CN101011462A - Kidney-tea effervescence tablet and its preparing process - Google Patents
Kidney-tea effervescence tablet and its preparing process Download PDFInfo
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- CN101011462A CN101011462A CN 200710065659 CN200710065659A CN101011462A CN 101011462 A CN101011462 A CN 101011462A CN 200710065659 CN200710065659 CN 200710065659 CN 200710065659 A CN200710065659 A CN 200710065659A CN 101011462 A CN101011462 A CN 101011462A
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Abstract
Disclosed is kidney-tonifying effervescent tablet which is prepared from the raw materials of (by weight portion) dried kidney tea water extract 60-140, sodium hydrogen carbonate 34-78, dihydroxysuccinic acid 30-70, carboxymethyl cellulose 18-42, crystalline cellulose 27-63 through steps of extracting, concentrating, spray drying, proportioning, disintegrating, passing through 80 mesh sieve, mixing homogeneously, tabletting, drying, granulating, detecting, radiation sterilizing and packaging.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation that contains plant amedica kidney tea, kidney tea is the dry aerial parts of labiate Herba clerodendranthi spicati Clerodendranthus spicatus (Thunb.) C.Y.Wu, and can adopt the whole year, and among the people always the habit is called kidney tea.That concrete is kidney-tea effervescence tablet and preparation technology thereof.
Background technology
Urgent micturition due to the damp-heat in the urinary bladder, dysurea, non-specific lower urinary tract infection and above-mentioned patient are a kind of common nephropathy.Also be morbidity of current height and commonly encountered diseases, have protracted course of disease, the characteristics of renal insufficiency late period appears in often outbreak repeatedly, serious the healthy of people that endangering.This class disease doctor trained in Western medicine adopts adrenocortical hormone and immune inhibitor or antibiotic etc treatment more, certain curative effect is arranged clinically, but toxic and side effects is bigger.
It is important component parts of China's traditional medicine that Xishuangbannadaizu area, Yunnan has more than 2000 year historical Dai Nationality's medicine and pharmacology, and Dai Nationality's medical science has the ethnomedicine system of complete theory of medicine and the medical content of enriching.The advantage of Dai Nationality's medicine is Special geography and climatic environment, and the medical material component content of use is many, biological activity is strong, pollution-free.Kidney tea commonly used is treated this type of nephropathy among the doctor of the Dai Nationality, but extremely unstable behind the effective Cheng Yure in the kidney tea, under the high temperature more than 85 ℃, decompose easily, cause curative effect to reduce, and traditional its active constituent content of bag tea agent using method is low, uses and carry also inconvenience.
Summary of the invention
The objective of the invention is to propose a kind of active constituent content height, use and easy to carry, kidney-tea effervescence tablet of being convenient to absorb and preparation technology thereof.
Technical scheme of the present invention is that kidney-tea effervescence tablet is the medicament of being made by the following weight proportion raw material: kidney tea is carried extractum dry product 60-140, sodium bicarbonate 34-78, tartaric acid 30-70, carboxymethyl cellulose 18-42, microcrystalline Cellulose 27-63.
It is to be lower than 85 ℃ of extractions that its middle kidney tea is carried extractum.
The preparation technology of kidney-tea effervescence tablet is characterized in that;
(1) kidney tea concentrates in extracting below 85 ℃, and spray drying becomes kidney tea and carries extractum;
(2) press: kidney tea is carried extractum dry product 60-140, sodium bicarbonate 34-78, and tartaric acid 30-70, carboxymethyl cellulose 18-42, microcrystalline Cellulose 27-63 gets the raw materials ready;
(3) kidney tea is carried the extractum dry product and is pulverized mistake 80 mesh sieves, extracting screen underflow once more;
(4) mix homogeneously;
(5) tablet machine tabletting;
(6) dry, granulate;
(7) check;
(8) radiation sterilization;
(9) pack, dispatch from the factory after the assay was approved once more.
Kidney tea Cerodendranthus spicatus (thumb) c Y.Wu is the Labiatae herbaceos perennial, claims Herba clerodendranthi spicati again.All herbal medicine has clearing away heat and promoting diuresis, the effect that calculus is treating stranguria.The diseases such as acute and chronic nephritis, cystitis, urinary system calculus that are used for the treatment of among the people.Kidney tea Dai Nationality name " refined glutinous second ", Dai Nationality's medical book " pattra leaves warp " record kidney tea is used for the treatment of the hot puckery pain of urine, and diseases of urinary system such as soreness of waist root pain have more than 2000 year history
The record that China uses kidney tea effect is mainly seen in documents such as " Yunnan plant topography ", " Hainan flora ", " Chinese medicine resource will ", " Chinese medicine voluminous dictionary ".Call its " the property slightly sweet flavor is little bitter cool ", " energy clearing heat and expelling damp, calculus diuretic as " Chinese medicine voluminous dictionary ".Treating acute and chronic nephritis, cystitis, urine is coughed up calculus, rheumatic arthritis." record of all the other documents is similar.
Chemical analysis to kidney tea shows, kidney tea main chemical have: flavone compound, steroid oside, anthraquinone class and glycoside, aminoacid, polypeptide, protein, organic acid, saccharide, polysaccharide, polyphenol compound etc.So far from the aerial parts of kidney tea, 12 glycosides millions, 2 flavonol glycosides, phenolic acids composition Sumaryono report, the rosmarinic acid of telling from kidney tea are that kidney tea does one of scorching effective effective constituent.Its anti-inflammatory mechanisms one is possible relevant with the 5-lipoxidase in suppressing arachidonic acid metabolic, the 2nd, and rosmarinic acid is to complement-dependent PGI
2Synthetic inhibitory action arranged, can disturb different approaches G
3The activity of invertase; The 3rd, antioxidation and elimination free radical have protective effect to biomembranous peroxidating damage.Rosmarinic acid also has weak anti-mice s-180 sarcoma tumor effect in addition.
