CN100551433C - The Chinese medicine preparation of treatment infertility - Google Patents

The Chinese medicine preparation of treatment infertility Download PDF

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CN100551433C
CN100551433C CNB2007100547348A CN200710054734A CN100551433C CN 100551433 C CN100551433 C CN 100551433C CN B2007100547348 A CNB2007100547348 A CN B2007100547348A CN 200710054734 A CN200710054734 A CN 200710054734A CN 100551433 C CN100551433 C CN 100551433C
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radix
rhizoma
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infertility
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CN101095897A (en
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徐汉民
史清菊
徐春玲
徐可军
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Abstract

The invention discloses a kind of Chinese medicine preparation for the treatment of infertility, mainly form, adopt prior art processes to can be made into soft extract, tablet, capsule, granule, pill, oral liquid by Radix Codonopsis, Rhizoma Atractylodis Macrocephalae part, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, the Cortex Eucommiae, Radix Dipsaci, Radix Morindae Officinalis, Herba Taxilli, the Radix Aucklandiae, Cortex Moutan, Herba Leonuri, Flos Carthami, Rhizoma Cyperi, Radix Bupleuri, Radix Curcumae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Colla Corii Asini crude drug.The present invention has functions such as benefiting qi and nourishing blood, blood circulation promoting and blood stasis dispelling, removing heat from blood detumescence, anti-inflammation, liver and kidney tonifying, strengthening the tendons and bones, soothing liver-QI for relieving depression, activating QI to eliminate phlegm, be used for the treatment of the infertility that the women causes because of obstruction of fallopian tube, instant effect, curative effect is lasting, short treating period, cure rate height, have no side effect, and the patient is taken like a shot.

Description

The Chinese medicine preparation of treatment infertility
Technical field
The invention belongs to field of pharmaceutical technology, be specifically related to a kind of Chinese medicine preparation for the treatment of infertility.
Background technology
Infertility cause of disease complexity, all can cause it infertile as salpingemphraxis, uterine hypoplasia, ovulation failure, inadequate luteal function, endometriosis, hysteromyoma, ovarian cyst etc., wherein again with obstruction of fallopian tube or logical and freely be not most commonly encountered diseases therefore.Doctor trained in Western medicine thinks that the infertility of obstruction of fallopian tube is that the adhesion of fallopian tube inflammatory is obstructed or logical and not smooth, sperm and ovum can not be combined through fallopian tube is normal, so Therapeutic Method mainly is that employing antibiotic anti-inflammation and operative therapy are main, but this Therapeutic Method fallopian tube often is temporarily unobstructed, but show effect repeatedly because of inflammation again very soon, adhesion and obstructed once more is so it is long to exist the course of treatment, curative effect is not good enough, easily the defective of recurrence; Adopt operative therapys such as interventional therapy, salpingoplasty, test-tube baby in addition, medical expense is extremely low up to tens thousand of units and success rate, and these Therapeutic Method have only the minority large hospital just can carry out, so the patient is difficult to receive.At present the traditional Chinese medical science is thought infertility except that physiological phenomenon, how with suffer from a deficiency of the kidney, due to the stagnation of liver-QI, phlegm-damp.The congenital kidney qi of person who suffer from deficiency of kidney Yang is not filled, asthenia of essence and blood, and towards conception vessel void, vessels of the uterus loses supports, and can not become pregnant by consolidating semen.Stagnation of liver-QI person, feelings will is not smooth, depression of liver-QI, catharsis is not normal, and disharmony between QI and blood dash to be appointed and can not be supported mutually and cause infertile.The phlegm-damp person eats savoury for a long time; Expectorant Wen Neisheng, vessels of the uterus resistance and not smooth can not be become pregnant.The traditional Chinese medical science many with the kidney tonifying nourishing the liver, transfer dash appoint, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, soothing liver-QI for relieving depression, the treatment of methods such as drying dampness to eliminate phlegm.The Chinese patent medicine of existing treatment obstruction of fallopian tube is less on the market, as FUKE QIANJIN PIAN; The traditional Chinese medical science is many to be many with the decoction decoction, exists the course of treatment longer, the unsettled defective of curative effect.
