CN100518735C - 色胺衍生物和类似物以及含有它们的药物组合物 - Google Patents

色胺衍生物和类似物以及含有它们的药物组合物 Download PDF

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Publication number
CN100518735C
CN100518735C CNB018168043A CN01816804A CN100518735C CN 100518735 C CN100518735 C CN 100518735C CN B018168043 A CNB018168043 A CN B018168043A CN 01816804 A CN01816804 A CN 01816804A CN 100518735 C CN100518735 C CN 100518735C
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China
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alkyl
chemical compound
aryl
melatonin
dinitro
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Expired - Fee Related
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CNB018168043A
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Chinese (zh)
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CN1582147A (zh
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纳瓦·奇撒贝尔
姆士·劳丹
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Neurim Pharmaceuticals 1991 Ltd
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Neurim Pharmaceuticals 1991 Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018168043A 2000-10-03 2001-09-25 色胺衍生物和类似物以及含有它们的药物组合物 Expired - Fee Related CN100518735C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL138825A IL138825A (en) 2000-10-03 2000-10-03 Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds
IL138825 2000-10-03

Publications (2)

Publication Number Publication Date
CN1582147A CN1582147A (zh) 2005-02-16
CN100518735C true CN100518735C (zh) 2009-07-29

Family

ID=11074694

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Application Number Title Priority Date Filing Date
CNB018168043A Expired - Fee Related CN100518735C (zh) 2000-10-03 2001-09-25 色胺衍生物和类似物以及含有它们的药物组合物

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US (2) US6780884B2 (enExample)
EP (1) EP1331935B1 (enExample)
JP (1) JP2004533986A (enExample)
KR (1) KR100855385B1 (enExample)
CN (1) CN100518735C (enExample)
AR (1) AR035587A1 (enExample)
AT (1) ATE409474T1 (enExample)
AU (1) AU9416201A (enExample)
BG (1) BG107759A (enExample)
BR (1) BR0114464A (enExample)
CA (1) CA2423628C (enExample)
CL (1) CL2001002303A1 (enExample)
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CY (1) CY1110417T1 (enExample)
CZ (1) CZ301098B6 (enExample)
DE (1) DE60136003D1 (enExample)
DK (1) DK1331935T3 (enExample)
EA (1) EA005918B1 (enExample)
EE (1) EE05192B1 (enExample)
ES (1) ES2315307T3 (enExample)
GT (1) GT200100197A (enExample)
HN (1) HN2001000218A (enExample)
HU (1) HU227163B1 (enExample)
IL (1) IL138825A (enExample)
IS (1) IS2607B (enExample)
MX (1) MXPA03002612A (enExample)
NO (1) NO20031396L (enExample)
NZ (1) NZ525587A (enExample)
PA (1) PA8529801A1 (enExample)
PE (1) PE20020411A1 (enExample)
PL (1) PL365679A1 (enExample)
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UY (1) UY26946A1 (enExample)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2550091A1 (en) * 2003-12-19 2005-07-07 Elixir Pharmaceuticals, Inc. Methods of treating a disorder
WO2005082143A1 (en) * 2004-02-20 2005-09-09 Lifescape Biosciences Incorporated Compositions and methods for sleep regulation
WO2006135873A2 (en) * 2005-06-10 2006-12-21 Bipar Sciences, Inc. Parp modulators and treatment of cancer
US7622495B2 (en) 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
EP2173344B1 (en) 2007-06-29 2016-04-06 Clarencew Pty Ltd. Treatment or prophylaxis or neurological or neuropsychiatric disorders via ocular administration
US8852630B2 (en) 2008-05-13 2014-10-07 Yale University Chimeric small molecules for the recruitment of antibodies to cancer cells
JP5746615B2 (ja) * 2008-05-13 2015-07-08 エール ユニヴァーシティ 癌細胞への抗体の動員のためのキメラ小分子
JP6555884B2 (ja) 2011-05-31 2019-08-07 クラレンシュウ・プロプライエタリー・リミテッド 運動に関連する神経障害を予防および治療する方法
CA2853729A1 (en) * 2011-10-28 2013-05-02 Board Of Regents, The University Of Texas System Novel compositions and methods for treating cancer
CN102816103B (zh) * 2012-08-20 2014-05-07 冉瑞琼 硫化天冬氨酸修饰的退黑素衍生物及其应用
EP3430022B1 (en) * 2016-03-14 2020-03-11 Somalogic, Inc. Compounds and methods for the synthesis of 5-(n-protected-tryptaminocarboxyamide)-2'-deoxyuridine phosphoramidite for incorporation into a nucleic acid sequence
CN116421600B (zh) * 2023-05-29 2024-08-23 重庆医科大学 色醇在制备治疗焦虑的药物中的应用
WO2025137730A1 (en) * 2023-12-22 2025-06-26 Alexander Shulgin Research Institute, Inc. N-substituted tryptamines and n-substituted lysergamides and their use as therapeutic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880826A (en) * 1986-06-27 1989-11-14 Nava Zisapel Melatonin antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310085B1 (en) * 1997-10-03 2001-10-30 Clarencew Pty Ltd. Method for the treatment of neurological or neuropsychiatric disorders
AUPO274596A0 (en) * 1996-10-04 1996-10-31 Armstrong, Stuart Maxwell Method for the treatment of neurological or neuropsychiatric disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880826A (en) * 1986-06-27 1989-11-14 Nava Zisapel Melatonin antagonist

