the pressure is removed. Of course, those skilled in the art will understand that other hoses or other materials may be used as long as the hoses or other materials can respond to the pressure of the pressing portion C in a deformation manner, so as to control the opening and closing of the flow path.
According to an embodiment of the present invention, the joint 222 may be constructed as a tee, and the material may be PP, etc., in order to reduce the residue of reagents at the joint. In addition, according to an embodiment of the present invention, the joint 222 may be further configured as a three-way cock valve, and accordingly, the fixing module 100 may be provided with a corresponding driving part, which imparts a driving force for switching the three-way cock valve, and the three-way cock valve may be detachably connected to the driving part. Referring to fig. 2, the medium transferring part 220 may further include a connecting part 223 connected to the container 230, the container 230 having an external threaded port S1, the connecting part 223 including a housing 2231 having an internal thread S2 (matching with the external threaded port S1), a rubber plug 2232 received in the housing 2231 and having at least one through hole S3 (not shown), and a connecting tube 2233 passing through the through hole S3 and the housing 2231, according to an embodiment of the present invention.
According to an embodiment of the present invention, the housing 2231 has a flange a and a side wall b connecting the flange a, the internal thread S2 is provided on the side wall b, and the connection pipe 2233 passes through the through hole S4 provided on the flange a; the rubber plug 2232 has a main body c and a rim portion d, the main body c can at least partially extend into the container 230, and the through hole S3 is disposed on the main body c. According to an embodiment of the present invention, the number of the through holes S3 may be 1, 2 or 3. When the connecting portion 223 is connected to the housing 2231, the flange a of the housing 2231 presses the edge portion d of the rubber plug 2232 between the wall 231 and the flange a of the container 230 to form a seal by screwing the housing 2231 so that the internal thread S2 of the screw housing 2231 engages with the external thread S1 of the container 230. The connecting tube 2233 includes an outer tube e and an inner tube f that are inserted together in an interference manner, the outer tube e is a silicone tube, and can be the end of the tube 221 directly extending from the cutting sleeve or be connected with the tube 221, the outer tube e is connected with the rubber plug 2232 through rubber sealing, and the length can be flush with or slightly protruding from the rubber plug 2232; the inner tube f is a peek tube and may be of varying lengths, longer extending to the bottom of the vessel for drawing liquid from the vessel and shorter flush with the outer tube e for venting gas or introducing liquid. According to an embodiment of the present invention, the connection part 223 may be connected to a container in advance in the reagent cartridge, and a tube near the connection part 223 may be caught to prevent the reagent from flowing out; it is also possible that the container is sealed by a separate lid which is unscrewed and the operator connects the connection to the container when in use. It is understood that other configurations of the connection 223 are possible. The medium transferring part 220 further includes a connection part 224 connected to the target solution, etc., and the pipe of the medium transferring part 220 is connected to the pipe of the target solution by internal and external threads or other connection structures, and the pipe of the medium transferring part 220 may also be connected to interfaces I (I1, I2, I3) preset on the installation module 100.
Referring to fig. 3 and 4, the base 210 may be provided with both a holding portion 211 and a guide portion 212, the medium transporting portion 220 being mounted on the base 210 through the holding portion 211, the holding portion 211 being configured as a plurality of protrusions 2111 on a flat plate and being integral with the base 210, and the guide portion 212 being configured as a groove on the flat plate. It will be appreciated by those skilled in the art that the retaining portion 211 may also be separately constructed and attached to the base. The protrusion 2111 is provided with a catching groove 2112 for catching the tube 221 and a receiving chamber 2113 through which the tube 221 passes. The notch 2112 has a converging section to prevent the tube from accidentally coming off the base 210. in particular, the notch 2112 includes a converging portion 2112a and an enlarged portion 2112b connected to the converging portion 2112a, the converging portion 2112a having a converging distance equal to or less than the outer diameter of the tube 221, and the enlarged portion 2112b having an enlarged distance greater than the outer diameter of the tube. According to an embodiment of the present invention, the slot 2112 is circular and matches with the shape of the tube 221, and the receiving cavity 2113 corresponds to and limits a pressing portion C (disposed on the fixing module 100 and described in detail later) for pressing the tube 221 to prevent the relative position between the pressing portion C and the base 210 from shifting when the tube 221 is pressed. The bottom of the receiving cavity 2113 has a flat surface which is slightly below the plane of the base or is flat with the plane of the base. Thus, the flat surface of the bottom of the accommodation portion 2113 can apply pressure to the tube 221 in cooperation with the pressing portion C, and uniformity can be improved, thereby preventing displacement of the tube due to uneven pressure. In addition, a boss 2114 may be further provided on the flat surface, and the boss 2114 cooperates with the pressing portion to press the tube 221 more reliably. According to an embodiment of the invention, the bosses 2114 extend in a manner not parallel to the grooves in the tube 221 or plate and protrude from the plane of the bottom of the receiving chamber 2113 or the plate surface of the susceptor, and according to an embodiment of the invention, the bosses 2114 extend perpendicular to the grooves in the tube 221 or plate and protrude from the plane of the bottom of the receiving chamber or the plate surface of the susceptor. It will be appreciated that the face of the boss which contacts the tube may be flat, arcuate, etc. According to the embodiment of the present invention, the opening and closing efficiency of the tube 221 can be improved by increasing the pressure of the pressing portion C, so that the boss 2114 is avoided.
According to the embodiment of the invention, the pressing part C can be a cylinder and has a cylindrical piston rod, the receiving cavity is correspondingly circular, the outer contour of the protruding part is also circular, so that 2 clamping grooves are oppositely arranged on each protruding part in the radial direction, and the pipe passes through the clamping grooves and the receiving cavity along the diameter of the protruding part. The number of the protruding portions 2111 is the same as that of the pressing portions, and the protruding portions are transversely arranged in two rows at two edges of the base corresponding to the long edges. Thus, the inlet and outlet of the flow path can be controlled, and the intermediate line can be connected in parallel by using a three-way valve or the like, so that a plurality of lines can be controlled by a small number of control nodes.
According to an embodiment of the present invention, the guide portion 212 guides the medium transporting portion, and the groove is formed in a circular arc shape matching the outer shape of the pipe 221 or the fitting 222 so that the pipe 221 and the fitting 222 can be partially received in the groove, and the groove has a concave distance smaller than the outer diameter of the pipe and extends at least partially through the holding portion 211 and communicates with the notch 2112 and the receiving chamber 2113, thereby guiding the medium transporting portion. According to the embodiment of the invention, the grooves comprise a transverse direction and a longitudinal direction, the grooves penetrating through the holding parts are all longitudinal, and the corresponding bosses are transverse long strips extending to the side walls of the accommodating cavity. In order to improve the stability, the auxiliary positioning part 213 is provided at the bending position of the pipe 221, the auxiliary positioning part 213 is configured as a protrusion 2131 on the base 210, a receiving groove 2132 is provided on the protrusion 2131, the groove extends through the protrusion 2131 and is communicated with the receiving groove 2132, the receiving groove is arc-shaped in the extending direction of the pipe 221, and the pipe 221 is guided and positioned in the arc-shaped groove. Preferably, the protrusion 2131 and the protrusion 2111 have the same height in the direction perpendicular to the plate surface of the base. Of course, one skilled in the art will appreciate that the protrusion 2131 may be lower than the protrusion 2111. The base 210 is further provided with a positioning member 214 for positioning and mounting the base to the fixing module, and according to the embodiment of the present invention, the positioning member is three through holes, two of the through holes are symmetrically arranged at one edge of the base corresponding to the short side, and one of the through holes is arranged at the middle position of the other edge of the base corresponding to the short side.
According to an embodiment of the present invention, the replaceable module 200 may further include a purification device 240 and an exhaust treatment device 250. According to the embodiment of the present invention, the purification device 240 is connected to the tubes 221 at both ends thereof to form a flow path for purification of the reaction medium, and may be connected in advance, or may be separately placed in the reagent kit and manually connected by an operator. According to an embodiment of the present invention, the purification apparatus 240 may be configured as a purification column (Z3, Z4) with different packing materials (described in detail later) inside the column tube of the purification column for different radioisotope operations, and the column tube may be made of acid and alkali corrosion resistant material such as teflon.