Summary of the invention
For solving the above-mentioned defective that prior art exists, the purpose of this invention is to provide a kind of Chinese medicine preparation that is used for the treatment of infertility.Particularly the infertility that women's obstruction of fallopian tube is caused has instant effect, and curative effect is lasting, short treating period, cure rate height, have no side effect, and the patient takes like a shot.
For achieving the above object, the technical solution used in the present invention is: the Chinese medicine preparation of this treatment infertility, make by the following materials based on weight medicine: Radix Codonopsis 40-50 part, Rhizoma Atractylodis Macrocephalae 30-50 part, Poria 30-50 part, Radix Glycyrrhizae 30-40 part, Radix Angelicae Sinensis 40-50 part, Rhizoma Chuanxiong 40-50 part, Radix Paeoniae Alba 30-50 part, Radix Rehmanniae Preparata 40-50 part, Cortex Eucommiae 40-50 part, Radix Dipsaci 50-60 part, Radix Morindae Officinalis 40-50 part, Herba Taxilli 40-50 part, Radix Aucklandiae 30-40 part, Cortex Moutan 40-50 part, Herba Leonuri 40-50 part, Flos Carthami 30-50 part, Rhizoma Cyperi 30-40 part, Radix Bupleuri 40-50 part, Radix Curcumae 30-50 part, Rhizoma Pinelliae 30-40 part, Pericarpium Citri Reticulatae 40-50 part, Fructus Foeniculi 30-40 part, Colla Corii Asini 30-40 part.
The best proportioning for preparing this Chinese medicine preparation is to press the row parts by weight: 45 parts of Radix Codonopsis, 40 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts of Poria, 35 parts in Radix Glycyrrhizae, 45 parts of Radix Angelicae Sinensis, 45 parts of Rhizoma Chuanxiongs, 35 parts of the Radix Paeoniae Albas, 45 parts in Radix Rehmanniae Preparata, 45 parts of the Cortexs Eucommiae, 55 parts of Radix Dipsaci, 45 parts of Radix Morindae Officinaliss, 45 parts of Herba Taxillis, 35 parts of the Radix Aucklandiae, 45 parts of Cortex Moutans, 45 parts of Herba Leonuris, 40 parts on Flos Carthami, 35 parts of Rhizoma Cyperis, 45 parts of Radix Bupleuri, 40 parts of Radix Curcumaes, 35 parts of the Rhizoma Pinelliaes, 45 parts of Pericarpium Citri Reticulataes, 35 parts of Fructus Foeniculi, 35 parts in Colla Corii Asini.
The above-mentioned Chinese medicine compositions of the present invention adds any dosage form that conventional adjuvant is made clinical acceptance, as soft extract, tablet, capsule, granule, pill, oral liquid.
