CN101045137A

CN101045137A - Capsule for treating epilepsia and its preparing method

Info

Publication number: CN101045137A
Application number: CNA2006100174460A
Authority: CN
Inventors: 刘宗银
Original assignee: Individual
Current assignee: Liu Zhenbing
Priority date: 2006-02-22
Filing date: 2006-02-22
Publication date: 2007-10-03
Anticipated expiration: 2026-02-22
Also published as: CN100528214C

Abstract

A Chinese medicine in the form of capsule for treating epilepsy is prepared from 15 Chinese-medicinal materials including gastrodia tuber, pepper, scorpion, red sage root, etc. Its preparing process is also disclosed.

Description

The capsule and the preparation method of treatment epileptics

One, technical field: the present invention relates to a kind of medicine for the treatment of epileptics, especially treat the capsule and the preparation method of epileptics.

Two, background technology: epilepsy is commonly called as " St. John's evil, take out crazy ", and epilepsy is a kind of chronic brain diseases, also is a kind of nervous system common disease.The traditional Chinese medical science thinks that epilepsy belongs to the epilepsy category.Its cause of disease is many because of spirit, diet or congenital factors cause visceral dysfunction, and liver-wind is held under the arm due to the expectorant.Some people's mistake thinks that epilepsy is an incurable disease.Make some patients lack systemic normality treatment, make the patient that can cure originally lose chance, cause outbreak repeatedly, patient is lost the confidence, because a variety of causes causes the epilepsy invasion rate progressively to increase to epilepsy.The whole nation this patient of annual trouble can reach more than 70 ten thousand people, and this sick treatment time is long, and cost is many, brings misery and burden to the patient.And traditional therapy is exactly an oral western medicine, and the treatment epileptics needs the time of 3---5.Because the oral time of Western medicine is long, and liver and leukocyte are had infringement, the effect of paying is big, especially child's epilepsy is easily caused diet and dysnoesia.

Three, summary of the invention: the objective of the invention is according to cause of disease mechanism and pharmacology, adopt tranquillizing the mind by relieving convulsion, the endogenous wind stopping relieving convulsion, pleasant eliminating phlegm, collateral dredging is had one's ideas straightened out, blood circulation promoting and blood stasis dispelling, invigorating the spleen and benefiting QI, decide the principle effect that epilepsy is only taken out, the capsule that has prepared the treatment epileptics, it has overcome the shortcoming that other medicines treatment epileptics exists, the object of the present invention is achieved like this, it is made by following medicine, Arisaema Cum Bile 20g, Concretio Silicea Bambusae 32g, Cinnabaris 3g, Rhizoma Gastrodiae 30g, Fructus Piperis 6g, Scorpio 4g, Bombyx Batryticatus 30g, Rhizoma Acori Graminei 30g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Semen Sesami Nigrum 30g, Borneolum Syntheticum 3g, Ramulus Uncariae Cum Uncis 10g, 20 of Scolopendras, Os Draconis 20g.