According to the embodiment of the invention, a large amount of strong acid waste gas and radioactive volatile substances are generated in the chemical reaction process of isotope operation, and most of the existing equipment does not treat the waste gas generated in the reaction process, so that the energy conservation and the environmental protection are not facilitated, and the equipment is corroded; some parts are condensed by liquid nitrogen firstly, and the parts which are not condensed are compressed by a gas storage tank and then stored, so that the liquid nitrogen needs to be replaced frequently, and the equipment has large volume and higher use cost. According to an embodiment of the present invention, the exhaust gas treatment device 250 is connected at one end to an exhaust gas passage (described in detail later) of the installation module 100, and is used for reducing corrosion of equipment and environmental pollution caused by acidic gases and radioactive volatiles discharged during operation.
Referring to fig. 5, the exhaust gas treatment device 250 includes an inlet 251, an outlet 252, a housing 253 communicating the inlet 251 and the outlet 252, and at least two different packings 254 disposed in the housing 253, and exhaust gas enters from the inlet 251 and exits from the outlet 252 through the packings 254. According to an embodiment of the present invention, the exhaust gas treatment device 250 is configured as an exhaust gas treatment column (Z1, Z2), the housing 253 is a column tube, which may be made of acid and alkali resistant material such as teflon, and the inlet 251 and the outlet 252 are disposed at both ends of the column tube, and at least two different fillers 254 are separated by at least one screen plate 255 disposed inside the column tube. Those skilled in the art can understand that other arrangement modes can be adopted according to actual requirements. The filling 254 is, in order from the inlet to the outlet, moist cotton, soda lime-containing cotton, activated carbon. The wet cotton can rapidly absorb acid components in the exhaust gas by containing a proper amount of water (for example, 5% -10%) inside the cotton, and the rest gas can flow through the cotton; the soda lime can be conventional loose porous granular soda lime sold in market, which adsorbs a small amount of moisture contained in the gas after passing through the cotton and neutralizes acid-containing components in the moisture; the active carbon can be selected from active carbon particles with the aperture of 10-500A degrees, and the active carbon can be used for adsorbing other possible components after the two steps are carried out. It will be appreciated that the filler 254 could have other configurations, cotton could be replaced by other fibrous materials, soda lime could be replaced by other acid removing substances, and activated carbon could be replaced by other adsorbent substances. The amount of each filler to be filled may be set according to the desired column volume, and it will be understood that the larger the column volume, the larger the flow rate per unit time of the exhaust gas allowed for the column volume, and the longer the life. Each filler 254 is arranged between two sieve plates 255 and accommodated in a space formed by the sieve plates 255 and the column tubes, the sieve plates 255 are flat, through holes are formed in the plate surfaces of the sieve plates 255, and the shapes of the cross sections of the inner walls of the column tubes are matched with the shapes of the cross sections of the sieve plates 255, so that different fillers 254 can be mutually separated, and waste gas can sequentially pass through the fillers. The waste gas treatment device has simple structure and low cost, can be used for a plurality of times, is convenient to replace, and can also be used for other products.
In addition, according to an embodiment of the present invention, a portion of the housing 253 may be made of a transparent material, so that a user can determine whether the entire exhaust gas treatment device 250 needs to be replaced by observing the form change of the filler 254, for example, when soda lime is used for a certain period of time, the form change is obvious.
In addition, different flow paths can be formed on the base in different arrangement modes by selecting the required medium transmission part consisting of the pipe and the joint according to different reactions of different radioisotope operations. The medium transferring part, the base, the container, etc. required for one reaction are constructed as one process cartridge (replaceable module 200) to be convenient to operate, and at the same time, one process cartridge is generally used for one or several operations due to the radioactivity remaining, and then a new process cartridge can be replaced without cleaning.
According to an embodiment of the present invention, the fixing module 100 may be a component having a cubic shape or a substantially cubic shape, and includes a main body 110 and a door 120. In the following description, the vertical direction, the front-rear direction, and the left-right direction refer to the orientation in which the installation surface side of the main body 110 is the lower side and the side surface to which the replaceable module 200 is attached is the front side. The front surface of the body 110 is provided with a mounting portion 111 to which the base 210 of the replaceable module 200 is mounted. The mounting portion 111 has a mounting member 1111 corresponding to the positioning member 214 on the base 210, which is a positioning pin according to an embodiment of the present invention; the mounting portion 111 further has a stopper 1112 for preventing the base 210 from being detached from the body portion 110. When mounted, the base 210 extends in the vertical direction of the body 110. The installation module 100 further comprises a receiving portion 130 in which the container 230 is placed.
According to an embodiment of the present invention, the receiving part 130 may include first, second, and third receiving parts 131, 132, and 133. The first receiving portion 131 is disposed on the upper surface of the main body 110, and is a rectangular parallelepiped, and has a plurality of receiving grooves 1311 formed on the upper surface thereof for receiving at least a part of a reagent bottle, a target water bottle, a middle bottle, and the like, and the front surface of the receiving groove may be open for an operator to observe the containers in the receiving groove. Referring to fig. 6, the second accommodating portion 132 is disposed on the front surface of the main body portion 110 and below the mounting portion 111, and has a T-shape as a whole, and a plurality of through holes 1321 are formed in the middle thereof for accommodating product bottles, waste liquid bottles, reaction bottles, and the like; the shorter parts of the two sides are respectively provided with a through hole 1322 for accommodating the purifying device 240, the purifying device 240 is provided with a flange 241, the flange 241 can be clamped on the upper surface of the second accommodating part 132, and the two ends of the purifying device 240 are respectively connected with the pipes 221; the through hole 1322 is completely communicated with the side 1323 in the up and down direction so that the tube 221 can pass through the side 1323 after the purification apparatus 240 is connected to the tube 221, thereby allowing the purification apparatus 240 to be disassembled without disassembling the tube 221. The third receiving portion 133 is disposed on a side surface of the main body portion 110, and has a plurality of through holes 1331 for receiving the exhaust gas treatment device 250, the exhaust gas treatment device 250 has a flange 256, the flange 256 can be clamped on an upper surface of the third receiving portion 133, and the through holes of the third receiving portion may be completely communicated with the side edges in an up-down direction. It is understood that the purification apparatus may be installed in the third receiving part.
According to the embodiment of the present invention, the first, second and third receiving portions 131, 132 and 133 are detachably fixed to the main body portion 110, such as by screw connection or snap connection, and can be replaced according to the type of product, and it is understood that they may be non-detachably connected or integrated. Each container is selectively placed in the receiving groove or the receiving hole of each receiving portion according to a specific operation. It is understood that the first, second and third receiving portions 131, 132 and 133 may be arranged in other manners.
According to the embodiment of the present invention, the door portion 120 is pivotally connected to the main body portion 110, and can at least partially close or open a portion of the front surface of the main body portion 110, and in the closed position, the door portion 120 covers the base 210 mounted on the front surface of the main body portion 110. According to the embodiment of the present invention, in the closed position, the door 120 is fixed to the body 110 by the fixing device 121, and the fixing device 121 is unlocked when the door is opened. Referring to fig. 7 and 8, the fixing device 121 includes a support 1211, an operating element 1212, and a locking element 1213, the support 1211 is fixedly mounted on the door leaf 120 by screws, the operating element 1212 is pivotally disposed on the support 1211 and can drive the locking element 1213 to move, the main body 110 is provided with an engaging element 112 engaged with the locking element 1213, and the locking element 1213 and the engaging element 112 are respectively provided with an interacting inclined surface A, B. The operating element 1212 is provided with an operating hole D in which the lock member 1213 is biased by a spring or the like to a lock position and can be locked by the locking member 112; the operating element 1212 is pulled by the operating hole D to rotate with respect to the support 1211, and the locking member 1213 can move to the release position and can be disengaged from the engaging member 112. It will be appreciated that the operating member and the locking member may be arranged in other ways and that the fixing means may take other forms, such as screws or the like.
A plurality of cylinders C (pressing portions) are provided at predetermined positions inside the door portion 120, the cylinders C are powered by an air compressor (not shown), air is supplied to each cylinder C through an air pipe (not shown) extending from the body portion 110, the cylinders C correspond to the housing chambers 2113 on the base 210 one-to-one, and when the door portion 120 is closed, the cylinders C can extend into the housing chambers 2113 to press the tubes 221, and function as opening and closing valves V for flattening or restoring the tubes 221. A pressure reducing valve 140 is provided on a side surface of the body 110 for adjusting a gas pressure. It is understood that other configurations of the pressing portion are possible. According to the embodiment of the invention, a large amount of space can be saved by arranging the cylinder C (the pressing part C) on the door leaf part, and in addition, when the door leaf part is closed, each pipeline can be ensured to be in a closed state when being started, so that the operation safety is improved.
