CN101062076A - Nature plant echinacea purpurea effervescent tablets and the method for preparing the same - Google Patents
Nature plant echinacea purpurea effervescent tablets and the method for preparing the same Download PDFInfo
- Publication number
- CN101062076A CN101062076A CN 200610035175 CN200610035175A CN101062076A CN 101062076 A CN101062076 A CN 101062076A CN 200610035175 CN200610035175 CN 200610035175 CN 200610035175 A CN200610035175 A CN 200610035175A CN 101062076 A CN101062076 A CN 101062076A
- Authority
- CN
- China
- Prior art keywords
- extract
- echinacea
- mixing
- acid
- effervescent tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a purple awl chrysanthemum effervescence slice as modifier traditional medicine to accelerate immune, which comprises the following steps: choosing purple awl chrysanthemum crude drugs; removing dust and impurity; disintegrating; refluxing with alcohol; extracting; removing impurity; condensing; vacuum-drying; sieving dry plaster powder and other findings; mixing half of 7%-22% dry plaster powder and half of 35%-40% citric acid and 0. 2%-1. 0% Aspata evenly; pelleting; forming particle; getting component A; mixing other half of 7%-22% dry plaster powder and the other half of 42%-50% baking soda and 0. 2%-1. 0% Aspata; pelleting; forming particle; getting component B; mixing A and B evenly; forming particle; adding into 0. 4%-0. 9% perfume compounds and 0. 4%-1. 1% dolomol; mixing; sheeting. This invention possesses high bioavailability, good effect and wide prospect, which is fit for children and the elderly.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of natural plants Zizhuiju effervescent tablets and preparation technology and method.
Technical background
Genus echinacea (Echinacea Moenck.) is the wild flowers of a class Compositae that originate in America, also claims " SONGGUOJU ".This platymiscium has 8 kinds and several mutation, is perennial herb, and the head inflorescence list is born in stem or skill item, and its principal character is that holder is conical, has tubular flower and ligulate flower, is generally rose-colored or purple.The person is mainly Echinacea Echinacean Purpurea (also claiming Echinacea purpurea Moench) and Echinacea angustifolia E.angustifolia (SONGGUOJU) wherein to be developed as the medicine, white SONGGUOJU E.pallia.The main distinction of Echinacea and Echinacea angustifolia is the high 60～180cm of the former plant, basal leaf impression, and the high 10～60cm of the latter's plant, and basal leaf drapes over one's shoulders profile.Its medicinal history can be traced back to North America Indians period, and this platymiscium is used as the optimal drug that treatment wound, Serpentis sting, have a headache and catch a cold, even the division of the territory of clan all with the substantial connection that is distributed with of this platymiscium.Europe is imported in its use early in the twentieth century into.
The genus echinacea galenical was just listed in 2000 the most frequently used prescriptions as far back as 1989 in Germany as immunological enhancement and regulator, 131 of ranks, and nineteen eighty-two Echinacea kind single and compound formulation just reaches 300 kinds more than.And there have many dosage forms to be used in a large number to be clinical, as be used for the treatment of virus or bacterial acute and chronic respiratory tract infection, the auxiliary various serious bacterial infections of various antibiotic therapies etc.Echinacea is ranked first on U.S.'s health food situation of selling well billboards in 1999, and the Echinacea preparation also has the trend of popularizing day by day in the world at present.
" one one of Chinese pharmacopoeia has been recorded this dosage form of effervescent tablet to version in 2005.Effervescent tablet means and contains sodium bicarbonate and organic acid, meets that water can be emitted great amount of carbon dioxide and the tablet that is the effervescent shape.Though its preparation method is being grasped by some pharmaceutical personnels of west decades ago, up to early 1970s real medicinal effervescent tablet listing is arranged just abroad, and the Chinese medicine effervescent tablet of China just there had been very big progress in recent years.
Effervescent tablet can produce a large amount of bubbles in water, and can dissolve in the short period of time, have that drug effect is rapid, bioavailability is high, convenient carrying, the patient who is specially adapted to child, old man and can not swallows solid preparation, so effervescent tablet has the dosage form novelty, the characteristics that market prospect is wide.In the preparation process of effervescent tablet, main difficult point is how to choose the ratio of principal agent and pharmaceutic adjuvant, and messenger drug is with under the less situation of supplementary product consumption, and the effervescent speed of effervescent tablet is fast, foaming effect good.