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Binding of 2,4-dinitrophenyl compounds and other smallmolecules to a crystalline λ-type Bence-Jones dimer. EDMUNDSON et al.Biochemistry.27 August,Vol.13 No.18. 1974 *

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WO2002028347A3 (en) 2002-07-04
MXPA03002612A (es) 2004-04-02
IL138825A0 (en) 2001-10-31
PA8529801A1 (es) 2002-12-30
HUP0302616A2 (hu) 2003-11-28
HK1074163A1 (zh) 2005-11-04
CA2423628C (en) 2011-04-26
NO20031396D0 (no) 2003-03-27
CN1582147A (zh) 2005-02-16
EA200300436A1 (ru) 2003-10-30
CZ2003940A3 (cs) 2003-10-15
ATE409474T1 (de) 2008-10-15
EE05192B1 (et) 2009-08-17
EP1331935B1 (en) 2008-10-01
SK4042003A3 (en) 2003-09-11
CY1110417T1 (el) 2015-04-29
HU227163B1 (en) 2010-09-28
KR100855385B1 (ko) 2008-09-04
UY26946A1 (es) 2001-11-30
US6780884B2 (en) 2004-08-24
DE60136003D1 (de) 2008-11-13
EA005918B1 (ru) 2005-06-30
EE200300135A (et) 2003-08-15
EP1331935A4 (en) 2004-12-01
PT1331935E (pt) 2009-01-19
CZ301098B6 (cs) 2009-11-04
UA75091C2 (en) 2006-03-15
HN2001000218A (es) 2002-05-09
IL138825A (en) 2006-06-11
CL2001002303A1 (es) 2010-06-25
KR20030051689A (ko) 2003-06-25
EP1331935A2 (en) 2003-08-06
AU9416201A (en) 2002-04-15
CA2423628A1 (en) 2002-04-11
US20050020664A1 (en) 2005-01-27
JP2004533986A (ja) 2004-11-11
AR035587A1 (es) 2004-06-16
PE20020411A1 (es) 2002-05-16
TWI270544B (en) 2007-01-11
NO20031396L (no) 2003-03-27
BG107759A (bg) 2004-01-30
CR6968A (es) 2004-02-25
GT200100197A (es) 2002-05-08
BR0114464A (pt) 2004-01-20
NZ525587A (en) 2005-03-24
PL365679A1 (en) 2005-01-10
US20040029950A1 (en) 2004-02-12
ES2315307T3 (es) 2009-04-01
WO2002028347A2 (en) 2002-04-11
SI1331935T1 (sl) 2009-04-30
DK1331935T3 (da) 2009-02-02
ZA200303113B (en) 2004-07-23
IS2607B (is) 2010-04-15
IS6752A (is) 2003-03-21

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