The monarch of compatibility of drugs of the present invention, minister, help, make relation.Monarch drug: Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata; Ministerial drug: the Cortex Eucommiae, Radix Dipsaci, Radix Morindae Officinalis, Herba Taxilli, Flos Carthami, Cortex Moutan, Herba Leonuri, Colla Corii Asini; Adjuvant drug: Radix Bupleuri, Radix Curcumae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae; Messenger drug: Fructus Foeniculi, the Radix Aucklandiae, Rhizoma Cyperi.Dialectical opinion according to the traditional Chinese medical science is controlled and pharmacology analysis, monarch, minister, helps, makes and coordinate rationally, and dose rational allocation, the efficacy of a drug are directly got disease institute.Monarch's Fang Zhongsi soup, i.e. Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, air making-up and spleen enlivening, to support the day after tomorrow; SIWU TANG, promptly Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata nourish blood and enrich blood, the removing blood stasis tissue regeneration promoting; The Cortex Eucommiae, Herba Taxilli, Radix Morindae Officinalis, Radix Dipsaci, kidney-supplementing liver-boosting increase smart strong muscle, to support the day after tomorrow; Rhizoma Cyperi, the Radix Aucklandiae, promoting the circulation of QI to relieve pain, priming are descending; Fructus Foeniculi uterus warming for dispelling cold, Flos Carthami blood circulation promoting and blood stasis dispelling; Radix Bupleuri, Radix Curcumae dispersing the stagnated live-QI to relieve the stagnation of QI; Pericarpium Citri Reticulatae, Rhizoma Pinelliae regulating qi-flowing for strengthening spleen, reduce phlegm; Cortex Moutan, Herba Leonuri clearing away heat and cooling blood, dissipating blood stasis; Colla Corii Asini nourishing blood nourishes blood.Have functions such as benefiting qi and nourishing blood, blood circulation promoting and blood stasis dispelling, removing heat from blood detumescence, anti-inflammation, liver and kidney tonifying, strengthening the tendons and bones, soothing liver-QI for relieving depression, activating QI to eliminate phlegm.The traditional Chinese medical science is thought: women's QI and blood and, kidney qi is prosperous, essence and blood is abundant, feelings will is smooth, dashes and appoints money mutually, the smooth vessels of the uterus of mechanism of qi is logical, two essences are rich mutually, can become pregnant.Everyone does his best for this prescription Chinese medicine, and all medicines merge, and medicine reaches the purpose of treatment with the card plus-minus.
In recent years, use this medicine to every year tens thousand of patients from various parts of the country treat, evident in efficacy, welcome by the patient, do not find untoward reaction.For further specifying curative effect of medication of the present invention, it is as follows below the infertility of being done in 2006 to causing because of the fallopian tube factor to be carried out the GP TH briefing.
One, basic condition
Case 300 examples, the age is the women between 25 years old to 36 years old all, and marriageable age, 2-10 was all the infertility that causes because of the fallopian tube factor, all turned out to be one-sided or the bilateral obstruction of fallopian tube through Salpingography, or logical and not smooth.The patient is divided into three groups of A, B, C, every group 100 example, and the A group adopts the soft extract of medicine of the present invention, and the B group adopts commercially available FUKE QIANJIN PIAN, and the C group adopts oral antibiotic, and uterine cavity injection of antibiotics and transfusion do not contain operative therapy.
Two, treatment standard:
Recovery from illness: through treating pregnancy;
Effectively: check respectively that after treating index is clearly better;
Invalid: no change before and after the treatment.
Three, Therapeutic Method:
Adopt the soft extracts dosage form of medicine of the present invention, oral, take every day sooner or later, and each 10ml converts 250ml eliminating cold for resuscitation mouth of a river clothes, and 30 days is a course of treatment.
Four, therapeutic outcome:
Three months with preventing clinical observation statistical result such as following table:
Grouping Total routine number Cure (people) Effectively (people) Invalid (people) Total effective rate (%)
The A group 100 87 10 3 97
The B group 100 45 40 15 85
The C group 100 42 38 20 80
Above-mentioned data show that the cure rate of medicine of the present invention reaches 87%, and the cure rate of B group and C group is respectively 45% and 42%, and total effective rate medicine of the present invention reaches 97%, and B group and C group are respectively 85%, 80%, learn by statistics and handle the difference significance.Any reaction does not appear, reasonable recipe, and instant effect, curative effect is lasting, and short treating period is a kind of safe and effective, the women section good medicine that the patient takes like a shot.
Model case:
1, Zhang Yumin, the woman, 26 years old, people from Wuhan, Hubei, 3 years after marriage are infertile, on March 15th, 2006 examined, readme 2 years after marriage is infertile, once how tame hospital examine into: fallopian tube is logical not smooth, and causes infertile.Oral a large amount of antibiotic, transfusion, ultrashort wave physical therapy, hot compress, over one hundred dose in Chinese medicine is invalid.Menstruation was risen in 13 years old, cycle 28-32 days, amount less, suffer from abdominal pain, be afraid of cold, weakness of the waist and knees, spirit is not good enough, complexion dark, thready and weak pulse, white, the poor appetite of light red tongue.To sum up state dialectically, belong to two empty, the insufficiency of vital energy and bloods of spleen kidney and cause.Control with reinforcing spleen and kidney benefiting qi and nourishing blood.Ultrasound diagnosis: the uterus size, form is normal, and the bilateral adnexa is as good as.Hydrotubation; Fallopian tube is logical and not smooth.Lover's semen analysis: normal.March 15 in 2006 took medicine soft extract of the present invention and treats, and May 20 is because of one week of patient's delayed period, the further consultation of coming.Urine early pregnancy test (positive).