Summary of the invention
For these reasons, research worker of the present invention by the further investigation comparative optimization ratio of Echinacea extract and pharmaceutic adjuvant effervescent, need not to add other filler during formulation preparation, the relevant regulations that all meets effervescent tablet compressibility, dissolubility, mouthfeel and disintegration effervescent tablet that makes.Among the present invention, the extraction process of Echinacea extract, effervescent tablet prescription, the implementation process that preparation technology is concrete are as follows:
(1) extraction process:
A, alcohol reflux:,, filter and also collect filtrate and residue 40～80 ℃ of following reflux, extract, 2～4 hours with the ethanol of 30-60% solid-liquid ratio and Echinacea extract powder mixes with 1: 5～1: 30.Residue is mixed with alcoholic solution with concentration with 1: 5 solid-liquid ratio again, and reflux, extract, 2～4 hours again under uniform temp is filtered and is also collected filtrate, merges twice filtrate;
B, remove impurity: merging filtrate low temperature (0～4 ℃) is placed (12h～24h), remove by filter protein precipitation, cross 0.45 μ m microporous filter membrane except that degerming and high molecular weight protein then:
C, concentrate: filtrate is concentrated at 50 ℃ of following reduction vaporizations, is concentrated into thick shape, then in 70 ℃ of evaporates to dryness to paste;
D, vacuum drying: the extract that will be concentrated into paste is in 50-60 ℃ of following vacuum drying.Get final product solid extract.
(2) effervescent tablet preparation technology:
1. aspartame, sodium bicarbonate, citric acid, Echinacea extract dry extract pulverize separately are crossed 100 mesh sieves;
2. with half of extract dry extract, half mixing of citric acid, aspartame, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 40 mesh sieve granulate, component A;
3. with half of extract dry extract, half mixing of aspartame, sodium bicarbonate, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 14 mesh sieve granulate, B component;
4. with component A and B component mixing, behind the 40 mesh sieve granulate, add essence and magnesium stearate, after the mixing, tabletting.
(3) prescription:
Extract dry extract 7%～22% citric acid 35%～40%
Aspartame 0.2%～1.0% sodium bicarbonate 42%～50%
Essence 0.4%～0.9% magnesium stearate 0.4%～1.1%
The specific embodiment 1
A, alcohol reflux: the ethanol with 30% is with 1: 5 solid-liquid ratio and Echinacea plant powder mixes, 40 ℃ of following reflux, extract, 2 hours, filters and also collects filtrate and residue.Residue is mixed with alcoholic solution with concentration with 1: 5 solid-liquid ratio again, and reflux, extract, 2 hours again under uniform temp is filtered and is also collected filtrate, merges twice filtrate;
B, remove impurity: merging filtrate low temperature (0-4 ℃) is placed 12h, remove by filter protein precipitation, cross 0.45 μ m microporous filter membrane except that degerming and high molecular weight protein then;
C, concentrate: filtrate is concentrated at 50 ℃ of following reduction vaporizations, is concentrated into thick shape, then in 70 ℃ of evaporates to dryness to paste;
D, vacuum drying: the extract that will be concentrated into paste is in 50 ℃ of following vacuum dryings.Get final product solid extract.
Prescription:
Extract dry extract 16.5% citric acid 35%
Aspartame 1.5% sodium bicarbonate 45%
Essence 0.9% magnesium stearate 1.1%
Technology:
(1) aspartame, sodium bicarbonate, citric acid, Echinacea extract dry extract pulverize separately are crossed 100 mesh sieves;
(2) with half of extract dry extract, half mixing of citric acid, aspartame, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 40 mesh sieve granulate, component A;
(3) with half of extract dry extract, half mixing of sodium bicarbonate, aspartame, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 14 mesh sieve granulate, B component;
(4) with component A and B component mixing, behind the 40 mesh sieve granulate, add essence and magnesium stearate, after the mixing, tabletting.
