CN100558363C - A kind of pharmaceutical composition for the treatment of condyloma acuminatum - Google Patents
A kind of pharmaceutical composition for the treatment of condyloma acuminatum Download PDFInfo
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- CN100558363C CN100558363C CNB2007100213046A CN200710021304A CN100558363C CN 100558363 C CN100558363 C CN 100558363C CN B2007100213046 A CNB2007100213046 A CN B2007100213046A CN 200710021304 A CN200710021304 A CN 200710021304A CN 100558363 C CN100558363 C CN 100558363C
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- pharmaceutical composition
- treatment
- acetic acid
- condyloma acuminatum
- glacial acetic
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Abstract
The invention discloses a kind of pharmaceutical composition for the treatment of condyloma acuminatum, the active ingredient of this pharmaceutical composition is made up of acyclovir, 5-fluorouracil and glacial acetic acid, wherein the consumption of active ingredient is an acyclovir in every part of pharmaceutical composition (with 500～3000g is portion, preferred 1000g): 5-fluorouracil: glacial acetic acid=20～30g: 2～3g: 80～150ml.The present invention has characteristics such as using method is simple, determined curative effect, side effect is little, medical expense is low, convenience is provided, has effectively treated the selection approach to extensive patients.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, be specifically related to a kind of the medicative pharmaceutical composition of condyloma acuminatum.
Background technology
Condyloma acuminatum is a kind of good sending out in the sharp-pointed warty condyloma latum of skin and mucosa intersection, causes by human papillomavirus, and be common a kind of sexually transmitted disease (STD).Be common in relatively poor, local moist unclean, the redundant prepuce person of living habit, incubation period about one is to the several months.In the especially good occurring in YIN part of the body stem coronary sulcus of male patient, the foreskin, just send out to the small pale red pimple of minority, increase gradually later on, tendency merges.Because local humidity and chronic stimulation, normal increase rapidly forms mamillary, gill fungus umbrella or cockscomb sample propagation.The wart basilar part often has the base of a fruit, and the wart body is dirty Lycoperdon polymorphum Vitt or redness, the matter softness, and that touches is easily hemorrhage, the surface wettability erosion, conscious pruritus, easily the secondary bacterial infection is often secreted purulent secretion in the crack, distributes stench.As untimely, correctly treat, often can develop into huge tumor shape infringement, even minority cancerates.
Show that according to the WHO statistics whole world has 3,000 ten thousand condyloma acuminatum cases to take place every year.In China, the report of condyloma acuminatum example number is only second to gonorrhea, occupies second of sexually transmitted disease (STD), and nearly 10 annual average rates of increase reach 19.48%.
Show according to relevant survey data, aspect the condyloma acuminatum treatment, have greatly comparatively outstanding problem of " disorderly, difficult, expensive " three at present.So-called " unrest " is exactly that Therapeutic Method is various, along with the appearance of various commercial advertisements, introduces what advanced foreign technology inspection, treats this disease, perhaps deceives the patient with some unnecessary Therapeutic Method, makes the patient not know what is from selecting." difficulty " is exactly that therapeutic effect is poor, the relapse rate height.See recurrence behind many patient treatments in a short time again, be difficult to radical cure." expensive " is exactly the medical expense height, comprising some unnecessary inspections, medical expense.According to investigations, once control " healing " at present and generally need about 1500～4000 yuan.
Summary of the invention
The objective of the invention is to overcome the problem that existing treatment condyloma acuminatum aspect exists, provide that a kind of using method is simple, determined curative effect, pharmaceutical composition that medical expense is low.
Purpose of the present invention can reach by following measure:
A kind of pharmaceutical composition for the treatment of condyloma acuminatum, the active ingredient of this pharmaceutical composition is made up of acyclovir, 5-fluorouracil and glacial acetic acid, wherein the consumption of active ingredient is an acyclovir in every part of pharmaceutical composition (with 500～3000g is portion, preferred 1000g): 5-fluorouracil: glacial acetic acid=20～30g: 2～3g: 80～150ml.
The active ingredient and the acceptable accessories of this pharmaceutical composition are made ointment formulation, preferred emulsifiable paste.
Wherein acceptable accessories can be selected vaseline, paraffin, wool grease, Cera Flava, dimethicone, propylene glycol, stearic acid, tristerin, Oleum Ricini, ethyl hydroxybenzoate, white vaseline, liquid paraffin, glycerol, triethanolamine, octadecanol, water etc. for use.