According to an embodiment of the present invention, the fixed module 100 may further include first and second exhaust gas channels T1 and T2 (not shown in fig. 1) disposed in the main body 110, wherein the waste liquid bottles, product bottles, etc. of the detachable module 200 are connected to a preset exhaust gas inlet (preset interface) I1 of the main body through an exhaust gas pipe (pipe) connected to the connecting portion 223, the exhaust gas inlet I1 is connected to the first exhaust gas channel T1, the first exhaust gas channel T1 is connected to a preset exhaust gas outlet I2 of the main body 110, the exhaust gas outlet I2 is connected to the first exhaust gas treatment column Z1, and the exhaust gas in the waste liquid bottles, product bottles, etc. is exhausted through the exhaust gas pipe, the first exhaust gas channel T1, and the first exhaust gas treatment column Z1. The target water bottle and the (target washing) waste liquid bottle are connected with the second waste gas channel T2 and the second waste gas treatment column Z2 in the same way, the second waste gas treatment column Z2 is connected with a vacuum pump P3 (not shown in figure 1) arranged in the main body part through a vacuum pump inlet I3 preset on the main body part, waste gas in the target water bottle and the (target washing) waste liquid bottle is exhausted after passing through a waste gas pipe, the second waste gas channel T2, the second waste gas treatment column Z2 and the vacuum pump P3 under positive pressure of accelerator target transferring and negative pressure of the vacuum pump, and the vacuum pump P3 increases negative pressure so as to shorten target transferring time of the accelerator, reduce residual loss of pipelines and increase target transferring recovery rate. It will be appreciated that the vacuum pump may not be provided, and that there may be only one exhaust gas passage; the exhaust gas passage may not be provided.
For convenience of connection, the exhaust gas outlet I2 may be disposed above the third container 133, the inlet 251 of the exhaust gas treatment device 250 is connected to the exhaust gas outlet I2 through a pipe, and the outlet 252 of the exhaust gas treatment device 250 is opened to discharge the treated exhaust gas directly to the atmosphere or connected to the vacuum pump inlet I3 to discharge the treated exhaust gas to the atmosphere through the vacuum pump P3, it being understood that the exhaust gas outlet I2 may be disposed elsewhere as long as the connection with the exhaust gas treatment device 250 is facilitated near the third container 133.
According to the embodiment of the invention, the waste gas channel, the waste gas treatment column, the vacuum pump and the like form a waste gas treatment system, so that the problems of corrosion of acidic gas and radioactive volatile matters discharged in the process of metallic nuclide purification, labeling synthesis and other processes to equipment and environmental pollution are solved. To verify the effectiveness of the exhaust treatment, the following comparative tests were performed:
the following sequence of operations was performed in the column: placing a sieve plate, filling 400mg of cotton and 400uL of water, placing the sieve plate, filling the cotton and granular soda lime at intervals for 3 times (the total amount of the soda lime is about 2.5 g), placing the sieve plate, filling activated carbon, placing the sieve plate and pressing. Use nitrogen gas to let in the sealed glass bottle that is equipped with concentrated hydrochloric acid, introduce the long test tube that is full of water with the combustion gas with the pipeline, the hydrogen chloride gas that volatilizees from the glass bottle can be adsorbed by water to lead to long test tube normal water to be acidity, this experiment installs the exhaust-gas treatment post additional in the blast pipeline, if long test tube normal water is not acidity, then proves that volatilizing hydrogen chloride gas is detached by the exhaust-gas treatment post.
In a comparative test without adding an exhaust gas treatment column, 8mL of concentrated hydrochloric acid is directly bubbled with nitrogen into a long test tube filled with water (the water amount is about 20mL), and the pH value of the water in the test tube is measured after a few seconds and is less than 1.
In the adsorption experiment of the waste gas treatment column, 8mL of concentrated hydrochloric acid is sequentially connected into the waste gas treatment column, 1mL of water, 10mL of water and 200mL of water. The pH was measured to be 5 for 1mL of water after 30min of nitrogen bubbling.
And (4) continuously verifying the service life experiment of the treatment column after confirming the type of the empty column and replacing the filling mode.
The above test data show that the waste gas treatment column has obvious deacidification effect.
According to an embodiment of the present invention, the set module 100 further includes a media control part 180(P1, P2, P4), and referring to fig. 9, the media control part 180 includes a driving assembly 181, a rotor 182 driven to rotate by the driving assembly 181, a roller 183 provided on the rotor 182, and a cover 184 surrounding the rotor 182 and the roller 183. The driving assembly 181 is at least partially disposed inside the main body 110, and the rotor 182, the roller 183, and the cover 184 are disposed at both sides of the second receiving portion 132 at the front surface of the main body 110 according to an embodiment of the present invention, it being understood that the rotor, the roller, and the cover may be disposed at other positions, such as the upper surface of the main body. After the operator mounts the detachable module 200 to the mounting portion 111, a predetermined tube 221 is interposed between the roller 183 and the housing 184, the roller 183 rotates with respect to the rotor 182 in addition to rotating with the rotor 182, and the roller 183 rotates to press the tube 221 to deliver the fluid E by a pressing and releasing force. The number of the rollers 183 is at least 2, and the rollers 183 press and crush the tubes 221 in sequence while rotating with the rotor 182, and move with the rollers 183 to form a positive pressure in the front tube to push the fluid to flow forward, and move with the rollers 183 to form a negative pressure in the rear tube to continuously suck the fluid, so that the fluid circulates and flows along with the fluid. It will be appreciated that the roller 183 may be replaced by other pressing elements which are rotatable with the rotor and which are movable relative to the rotor. The flow velocity of the fluid can be controlled by controlling the rotating speed of the rotor, the flow velocity is stable and can be adjusted and controlled, the purification effect of the fluid passing through the purification column can be controlled, and full adsorption and rapid elution are realized; by controlling the rotation direction of the rotor, the fluid can flow in the forward direction or the reverse direction, so that the equipment is easier to operate and has multiple functions. The medium control part according to the embodiment of the invention isolates the medium in the pump pipe, and the medium is not contacted with the medium control part or other parts of the fixed module, so that the corrosion of strong acid to equipment is avoided, and the durability and the service life of the equipment are prolonged.
Depending on the type of radioisotope operation, the setup module 100 may further include a heating device 190(H1, H2, H3, not shown in the figure) for heating the reaction vial, and the heating device 190 may be electrically connected to the inside of the main body 110, may be disposed below the second container 132 when heating the reaction vial, may be fixed to the second container 132 to be separated from the main body 110 together with the second container 132, or may be directly fixed to the main body 110. It is understood that the fixed module 100 may be further provided with a cooling means for cooling the reaction flask, a pressure sensor for confirming the pressure inside the reaction flask, a thermometer for confirming the temperature inside the reaction flask, a radiation sensor for confirming the amount of radiation contained in the reaction flask, an electric furnace for heating gas on line, a mass flow controller for controlling the flow rate of gas, and the like.
Referring to fig. 10, according to an embodiment of the present invention, the radioisotope operating device 10 further includes a control module 300, wherein the control module 300 is electrically connected to the installation module 100, and is capable of remotely controlling the operation of the radioisotope operating device 10. The control module 300 controls the operations of the on-off valve V, the medium control unit 180, the vacuum pump P3, the heating device 190, and the like to operate the transport and reaction of the medium in the medium transport unit 220 and the various containers 230. It will be appreciated that the control module may also control other components of the fixture module. The control module 300 controls the opening or closing of each opening and closing valve V by supplying power to each cylinder C; the medium flow rate can be controlled by setting the gear position by controlling the opening and closing of the medium control unit 180 and the vacuum pump P3; and the opening and closing of the heating device 190 and the setting of the heating temperature. The control module 300 includes a manual mode, an automatic mode, and a semi-automatic mode. In the manual mode, the operation of the equipment is controlled by clicking corresponding controls on an operation interface of the control module 300, such as each opening and closing valve V, the medium control part 180, the vacuum pump P3, the heating device 190 and the like, and the current state is kept before the next command is sent out; the full-automatic mode automatically runs according to a software design time sequence after a corresponding reaction program is selected until all steps under the program are finished; the semi-automatic mode can manually click each step under a corresponding reaction program and fully automatically run according to time sequence until the step is finished. The running time of the steps can also be set manually in fully automatic and semi-automatic modes.
Hereinafter, an example of the radioisotope manipulation apparatus used for radioisotope purification will be described with reference to fig. 11 to 16. For convenience of explanation, only the action parts of the replaceable module and the fixed module related to the purification reaction are shown in the figure, the medium conveying part is explained by a flow path L formed by a pipe and a joint, a connecting part is not shown, and opening and closing valves formed by the pressing part and the accommodating cavity are sequentially arranged from the left to the top in V1-V22. By irradiating a metal target with a charged particle beam at an accelerator end (not shown), a trace amount of radioisotope is generated in the target. Examples of the radioactive isotope which can be purified include89Zr、 64Cu、 68Ga and the like; the accelerator can be a cyclotron or a linear accelerator; irradiationThe charged particles are protons, deuterium, alpha particles,3He, electron, or the like; examples of the target material include90Y、 64Ni、 68Zn, and the like.
Example 1[ 2 ]89Purification of Zr (zirconium oxalate)]
For89The replaceable module for Zr (zirconium oxalate) purification comprises a base 210, a medium transmission part 220 consisting of flow paths L111-L122, waste gas treatment columns Z1 and Z2, a purification column Z3, a target water bottle R1, reagent bottles R3, R4 and R5, waste liquid bottles R10 and R12 and a product bottle R13; the fixed module is provided with a medium control part P1, exhaust channels T1 and T2 and a vacuum pump P3. The packing material of the purification column Z3 is a hydroxamate functional group-containing resin.
Refer to FIG. 11 for89The Zr (zirconium oxalate) purified medium transfer part is formed into flow paths L111-L122. L111 extends from the accelerator respective port to a waste bottle R10, through valves V1 and V12; l112 extends from L111 to the target bottle R1, through valve V2; l113 extends from the target water bottle R1 to the purification column Z3, through valve V3 and media control P1; l114 extends from purification column Z3 to waste bottle R12, through valve V17; l115 extends from L114 to product bottle R13, through valve V18; l116 extends from reagent bottle R3 to L113, through valve V4; l117 extends from reagent bottle R4 to L113, through valve V5; l118 extends from reagent bottle R5 to L117, through valve V6; l119 and L120 respectively extend from a target water bottle R1 and a waste liquid bottle R10 to be connected to an exhaust gas channel T2, the exhaust gas channel T2 is connected to the inlet of an exhaust gas treatment column Z2, and the outlet of the exhaust gas treatment column Z2 is connected to a vacuum pump P3; l121 and L122 extend out from a waste liquid bottle R12 and a product bottle R13 respectively and are connected to an exhaust gas channel T1, the exhaust gas channel T1 is connected to an inlet of an exhaust gas treatment column Z1, and an outlet of the exhaust gas treatment column Z1 is communicated with the atmosphere.
The use of the above modules is then carried out89The reaction for the purification of Zr (zirconium oxalate) will be explained. In the following, all the valves and the media control units, the vacuum pumps, the heating devices, etc. of the fixed modules are in the closed state, and in the operation process, the valves and the media control units, the vacuum pumps, the heating devices, etc. are in the closed state except for the open state.
Target transfer is performed first, L111 is connected to the accelerator (not shown) port,after bombardment by 12MeV proton beam of cyclotron90The Y target piece was dissolved with 6M hydrochloric acid at the accelerator end and then flowed out of the accelerator port. The valves V1 and V2 are opened, the valve of the accelerator port is opened, the vacuum pump P3 is started, under the action of positive pressure of the accelerator and the vacuum pump P3, target water flows into the target water bottle R1 through L111 and L112, and exhaust gas flows through the exhaust gas treatment column Z2 through L119 and an exhaust gas channel T2 and is discharged through the vacuum pump P3. After target conveying is finished, the accelerator end is operated, so that the accelerator target washing waste liquid flows out from the accelerator port, V1 and V12 are opened, a valve of the accelerator port is opened, a vacuum pump P3 is started, the target washing waste liquid flows to a waste liquid bottle R10 through L111 under the action of positive pressure of the accelerator and the vacuum pump P3, and the waste gas flows through a waste gas treatment column Z2 through L120 and a waste gas channel T2 and is discharged through the vacuum pump P3.
Then purification adsorption is carried out, valves V3 and V17 are opened, a medium control part P1 is started, liquid in a target water bottle R1 flows through a purification column Z3 through L113 and L114 under the pushing action of the medium control part,89zr is absorbed by a purification column Z3, waste liquid enters a waste liquid bottle R12, and waste gas flows through a waste gas treatment column Z1 through L121 and a waste gas channel T1 and then is discharged.
Then cleaning the purification column Z3, opening V4 and V17, starting a medium control part P1, enabling liquid (2M, 10mL hydrochloric acid) in a reagent bottle R3 to flow through the purification column Z3 through L116, L113 and L114 under the pushing action of the medium control part, eluting impurities such as target materials and the like on the column, enabling waste liquid to enter a waste liquid bottle R12, and enabling waste gas to flow through a waste gas treatment column Z1 through L121 and a waste gas channel T1 and then discharging; opening V5 and V17, starting a medium control part P1, enabling liquid (10mL of ultrapure water) in a reagent bottle R4 to flow through a Z3 purification column through L117, L113 and L114 under the pushing action of the medium control part, eluting residual impurities on the column, enabling waste liquid to enter a waste liquid bottle R12, enabling waste gas to flow through a waste gas treatment column Z1 through L121 and a waste gas channel T1, and then discharging.
Finally eluting the product, opening V6 and V18, starting a medium control part P1, enabling the liquid (1M, 2mL oxalic acid solution) in the reagent bottle R5 to flow through the Z3 purification column through L118, L117, L113, L114 and L115 under the pushing action of the medium control part, and eluting the product on the column89Zr enters a product collecting bottle R13, and the waste gas is discharged after flowing through a waste gas treatment column Z1 through L122 and a waste gas channel T1.
Example 2[ alpha ], [ alpha ] an89Purification of Zr (zirconium chloride hydrochloride)]
For89The replaceable module for Zr (zirconium chloride hydrochloride) purification comprises a base 210, a medium transmission part 220 consisting of flow paths L211-L229, waste gas treatment columns Z1 and Z2, purification columns Z3 and Z4, a target water bottle R1, an intermediate bottle R2, reagent bottles R3, R4, R5, R8 and R9, a waste liquid bottle R10, a waste liquid bottle R12 and a product bottle R13; the fixed module is provided with medium control parts P1 and P2, exhaust gas channels T1 and T2 and a vacuum pump P3. The packing of the purification column Z3 is a resin containing hydroxamic acid functional groups, and the packing of the purification column Z4 is a hydrophilic strong anion exchange adsorbent.
Refer to FIG. 12 for89The Zr (zirconium chloride hydrochloride) purified medium transfer part forms flow paths L211-L225 and L227-L229. L211-L214, L216-L222 and89the flow paths L111-L114 and L116-L122 for Zr (zirconium oxalate) purification are the same. L215 extends from L214 to intermediate bottle R2, through valve V7; l223 extends from the middle bottle R2 and is connected to an exhaust channel T1; l224 extends from intermediate bottle R2 to purification column Z4, through valve V8 and media control P2; l225 extends from purification column Z4 to waste bottle R12, through valve V19; l227 extends from reagent bottle R8 to L224, through valve V10; l228 extends from reagent bottle R9 to L227, through valve V11; l229 extends from L225 to product bottle R13 through valve V20.
The use of the above modules is then carried out89The reaction for Zr (zirconium chloride hydrochloride) purification is explained.
Wherein the steps of target transfer, purification adsorption and cleaning of the purification column Z3 are as follows89The same procedure was used for Zr (zirconium oxalate) purification.
After the purification column Z3 is cleaned, the elution column enters zirconium oxalate, V6 and V7 are opened, the medium control part P1 is started, liquid (1M, 2mL oxalic acid solution) in the reagent bottle R5 flows through the Z3 purification column through L218, L217, L213, L214 and L215 under the pushing action of the medium control part, and the solution is eluted on the column89Zr (zirconium oxalate), enters an intermediate bottle R2, and the exhaust gas flows through an exhaust gas treatment column Z1 through L223 and an exhaust gas channel T1 and then is discharged.
Then zirconium oxalate is loaded on the column, V8 and V19 are opened, and a medium control part P2 is started,the liquid in the middle bottle R2 flows through the Z4 purification column through L224 and L225 under the pushing action of the medium control part,89zr was adsorbed on the column and oxalic acid flowed into a waste bottle R12.
Then, the purification column Z4 is cleaned, V10 and V19 are opened, the medium controller P2 is started, the liquid (10mL water) in the reagent bottle R8 flows through the purification column Z4 via L227, L224 and L225 under the pushing action of the medium controller, and the oxalic acid on the column is eluted to the waste liquid bottle R12.
