CN101068850B - 高纯度、高分子量甲氧基-聚乙二醇(mpeg) - Google Patents

高纯度、高分子量甲氧基-聚乙二醇(mpeg) Download PDF

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Publication number
CN101068850B
CN101068850B CN2005800346808A CN200580034680A CN101068850B CN 101068850 B CN101068850 B CN 101068850B CN 2005800346808 A CN2005800346808 A CN 2005800346808A CN 200580034680 A CN200580034680 A CN 200580034680A CN 101068850 B CN101068850 B CN 101068850B
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CN
China
Prior art keywords
mpeg
molecular weight
peg
ethylene glycol
polymer
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Expired - Fee Related
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CN2005800346808A
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English (en)
Chinese (zh)
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CN101068850A (zh
Inventor
C·M·沙普勒
E·D·道格斯
S·C·加特林
K·D·西克马
M·图罗夫斯基
R·A·沃林福德
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Dr Reddys Laboratories Ltd
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Dr Reddys Laboratories Ltd
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Publication of CN101068850A publication Critical patent/CN101068850A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2005800346808A 2004-09-01 2005-08-25 高纯度、高分子量甲氧基-聚乙二醇(mpeg) Expired - Fee Related CN101068850B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/932,629 US20060045866A1 (en) 2004-09-01 2004-09-01 Novel high purity and high molecular weight mPEG alcohol compositions
US10/932,629 2004-09-01
PCT/US2005/030518 WO2006028745A1 (en) 2004-09-01 2005-08-25 High purity, high molecular weight methoxy-polyethylenglycols (mpeg)

Publications (2)

Publication Number Publication Date
CN101068850A CN101068850A (zh) 2007-11-07
CN101068850B true CN101068850B (zh) 2011-09-28

Family

ID=35355094

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800346808A Expired - Fee Related CN101068850B (zh) 2004-09-01 2005-08-25 高纯度、高分子量甲氧基-聚乙二醇(mpeg)

Country Status (6)

Country Link
US (2) US20060045866A1 (https=)
EP (1) EP1789473A1 (https=)
JP (1) JP2008511729A (https=)
KR (1) KR20070058549A (https=)
CN (1) CN101068850B (https=)
WO (1) WO2006028745A1 (https=)

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JP5543068B2 (ja) * 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
WO2008101311A1 (en) * 2007-02-22 2008-08-28 Biovectra Inc. Process for purification of water soluble polymers
KR100922113B1 (ko) * 2007-12-29 2009-10-16 아이디비켐(주) 고순도의 벤질옥시폴리에틸렌글리콜 및 그의 유도체의제조방법
JP5001184B2 (ja) * 2008-01-29 2012-08-15 三洋化成工業株式会社 ポリオキシアルキレンエーテル組成物の製造法
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
JP5713274B2 (ja) 2009-03-31 2015-05-07 日油株式会社 高分子量ポリオキシアルキレン誘導体の精製方法
JP5569787B2 (ja) * 2009-03-31 2014-08-13 日油株式会社 高分子量ポリエチレングリコール化合物の精製方法
ES2379571T3 (es) 2009-06-18 2012-04-27 Basf Se Procedimiento para la obtención de óxidos de monohidroxipolialquileno
WO2011146793A1 (en) 2010-05-21 2011-11-24 Zephyros,Inc. Method for application of structural materials
GB201207481D0 (en) 2012-04-26 2012-06-13 Zephyros Inc Applying flowable materials to synthetic substrates
CN107321128B (zh) * 2017-05-31 2020-11-03 南京威尔药业集团股份有限公司 一种用于生产高纯单甲氧基聚乙二醇的反应系统
US10988489B2 (en) * 2018-11-27 2021-04-27 Clark Atlanta University Organoboranes useful as electrolytes for lithium batteries
CN112724396A (zh) * 2020-12-28 2021-04-30 苏州欣影生物医药技术有限公司 一种提高聚乙二醇类衍生物分子量分布的纯化方法
CN114636773B (zh) * 2022-05-23 2022-08-23 广东国标医药科技有限公司 一种药用辅料中聚乙二醇单甲醚2000的含量测定方法

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CN1100337A (zh) * 1993-06-30 1995-03-22 普拉塞尔技术有限公司 用于增强流体分离的改性聚苯醚薄膜
US6323322B1 (en) * 1997-04-30 2001-11-27 Enzon, Inc. Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
US6455639B1 (en) * 1998-03-24 2002-09-24 Nof Corporation Oxirane derivative and process for the preparation thereof

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US2983763A (en) * 1956-04-12 1961-05-09 Jefferson Chem Co Inc Decolorizing the product of reacting an alkylene oxide with a hydroxylcontaining organic compound in the presence of an alkaline reacting catalyst
US3974127A (en) * 1973-09-17 1976-08-10 E. I. Du Pont De Nemours And Company Alkylene oxide condensates of tetramethylpiperidine alcohols or glycols
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
FR2686088B1 (fr) * 1992-01-10 1995-06-23 Atochem Elf Sa Procede de fabrication de polycondensats multisequences, en etoile ou en reseaux par couplage a l'aide de di- ou multi-aldehydes, et polycondensats ainsi obtenus.
FR2689895A1 (fr) * 1992-04-10 1993-10-15 Chryso Procédé de préparation d'amines polyoxyalkylées.
US5308881A (en) * 1993-10-25 1994-05-03 The Celotex Corporation Surfactant for polyisocyanurate foams made with alternative blowing agents
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
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CN1100337A (zh) * 1993-06-30 1995-03-22 普拉塞尔技术有限公司 用于增强流体分离的改性聚苯醚薄膜
US6323322B1 (en) * 1997-04-30 2001-11-27 Enzon, Inc. Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
US6455639B1 (en) * 1998-03-24 2002-09-24 Nof Corporation Oxirane derivative and process for the preparation thereof

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Also Published As

Publication number Publication date
EP1789473A1 (en) 2007-05-30
CN101068850A (zh) 2007-11-07
KR20070058549A (ko) 2007-06-08
JP2008511729A (ja) 2008-04-17
US20100041160A1 (en) 2010-02-18
US20060045866A1 (en) 2006-03-02
WO2006028745A1 (en) 2006-03-16

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Free format text: FORMER OWNER: THE DOW GLOBAL TECHNOLOGIES INC.

Effective date: 20100513

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TA01 Transfer of patent application right

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Address after: The British East Yorkshire

Applicant after: Dr.reddy's Laboratories Ltd.

Address before: michigan

Applicant before: Dow Global Technologies Inc.

C14 Grant of patent or utility model
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110928

Termination date: 20120825