Preferred group of the present invention becomes:
1, adjuvant preparation: get stearic acid 100～300g, ethyl hydroxybenzoate 0.1～10g, white vaseline 10～30g, liquid paraffin 100～200g, glycerol 30～80g, triethanolamine 1～20g, octadecanol 50～100g, wool grease 50～70g, distilled water is an amount of, it is standby to be mixed with 1000g substrate.
2, emulsifiable paste preparation and preserving: with acyclovir, 5-fluorouracil, glacial acetic acid (analytical pure) ratio in 20-30g/2-3g/80-150ml, be added to and be mixed with compound cream preparation 1000g in an amount of substrate, fully mix, by every 15g packing, place under the 4-20 ℃ of temperature environment and preserve, about 2 years shelf-lifves.
The mechanism of action of this medicine composite for curing condyloma acuminatum can be summarized as following some:
1, chemical cauterization effect.
2, absorption, the conversion by medicine, the DNA of viral interference attached cell and proteinic synthetic.
3, suppress duplicating of virus by viral interference DNA polymerase, stimulate body to produce specific immune response.
4, by the rational proportion of several drugs, the untoward reaction that as far as possible reduces medicine stimulates, and brings into play its synergism, reaches the effect of eliminating the wart body, removing virus.
Administrated method: before the medication, the part cleans up, and a little is applied to the wart surface to be stained with this product with cotton swab, every day 2～3 times.Wart body the greater can be fixed to increase drug treating time and to protect surrounding skin by adhesive bandage behind coating, and this method more is applicable to paranal big condyloma latum.
This pharmaceutical composition also has better effects to treatment verruca vulgaris (verruca vulgaris).
When using, this pharmaceutical composition notes protection normal skin, mucosa on every side, the careful usefulness of vagina condyloma latum patient.
At present method, the medicine of treatment condyloma acuminatum are a lot, mainly comprise: 5% imiquimod cream, the clean ointment of wart, podophyllum, send the Trane, control wart spirit emulsifiable paste etc.; Sai Nuojin partial closure therapy, CO2 laser associating 5-Fu office envelope therapy, the clean health of Lan Zuyin are united the wart soup therapy that disappears, microwave combined BCG vaccine polysaccharide and 5-Fu office envelope therapy, 5-linked therapy (surgical operation+local injection interferon+from body wart transplanting+oral immunity answer-reply regulator+Chinese medicine fumigation and washing demibain) and Chinese and Western combined therapy etc., from aspects such as cost, curative effect, relapse rate, side effect relatively, this compound preparation all has significant advantage, at present domestic still do not have a kind of therapy and can have very high exploitation and be worth by comparison.
By the multiple medications preparation, this compound preparation needs about 7 yuan of costs approximately, if produce in enormous quantities, cost may be lower.
Characteristics such as (spent cost are less than this sick expense of present common treatment far away) that this compound external-use preparation has using method simple (only needing external), determined curative effect, side effect is little, medical expense is low, succeeding in developing of it, overcome the not enough problem that exists in the treatment of present condyloma acuminatum, verruca vulgaris, convenience is provided, has effectively treated the selection approach to extensive patients.
The specific embodiment
The preparation of preparation example 1 substrate
Get stearic acid 200g, ethyl hydroxybenzoate 1g, white vaseline 20g, liquid paraffin 160g, glycerol 50g, triethanolamine 10g, octadecanol 80g, wool grease 60g, distilled water is an amount of, it is standby to be mixed with 1000g substrate.
Embodiment 1
Getting acyclovir 20g, 5-fluorouracil 2g, glacial acetic acid 100ml is added in the substrate of preparation example 1 gained and is mixed with 1000g compound cream preparation.
Embodiment 2
Getting acyclovir 24g, 5-fluorouracil 2.5g, glacial acetic acid 120ml is added in the substrate of preparation example 1 gained and is mixed with 1000g compound cream preparation.
Embodiment 3
Getting acyclovir 30g, 5-fluorouracil 2.8g, glacial acetic acid 140ml is added in the substrate of preparation example 1 gained and is mixed with 1000g compound cream preparation.
Embodiment 4
Getting acyclovir 20g, 5-fluorouracil 2g, glacial acetic acid 80ml is added in the substrate of preparation example 1 gained and is mixed with 1000g compound cream preparation.