The specific embodiment 2
A, alcohol reflux: the ethanol with 40% is with 1: 15 solid-liquid ratio and Echinacea plant powder mixes, 60 ℃ of following reflux, extract, 3 hours, filters and also collects filtrate and residue.Residue is mixed with alcoholic solution with concentration with 1: 5 solid-liquid ratio again, and reflux, extract, 3 hours again under uniform temp is filtered and is also collected filtrate, merges twice filtrate;
B, remove impurity: merging filtrate low temperature (0～4 ℃) is placed 18h, remove by filter protein precipitation, cross 0.45 μ m microporous filter membrane except that degerming and high molecular weight protein then;
C, concentrate: filtrate is concentrated at 50 ℃ of following reduction vaporizations, is concentrated into thick shape, then in 70 ℃ of evaporates to dryness to paste;
D, vacuum drying: the extract that will be concentrated into paste is in 50 ℃ of following vacuum dryings.Get final product solid extract.
Prescription:
Extract dry extract 12.5% citric acid 37%
Aspartame 1.5% sodium bicarbonate 47%
Essence 0.9% magnesium stearate 1.1%
Technology:
(1) aspartame, sodium bicarbonate, citric acid, Echinacea extract dry extract pulverize separately are crossed 100 mesh sieves;
(2) with half of extract dry extract, half mixing of citric acid, aspartame, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 40 mesh sieve granulate, component A;
(3) with the extract dry extract half, aspartame half, the sodium bicarbonate mixing, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 40 mesh sieve granulate, B component;
(4) with component A and B component mixing, behind the 40 mesh sieve granulate, add essence and magnesium stearate, after the mixing, tabletting.
The specific embodiment 3
A, alcohol reflux: the ethanol with 60% is with 1: 30 solid-liquid ratio and Echinacea plant powder mixes, 80 ℃ of following reflux, extract, 4 hours, filters and also collects filtrate and residue.Residue is mixed with alcoholic solution with concentration with 1: 5 solid-liquid ratio again, and reflux, extract, 4 hours again under uniform temp is filtered and is also collected filtrate, merges twice filtrate;
B, remove impurity: merging filtrate low temperature (0～4 ℃) is placed 24h, remove by filter protein precipitation, cross 0.45 μ m microporous filter membrane except that degerming and high molecular weight protein then;
C, concentrate: filtrate is concentrated at 50 ℃ of following reduction vaporizations, is concentrated into thick shape, then in 70 ℃ of evaporates to dryness to paste;
D, vacuum drying: the extract that will be concentrated into paste is in 50 ℃ of following vacuum dryings.Get final product solid extract.
Prescription:
Extract dry extract 7.5% citric acid 39%
Aspartame 1.5% sodium bicarbonate 50%
Essence 0.9% magnesium stearate 1.1%
Technology:
(1) aspartame, sodium bicarbonate, citric acid, Echinacea extract dry extract pulverize separately are crossed 100 mesh sieves;
(2) with half of extract dry extract, half mixing of citric acid, aspartame, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 40 mesh sieve granulate, component A;
(3) with the extract dry extract half, aspartame half, the sodium bicarbonate mixing, put pelletize in the fluidized bed pelletizer, keep atomizing pressure 0.1～0.4Mpa, 20 ℃ of hot air dryings are to pellet moisture below 1.5%, 40 mesh sieve granulate, B component;
(4) with component A and B component mixing, behind the 40 mesh sieve granulate, add essence and magnesium stearate, after the mixing, tabletting.
Claims (3)
1. a preparation of being made by the extract of introducing and carrying out in Chinese many places the plant amedica Echinacea that the GAP kind plants from the North America is characterized by the technology of utilizing effervescent tablet, is made into Zizhuiju effervescent tablets.
2. a kind of according to claim 1 effervescent tablet of making by the plant amedica Echinacea extract, its raw material is made up of Echinacea and relevant auxiliary materials, and its adjuvant feature is: acid source is a kind of in the citric acid, tartaric acid, fumaric acid, adipic acid, malic acid of hydration or anhydrous form or several; Carbon dioxide source is acceptable alkali metal of physiology or alkaline earth metal carbonate, for example sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium carbonate; Excipient can be a kind of in diluent, sweeting agent, aromatic, pigment, lubricant, the binding agent or several.
