CN101049341A

CN101049341A - Chinese traditional medicine preparation for treating psoriasis

Info

Publication number: CN101049341A
Application number: CNA2007100556366A
Authority: CN
Inventors: 刘辉
Original assignee: CHANGCHUN TONGCHUNTANG SKIN DISEASE HOSPITAL
Current assignee: CHANGCHUN TONGCHUNTANG SKIN DISEASE HOSPITAL
Priority date: 2007-05-16
Filing date: 2007-05-16
Publication date: 2007-10-10
Anticipated expiration: 2027-05-16
Also published as: CN101049341B

Abstract

A Chinese medicine for treating psoriasis is proportionally prepared from 9 Chinese-medicinal materials including rhubarb, honeysuckle flower, Chuan-xiong rhizome, liquorice root, etc.

Description

The psoriatic Chinese medicine preparation of a kind of treatment

Technical field

The present invention discloses the psoriatic Chinese medicine preparation of a kind of treatment, is used for the treatment of each psoriasis pustulosa, belongs to Chinese medicine pharmaceutical technology field.

Background technology

Motherland's tcm theory is thought, psoriasis is that invasion, impatency meridians, the QI-blood circulation of void, weakened defensive QI, wind-cold damp pathogen freely do not make meridian and vessels obstruction, QI and blood stasis of blood knot, failure of skin and muscle to be nourished partially because of innate deficiency, the loss of Liver and kidney vital essence, QI and blood, diseases such as the appearance skin lesion thickens, and the color purple is dark or dark red.So-called natural endowment deficiency should comprise the influence of inherited genetic factors to primary disease; Deficiency of vital energy general reference body function is low, comprises the function of immune system imbalance, and exopathogen refers to wind, wet, cold-evil and infective agent (comprising viral infection).The traditional Chinese medical science thinks that phlegm-turbidity and blood stasis blood is the result of primary disease development.Be again paathogenic factor simultaneously, this and modern medicine think that primary disease influences microcirculation and causes circulatory disorders, and the viewpoint that increases the weight of the pathological change of normal structure infringement then matches.Motherland's medical science is having original advantage and experience aspect the treatment psoriasis (psoriasis).Find that in clinical practice for many years psoriatic morbidity has confidential relation with heredity and emotion.Method with traditional medicine often can make clinical cure rate improve.Its Therapeutic Principle serves as main the treatment with nourishing blood to expel wind, blood circulation promoting and blood stasis dispelling, and common drug has Chinese patent medicines such as Xiaoyinwan pill, FUFANG QINGDAI WAN, but in the clinic diagnosis process, list is cut with the uncertain therapeutic efficacy of a certain medicine, can only reach recent clinical effectiveness, and relapse rate is higher.

Summary of the invention

The present invention discloses the psoriatic Chinese medicine preparation of a kind of treatment, and it is remarkable to have a clinical efficacy, the characteristics that toxic and side effects is little.

Theory according to traditional Chinese medical science organic conception, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, reference for modern medical science is to the understanding of primary disease, draft out nourishing congenital, nourish the day after tomorrow, blood stasis dispelling dehumidifying, the skin moistening that nourishes blood, clearing away heat,cooling blood and removing toxin etc. and treat rules, selected following pure Chinese medicinal herbs, through the scientific composition compatibility, make Chinese medicine preparation: (by weight)

Living Radix Arnebiae (Radix Lithospermi) 250-300g, living Flos Sophorae Immaturus 250-300g, Radix Et Rhizoma Rhei 250-300g, Flos Lonicerae 250-300g, Rhizoma Chuanxiong 160-200g, Radix Glycyrrhizae Preparata 250-300g, Radix Sophorae Flavescentis 250-300g, Periostracum Serpentis 50-100g, Radix Angelicae Sinensis 150-200;

Processing procedure is as follows:

Take by weighing medicine-feeding oven dry altogether in proportion, powder becomes 80 ~ 120 order smalls, crosses 120 mesh sieves and mixes thoroughly promptly.

Usage and consumption:

Morning and evening is warm boiled water after meal.Each 2～6 grams, every day 1～2 time, 30 days was 1 course of treatment.

Theory of Chinese medical science is thought: prolonged illness must the stasis of blood, and blood stasis is not dispelled, and fresh blood is not given birth to, and the present invention adds in tonify deficiency and uses drug for invigorating blood circulation and eliminating stasis, and every can proving effective is so select the product of blood circulation promoting and blood stasis dispelling such as Rhizoma Chuanxiong, Radix Glycyrrhizae Preparata, the skin moistening that nourishes blood for use.The Fang Zhongsheng Radix Arnebiae (Radix Lithospermi) is psoriatic key medicine for the present invention treats, and has effects such as heat-clearing and toxic substances removing, expelling wind and removing dampness, reducing swelling and alleviating pain, promoting blood circulation to remove obstruction in the collateral.The anticarcinogen of living Radix Arnebiae (Radix Lithospermi) and other cytotoxic effects the same can inflammation-inhibiting medium prostatitis element synthetic, directly suppress the generation and the division of lymphocyte, mononuclear cell and macrophage, can also resist the TH cell, be the immunosuppressant that suppresses body fluid indirectly.Its immunosuppressive action is not substituting of exogenous hormones, but has cRF and the effect of AcT sample by hypothalmus-pituitary-adrenal axis, and promotes the synthetic increase of 17-hydroxy-11-dehydrocorticosterone.But living Radix Arnebiae (Radix Lithospermi) is poisonous Chinese medicinal herbs, and stronger cell toxicant, reproduction poison and other specific toxicity effects are arranged, and its toxicity has sure dose-effect relationship.The present invention selects for use the living Flos Sophorae Immaturus, Radix Et Rhizoma Rhei, Periostracum Serpentis, Flos Lonicerae etc. to have clearing away heat,cooling blood and removing toxin, regulates the equilibrated effect of QI and blood, and rate of side effects is greatly lowered.

