CN101072879B - 改良的腺病毒载体及其应用 - Google Patents
改良的腺病毒载体及其应用 Download PDFInfo
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- CN101072879B CN101072879B CN2005800351365A CN200580035136A CN101072879B CN 101072879 B CN101072879 B CN 101072879B CN 2005800351365 A CN2005800351365 A CN 2005800351365A CN 200580035136 A CN200580035136 A CN 200580035136A CN 101072879 B CN101072879 B CN 101072879B
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10344—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61846904P | 2004-10-13 | 2004-10-13 | |
| EP04105005 | 2004-10-13 | ||
| US60/618,469 | 2004-10-13 | ||
| EP04105005.5 | 2004-10-13 | ||
| US69772405P | 2005-07-08 | 2005-07-08 | |
| US60/697,724 | 2005-07-08 | ||
| PCT/EP2005/055183 WO2006040330A2 (en) | 2004-10-13 | 2005-10-12 | Improved adenoviral vectors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101072879A CN101072879A (zh) | 2007-11-14 |
| CN101072879B true CN101072879B (zh) | 2011-05-11 |
Family
ID=34929696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800351365A Expired - Fee Related CN101072879B (zh) | 2004-10-13 | 2005-10-12 | 改良的腺病毒载体及其应用 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP4843613B2 (https=) |
| CN (1) | CN101072879B (https=) |
| AT (1) | ATE492643T1 (https=) |
| DE (1) | DE602005025512D1 (https=) |
| ES (1) | ES2358523T3 (https=) |
| ZA (1) | ZA200702792B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111108192A (zh) * | 2017-07-05 | 2020-05-05 | Nouscom股份公司 | 非人类人猿腺病毒核酸序列和氨基酸序列、含有其的载体及其用途 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2391638T3 (pl) * | 2009-02-02 | 2018-11-30 | Glaxosmithkline Biologicals Sa | Sekwencje nukleotydowe i aminokwasowe małpiego adenowirusa, zawierające je wektory i ich zastosowania |
| WO2011022002A1 (en) * | 2009-08-18 | 2011-02-24 | The Rockefeller University | Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes |
| EP2558481B1 (en) * | 2010-04-14 | 2017-12-20 | Mogam Biotechnology Research Institute | Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same |
| DK2655604T3 (en) * | 2010-12-14 | 2018-08-06 | Us Gov Health & Human Services | ADENOVIRUS SEROTYPE-26- AND SEROTYPE-35-FILOVIRUS VACCINES |
| CN102199616B (zh) * | 2011-03-07 | 2013-04-24 | 首都医科大学附属北京佑安医院 | Hiv-1表型耐药检测载体及其构建方法 |
| JP6757120B2 (ja) * | 2011-10-05 | 2020-09-16 | ジェンヴェック エルエルシー | アーフェンアデノウイルス(ゴリラ)又はアデノウイルスベクター、及び使用方法 |
| JP5805908B2 (ja) * | 2012-03-22 | 2015-11-10 | クルセル ホランド ベー ヴェー | Rsvに対するワクチン |
| IL315940A (en) | 2015-07-28 | 2024-11-01 | Univ Pennsylvania | Altered monocytes/macrophages expressing chimeric antigen receptors and their uses |
| EP3532082A4 (en) * | 2016-12-12 | 2020-08-26 | Salk Institute for Biological Studies | SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES |
| CN106868047B (zh) * | 2017-03-07 | 2020-04-28 | 南方医科大学 | 一种重组腺病毒载体及其构建方法和用途 |
| CN107267469B (zh) * | 2017-08-22 | 2020-06-16 | 广州医科大学附属第一医院 | 纤毛蛋白嵌合型重组人b型腺病毒及其制备方法 |
| CN111372943B (zh) * | 2017-10-31 | 2023-12-05 | 扬森疫苗与预防公司 | 腺病毒及其用途 |
| WO2019086461A1 (en) * | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
| EP3774852A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Antibody-evading virus vectors |
| EP4079750A3 (en) * | 2018-11-21 | 2023-01-04 | Mayo Foundation for Medical Education and Research | Adenoviruses and methods for using adenoviruses |
| EP3927833A4 (en) * | 2019-02-21 | 2022-11-30 | Unleash Immuno Oncolytics, Inc. | ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE |
| EP4161536A4 (en) | 2020-06-04 | 2024-08-14 | Carisma Therapeutics Inc. | Novel constructs for chimeric antigen receptors |
| CN114262692A (zh) * | 2021-11-30 | 2022-04-01 | 华中科技大学同济医学院附属同济医院 | 一种携带tmvp1和hsv-tk的溶瘤腺病毒重组体,其构建方法及应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| US5922315A (en) * | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
| EP1409748B1 (en) * | 2001-06-22 | 2011-10-26 | The Trustees of The University of Pennsylvania | Recombinant Adenoviruses comprising simian adenovirus proteins and uses thereof. |
-
2005
- 2005-10-12 DE DE602005025512T patent/DE602005025512D1/de not_active Expired - Lifetime
- 2005-10-12 AT AT05815456T patent/ATE492643T1/de active
- 2005-10-12 CN CN2005800351365A patent/CN101072879B/zh not_active Expired - Fee Related
- 2005-10-12 JP JP2007536171A patent/JP4843613B2/ja not_active Expired - Fee Related
- 2005-10-12 ES ES05815456T patent/ES2358523T3/es not_active Expired - Lifetime
-
2007
- 2007-04-03 ZA ZA200702792A patent/ZA200702792B/en unknown
Non-Patent Citations (5)
| Title |
|---|
| Gall J, et al.Construction and characterization of hexon-chimericadenoviruses: specification of adenovirus serotype.Journal of Virology72 12.1998,72(12),第10260-10264页. |
| Gall J, et al.Construction and characterization of hexon-chimericadenoviruses: specification of adenovirus serotype.Journal of Virology72 12.1998,72(12),第10260-10264页. * |
| Sakurai F, et al.Efficient gene transfer into human CD34+ cells by anadenovirus type 35 vector.Gene Therapy10.2003,10第1041-1048页. * |
| Shayakhmetov DM, et al.The interaction between the fiber knob domain and thecellular attachment receptor determines the intracellular.Journal of Virology77 6.2003,77(6),第3712-3723页. |
| Shayakhmetov DM, et al.The interaction between the fiber knob domain and thecellular attachment receptor determines the intracellular.Journal of Virology77 6.2003,77(6),第3712-3723页. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111108192A (zh) * | 2017-07-05 | 2020-05-05 | Nouscom股份公司 | 非人类人猿腺病毒核酸序列和氨基酸序列、含有其的载体及其用途 |
| CN111108192B (zh) * | 2017-07-05 | 2023-12-15 | Nouscom股份公司 | 非人类人猿腺病毒核酸序列和氨基酸序列、含有其的载体及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2358523T3 (es) | 2011-05-11 |
| JP2009523007A (ja) | 2009-06-18 |
| CN101072879A (zh) | 2007-11-14 |
| JP4843613B2 (ja) | 2011-12-21 |
| DE602005025512D1 (de) | 2011-02-03 |
| ZA200702792B (en) | 2007-12-27 |
| ATE492643T1 (de) | 2011-01-15 |
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| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
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| CF01 | Termination of patent right due to non-payment of annual fee |