Finally eluting product, opening V11 and V20, starting medium control part P2, making the liquid (1M, 1mL hydrochloric acid) in reagent bottle R9 flow through purification column Z4 via L228, L227, L224, L225 and L229 under the push of medium control part, eluting89Zr products enter a product bottle R13, and waste gas is discharged after flowing through a waste gas treatment column Z1 through L222 and a waste gas channel T1.
Example 3[ alpha ], [ alpha ] an64Purification of Cu (cupric chloride hydrochloride)]
For64The replaceable module for purifying Cu (copper chloride hydrochloride) comprises a base 210, a medium transmission part 220 consisting of flow paths L311-L322, L330 and L331, waste gas treatment columns Z1 and Z2, a purification column Z3, a target water bottle R1, reagent bottles R3, R4 and R5, waste water bottles R10 and R12, a target recovery bottle R11 and a product bottle R13; the fixed module is provided with a medium control part P1, exhaust channels T1 and T2 and a vacuum pump P3. The packing of the purification column Z3 is an anion exchange resin.
Refer to FIG. 13 for64The medium transfer part for Cu (copper chloride hydrochloride) purification is formed into flow paths L311-L322, L330 and L331. L311-L322 and89the flow paths L111 to L122 for Zr (zirconium oxalate) purification are the same. L330 extends from L314 to target recovery bottle R11, through valve V12; l331 extends from the target recovery bottle R11 and is connected to an exhaust passage T2.
The use of the above modules is then carried out64The reaction for Cu (copper chloride hydrochloride) purification is illustrated.
Firstly, the target is transferred, L311 is connected to the port of an accelerator (not shown in the figure), and the target is bombarded by a 12MeV proton beam of the cyclotron64The Ni target piece was dissolved with 6M hydrochloric acid at the accelerator end and then flowed out of the accelerator end. OpenV1 and V2, and opening the valve of the accelerator port, starting the vacuum pump P3, under the action of positive pressure of the accelerator and the vacuum pump P3, the target water flows into the target water bottle R1 through L311 and L312, and the exhaust gas flows through the exhaust gas treatment column Z2 through L319 and an exhaust gas channel T2 and is discharged through the vacuum pump P3. After target conveying is finished, the accelerator end is operated, so that the accelerator target washing waste liquid flows out from the accelerator port, V1 and V12 are opened, a valve of the accelerator port is opened, a vacuum pump P3 is started, the target washing waste liquid flows to a waste liquid bottle R10 through L311 under the action of positive pressure of the accelerator and the vacuum pump P3, and the waste gas flows through a waste gas treatment column Z2 through L320 and a waste gas channel T2 and is discharged through the vacuum pump P3.
Then, purification adsorption is carried out, valves V3 and V16 are opened, a medium control part P1 is started, liquid in a target water bottle R1 flows through a purification column Z3 through L313, L314 and L330 under the pushing action of the medium control part, 64Cu is adsorbed by a purification column Z3, and target materials64The Ni recovery liquid enters a target recovery bottle R11, and the waste gas flows through a waste gas treatment column Z1 through an L331 and a waste gas channel T1 and is discharged.
Then cleaning the purification column Z3, opening V4 and V16, starting the medium control part P1, under the pushing action of the medium control part, the liquid (6M, 2mL hydrochloric acid) in the reagent bottle R3 flows through the purification column Z3 through L316, L313, L314 and L330, and the target material remained on the elution column64Ni enters a target material recovery bottle R11, and waste gas flows through a waste gas treatment column Z1 through an L331 and a waste gas channel T1 and is discharged; opening V5 and V17, starting a medium control part P1, enabling liquid (6M, 10mL hydrochloric acid) in a reagent bottle R4 to flow through a Z3 purification column through L317, L313 and L314 under the pushing action of the medium control part, eluting residual impurities on the column, enabling waste liquid to enter a waste liquid bottle R12, and enabling waste gas to flow through a waste gas treatment column Z1 through L321 and a waste gas channel T1 and then be discharged.
Finally eluting the product, opening V6 and V18, starting a medium control part P1, enabling the liquid (1M, 2mL hydrochloric acid) in the reagent bottle R5 to flow through the Z3 purification column through L318, L317, L313, L314 and L315 under the pushing action of the medium control part, and eluting the product on the column64Ni enters a product collecting bottle R13, and the waste gas flows through a waste gas treatment column Z1 through L322 and a waste gas channel T1 and is discharged.
Example 4[ alpha ], [ alpha ] an64Purification of Cu (neutral copper chloride)]
For64The replaceable module for purifying Cu (neutral copper chloride) comprises a base 210, a medium transmission part 220 consisting of flow paths L411-L431, waste gas treatment columns Z1 and Z2, purification columns Z3 and Z4, a target water bottle R1, an intermediate bottle R2, reagent bottles R3, R4, R5, R7, R8 and R9, waste water bottles R10 and R12, a target recovery bottle R11 and a product bottle R13; the fixed module is provided with medium control parts P1 and P2, exhaust gas channels T1 and T2 and a vacuum pump P3. The packing of the purification columns Z3 and Z4 is anion exchange resin.
Refer to FIG. 14 for64The medium transport section for Cu (neutral copper chloride) purification is formed into flow paths L411-L431. L411-L425, L427-L429 and89the flow paths L211 to L225 and L227 to L229 for Zr (zirconium chloride hydrochloride) purification are the same. L430, L431 and64the flow paths L330 and L331 for Cu (copper chloride hydrochloride) purification are the same. L426 extends from reagent bottle R7 to L424, through valve V9.
The use of the above modules is then carried out64The reaction for Cu (neutral copper chloride) purification is illustrated.
Wherein the steps of target transfer, purification adsorption and cleaning of the purification column Z3 are as follows64The same procedure was used for the purification of Cu (cupric chloride hydrochloride).
After the purification column Z3 is cleaned, copper chloride enters the elution column, V6 and V7 are opened, the medium control part P1 is started, liquid (1M, 2mL hydrochloric acid) in the reagent bottle R5 flows through the Z3 purification column through L418, L417, L413, L414 and L415 under the pushing action of the medium control part, and the liquid is eluted on the column64Cu (hydrochloric acid copper chloride) enters an intermediate bottle R2, and exhaust gas flows through an exhaust gas treatment column Z1 through L423 and an exhaust gas channel T1 and then is discharged.
Then loading copper chloride hydrochloride on the column, opening V8 and V19, starting a medium control part P2, enabling the liquid in the middle bottle R2 to flow through the Z4 purification column through L424 and L425 under the pushing action of the medium control part,64cu is adsorbed on the column and hydrochloric acid flows into a waste bottle R12.
Then cleaning the purification column Z4, opening V9 and V19, starting a medium control part P2, enabling liquid (8M, 1.5mL hydrochloric acid) in a reagent bottle R7 to flow through the purification column Z4 through L426, L424 and L425 under the pushing action of the medium control part, and eluting impurities on the column to a waste liquid bottle R12; v10 and V19 are opened, a medium control part P2 is started, liquid (0.2mL of ultrapure water) in a reagent bottle R8 flows through a purification column Z4 through L427, L424 and L425 under the pushing action of the medium control part, and hydrochloric acid on the column is eluted to a waste liquid bottle R12.
Finally eluting the product, opening V11 and V20, starting the medium control part P2, enabling the liquid (1mL of ultrapure water) in the reagent bottle R9 to flow through the purification column Z4 by the pushing action of the medium control part through L428, L427, L424, L425 and L429, and eluting64Cu products are conveyed to a product bottle R13, and exhaust gas flows through an exhaust gas treatment column Z1 through an L422 and an exhaust gas channel T1 and is discharged.
Example 5[ alpha ], [ alpha ] an68Purification of Ga (gallium chloride hydrochloride)]
For68The replaceable module for purifying Ga (gallium chloride hydrochloride) comprises a base 210, a medium transmission part 220 consisting of flow paths L511-L522, L530 and L531, waste gas treatment columns Z1 and Z2, a purification column Z3, a target water bottle R1, reagent bottles R3, R4 and R5, waste water bottles R10 and R12, a target recovery bottle R11 and a product bottle R13; the fixed module is provided with a medium control part P1, exhaust channels T1 and T2 and a vacuum pump P3. The packing material of the purification column Z3 is a hydroxamate functional group-containing resin.
