CN100542415C - The coated granzyme production technology - Google Patents
The coated granzyme production technology Download PDFInfo
- Publication number
- CN100542415C CN100542415C CNB2004100612875A CN200410061287A CN100542415C CN 100542415 C CN100542415 C CN 100542415C CN B2004100612875 A CNB2004100612875 A CN B2004100612875A CN 200410061287 A CN200410061287 A CN 200410061287A CN 100542415 C CN100542415 C CN 100542415C
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- CN
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- Prior art keywords
- enzyme
- granzyme
- coated
- starch
- feed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000001398 Granzyme Human genes 0.000 title claims abstract description 22
- 108060005986 Granzyme Proteins 0.000 title claims abstract description 22
- 238000005516 engineering process Methods 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- 102000004190 Enzymes Human genes 0.000 claims abstract description 45
- 108090000790 Enzymes Proteins 0.000 claims abstract description 45
- 238000000034 method Methods 0.000 claims abstract description 23
- 229920002472 Starch Polymers 0.000 claims abstract description 18
- 239000008107 starch Substances 0.000 claims abstract description 18
- 235000019698 starch Nutrition 0.000 claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 11
- 235000013312 flour Nutrition 0.000 claims abstract description 11
- 239000000853 adhesive Substances 0.000 claims abstract description 10
- 230000001070 adhesive effect Effects 0.000 claims abstract description 10
- 239000002002 slurry Substances 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000001125 extrusion Methods 0.000 claims description 5
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 9
- 235000013339 cereals Nutrition 0.000 abstract description 4
- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 238000005507 spraying Methods 0.000 abstract description 2
- 229940088598 enzyme Drugs 0.000 description 36
- 108091005508 Acid proteases Proteins 0.000 description 3
- 108010001682 Dextranase Proteins 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 108010011619 6-Phytase Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000009193 crawling Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000012407 engineering method Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Fodder In General (AREA)
Abstract
A kind of coated granzyme production technology, the fodder enzyme that various plans are added is (with starch and the flour as carrier, and the edible adhesive that increases degree of adhesion fully mixes, the starch slurry that adds normal concentration (5-15%), by wet method (or extruding) granulation, fluidized drying, start spraying system at the later stage of drying, wrap quilt, obtain the circular coated granzyme of 40-120 order through sub-sieve with spray-on process.The inventive method production technology is simple, and stability is high, and its productive rate height reaches 90～95%, and the flowability of its coated granzyme, dispersiveness, temperature tolerance are good.The inventive method is suitable for the bag quilt of all feeding enzymes.Grain number of the present invention reaches 6500-9000 grain/g, can guarantee in the interpolation journey of feed granulating, and every feed can contain 5-6 granzyme.Can reduce and control enzyme preparation amount effectively, the activity stable and enzyme of enzyme content is without prejudice in the feed product of assurance interpolation enzyme preparation.
Description
Technical field
The present invention relates to a kind of production technology of feed addictive, a kind of specifically granzyme production technology.
Technical background
Enzyme is a kind of active material that organism produces, and is the catalyst of various biochemical reactions in the body, and the digestion of various nutriments, absorption and utilization all must rely on the effect of enzyme.Enzyme has characteristics such as selectivity, high efficiency and specificity.The enzyme class of having found at present has several thousand kinds, and that can manually produce has kind more than 300, an existing kind more than 20 of extensive use in feed industry.Produce enzyme product by biological engineering method, be called enzyme preparation with activity.Enzyme preparation as feed addictive mainly contains function enzyme and nutrition enzyme, enzyme preparation is a kind of environmental protection and green feed additive owing to can effectively improve harmful effects such as efficiency of feed utilization, saving feed resource, the medicament residue that has no side effect, do not exist medicated premix and generation drug resistance.Scientific knowledge enzyme preparation and rational Application enzyme preparation class feed addictive have very big effect to action effect and the raising quality of the fodder level that improves enzyme preparation.Weighing the quality level of enzyme preparation and the foundation of action effect, mainly is the kind and the content of enzyme, the activity of enzyme and stable.In recent years, enzyme preparation was used widely at feedstuff industry.But normally used enzyme preparation is a powdery on the market, and is mobile, dispersed, temperature tolerance is all undesirable, therefore in the interpolation process, easily produce dust, consumption is big, and is difficult for being mixed evenly, causes the activity and the stability of enzyme in the feed that adds enzyme preparation all undesirable.This is that enzyme is a protein because the main component of enzyme preparation is an organized enzyme, and is responsive to heat, light, acid etc., and feed in process of production, because the influence of pulverizing, premix, granulation and other additives all may make the active impaired even sex change of enzyme.
Summary of the invention
The technical problem to be solved in the present invention is to provide the production technology of a kind of flowability, dispersiveness, coated granzyme that temperature tolerance is good.
The technical scheme that the present invention solves the problems of the technologies described above is: a kind of coated granzyme production technology, the fodder enzyme that various plans are added (comprises pure enzyme or complex enzyme, as zytase, the dextranase of crawling, α-amylase, acid protease, phytase, the single pure enzyme of pectase or wherein two kinds and multiple complex enzyme) and as the starch and the flour of carrier, and the edible adhesive that increases degree of adhesion fully mixes, the starch slurry that adds normal concentration (5-15%), granulate by wet method (or extruding), fluidized drying, start spraying system at the later stage of drying, wrap quilt with spray-on process, obtain the circular coated granzyme of 40-120 order through sub-sieve.
Above-mentioned consumption weight portion edible or feeding enzyme, starch, flour and edible adhesive is: edible or feeding enzyme 35-45, starch 35-62, flour 0-25, edible adhesive 0.5-1.5;
Above-mentioned spray-on process be exactly the existing conventional bag by spray-on process, promptly soak the capsulating material ethyl cellulose and carboxymethyl cellulose is sprayed with edible ethanol.