Pharmaceutical analysis: Scorpio, claim Scorpio, endogenous wind stopping relieving convulsion, detoxicating and resolving stagnation of pathogens, collateral dredging effect are arranged, it is similar to the neural poison in the snake venom that Scorpio contains toxalbumin, and the effect of convulsion abirritative is arranged; Bombyx Batryticatus claims flying worm, returns the liver lung meridian, and endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, detoxicating and resolving stagnation of pathogens effect are arranged; Rhizoma Acori Graminei, the merit that resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach, mind tranquilizing and the heart calming are arranged, the contained active substance of Rhizoma Acori Graminei has sedation to nervus centralis, and metabolism has good action to the part central neurotransmitter, contains α in the Rhizoma Acori Graminei--and the asaricin injection is to rescue the status epilepticus active drug; Flos Carthami, the effect of blood circulation promoting and blood stasis dispelling is arranged, stimulating the menstrual flow, modern medicine study discovery blood-activating and stasis-removing can also be improved systemic microcirculation, the local blood supply of brain is improved, and can change blood property, thereby help the control of seizures of epilepsy; Ramulus Uncariae Cum Uncis has good heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion effect; Rhizoma Gastrodiae, has blood circulation promoting and blood stasis dispelling, find through modern study, main effective ingredient is a vanillyl alcohol in the Rhizoma Gastrodiae, the high oxalic acid of metabolism product of vanillyl alcohol chemical constitution and catecholamines is similar, can influence the degraded of careless amine medium in vivo, improved the concentration of inhibition medium in the brain relatively, the antiepileptic mechanism of Rhizoma Gastrodiae may be that selectivity is by increasing the interior changes of Catecholamine Content of maincenter catecholamine neurocyte by influencing the metabolism of the different brains of maincenter district catecholamines neurotransmitter, coordinate the excitement of brain and suppress balance, reach the effect of preventing epilepsy; Os Draconis, contain the inorganic salts composition, what modern medicine application inorganic salts Drug therapy epilepsy was common is bromide, can strengthen and concentrate corticocerebral process of inhibition, Os Draconis contain a large amount of calcium, increase the concentration of calcium, the neurocyte irritability is weakened and reach treatment epilepsy purpose, confirm that now for oral administration or quiet calcium salt class has certain anti-frightened effect; Arisaema Cum Bile, the effect that removing heat-phlegm, dispelling wind and relieving convulsion are arranged, Arisaema Cum Bile contains r---aminobutyric acid and alkaloid, think that inhibitory transmitter r---aminobutyric acid (GABA) in epileptic's brain truly has reduction in various degree, increasing GABA is the active drug of treatment epilepsy, because of GABA content in the brain higher, average level is 2---4 μ mol/g, synapse is GABA in the brain, can cause automatic epilepsy when GABA concentration reduces by 40% in the brain, determines that therefore GABA is the inhibitory transmitter of brain; Semen Sesami Nigrum has glossy greasiness, the energy blood enriching and dryness moistening, the laxation relieving constipation, tonifying five ZANG-organs six internal organs, physical strength profiting, longue meat is filled out brains, because Semen Sesami Nigrum is to contain the highest product of zinc calcium ferrum, find through modern scientific research, epileptic patient can reach 80% above ferrum zinc calcium, particularly child, because of ferrum zinc can hinder the differentiation division of neurocyte and the metabolism of neurotransmitter, thereby influence intellectual development, zinc supplement in time can make the patient recover normal.

Treatment epileptics capsular preparation method is: the first step, the Scorpio sieve to be desalted, and Scolopendra, Semen Sesami Nigrum choose behind the decontamination all parchings to brown in pot, are ground into fine flour then, simultaneously Cinnabaris, Borneolum Syntheticum are ground into behind the fine flour standby; In second step, Arisaema Cum Bile, Concretio Silicea Bambusae, Rhizoma Gastrodiae, Fructus Piperis, Bombyx Batryticatus, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, Flos Carthami, Ramulus Uncariae Cum Uncis, Os Draconis are required to go fabrication and processing to be ground into fine flour according to the brewing method of Chinese medicine; The 3rd step, the fine flour mixing of above medicine is sieved, leach medicinal residues, right rear packing is dressed up 1000 capsules and is got final product.

Treatment method: press oral this medicine of all ages and classes, in 2---5 year, obey each 1 every day 2 times; 6---14 year, every day 2 times, each 2; Extremely be grown up every day 2 times, each 3---4 grain more than 15 years old.