Refer to FIG. 15 for68The Ga (gallium chloride hydrochloride) purified medium transfer part forms flow paths L511-L522, L530 and L531. And64the flow paths L311-L322, L330 and L331 for Cu (copper chloride hydrochloride) purification are the same.
The use of the above modules is then carried out68The reaction for Ga (gallium chloride hydrochloride) purification is illustrated.
Firstly, the target is transferred, L511 is connected to the port of an accelerator (not shown in the figure), and the target is bombarded by a 12MeV proton beam of the cyclotron68The Zn target was dissolved with 10M hydrochloric acid at the accelerator end and then flowed out of the accelerator end. The valves V1 and V2 are opened, the valve of the accelerator port is opened, the vacuum pump P3 is started, under the action of positive pressure of the accelerator and the vacuum pump P3, target water flows into the target water bottle R1 through L511 and L512, and exhaust gas flows through the exhaust gas treatment column Z2 through L519 and an exhaust gas channel T2 and is discharged through the vacuum pump P3. After the target transmission is finished, the accelerator end is operated,and (3) enabling the accelerator target washing waste liquid to flow out from the accelerator port, opening V1 and V12, opening a valve at the accelerator port, starting a vacuum pump P3, enabling the target washing waste liquid to flow to a waste liquid bottle R10 through L511 under the action of positive pressure of the accelerator and the vacuum pump P3, enabling the waste gas to flow through a waste gas treatment column Z2 through L520 and a waste gas channel T2, and then discharging the waste gas through the vacuum pump P3.
Then, purification adsorption is carried out, valves V3 and V16 are opened, a medium control part P1 is started, liquid in a target water bottle R1 flows through a purification column Z3 through L513, L514 and L530 under the pushing action of the medium control part, 68Ga is adsorbed by a purification column Z3, and target materials are adsorbed68The Zn recovery liquid enters a target recovery bottle R11, and the waste gas flows through a waste gas treatment column Z1 through an L531 and waste gas channel T1 and is discharged.
Then, the purification column Z3 was cleaned, the V4 and V16 valves were opened, the medium controller P1 was started, and the liquid (10M, 2mL hydrochloric acid) in the reagent bottle R3 was pushed by the medium controller to flow through the purification column Z3 via L516, L513, L514 and L530, thereby eluting the target remaining on the column68Zn enters a target material recovery bottle R11, and waste gas flows through a waste gas treatment column Z1 through an L531 and waste gas channel T1 and is discharged; opening V5 and V17, starting a medium control part P1, enabling liquid (10M, 2mL hydrochloric acid) in a reagent bottle R4 to flow through a Z3 purification column through L517, L513 and L514 under the pushing action of the medium control part, eluting residual impurities on the column, enabling waste liquid to enter a waste liquid bottle R12, and enabling waste gas to flow through a waste gas treatment column Z1 through L521 and a waste gas channel T1 and then be discharged.
Finally eluting the product, opening V6 and V18, starting a medium control part P1, enabling the liquid (2M, 2mL hydrochloric acid) in the reagent bottle R5 to flow through a Z3 purification column through L518, L517, L513, L514 and L515 under the pushing action of the medium control part, and eluting the product on the column68Ga enters a product collecting bottle R13, and the waste gas flows through a waste gas treatment column Z1 through an L522 and a waste gas channel T1 and is discharged.
In the above embodiment, the target sheet bombarded by the proton beam of the cyclotron is dissolved at the accelerator end, and then directly flows out from the accelerator port and is connected to the corresponding interface of the medium transfer part, and it can be understood that the target sheet may also be dissolved in the radioisotope operating device after being delivered from the accelerator end, and then the next operation is performed, that is, the radioisotope operation is performedThe apparatus further includes a target dissolving section (composed of a target dissolution bottle R0, a heating device H1, a filter F1, and a medium control section P4 described below). Refer to fig. 16 in order89For the purification of Zr (zirconium chloride hydrochloride), the replaceable module is added with the target dissolution bottle R0 and the filter F1, and the fixed module is added with the heating device H1 and the medium controller P4 for heating the target dissolution bottle R0, and the waste bottle R10 is eliminated, as compared with the embodiment shown in fig. 12. The medium transporting section forms flow paths L611-L619, L621-L625, and L627-L629, wherein L613-L619, L621-L625, and L627-L629 are the same as L213-L219, L221-L225, and L227-L229. L611 extends from target dissolution bottle R0 to filter F1, through media control P4; l612 extends from filter F1 to the target water bottle R1. It is understood that L611 and L612 can also control their flow paths through valves, only through the medium control part P4 according to the embodiment of the present invention.
After bombardment by 12MeV proton beam of cyclotron90The Y target piece, after coming out of the accelerator end, was transported to the radioisotope handling device end using a lead shielded canister, and was placed in the target piece dissolution bottle R6. Firstly, target tablet dissolution is carried out, hydrochloric acid (usually 6M, 3mL) with required concentration is added into a target tablet dissolution bottle R6 in advance, and a heating device H1 is started to heat the target tablet dissolution bottle R6 to 40-60 ℃ for auxiliary dissolution for 2 min. Then, the target transfer was performed, the medium controller P4 was opened, and the liquid in the target piece dissolving bottle R6 was passed through the filter F1 to remove undissolved solid impurities, and then entered the target water bottle R1. Steps after target transfer and not involving target dissolving part89The same procedure was used for the Zr (zirconium chloride hydrochloride) purification reaction.
Hereinafter, an example of the case where the radioisotope manipulation apparatus is used for radioisotope label synthesis will be described with reference to fig. 17 to 18. For convenience of explanation, only the action parts of the replaceable module and the fixed module related to the label synthesis reaction are shown in the figure, the medium conveying part is explained by a flow path L formed by a pipe and a joint, the connecting part is not shown, and the opening and closing valves formed by the pressing part and the accommodating cavity are sequentially arranged from the left to the top in a V1-V26 mode. Different radioactive isotopes include, for example, 68Ga, 64Cu, 89Zr, and different substances can be labeled, including, for example, small molecules, polypeptides, proteins, mabs, and the like.
Example 6[ alpha ], [ alpha89Zr (zirconium oxalate) marked DFO modified monoclonal antibody]
For89The replaceable module of the Zr (zirconium oxalate) marked DFO modified monoclonal antibody comprises a base 210, a medium transmission part 220 consisting of flow paths L711-L722, a purification column Z3, a middle bottle R2, reagent bottles R3-R8, a waste liquid bottle R12, a product bottle R13, a reaction bottle R14 and a sterile filter membrane F2; the fixed module has medium control parts P1, P2, and a heating device H2. Wherein89Zr (zirconium oxalate) can be synthesized by the radioisotope operating device in the above-described example for radioisotope purification89The Zr-oxalic acid solution is put into the middle bottle R2 according to the embodiment of the invention, and the automatic labeling synthesis can be carried out by the radioisotope operating device according to the embodiment of the invention89Zr-DFO-mAb. The purification column Z3 is a protein purification column.
Refer to FIG. 17 for89The medium transport part of the DFO modified monoclonal antibody labeled with Zr (zirconium oxalate) was formed into a flow path L711-L122. L711 extends from intermediate bottle R2 to reactor bottle R14, passing through valves V3, V17 and medium controller P1; l712 extends from reagent bottle R3 to L711, through valve V1; l713 extends from reagent bottle R4 to L711, through valve V2; l714 extends from L711 to intermediate bottle R2, through valve V4; l715 extends from reagent bottle R5 to purification column Z3, through valve V5 and media control P2; l716 extends from reagent bottle R6 to L715, through valve V6; l717 extends from reagent bottle R7 to L715, through valve V7; l718 extends from reagent bottle R8 to L717 through valve V8; l719 extends from reaction vial R14 to L715, through valve V18; l720 extends from purification column Z3 to waste bottle R12, through valve V22; l721 extends from L720 to product bottle R13, through valve V21 and sterile filter F2.
The following is made using the above module89The reaction of the DFO-modified monoclonal antibody labeled with Zr (zirconium oxalate) will be described.
Neutralizing: v1 and V4 were opened, the medium controller P1 was started, and the solution (0.15M, 0.5mL acetic acid/sodium acetate buffer solution (or HEPES solution) +0.1mL, 1M Na2CO3 solution) in the reagent bottle R3 was passed throughL712, L711, L714 are transferred to pre-join89In an intermediate bottle R2 of Zr-oxalic acid solution, the transfer was completed and the solution was held for 20 seconds to neutralize89Zr solution to pH 7 to obtain89Zr neutralizing solution.