To psoriatic clinical observation, and domestic various places experience explanation is treated 2806 examples altogether to homeliness type, pus kitchen type, arthrosis type and erythrodermic psoriasis, tangible curative effect is all arranged, and stand the recurrence test according to for many years.

Since June nineteen ninety, statistics psoriasis out-patient, and set up scientific research and observe case history 2806 examples, except that pregnant and lying-in women, child below 12 years old and light disease patient, all the other all adopt this method treatment.This group is to treat 1 month 2806 routine psoriatics as analysis of data.Wherein male 1406 examples, women 1400 examples. at 13～68 years old age, stadium is the shortest 20 days, and is the longest 48 years.Be responsible for observing therapeutic effect and side effect by full-time doctor more than two, have a blood test before and after every example treatment, routine urinalysis and liver, renal function.

This group data shows has obvious effects with each psoriasis pustulosa of Drug therapy of the present invention, and 2806 routine patients cure 2528 examples, account for 90.09 ‰, and produce effects 2796 examples account for 99.64%, and effective percentage is 99.6%.Average 5 days take effect, reach positive effect about 20 days.Clinical manifestation is that skin lesion is dark by red commentaries on classics, and squama reduces, and pruritus alleviates.Cure about 60-90 days average time, the shortest 20 days, the longest 240 days.

The comparatively common side effect of this group case has epigastric discomfort 127 examples, accounts for 20.95%; Just rare 105 examples account for 17.33%; 26 examples of suffering from abdominal pain account for 4.29% skin lesion position pigmentation 32 examples, account for 5.28%. but recover normal after drug withdrawal or the decrement gradually.

Model case 1

Grandson, the man, 48 years old, the oblique shop village people in Guan County, Shandong Province, first visit in April nineteen ninety was diagnosed as psoriasis vulgaris 8 years, and head, extremity thoracic dorsal account for about 60% of body surface area, and back monolithic skin lesion maximum area is 10～20cm., erythema pimple squama is thicker, recovery from illness after taking medicine of the present invention 3 courses of treatment (totally 90 days), and the patient adds prevention in season in spring and autumn and consolidates medicine, does not see recurrence through following up a case by regular visits to (in December, 2003).

Model case 2

Liu. woman, 38 years old, Qinhuangdao, Hebei province high school teachers.Be diagnosed as psoriasis pustulosa in August, 1993, head, chest, extremity account for about 40% of body surface area, and recovery from illness after taking 4 courses of treatment of medicine of the present invention (120 days) has added prevention and consolidated medicine, follows up a case by regular visits to and does not see recurrence so far.

Good effect of the present invention is: pure Chinese medicinal preparation, and drug effect is rapid, and toxic and side effects is little, and treating both the principal and secondary aspects of a disease is evident in efficacy, and clinical symptom disappearance is rapid, cures the back and is difficult for recurrence.

The specific embodiment

Embodiment 1

Will living Radix Arnebiae (Radix Lithospermi) 250g, living Flos Sophorae Immaturus 250g, Radix Et Rhizoma Rhei 250g, Flos Lonicerae 250g, Rhizoma Chuanxiong 160g, Radix Glycyrrhizae Preparata 250g, Radix Sophorae Flavescentis 250g, Periostracum Serpentis 50g, Radix Angelicae Sinensis 150g take by weighing oven dry respectively, and powder becomes 80 ~ 120 order smalls, crosses 120 mesh sieves and mixes thoroughly promptly.

Embodiment 2

Will living Radix Arnebiae (Radix Lithospermi) 300g, living Flos Sophorae Immaturus 280g, Radix Et Rhizoma Rhei 280g, Flos Lonicerae 300g, Rhizoma Chuanxiong 180g, Radix Glycyrrhizae Preparata 300g, Radix Sophorae Flavescentis 250g, Periostracum Serpentis 80g, Radix Angelicae Sinensis 180g take by weighing oven dry respectively, and powder becomes 80 ~ 120 order smalls, crosses 120 mesh sieves and mixes thoroughly and dress up capsule promptly.

Embodiment 3

Will living Radix Arnebiae (Radix Lithospermi) 300g, living Flos Sophorae Immaturus 250g, Radix Et Rhizoma Rhei 300g, Flos Lonicerae 250g, Rhizoma Chuanxiong 200g, Radix Glycyrrhizae Preparata 250g, Radix Sophorae Flavescentis 280g, Periostracum Serpentis 100g, Radix Angelicae Sinensis 150 take by weighing respectively, and extracting technique of Chinese medicine is routinely made honeyed pill or watered pill preparation after purifying.

Claims

1, the psoriatic Chinese medicine preparation of a kind of treatment, by following raw materials by weight portion than making:

Take by weighing living Radix Arnebiae (Radix Lithospermi) 250-300g respectively, living Flos Sophorae Immaturus 250-300g, Radix Et Rhizoma Rhei 250-300g, Flos Lonicerae 250-300g, Rhizoma Chuanxiong 160-200g, Radix Glycyrrhizae Preparata 250-300g, Radix Sophorae Flavescentis 250-300g, Periostracum Serpentis 50-100g, Radix Angelicae Sinensis 150-200g, oven dry, powder become 80 ~ 120 order smalls, cross 120 mesh sieves and mix thoroughly promptly.