2, Wang Ling, woman, 28 years old, people from Xinye County.5 years after marriage infertile, and in May, 2006, male woman both sides examine, and readme 3 years after marriage was once once pregnant, and because of work relationship, the pedestrian flows art.Require conceivedly after 1 year, do not educate so far, wrong after patient's menstruation, the few darkish complexion of amount: through two mammary swellings pains the last week.Uncomfortable in chest smooth, many angry, feelings will is displeased, stomachache, leukorrhagia increase, tongue Bai Weihuang, deep pulse, this genuss stagnation of QI due to depression of the liver, disharmony between QI and blood, dashes and appoints and can not support mutually, and is consequently infertile.Ultrasound diagnosis: the uterus size and form is normal, a small amount of hydrops in the pelvic cavity.Bridegroom's or husband's side semen analysis; Every up to standard.Hydrotubation: obstruction of fallopian tube.Accept medicine soft extract of the present invention in May, 2006 and treat, follow up a case by regular visits to after 3 months, through ultrasound diagnosis, 7 weeks of early pregnancy, single tire survival.
3, Liu Huamin, woman, 30 years old, people from Nanyang.Because of 5 years after marriage infertile, take the bridegroom's or husband's side in July, 2006 and come to go to a doctor.Readme is because of infertile, and in Beijing, Zhengzhou, Nanyang Duo Jia examines and be obstruction of fallopian tube, it is invalid that Chinese and western medicine is cured in many ways frequently, and only one of test-tube baby is spent nearly 60,000 yuan, and the back is because of refusal fallopian tube plastic operation and interventional therapy abandoning cure.About patient's menstrual cycle 50 days, hypomenorrhea has bulk, and is uncomfortable in chest nauseating, obesity, excessive phlegm.Assertive evidence is living, a functional activity of QI being not smooth in the phlegm-damp, affectionately is obstructed, and is difficult for consolidating semen and becomes pregnant.Ultrasound diagnosis: retroposition of uterus, the bilateral adnexa is as good as.Bridegroom's or husband's side semen analysis: normal, Salpingography shows: the right side obstruction of fallopian tube, the left side is logical and not smooth.Accept medicine soft extract treatment of the present invention in July, 2006, November, the patient examined because of delayed period.B ultrasonic shows: 8 weeks of early pregnancy, single tire survival.
The specific embodiment
Embodiment 1
Prepare the Chinese medicine preparation of Drug therapy infertility of the present invention, press following weight portion weighting raw materials: 40 parts of Radix Codonopsis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Poria, 30 parts in Radix Glycyrrhizae, 40 parts of Radix Angelicae Sinensis, 40 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Paeoniae Albas, 40 parts in Radix Rehmanniae Preparata, 40 parts of the Cortexs Eucommiae, 50 parts of Radix Dipsaci, 40 parts of Radix Morindae Officinaliss, 40 parts of Herba Taxillis, 30 parts of the Radix Aucklandiae, 40 parts of Cortex Moutans, 40 parts of Herba Leonuris, 30 parts on Flos Carthami, 30 parts of Rhizoma Cyperis, 40 parts of Radix Bupleuri, 30 parts of Radix Curcumaes, 30 parts of the Rhizoma Pinelliaes, 40 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Foeniculi, 30 parts in Colla Corii Asini.After the purification of above-mentioned raw materials medicine, mix, be ground into the fine powder of No. five sieves of 80 orders, encapsulated, every 400mg/ grain, every day 2 times, each 2-3 grain, taking medicine before meal is used.Or putting into the sand jar after above-mentioned raw materials medicine (except that Colla Corii Asini) purified, to add water an amount of, got liquid after being fried boiling 30 minutes, 2 times repeatedly, filter, and slow fire concentrates, oven dry, and is ground into the fine powder of No. five sieves of 80 orders together with Colla Corii Asini, and encapsulated, bottling gets final product.
Embodiment 2
Prepare the Chinese medicine preparation of Drug therapy infertility of the present invention, press following weight portion weighting raw materials: 45 parts of Radix Codonopsis, 40 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts of Poria, 35 parts in Radix Glycyrrhizae, 45 parts of Radix Angelicae Sinensis, 45 parts of Rhizoma Chuanxiongs, 35 parts of the Radix Paeoniae Albas, 45 parts in Radix Rehmanniae Preparata, 45 parts of the Cortexs Eucommiae, 55 parts of Radix Dipsaci, 45 parts of Radix Morindae Officinaliss, 45 parts of Herba Taxillis, 35 parts of the Radix Aucklandiae, 45 parts of Cortex Moutans, 45 parts of Herba Leonuris, 40 parts on Flos Carthami, 35 parts of Rhizoma Cyperis, 45 parts of Radix Bupleuri, 40 parts of Radix Curcumaes, 35 parts of the Rhizoma Pinelliaes, 45 parts of Pericarpium Citri Reticulataes, 35 parts of Fructus Foeniculi, 35 parts in Colla Corii Asini.Putting into the sand jar after above-mentioned raw materials medicine (except that Colla Corii Asini) purified, to add water an amount of, got liquid after being fried boiling 30 minutes, 2 times repeatedly, slow fire concentrates, oven dry, and be ground into the fine powder of No. five, 80 orders sieve together with Colla Corii Asini, its add amylum pregelatinisatum, hard magnesium is made tablet or pill according to a conventional method, every/or ball be 100mg/ sheet or ball, oven dry, bottling gets final product.Every day 2 times sooner or later, each 3-4 grain, taking medicine before meal is used.
Embodiment 3
Prepare the Chinese medicine preparation of Drug therapy infertility of the present invention, press following weight portion weighting raw materials: 48 parts of Radix Codonopsis, 35 parts of the Rhizoma Atractylodis Macrocephalaes, 35 parts of Poria, 30 parts in Radix Glycyrrhizae, 40 parts of Radix Angelicae Sinensis, 48 parts of Rhizoma Chuanxiongs, 40 parts of the Radix Paeoniae Albas, 50 parts in Radix Rehmanniae Preparata, 48 parts of the Cortexs Eucommiae, 50 parts of Radix Dipsaci, 50 parts of Radix Morindae Officinaliss, 42 parts of Herba Taxillis, 32 parts of the Radix Aucklandiae, 42 parts of Cortex Moutans, 50 parts of Herba Leonuris, 45 parts on Flos Carthami, 38 parts of Rhizoma Cyperis, 40 parts of Radix Bupleuri, 35 parts of Radix Curcumaes, 32 parts of the Rhizoma Pinelliaes, 42 parts of Pericarpium Citri Reticulataes, 38 parts of Fructus Foeniculi, 40 parts in Colla Corii Asini.Putting into the sand jar after above-mentioned raw materials medicine (except that Colla Corii Asini) purified, to add water an amount of, got liquid after being fried boiling 30 minutes, and 2 times repeatedly, add Colla Corii Asini, brown sugar, slow fire is condensed into thick paste, makes soft extract, bottled getting final product.Every day 2 times sooner or later, get the 10ml soft extracts and convert eliminating cold for resuscitation water 250ml one after each meal.
Embodiment 4
Prepare the Chinese medicine preparation of Drug therapy infertility of the present invention, press following weight portion weighting raw materials: 50 parts of Radix Codonopsis, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts of Poria, 40 parts in Radix Glycyrrhizae, 50 parts of Radix Angelicae Sinensis, 50 parts of Rhizoma Chuanxiongs, 50 parts of the Radix Paeoniae Albas, 50 parts in Radix Rehmanniae Preparata, 50 parts of the Cortexs Eucommiae, 60 parts of Radix Dipsaci, 50 parts of Radix Morindae Officinaliss, 50 parts of Herba Taxillis, 40 parts of the Radix Aucklandiae, 50 parts of Cortex Moutans, 50 parts of Herba Leonuris, 50 parts on Flos Carthami, 40 parts of Rhizoma Cyperis, 50 parts of Radix Bupleuri, 50 parts of Radix Curcumaes, 40 parts of the Rhizoma Pinelliaes, 50 parts of Pericarpium Citri Reticulataes, 40 parts of Fructus Foeniculi, 40 parts in Colla Corii Asini.Putting into the sand jar after above-mentioned raw materials medicine (except that Colla Corii Asini) purified, to add water an amount of, got liquid after being fried boiling 30 minutes, 2 times repeatedly; add Colla Corii Asini, slow fire concentrates not thick paste, adds an amount of dextrin and mix and stir in thick paste; by the comminutor pelletize, pack after the drying, make granule.Every bag 8 gram, takes after mixing it with hot water at every day 2 times sooner or later.
The above-mentioned Chinese medicine compositions of the present invention also can add any dosage form that conventional adjuvant is made clinical acceptance, as oral liquid, fluid extract, mixture, syrup, powder etc.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of infertility is characterized in that being made by the following materials based on weight medicine: Radix Codonopsis 40-50 part, Rhizoma Atractylodis Macrocephalae 30-50 part, Poria 30-50 part, Radix Glycyrrhizae 30-40 part, Radix Angelicae Sinensis 40-50 part, Rhizoma Chuanxiong 40-50 part, Radix Paeoniae Alba 30-50 part, Radix Rehmanniae Preparata 40-50 part, Cortex Eucommiae 40-50 part, Radix Dipsaci 50-60 part, Radix Morindae Officinalis 40-50 part, Herba Taxilli 40-50 part, Radix Aucklandiae 30-40 part, Cortex Moutan 40-50 part, Herba Leonuri 40-50 part, Flos Carthami 30-50 part, Rhizoma Cyperi 30-40 part, Radix Bupleuri 40-50 part, Radix Curcumae 30-50 part, Rhizoma Pinelliae 30-40 part, Pericarpium Citri Reticulatae 40-50 part, Fructus Foeniculi 30-40 part, Colla Corii Asini 30-40 part.
2, the Chinese medicine preparation of treatment infertility according to claim 1 is characterized in that being made by the following materials based on weight medicine: 45 parts of Radix Codonopsis, 40 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts of Poria, 35 parts in Radix Glycyrrhizae, 45 parts of Radix Angelicae Sinensis, 45 parts of Rhizoma Chuanxiongs, 35 parts of the Radix Paeoniae Albas, 45 parts in Radix Rehmanniae Preparata, 45 parts of the Cortexs Eucommiae, 55 parts of Radix Dipsaci, 45 parts of Radix Morindae Officinaliss, 45 parts of Herba Taxillis, 35 parts of the Radix Aucklandiae, 45 parts of Cortex Moutans, 45 parts of Herba Leonuris, 40 parts on Flos Carthami, 35 parts of Rhizoma Cyperis, 45 parts of Radix Bupleuri, 40 parts of Radix Curcumaes, 35 parts of the Rhizoma Pinelliaes, 45 parts of Pericarpium Citri Reticulataes, 35 parts of Fructus Foeniculi, 35 parts in Colla Corii Asini.
3, the Chinese medicine preparation of treatment infertility according to claim 1 and 2 is characterized in that: above-mentioned bulk drugs can be made into soft extract, tablet, capsule, granule, pill, oral liquid.
CNB2007100547348A 2007-06-23 2007-06-23 The Chinese medicine preparation of treatment infertility Active CN100551433C (en)

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CN103341131A (en) * 2013-07-17 2013-10-09 杜爱芝 Medicament for treating infertility and preparation method thereof
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CN105412792A (en) * 2015-12-17 2016-03-23 刘妮娜 Traditional Chinese medicine preparation for treating female infertility
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