Therefore about the pharmacological research of kidney tea, nineteen twenty-seven Gruber tentatively proves a nontoxic extract in the kidney tea, diuresis is arranged, and it is effective to treat nephritis.The high South-South report that waits of China adopts methods such as mice metabolic cage method, mice ear method and antibacterial (MIC) test, proves that the kidney tea set has diuresis, antiinflammatory, antibiotic, strong kidney and the regulating action of exempting from service.
Kidney tea is many clinically to be fried in shallow oil juice with stem and leaf and takes, respond well to chyluria, vesical calculus, ureteral calculus.But because active constituent content is low, curative effect is slow, use is also inconvenient.
The present invention is based on understanding and the Therapeutic Principle of ethnomedicine to nephropathy mechanism, achievement with reference to modern pharmacological research, adopt modern advanced pharmaceutical technology, kidney tea is carried the extractum dry product to be added adjuvant and makes effervescent tablet, the present invention has that disintegrate is rapid, dissolubility is high, curative effect is fast, and volume is urinated in characteristics such as taking and carry.
Through clinical trial for many years, kidney-tea effervescence tablet is not found incompatibility and clinical adverse as yet.Be used for the treatment of urgent micturition, dysurea due to the damp-heat in the urinary bladder, non-specific lower urinary tract infection etc.Dai Nationality doctor transliteration: separate Huang and separate and force, logical difficult difficult to understand excellent, reprint; The soldier holds together that cattle breathes out the war ripple, excellently connects, excellently dares, excellent Huang.Three times on the one, a 1-3 sheet can be taken for a long time.
Specific implementation method
According to the form below is got the raw materials ready
Prescription | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
Kidney tea is carried the extractum dry product | 60 grams | 140 grams | 100 grams | 80 grams |
Sodium bicarbonate | 78 grams | 34 grams | 50 grams | 60 grams |
Tartaric acid | 70 grams | 30 grams | 40 grams | 60 grams |
Carboxymethyl cellulose | 42 grams | 18 grams | 40 grams | 30 grams |
Microcrystalline Cellulose | 27 grams | 63 grams | 45 grams | 45 grams |
Its middle kidney tea is carried extractum for extracting when being lower than 85 ℃.
Preparation method is as follows:
(1) kidney tea is carried the extractum dry product and is pulverized once more, crosses 80 mesh sieves, extracting screen underflow,
(2) mix homogeneously,
(3) tablet machine is compressed to 200 of the effervescent tablets of 1g,
(4) dry, granulate,
(5) check,
(6) radiation sterilization,
(7) pack, dispatch from the factory after the assay was approved once more.
Claims (3)
1, kidney-tea effervescence tablet is characterized in that it being the medicament of being made by the following weight proportion raw material:
Kidney tea is carried extractum dry product 60-140, sodium bicarbonate 34-78, tartaric acid 30-70, carboxymethyl cellulose 18-42, microcrystalline Cellulose 27-63.
2, kidney-tea effervescence tablet as claimed in claim 1 is characterized in that; It is to be lower than 85 ℃ of extractions that kidney tea is carried extractum.
3, the preparation technology of kidney-tea effervescence tablet as claimed in claim 1 is characterized in that;
(1) kidney tea concentrates in extracting below 85 ℃, and spray drying becomes kidney tea and carries extractum;
(2) press: kidney tea is carried extractum dry product 60-140, sodium bicarbonate 34-78, and tartaric acid 30-70, carboxymethyl cellulose 18-42, microcrystalline Cellulose 27-63 gets the raw materials ready;
(3) kidney tea is proposed the pulverizing of extractum dry product, crosses 80 mesh sieves, extracting screen underflow;
(4) mix homogeneously;
(5) tablet machine tabletting;
(6) dry, granulate;
(7) check;
(8) radiation sterilization;
(9) pack, dispatch from the factory after the assay was approved once more.
Priority Applications (1)
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CN 200710065659 CN101011462A (en) | 2007-02-06 | 2007-02-06 | Kidney-tea effervescence tablet and its preparing process |
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CN 200710065659 CN101011462A (en) | 2007-02-06 | 2007-02-06 | Kidney-tea effervescence tablet and its preparing process |
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CN 200710065659 Pending CN101011462A (en) | 2007-02-06 | 2007-02-06 | Kidney-tea effervescence tablet and its preparing process |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101669988B (en) * | 2009-07-31 | 2012-06-27 | 芜湖梁氏新材料有限公司 | Extraction process of clerodendranthus spicatus |
CN113116857A (en) * | 2021-03-23 | 2021-07-16 | 浙江理工大学 | Effervescent granule with adhesion function and application thereof |
-
2007
- 2007-02-06 CN CN 200710065659 patent/CN101011462A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101669988B (en) * | 2009-07-31 | 2012-06-27 | 芜湖梁氏新材料有限公司 | Extraction process of clerodendranthus spicatus |
CN113116857A (en) * | 2021-03-23 | 2021-07-16 | 浙江理工大学 | Effervescent granule with adhesion function and application thereof |
CN113116857B (en) * | 2021-03-23 | 2022-07-05 | 浙江理工大学 | Effervescent granule with adhesion function and application thereof |
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Open date: 20070808 |