CN101039702A - 作为靶向试剂用于内皮－特异性体内转导的热激蛋白 - Google Patents

作为靶向试剂用于内皮－特异性体内转导的热激蛋白 Download PDF

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Publication number
CN101039702A
CN101039702A CNA2005800351346A CN200580035134A CN101039702A CN 101039702 A CN101039702 A CN 101039702A CN A2005800351346 A CNA2005800351346 A CN A2005800351346A CN 200580035134 A CN200580035134 A CN 200580035134A CN 101039702 A CN101039702 A CN 101039702A
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CN
China
Prior art keywords
compound
sig
lox
group
peptide
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Pending
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CNA2005800351346A
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English (en)
Chinese (zh)
Inventor
F·休德
M·赵
A·托雷斯
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General Electric Co
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General Electric Co
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Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN101039702A publication Critical patent/CN101039702A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2005800351346A 2004-08-13 2005-08-11 作为靶向试剂用于内皮－特异性体内转导的热激蛋白 Pending CN101039702A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/917,326 2004-08-13
US10/917,326 US7575738B2 (en) 2004-08-13 2004-08-13 Heat shock protein as a targeting agent for endothelium-specific in vivo transduction

Publications (1)

Publication Number Publication Date
CN101039702A true CN101039702A (zh) 2007-09-19

Family

ID=35431037

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800351346A Pending CN101039702A (zh) 2004-08-13 2005-08-11 作为靶向试剂用于内皮－特异性体内转导的热激蛋白

Country Status (5)

Country Link
US (1) US7575738B2 (https=)
EP (1) EP1776144A2 (https=)
JP (1) JP2008509921A (https=)
CN (1) CN101039702A (https=)
WO (1) WO2006020743A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US8440167B2 (en) * 2008-10-27 2013-05-14 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to LOX-1
EP2488097B1 (en) 2009-10-16 2021-01-13 Koninklijke Philips N.V. Photoacoustic contrast agent based active ultrasound imaging
GB201102189D0 (en) * 2011-02-08 2011-03-23 King S College London Materials and methods relating to cardiovascular imaging
JP6410339B2 (ja) * 2013-03-25 2018-10-24 国立大学法人千葉大学 放射性核種標識オクトレオチド誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4752141A (en) 1985-10-25 1988-06-21 Luxtron Corporation Fiberoptic sensing of temperature and/or other physical parameters
US4986671A (en) 1989-04-12 1991-01-22 Luxtron Corporation Three-parameter optical fiber sensor and system
US5275594A (en) 1990-11-09 1994-01-04 C. R. Bard, Inc. Angioplasty system having means for identification of atherosclerotic plaque
US5217456A (en) 1992-02-24 1993-06-08 Pdt Cardiovascular, Inc. Device and method for intra-vascular optical radial imaging
WO1999048914A1 (en) * 1998-03-26 1999-09-30 The University Of New Mexico Methods for using heat shock proteins
DE69941156D1 (de) * 1998-11-24 2009-09-03 Bristol Myers Squibb Co Intranukleärer, gerichteter transport von verbindungen durch das 70kd-hitzeschockprotein
EP1377321A4 (en) 2001-02-23 2006-01-11 Bristol Myers Squibb Co RECOVERY ANTAGONISTS RECEIVING DETECTABLE MACROPHAGE RECEPTORS FOR THE IDENTIFICATION OF ATHEROSCLEROSIS AND VULNERABLE PLAQUE BY IMAGING
US20040071656A1 (en) * 2001-12-26 2004-04-15 Felix Wieland Modulation of heat-shock-protein-based immunotherapies
US20050089471A1 (en) * 2003-10-24 2005-04-28 Johnson Bruce F. Labeled ligands for lectin-like oxidized low-density lipoprotein receptor (LOX-1)

Also Published As

Publication number Publication date
JP2008509921A (ja) 2008-04-03
EP1776144A2 (en) 2007-04-25
WO2006020743A2 (en) 2006-02-23
US7575738B2 (en) 2009-08-18
US20060034761A1 (en) 2006-02-16
WO2006020743A3 (en) 2006-07-20

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20070919