Observation experiment 500 routine children and adult's epilepsy, all the epilepsy diagnostic criteria of formulating by international epilepsy association in 1998 is made as respectively 500 examples of observation group, matched group, all by same age group, with the template epilepsy, the capsule of observation group's oral medication epileptics, is refused to obey various Western medicine at every day twice; Matched group oral western medicine sodium valproate, phenobarbital etc. all calculate drug administration oral administration by per kilogram, all do EEG (electrocardiogram) examination to the patient to make a definite diagnosis; Epilepsy curative effect determinate standard: 1, produce effects: electroencephalogram recovers normal, observes in 1 year after the drug withdrawal and does not recur; 2, effective: electroencephalogram before has improvement, and attack times and persistent period reduce, sx; 3, take a turn for the better: electroencephalogram does not have significant change, and attack times reduces, sx; 4, invalid: electroencephalogram does not have improvement, attack times and symptom no change.Two groups of comparing results are taken epilepsy medicament capsule effective percentage and are reached 91%, take the Western medicine effective percentage and reach 78.2%, two group of contrast marked difference arranged.Concrete data are to take capsular 500 examples of treatment epileptics, produce effects 216 examples, effective 190 examples, take a turn for the better 48 examples, invalid 46 examples, total effective rate 91%; Take 500 examples of Western medicine, produce effects 190 examples, effective 160 examples, take a turn for the better 41 examples, invalid 109 examples, total effective rate 78.2%.

Therapeutic effect of the present invention is definite, the medicine source is wide, cost is low, cure rate is high, taking convenience, nontoxic pair of effect.

Four, the specific embodiment: the present invention is made by following medicine, Arisaema Cum Bile 20g, Concretio Silicea Bambusae 32g, Cinnabaris 3g, Rhizoma Gastrodiae 30g, Fructus Piperis 6g, Scorpio 4g, Bombyx Batryticatus 30g, Rhizoma Acori Graminei 30g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Semen Sesami Nigrum 30g, Borneolum Syntheticum 3g, Ramulus Uncariae Cum Uncis 10g, 20 of Scolopendras, Os Draconis 20g; Its preparation method is: the first step, Scorpio sieve to be desalted, and Scolopendra, Semen Sesami Nigrum choose behind the decontamination all parchings to brown in pot, are ground into fine flour then, simultaneously Cinnabaris, Borneolum Syntheticum are ground into behind the fine flour standby; In second step, Arisaema Cum Bile, Concretio Silicea Bambusae, Rhizoma Gastrodiae, Fructus Piperis, Bombyx Batryticatus, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, Flos Carthami, Ramulus Uncariae Cum Uncis, Os Draconis are required to go fabrication and processing to be ground into fine flour according to the brewing method of Chinese medicine; The 3rd step, the fine flour mixing of above medicine is sieved, leach medicinal residues, right rear packing is dressed up 1000 capsules and is got final product.

Claims

1, the capsule of treatment epileptics, it is characterized in that: it is made by following medicine, Arisaema Cum Bile 20g, Concretio Silicea Bambusae 32g, Cinnabaris 3g, Rhizoma Gastrodiae 30g, Fructus Piperis 6g, Scorpio 4g, Bombyx Batryticatus 30g, Rhizoma Acori Graminei 30g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Semen Sesami Nigrum 30g, Borneolum Syntheticum 3g, Ramulus Uncariae Cum Uncis 10g, 20 of Scolopendras, Os Draconis 20g.

2, the capsular preparation method of the described treatment epileptics of claim 1 is characterized in that: the first step, Scorpio sieve to be desalted, and Scolopendra, Semen Sesami Nigrum choose behind the decontamination all parchings to brown in pot, are ground into fine flour then, simultaneously Cinnabaris, Borneolum Syntheticum are ground into behind the fine flour standby; In second step, Arisaema Cum Bile, Concretio Silicea Bambusae, Rhizoma Gastrodiae, Fructus Piperis, Bombyx Batryticatus, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, Flos Carthami, Ramulus Uncariae Cum Uncis, Os Draconis are required to go fabrication and processing to be ground into fine flour according to the brewing method of Chinese medicine; The 3rd step, the fine flour mixing of above medicine is sieved, leach medicinal residues, right rear packing is dressed up 1000 capsules and is got final product.