The inventive method production technology is simple, and stability is high, and its productive rate height reaches 90～95%, and the flowability of its coated granzyme, dispersiveness, temperature tolerance are good.The inventive method is suitable for the bag quilt of all feeding enzymes.Grain number of the present invention reaches 6500-9000 grain/g, can guarantee in the interpolation journey of feed granulating, and every feed can contain 5-6 granzyme.Can reduce and control enzyme preparation amount effectively, the activity stable and enzyme of enzyme content is without prejudice in the feed product of assurance interpolation enzyme preparation.
The specific embodiment
Embodiment 1:(aquatic product feed adds granzyme) zytase 35kg, starch 35kg, flour 17kg and edible adhesive (Tsing-Hua University's sunlight) 0.5kg is fully mixed, add concentration then and be 15% starch slurry, by wet method or extrusion granulate, fluidized drying, with spray-on process bag quilt, sub-sieve, make 80-120 order coated granzymes at the later stage of drying.
Embodiment 2:(bird feed interpolation granzyme) zytase 25kg, dextranase 10kg, amylase 5kg, acid protease 5kg, starch 30kg, flour 25kg fully mix, add concentration then and be 5% starch slurry, by wet method or extrusion granulate, fluidized drying, in dry run,, make 40-120 order coated granzymes with spray-on process bag quilt, sub-sieve.
Embodiment 3:(pig's feed adds granzyme) zytase 40kg, starch 37.5kg, flour 20kg and edible adhesive 1.5kg are fully mixed, add concentration then and be 20% starch slurry, by wet method or extrusion granulate, fluidized drying, in dry run,, make 40-120 order coated granzymes with spray-on process bag quilt, sub-sieve.
Embodiment 4:(ruminates the type animal feed and adds granzyme) zytase 20kg, dextranase 5kg, acid protease 10kg, amylase 5kg, starch 35kg, flour 25kg and edible adhesive 0.5kg are fully mixed, add concentration then and be 15% starch slurry, by wet method or extrusion granulate, fluidized drying, in dry run,, make 40-120 order coated granzymes with spray-on process bag quilt, sub-sieve.
Claims (1)
1, a kind of production technology of granzyme, it is characterized in that to eat or feeding enzyme, starch, flour and edible adhesive fully mix, add concentration then and be 5-15% starch slurry, by wet method or extrusion granulate, fluidized drying, with conventional spray-on process bag quilt, sub-sieve, make 40-120 order coated granzymes at the later stage of drying;
The consumption weight portion of above-mentioned edible or feeding enzyme, starch, flour, edible adhesive is: edible or feeding enzyme 35-45, starch 35-62, flour 17-25, edible adhesive 0.5-1.5;
Used capsulating material is an ethyl cellulose in the above-mentioned spray-on process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100612875A CN100542415C (en) | 2004-12-07 | 2004-12-07 | The coated granzyme production technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100612875A CN100542415C (en) | 2004-12-07 | 2004-12-07 | The coated granzyme production technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1633877A CN1633877A (en) | 2005-07-06 |
| CN100542415C true CN100542415C (en) | 2009-09-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100612875A Active CN100542415C (en) | 2004-12-07 | 2004-12-07 | The coated granzyme production technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100542415C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102362696B (en) * | 2011-08-23 | 2013-10-16 | 上海欧耐施生物技术有限公司 | Envelope production process for granzyme for temperature-resistant feed |
| CN107080053A (en) * | 2017-03-21 | 2017-08-22 | 四川新华扬山野生物有限公司 | A kind of heat-resistance type coating bioactive substance and preparation method thereof |
-
2004
- 2004-12-07 CN CNB2004100612875A patent/CN100542415C/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 包被型耐高温颗粒饲用酶的生产方法.. 陆文清等.中国饲料.，第22期. 2001 |
| 包被型耐高温颗粒饲用酶的生产方法.. 陆文清等.中国饲料.，第22期. 2001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1633877A (en) | 2005-07-06 |
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Owner name: HU'NAN QIU ZEYOU PATENT STRATEGIC PLANNING CO., LT Free format text: FORMER OWNER: QIU ZEYOU Effective date: 20101028 |
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Free format text: CORRECT: ADDRESS; FROM: 410011 28/F, SHUNTIANCHENG, NO.59, SECTION 2 OF FURONG MIDDLE ROAD, CHANGSHA CITY, HU'NAN PROVINCE TO: 410205 JUXING INDUSTRY BASE, NO.8, LUJING ROAD, CHANGSHA HIGH-TECH. DEVELOPMENT ZONE, YUELU DISTRICT, CHANGSHA CITY, HU'NAN PROVINCE |
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Effective date of registration: 20101104 Address after: 430074 Hubei city of Wuhan province Kuanshan East Lake development zone two Road No. 1 International Business Center Patentee after: Wuhan Sunhy Biology Co., Ltd. Address before: 430074 Hubei city of Wuhan province Kuanshan East Lake development zone two Road No. 1 International Business Center Patentee before: Xinhuayang Biological Co., Ltd., Wuhan |
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Address after: 430074 Hubei city of Wuhan province East Lake New Technology Development Zone, Ling Shan Road No. 5 Patentee after: Wuhan Sunhy Biology Co., Ltd. Address before: 430074 Hubei city of Wuhan province Kuanshan East Lake development zone two Road No. 1 International Business Center Patentee before: Wuhan Sunhy Biology Co., Ltd. |
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Address after: No.98, guangguba Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan Sunhy Biology Co., Ltd. Address before: 430074, No. 5, Ling Nan Road, East Lake New Technology Development Zone, Wuhan, Hubei, China Patentee before: Wuhan Sunhy Biology Co., Ltd. |
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