CN100592908C - 包括氢氟烷和酰化环糊精的药用喷雾剂 - Google Patents

包括氢氟烷和酰化环糊精的药用喷雾剂 Download PDF

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Publication number
CN100592908C
CN100592908C CN200480040939A CN200480040939A CN100592908C CN 100592908 C CN100592908 C CN 100592908C CN 200480040939 A CN200480040939 A CN 200480040939A CN 200480040939 A CN200480040939 A CN 200480040939A CN 100592908 C CN100592908 C CN 100592908C
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CN
China
Prior art keywords
hfa
drug
cyclodextrin
formulation according
budesonide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200480040939A
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English (en)
Chinese (zh)
Other versions
CN101087600A (zh
Inventor
菲利普·罗格达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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AstraZeneca AB
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Publication date
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Publication of CN101087600A publication Critical patent/CN101087600A/zh
Application granted granted Critical
Publication of CN100592908C publication Critical patent/CN100592908C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN200480040939A 2003-11-26 2004-11-24 包括氢氟烷和酰化环糊精的药用喷雾剂 Expired - Fee Related CN100592908C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE03031796 2003-11-26
SE0303179A SE0303179D0 (sv) 2003-11-26 2003-11-26 Novel compounds

Publications (2)

Publication Number Publication Date
CN101087600A CN101087600A (zh) 2007-12-12
CN100592908C true CN100592908C (zh) 2010-03-03

Family

ID=29729189

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480040939A Expired - Fee Related CN100592908C (zh) 2003-11-26 2004-11-24 包括氢氟烷和酰化环糊精的药用喷雾剂

Country Status (23)

Country Link
US (1) US20070104652A1 (OSRAM)
EP (1) EP1708679B1 (OSRAM)
JP (1) JP4950666B2 (OSRAM)
KR (1) KR20060118509A (OSRAM)
CN (1) CN100592908C (OSRAM)
AT (1) ATE413868T1 (OSRAM)
AU (1) AU2004294775B2 (OSRAM)
BR (1) BRPI0416992A (OSRAM)
CA (1) CA2546441C (OSRAM)
CY (1) CY1108753T1 (OSRAM)
DE (1) DE602004017783D1 (OSRAM)
DK (1) DK1708679T3 (OSRAM)
ES (1) ES2314469T3 (OSRAM)
IL (1) IL175659A (OSRAM)
MX (1) MXPA06005643A (OSRAM)
NO (1) NO20062969L (OSRAM)
NZ (1) NZ547355A (OSRAM)
PL (1) PL1708679T3 (OSRAM)
PT (1) PT1708679E (OSRAM)
SE (1) SE0303179D0 (OSRAM)
SI (1) SI1708679T1 (OSRAM)
WO (1) WO2005053637A2 (OSRAM)
ZA (1) ZA200604330B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006008568A (ja) * 2004-06-24 2006-01-12 Cyclochem:Kk ＩｇＥ抗体抑制剤および食品
WO2023127219A1 (ja) * 2021-12-28 2023-07-06 リンテック株式会社 シリコーン系粘着剤、粘着シートおよび両面粘着シート

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1229355A (zh) * 1997-06-13 1999-09-22 奇斯药制品公司 药用气溶胶组合物
CN1303270A (zh) * 1998-04-03 2001-07-11 卡迪夫大学学院顾问有限公司 气雾剂组合物
CN1331581A (zh) * 1998-11-25 2002-01-16 奇斯药制品公司 含hfa227和hfa137的药物气雾剂组合物
DE10205087A1 (de) * 2002-02-07 2003-08-21 Pharmatech Gmbh Cyclodextrine als Suspensionsstabilisatoren in druckverflüssigten Treibmitteln

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
US5654442A (en) * 1989-11-14 1997-08-05 The Perkin-Elmer Corporation 4,7-dichlorofluorescein dyes as molecular probes
TW224942B (OSRAM) * 1990-04-04 1994-06-11 Adka Ueno Kk
EP0477931B1 (en) * 1990-09-28 1994-08-17 Mercian Corporation Novel adriamycin derivatives
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
US5916883A (en) * 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1229355A (zh) * 1997-06-13 1999-09-22 奇斯药制品公司 药用气溶胶组合物
CN1303270A (zh) * 1998-04-03 2001-07-11 卡迪夫大学学院顾问有限公司 气雾剂组合物
CN1331581A (zh) * 1998-11-25 2002-01-16 奇斯药制品公司 含hfa227和hfa137的药物气雾剂组合物
DE10205087A1 (de) * 2002-02-07 2003-08-21 Pharmatech Gmbh Cyclodextrine als Suspensionsstabilisatoren in druckverflüssigten Treibmitteln

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Influence of formulation technique for hydroxypropyl-β-cyclodextrin on the stability of aspirin in HFA 134a.Robert O.Williams III et al.European Journal of Phmarmaceutics and Biopharmaceutics,Vol.47 No.2. 1999 *

Also Published As

Publication number Publication date
ATE413868T1 (de) 2008-11-15
US20070104652A1 (en) 2007-05-10
SI1708679T1 (sl) 2009-04-30
CN101087600A (zh) 2007-12-12
WO2005053637A2 (en) 2005-06-16
HK1108390A1 (zh) 2008-05-09
PT1708679E (pt) 2008-12-29
NZ547355A (en) 2009-05-31
PL1708679T3 (pl) 2009-04-30
AU2004294775A1 (en) 2005-06-16
KR20060118509A (ko) 2006-11-23
JP4950666B2 (ja) 2012-06-13
SE0303179D0 (sv) 2003-11-26
IL175659A (en) 2010-02-17
DE602004017783D1 (de) 2008-12-24
CA2546441A1 (en) 2005-06-16
IL175659A0 (en) 2006-09-05
AU2004294775B2 (en) 2007-12-20
DK1708679T3 (da) 2009-02-16
CY1108753T1 (el) 2014-04-09
CA2546441C (en) 2011-11-22
ES2314469T3 (es) 2009-03-16
MXPA06005643A (es) 2006-08-17
WO2005053637A3 (en) 2007-06-28
NO20062969L (no) 2006-08-25
EP1708679B1 (en) 2008-11-12
JP2007515401A (ja) 2007-06-14
BRPI0416992A (pt) 2007-02-06
EP1708679A2 (en) 2006-10-11
ZA200604330B (en) 2007-11-28

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