Transferring a neutralizing solution: v3 and V17 were opened, and the medium controller P1 was started, and the neutralized solution in the intermediate flask R2 was transferred to the reaction flask R14 via L711.
Transferring antibodies: v2 and V17 were opened, the medium controller P1 was started, and the liquid in the reagent bottle R4 (DFO-mAb antibody solution) was transferred into the reaction bottle R14 via L713 and L711.
Chelating reaction and purification preparation: starting a heating device H2 to heat the reaction flask R14 to 30 ℃, and maintaining the reaction for 30-60 min; opening V5 and V22, starting the medium control part P2, allowing the liquid (35mL of ultrapure water) in the reagent bottle R5 to flow through the purification column Z3 through L715 and L720, washing, and allowing the waste liquid to flow into the waste liquid bottle R12; after completion, V6 and V22 are opened, a medium control part P2 is started, liquid (0.15M, 15mL acetic acid/sodium acetate buffer solution) in a reagent bottle R6 flows through a purification column Z3 through L716, L715 and L720 for salt saturation, and waste liquid flows into a waste liquid bottle R12; v7 and V22 were opened, the medium controller P2 was started, and the liquid in the reagent bottle R7 (0.15M, 20mL acetic acid/sodium acetate buffer) was passed through the purification column Z3 via L717, L715 and L720, and was again saturated with salt, and the waste liquid flowed into the waste liquid bottle R12.
Separation and purification: after the reaction in the reaction flask R14 is finished, V18 and V22 are opened, the medium control part P2 is started, the reaction solution in the reaction flask R14 flows through the purification column Z3 through L719, L715 and L720, the waste liquid flows into the waste liquid flask R12, and the target product89The Zr-DFO-mAb was retained on the purification column Z3.
Eluting the product: opening V8 and V21, starting medium control part P2, flowing liquid (0.15M, 3mL acetic acid/sodium acetate solution) from reagent bottle R8 through L718, L717, L715, L720 and L721 through purification column Z3, and loading89Eluting with Zr-DFO-mAb, filtering with sterile filter membrane F2, and bottling in product bottle R13 to obtain final product.
Example 7[ alpha ], [ alpha68Ga (gallium chloride hydrochloride) labeled DOTA modified small molecule peptide]
For68Ga (gallium chloride hydrochloride)) The replaceable module for marking the DOTA modified small molecule peptide is provided with a base 210, a medium transmission part 220 consisting of flow paths L811-L822, a purification column Z3, a middle bottle R2, reagent bottles R3-R9, a waste liquid bottle R12, a product bottle R13, a reaction bottle R14 and a sterile filter membrane F2; the fixed module has medium control parts P1, P2, and heating devices H2, H3. Wherein68Ga (gallium chloride hydrochloride) can be synthesized by the radioisotope operating apparatus in the above-described example for radioisotope purification68Ga (gallium chloride hydrochloride) solution is put into a reagent bottle R3 according to an embodiment of the present invention, and can be automatically labeled and synthesized by a radioisotope operating device according to an embodiment of the present invention68Ga-DOTA-polypeptide. The purification column Z3 is a C-18 solid phase extraction column.
Refer to FIG. 18 for68The medium transport part of the Ga (gallium chloride hydrochloride) labeled DOTA modified small-molecule peptide forms a flow path L811-L822. L811 extends from intermediate bottle R2 to reaction bottle R14, through valves V3, V20 and medium controller P1; l812 extends from reagent bottle R3 to L811, through valve V1; l813 extends from reagent bottle R4 to L811, through valve V2; l814 extends from L811 to intermediate bottle R2, through valve V4; l815 extends from reagent bottle R5 to purification column Z3, through valves V5, V10 and media control P2; l816 extends from reagent bottle R6 to L815, through valve V6; l817 extends from reagent bottle R7 to L815, through valve V7; l818 extends from reagent bottle R8 to L817, through valve V8; l819 extends from reagent bottle R9 to L817 through valve V9; l820 extends from reactor vial R14 to L815, through valve V21; l821 extends from purification column Z3 to waste bottle R12, through valve V26; l822 extends from L821 to product bottle R13, through valve V25 and sterile filter F2; l823 extends from L815 to product bottle R13, through valve V24 and sterile filter F3.
The following is made using the above module68The reaction of Ga (gallium chloride hydrochloride) labeled DOTA to modify small molecule peptide is explained.
Transferring nuclides: v1 and V4 are opened, the medium control part P1 is started, and liquid (C) in the reagent bottle R368Ga-GaCl 3+ HCl solution) was transferred via L812, L811, L814 into an intermediate bottle R2.
Neutralizing: v2 and V4 were opened, medium controller P1 was started, and the liquid (0.1M NaOH solution) in reagent bottle R4 was transferred to intermediate bottle R2 via L813, L811 and L814, to neutralize the pH of the liquid in intermediate bottle R2 to 4.0.
Transferring a neutralizing solution: v3 and V20 are opened, a medium control part P1 is started, the neutralizing solution in the middle bottle R2 is transferred into a reaction bottle R14 through L811, and a DOTA-small molecule peptide solution to be labeled is added into a reaction bottle R14 in advance.
Chelating reaction and purification preparation: starting a heating device H2 to heat the reaction flask R14 to 80 ℃, and maintaining the reaction for 30-60 min; opening V5, V10 and V26, starting a medium control part P2, allowing the liquid (10mL of absolute ethyl alcohol) in a reagent bottle R5 to flow through a purification column Z3 through L815 and L821, washing, and allowing the waste liquid to flow into a waste liquid bottle R12; v6, V10 and V26 were opened, the medium controller P2 was started, and the liquid (20mL of ultrapure water) in the reagent bottle R6 was passed through the purification column Z3 via L816, L815 and L821 to wash the liquid, and the waste liquid flowed into the waste liquid bottle R12.
Separation and purification: after the reaction in the reaction bottle R14 is finished, opening V21, V10 and V26, starting the medium control part P2, allowing the reaction solution in the reaction bottle R14 to flow through the purification column Z3 via L820, L815 and L821, allowing the waste liquid to flow into the waste liquid bottle R12, and obtaining the target product68The Ga-DOTA-small molecular peptide is retained on a purification column Z3; v7, V10 and V26 were opened, the medium controller P2 was started, the liquid (10mL of ultrapure water) in the reagent bottle R7 was passed through the purification column Z3 via L817, L815 and L821, the impurities on the purification column Z3 were eluted, and the waste liquid flowed into the waste liquid bottle R12.
Eluting the product: opening V8, V10 and V25, starting medium control part P2, allowing the liquid (2mL absolute ethanol solution) in reagent bottle R8 to flow through purification column Z3 via L818, L817, L815, L821 and L822, and separating the column68Eluting Ga-DOTA-small molecular peptide, filtering with sterile filter membrane F2, introducing into product bottle R13, starting heating device H3, and naturally volatilizing anhydrous ethanol under 80 deg.C heating.
Dissolving the product: opening V9 and V24, starting medium control part P2, allowing liquid (2mL physiological saline solution) in reagent bottle R9 to pass through L819, L817, L815 and L823, and sterile filter membrane F3, and then entering product bottle R13 to dissolve68Ga-DOTA-small peptides.
It will be appreciated that the invention may also be applied to the handling of other radioisotopes; the packing, type and volume of the purification column used in the above embodiments can be changed or replaced by the same type of reagent within a certain range, and the arrangement of the flow path and the specific operation position of the valve can be adjusted appropriately.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention. In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims (33)

  1. A replaceable module for a radioisotope operating system, comprising:
    a base;
    a holding portion provided on the base, the holding portion protruding from a surface of the base; and
    a medium transporting portion including a tube, the medium transporting portion being mounted on the base through the holding portion;
    wherein the holding portion further comprises:
    a clamp slot configured to be adapted to secure the tube;
    a receiving cavity configured to receive the pressing part, and through which the tube passes.
  2. The replaceable module for a radioisotope operating system as recited in claim 1, further comprising:
    the boss is arranged in the accommodating cavity, and the boss protrudes out of the plane of the bottom of the accommodating cavity.
  3. A replaceable module for a radioisotope operating system as claimed in claim 2, wherein the boss is configured to extend in a non-parallel direction to the tube.
  4. A replaceable module for a radioisotope operating system as claimed in claim 2, wherein the boss is configured to extend in a direction perpendicular to the tube.
  5. A replaceable module for a radioisotope operating system as claimed in claim 2, wherein the face of the boss in contact with the tube is a flat face or a circular arc face.