3. as a kind of effervescent tablet of making by the plant amedica Echinacea as described in the claim 2, its feature is that also the crude drug extract is 7.0%～21.0%, pharmaceutic adjuvant is 79.0%～93.0%, wherein acid source is 32.0%～39.0%, alkali source is 44.0%～50.0%, sweeting agent is 1.5%～1.9%, and correctives is 0.7%～1.0%, and lubricant is 0.8%～1.1%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610035175 CN101062076A (en) | 2006-04-26 | 2006-04-26 | Nature plant echinacea purpurea effervescent tablets and the method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610035175 CN101062076A (en) | 2006-04-26 | 2006-04-26 | Nature plant echinacea purpurea effervescent tablets and the method for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101062076A true CN101062076A (en) | 2007-10-31 |
Family
ID=38963490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610035175 Pending CN101062076A (en) | 2006-04-26 | 2006-04-26 | Nature plant echinacea purpurea effervescent tablets and the method for preparing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101062076A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105115355A (en) * | 2015-09-07 | 2015-12-02 | 黄文佳 | Toy effervescent tablet and toy water gun using the same |
-
2006
- 2006-04-26 CN CN 200610035175 patent/CN101062076A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105115355A (en) * | 2015-09-07 | 2015-12-02 | 黄文佳 | Toy effervescent tablet and toy water gun using the same |
| CN105115355B (en) * | 2015-09-07 | 2016-08-31 | 黄文佳 | Toy effervescent tablet and use the water gun of this toy effervescent tablet |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101045106A (en) | Traditional Chinese medicine for treating lung heat cough and high fever | |
| CN101062076A (en) | Nature plant echinacea purpurea effervescent tablets and the method for preparing the same | |
| CN1927279A (en) | Chinese medicine composition for treating skin disease | |
| CN101028321A (en) | Zizhuiju effervescent tablets and preparing process thereof | |
| CN1745809A (en) | Liuwei Dihuang effervescent tablet and its preparation thereof | |
| CN1762425A (en) | Efervescence tablet with kudzuvine root, scutellarta root, Chinese goldthread and its preparation method | |
| CN100350948C (en) | Compound throat sucking-tablet of semen sterculiae scaphigerae and oral tonic thereof | |
| CN1857342A (en) | Seabuckthorn preparation and its preparing process | |
| CN1233401C (en) | Agastache capsule for restoring healthy energy andits prepn and application | |
| CN1247203C (en) | Helicidum oral disintegation tablet and its preparing method | |
| CN1631425A (en) | Lozenge for treating its pharyngitis and preparation process thereof | |
| CN1850132A (en) | Herba thesii granules and preparing method therefor | |
| CN1281232C (en) | Method for preparing compound licorice buccal tablet | |
| CN1559515A (en) | Application of active component volatile oil of pummelo peel in manufacture of medicine | |
| CN1840030A (en) | Effervescence granule of beautyberry and preparation method thereof | |
| CN1686382A (en) | Throat clearing drip pill and its preparation method | |
| CN1927372A (en) | Antiviral dispersant tablet and method for making same | |
| CN1593591A (en) | Method for preparing cyclodextrin inclusion compound of silybum mariamum extract and medicinal formulation thereof | |
| CN1368263A (en) | Nano medicine for treating infantile intractable cough and its preparing process | |
| CN1301102C (en) | Kekang drip pill used for treating cougha nd asthma and its preparation method | |
| CN1701806A (en) | 'Naodesheng' freeze dry powder injection and its preparation process | |
| CN1562093A (en) | Method for preparing mailuoning freeze-dried powder for injection | |
| CN1569169A (en) | 'Shuanghuanglian' effervescence tablet and its preparation | |
| CN1775270A (en) | Yuying preparation and new preparing method | |
| CN1785304A (en) | Guxian medicinal preparation for treating osteoproliferation and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Deng Yun Document name: Notification before expiration of term |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |