CN100528888C - 新的抗惊厥衍生物盐 - Google Patents

新的抗惊厥衍生物盐 Download PDF

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Publication number
CN100528888C
CN100528888C CNB2003801081824A CN200380108182A CN100528888C CN 100528888 C CN100528888 C CN 100528888C CN B2003801081824 A CNB2003801081824 A CN B2003801081824A CN 200380108182 A CN200380108182 A CN 200380108182A CN 100528888 C CN100528888 C CN 100528888C
Authority
CN
China
Prior art keywords
compound
formula
salt
ethyl acetate
topiramate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2003801081824A
Other languages
English (en)
Chinese (zh)
Other versions
CN1735626A (zh
Inventor
A·阿布德尔-马吉德
C·玛丽亚诺夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3 Dimensional Pharmaceuticals Inc
Original Assignee
3 Dimensional Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3 Dimensional Pharmaceuticals Inc filed Critical 3 Dimensional Pharmaceuticals Inc
Publication of CN1735626A publication Critical patent/CN1735626A/zh
Application granted granted Critical
Publication of CN100528888C publication Critical patent/CN100528888C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB2003801081824A 2003-01-03 2003-12-30 新的抗惊厥衍生物盐 Expired - Fee Related CN100528888C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/336,435 2003-01-03
US10/336,435 US7041650B2 (en) 2001-07-09 2003-01-03 Anticonvulsant derivative salts

Publications (2)

Publication Number Publication Date
CN1735626A CN1735626A (zh) 2006-02-15
CN100528888C true CN100528888C (zh) 2009-08-19

Family

ID=32710935

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801081824A Expired - Fee Related CN100528888C (zh) 2003-01-03 2003-12-30 新的抗惊厥衍生物盐

Country Status (17)

Country Link
US (1) US7041650B2 (https=)
EP (1) EP1581545A1 (https=)
JP (1) JP2006514071A (https=)
KR (1) KR20050092035A (https=)
CN (1) CN100528888C (https=)
AU (1) AU2003300149A1 (https=)
CA (1) CA2511682A1 (https=)
HR (1) HRP20050603A2 (https=)
IL (1) IL169505A0 (https=)
MX (1) MXPA05007253A (https=)
NO (1) NO20053673L (https=)
NZ (1) NZ540696A (https=)
PL (1) PL377766A1 (https=)
RU (1) RU2330041C2 (https=)
UA (1) UA82214C2 (https=)
WO (1) WO2004063210A1 (https=)
ZA (1) ZA200506167B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA78211C2 (en) * 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
US8779175B2 (en) * 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060233892A1 (en) * 2005-04-19 2006-10-19 Curt Hendrix Topiramate compositions for treatment of headache
US20090076128A1 (en) * 2007-09-15 2009-03-19 Protia Llc Deuterium-enriched topiramate
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1360500A (zh) * 1999-02-24 2002-07-24 辛辛那提大学 氨基磺酸酯衍生物用于治疗冲动控制障碍的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108787A (en) * 1980-01-31 1981-08-28 Sato Yakugaku Kenkyusho:Kk Camptothecin coline salt and its preparation
US4513006A (en) 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
US4751220A (en) * 1986-12-19 1988-06-14 E. R. Squibb & Sons, Inc. Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
IL103172A (en) * 1991-09-19 1997-01-10 Mcneilab Inc Preparation of chlorosulfate and sulfamate derivatives of 2, 3:4, 5-bis-o-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl) methanol
US5242942A (en) * 1992-04-28 1993-09-07 Mcneilab, Inc. Anticonvulsant fructopyranose cyclic sulfites and sulfates
US5384327A (en) 1992-12-22 1995-01-24 Mcneilab, Inc. Anticonvulsant sorbopyranose sulfamates
US5498629A (en) * 1993-12-23 1996-03-12 Ortho Pharmaceutical Corporation Anticonvulsant pseudofructopyranose sulfamates
US5998380A (en) * 1995-10-13 1999-12-07 New England Medical Center Hospitals, Inc. Treatment of migraine
US5753693A (en) * 1996-06-28 1998-05-19 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder
US6541520B1 (en) 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
UA78211C2 (en) 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
US6559293B1 (en) 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1360500A (zh) * 1999-02-24 2002-07-24 辛辛那提大学 氨基磺酸酯衍生物用于治疗冲动控制障碍的用途

Also Published As

Publication number Publication date
EP1581545A1 (en) 2005-10-05
ZA200506167B (en) 2007-03-28
PL377766A1 (pl) 2006-02-20
MXPA05007253A (es) 2005-12-14
UA82214C2 (en) 2008-03-25
WO2004063210A1 (en) 2004-07-29
IL169505A0 (en) 2007-07-04
NO20053673L (no) 2005-09-30
US7041650B2 (en) 2006-05-09
US20030176362A1 (en) 2003-09-18
KR20050092035A (ko) 2005-09-16
HRP20050603A2 (en) 2006-07-31
CN1735626A (zh) 2006-02-15
RU2330041C2 (ru) 2008-07-27
NZ540696A (en) 2007-11-30
CA2511682A1 (en) 2004-07-29
AU2003300149A1 (en) 2004-08-10
RU2005120782A (ru) 2006-01-20
NO20053673D0 (no) 2005-07-29
JP2006514071A (ja) 2006-04-27

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SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090819

CF01 Termination of patent right due to non-payment of annual fee