Clinical experiment
1, used medicine: the compound cream preparation that adopts the embodiment of the invention 2 gained.
2, treatment target: the 126 routine patients that accept this experiment are the male, and the age was at 19～62 years old, and is in the majority with 30～40 years old person.The wart body betides coronary sulcus, foreskin person 117 examples, accounts for 93%, and 9 examples of surplusing betide crissum, account for 7%, and the wart body is less than 10mm person's 115 examples, and 11 routine wart bodies are aided with ligation or operative treatment more greatly.
3, the course of treatment: need 7～14 days a general course of treatment approximately, through the treatment of a course of treatment, has 89 routine wart bodies to come off, and 33 examples are through two course of therapy, and the wart body disappears.
4, curative effect: through 1～2 course of therapy, 122 routine patients do not see recurrence through following up a case by regular visits to 1～2 year, and cure rate reaches 97%, 4 example little wart body recurrence repeatedly, difficult radical cure, relapse rate 3%.
5, the rate that cancerates: the patient that 126 examples are received treatment, none example cancerates between follow-up period.
6, untoward reaction: among the patient that 126 examples are received treatment, many, the big person of area of 7 routine wart body quantity is arranged, behind external used medicine, the ulcer of normal skin generation on every side, the medicine of stopping using is aided with anti-inflammatory treatment, partly sterilised, ulcer surface healing in 7～11 days.Mild pain occurs after part patient's medication just, take a turn for the better after 2～3 days.
7, minority wart body is bigger, needs underwent operative excision or ligation to handle, and treats behind the wound healing that external used medicine is to reach the radical cure purpose again.
8, Comparison of therapeutic:
8.1 with several drugs at present commonly used, therapy relatively: this is organized among the patient that 126 examples receive treatment, and it is recurrent cases that 107 examples are arranged, and once uses methods such as imiquimod cream, the clean ointment of wart, podophyllum, interferon and laser burn to treat.107 routine recurrent cases treatment situations are as shown in table 1.
Table 1 107 routine recurrent cases treatment situation catalogs:
8.2 single component therapeutic evaluation: this compound preparation main component acyclovir, glacial acetic acid, 5-fluorouracil, when using with the finished medicines that contains a kind of composition wherein, except glacial acetic acid has certain effect small wart body (2mm is following), other two kinds are not all had obvious curative effects, and after coming off with glacial acetic acid treatment wart body, major part recurred in the 1-2 month, and local burning pain is also more obvious, and many patients are difficult for accepting.
Claims (1)
1, a kind of pharmaceutical composition for the treatment of condyloma acuminatum, the active ingredient that it is characterized in that this pharmaceutical composition is made up of acyclovir, 5-fluorouracil and glacial acetic acid, and wherein the consumption of active ingredient is an acyclovir in every part of pharmaceutical composition: 5-fluorouracil: glacial acetic acid=20～30g: 2～3g: 80～150ml; The active ingredient and the acceptable accessories of this pharmaceutical composition are made ointment formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100213046A CN100558363C (en) | 2007-04-06 | 2007-04-06 | A kind of pharmaceutical composition for the treatment of condyloma acuminatum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100213046A CN100558363C (en) | 2007-04-06 | 2007-04-06 | A kind of pharmaceutical composition for the treatment of condyloma acuminatum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101028269A CN101028269A (en) | 2007-09-05 |
| CN100558363C true CN100558363C (en) | 2009-11-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2007100213046A Expired - Fee Related CN100558363C (en) | 2007-04-06 | 2007-04-06 | A kind of pharmaceutical composition for the treatment of condyloma acuminatum |
Country Status (1)
| Country | Link |
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| CN (1) | CN100558363C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751100B (en) * | 2013-11-28 | 2015-09-16 | 郑州韩都药业集团有限公司 | A kind of Virless Cream |
-
2007
- 2007-04-06 CN CNB2007100213046A patent/CN100558363C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 明竹欣联用复方冰醋酸液治疗复发性尖锐湿疣60例. 徐文欣，石苏英.中国药业，第10卷第6期. 2001 |
| 明竹欣联用复方冰醋酸液治疗复发性尖锐湿疣60例. 徐文欣，石苏英.中国药业，第10卷第6期. 2001 * |
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| Publication number | Publication date |
|---|---|
| CN101028269A (en) | 2007-09-05 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091111 Termination date: 20140406 |