  6. A replaceable module for a radioisotope operating system as claimed in claim 1, wherein said base is a flat plate.
  7. A replaceable module for a radioisotope operating system as claimed in claim 1, wherein said slot is open a distance not exceeding an outer diameter of said tube.
  8. A replaceable module for a radioisotope operating system as claimed in claim 1, wherein said base comprises:
    a protrusion on which the slot and the receiving cavity are disposed.
  9. A replaceable module for a radioisotope operating system as claimed in claim 8, wherein the external profile of said protrusion is circular, said receiving cavity is circular, and two of said slots are diametrically opposed on said protrusion.
  10. A replaceable module for a radioisotope operating system as claimed in claim 8, comprising a plurality of said projections, said plurality of projections being laterally distributed in two rows.
  11. A replaceable module for a radioisotope operating system as claimed in claim 1, wherein said card slot comprises:
    a closing-in part, wherein the closing-in distance of the closing-in part does not exceed the outer diameter of the tube;
    an enlarged portion, said enlarged portion being enlarged a distance no less than an outer diameter of said tube.
  12. A replaceable module for a radioisotope operating system as claimed in claim 11, wherein said converging portion has a converging distance less than an outer diameter of said tube and said expanding portion has an expanding distance greater than an outer diameter of said tube.
  13. The replaceable module for a radioisotope operating system as recited in claim 4, further comprising:
    a guide portion disposed on the base in the form of a groove having a concave distance less than the outer diameter of the tube.
  14. A replaceable module for a radioisotope operating system as claimed in claim 13, wherein said recess is in communication with said card slot and said receiving cavity.
  15. The replaceable module for a radioisotope operating system as recited in claim 13, further comprising:
    the auxiliary positioning part is arranged on the base in a protruding mode;
    a receiving groove provided on the protrusion and adapted to pass the pipe therethrough and guide the pipe.
  16. A replaceable module for a radioisotope operating system as claimed in claim 15, wherein the co-locating portion is removably or movably disposed on the base.
  17. A replaceable module for a radioisotope operating system as claimed in claim 15, wherein said recess communicates with said receiving slot.
  18. The replaceable module for a radioisotope operating system as claimed in claim 15, wherein said receiving slot extends in an arcuate direction.
  19. A replaceable module for a radioisotope operating system as claimed in claim 15, wherein the height of the protrusion does not exceed the protrusion.
  20. A replaceable module for a radioisotope operating system as claimed in claim 15, wherein said receiving slot is adapted to guide said tube at right angles.
  21. The replaceable module for a radioisotope operating system as recited in claim 1, further comprising:
    the container is a container, and the container is a container,
    wherein the medium transfer part includes a connection part, the connection part being connected with the container, the connection part including:
    a housing in threaded connection with the container;
    the rubber plug is arranged in the shell and is provided with at least one through hole, and the shell compresses the rubber plug to form a seal between the wall of the container and the shell; and
    the connecting pipe penetrates through the through hole and the shell, and the connecting pipe is connected with the rubber plug in a sealing mode through rubber.
  22. The replaceable module for a radioisotope operating system as recited in claim 1, further comprising:
    an exhaust gas treatment device, the exhaust gas treatment device comprising:
    an inlet;
    an outlet;
    an exhaust treatment device housing communicating the inlet and the outlet;
    at least two different fillers disposed within the exhaust treatment device housing.
  23. A replaceable module for a radioisotope operating system as claimed in claim 22, wherein said exhaust gas treatment device housing is configured in the form of a cylindrical tube, said inlet and said outlet being disposed at opposite ends of said cylindrical tube, wherein the exhaust gas treatment device further comprises:
    a screen plate disposed within the column tube to define a plurality of accommodation spaces within the column tube, the at least two different fillers being respectively disposed in at least one of the plurality of accommodation spaces,
    the screen plate is flat and is provided with a through hole on the plate surface, and the shape of the screen plate is matched with the shape of the cross section of the inner wall of the column tube.
  24. A replaceable module for a radioisotope operating system as claimed in claim 23, wherein said at least two of a fibrous material, an acid scavenging substance and an adsorbing substance.
  25. A replaceable module for a radioisotope operating system as claimed in claim 24, wherein said fibrous material, said acid scavenging substance and said adsorbing substance are disposed in sequence in a direction from said inlet to said outlet.
  26. The replaceable module for a radioisotope operating system as recited in claim 25,
    the fibrous material is cotton;
    the acid removing substance is an alkaline substance; and/or
    The adsorption substance is activated carbon.
  27. The replaceable module for a radioisotope operating system as recited in claim 26,
    the cotton has a water content of 5-10 wt%;
    the alkaline substance is cotton containing soda lime, and the soda lime is porous granular soda lime; and/or
    The aperture of the active carbon is 10-500 angstrom meters.
  28. The replaceable module for a radioisotope operating system as recited in claim 1, further comprising:
    and a purification device, both ends of which are respectively connected with the pipes and formed in the flow path.
  29. A radioisotope manipulation system, comprising:
    fixedly arranging a module; and
    a replaceable module for a radioisotope operating system as claimed in any one of the preceding claims,
    wherein the set module comprises:
    a body portion configured to mount the replaceable module; and
    a pressing portion configured to be movably accommodated in the accommodation cavity.
  30. A radioisotope operating system as claimed in claim 29, wherein the setup module further comprises:
    the door leaf part is pivotally connected with the main body part, and the pressing part is arranged on the door leaf part.
  31. A radioisotope operating system as claimed in claim 29, wherein the setup module further comprises:
    an accommodating portion detachably provided on the main body portion, the accommodating portion being configured to accommodate the container, the exhaust gas treatment device, and the purification device; and
    a media control section including:
    a drive assembly;
    a rotor driven in rotation by the drive assembly;
    a pressing element arranged on the rotor and suitable for rotating with the rotor and moving relative to the rotor;
    a cover surrounding the rotor,
    at least a portion of the drive assembly is disposed within the body portion,
    the rotor, the pressing member and the cover are disposed on a front surface of the main body,
    at least a portion of the tube is disposed between the compression member and the housing,
    the squeezing element is configured and adapted to squeeze and release the tube by movement so as to deliver the fluid within the tube.
  32. A radioisotope operating system as claimed in claim 29, further comprising:
    a reaction vessel disposed in the replaceable module and configured for radioisotope operation;
    an exhaust gas pipe connected to the reaction vessel; and
    an exhaust gas channel disposed in the stationary module and connected to the exhaust gas pipe and the exhaust gas treatment device, respectively.
  33. A radioisotope operating system as claimed in claim 29, further comprising:
    and the vacuum pump is arranged in the fixed module.
CN201980079355.5A 2018-12-03 2019-12-02 Replaceable module for a radioisotope operating system and radioisotope operating system Pending CN113490514A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2018114652850 2018-12-03
CN201811465285.0A CN111261309A (en) 2018-12-03 2018-12-03 Radioisotope operation system and exhaust gas treatment device thereof
CN2018114652899 2018-12-03
CN201811465289.9A CN111257921A (en) 2018-12-03 2018-12-03 Radioisotope operating system and replaceable module thereof
PCT/CN2019/122428 WO2020114353A1 (en) 2018-12-03 2019-12-02 Replaceable module for radioisotope operating system and radioisotope operating system

Publications (1)

Publication Number Publication Date
CN113490514A true CN113490514A (en) 2021-10-08

Family

ID=77933284

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980079355.5A Pending CN113490514A (en) 2018-12-03 2019-12-02 Replaceable module for a radioisotope operating system and radioisotope operating system

Country Status (1)

Country Link
CN (1) CN113490514A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101081194A (en) * 2006-05-30 2007-12-05 住友重机械工业株式会社 Radioactive medical solution synthesizer and the using method thereof
CN103301484A (en) * 2012-03-13 2013-09-18 住友重机械工业株式会社 Cassette for radioactive isotope handling apparatus, radioactive isotope handling apparatus, and radioactive isotope handling system
CN205700056U (en) * 2016-06-14 2016-11-23 上海海洋大学 A kind of liquid phase waste liquid bottle emission-control equipment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101081194A (en) * 2006-05-30 2007-12-05 住友重机械工业株式会社 Radioactive medical solution synthesizer and the using method thereof
CN103301484A (en) * 2012-03-13 2013-09-18 住友重机械工业株式会社 Cassette for radioactive isotope handling apparatus, radioactive isotope handling apparatus, and radioactive isotope handling system
CN205700056U (en) * 2016-06-14 2016-11-23 上海海洋大学 A kind of liquid phase waste liquid bottle emission-control equipment

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