CN100518735C - 色胺衍生物和类似物以及含有它们的药物组合物 - Google Patents

色胺衍生物和类似物以及含有它们的药物组合物 Download PDF

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Publication number
CN100518735C
CN100518735C CNB018168043A CN01816804A CN100518735C CN 100518735 C CN100518735 C CN 100518735C CN B018168043 A CNB018168043 A CN B018168043A CN 01816804 A CN01816804 A CN 01816804A CN 100518735 C CN100518735 C CN 100518735C
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alkyl
chemical compound
aryl
melatonin
dinitro
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Expired - Fee Related
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CNB018168043A
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Chinese (zh)
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CN1582147A (zh
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纳瓦·奇撒贝尔
姆士·劳丹
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Neurim Pharmaceuticals 1991 Ltd
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Neurim Pharmaceuticals 1991 Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018168043A 2000-10-03 2001-09-25 色胺衍生物和类似物以及含有它们的药物组合物 Expired - Fee Related CN100518735C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL138825 2000-10-03
IL138825A IL138825A (en) 2000-10-03 2000-10-03 Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds

Publications (2)

Publication Number Publication Date
CN1582147A CN1582147A (zh) 2005-02-16
CN100518735C true CN100518735C (zh) 2009-07-29

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ID=11074694

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CNB018168043A Expired - Fee Related CN100518735C (zh) 2000-10-03 2001-09-25 色胺衍生物和类似物以及含有它们的药物组合物

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Country Link
US (2) US6780884B2 (enExample)
EP (1) EP1331935B1 (enExample)
JP (1) JP2004533986A (enExample)
KR (1) KR100855385B1 (enExample)
CN (1) CN100518735C (enExample)
AR (1) AR035587A1 (enExample)
AT (1) ATE409474T1 (enExample)
AU (1) AU9416201A (enExample)
BG (1) BG107759A (enExample)
BR (1) BR0114464A (enExample)
CA (1) CA2423628C (enExample)
CL (1) CL2001002303A1 (enExample)
CR (1) CR6968A (enExample)
CY (1) CY1110417T1 (enExample)
CZ (1) CZ301098B6 (enExample)
DE (1) DE60136003D1 (enExample)
DK (1) DK1331935T3 (enExample)
EA (1) EA005918B1 (enExample)
EE (1) EE05192B1 (enExample)
ES (1) ES2315307T3 (enExample)
GT (1) GT200100197A (enExample)
HN (1) HN2001000218A (enExample)
HU (1) HU227163B1 (enExample)
IL (1) IL138825A (enExample)
IS (1) IS2607B (enExample)
MX (1) MXPA03002612A (enExample)
NO (1) NO20031396L (enExample)
NZ (1) NZ525587A (enExample)
PA (1) PA8529801A1 (enExample)
PE (1) PE20020411A1 (enExample)
PL (1) PL365679A1 (enExample)
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SK (1) SK4042003A3 (enExample)
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UA (1) UA75091C2 (enExample)
UY (1) UY26946A1 (enExample)
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ZA (1) ZA200303113B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1694323A4 (en) * 2003-12-19 2009-05-13 Elixir Pharmaceuticals Inc METHOD FOR TREATING A DISEASE
MXPA06009377A (es) * 2004-02-20 2007-03-07 Lifescape Biosciences Inc Composiciones y metodos para regulacion del sueno.
AU2006257815A1 (en) * 2005-06-10 2006-12-21 Bipar Sciences, Inc. PARP modulators and treatment of cancer
US7622495B2 (en) * 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
KR101760139B1 (ko) 2007-06-29 2017-07-31 클라렌슈 피티와이 리미티드 안투여를 통한 신경 또는 신경정신 장애의 치료 또는 예방용 약학 조성물
HRP20151367T1 (hr) * 2008-05-13 2016-01-29 Yale University Kimerne male molekule za pojaäśanje odgovora protutijela na stanice raka
US8852630B2 (en) 2008-05-13 2014-10-07 Yale University Chimeric small molecules for the recruitment of antibodies to cancer cells
CN103841890B (zh) 2011-05-31 2017-10-27 克拉伦苏股份有限公司 预防和治疗运动相关神经系统疾病的方法
US9073851B2 (en) 2011-10-28 2015-07-07 Board Of Regents, The University Of Texas System Compositions and methods for treating cancer
CN102816103B (zh) * 2012-08-20 2014-05-07 冉瑞琼 硫化天冬氨酸修饰的退黑素衍生物及其应用
TWI733772B (zh) * 2016-03-14 2021-07-21 美商身體邏輯股份有限公司 用於合成吲哚環核鹼基結合物之組成物及方法
CN116421600B (zh) * 2023-05-29 2024-08-23 重庆医科大学 色醇在制备治疗焦虑的药物中的应用
WO2025137730A1 (en) * 2023-12-22 2025-06-26 Alexander Shulgin Research Institute, Inc. N-substituted tryptamines and n-substituted lysergamides and their use as therapeutic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880826A (en) * 1986-06-27 1989-11-14 Nava Zisapel Melatonin antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO274596A0 (en) * 1996-10-04 1996-10-31 Armstrong, Stuart Maxwell Method for the treatment of neurological or neuropsychiatric disorders
US6310085B1 (en) * 1997-10-03 2001-10-30 Clarencew Pty Ltd. Method for the treatment of neurological or neuropsychiatric disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880826A (en) * 1986-06-27 1989-11-14 Nava Zisapel Melatonin antagonist

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Binding of 2,4-dinitrophenyl compounds and other smallmolecules to a crystalline λ-type Bence-Jones dimer. EDMUNDSON et al.Biochemistry.27 August,Vol.13 No.18. 1974 *

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UY26946A1 (es) 2001-11-30
ZA200303113B (en) 2004-07-23
NO20031396D0 (no) 2003-03-27
GT200100197A (es) 2002-05-08
EA200300436A1 (ru) 2003-10-30
HU227163B1 (en) 2010-09-28
EE200300135A (et) 2003-08-15
JP2004533986A (ja) 2004-11-11
IS6752A (is) 2003-03-21
CZ301098B6 (cs) 2009-11-04
CA2423628C (en) 2011-04-26
PE20020411A1 (es) 2002-05-16
ES2315307T3 (es) 2009-04-01
US6780884B2 (en) 2004-08-24
HN2001000218A (es) 2002-05-09
KR100855385B1 (ko) 2008-09-04
CA2423628A1 (en) 2002-04-11
US20040029950A1 (en) 2004-02-12
EP1331935B1 (en) 2008-10-01
WO2002028347A2 (en) 2002-04-11
IL138825A0 (en) 2001-10-31
IS2607B (is) 2010-04-15
IL138825A (en) 2006-06-11
WO2002028347A3 (en) 2002-07-04
EP1331935A2 (en) 2003-08-06
NZ525587A (en) 2005-03-24
EE05192B1 (et) 2009-08-17
CZ2003940A3 (cs) 2003-10-15
EA005918B1 (ru) 2005-06-30
DK1331935T3 (da) 2009-02-02
AR035587A1 (es) 2004-06-16
MXPA03002612A (es) 2004-04-02
CN1582147A (zh) 2005-02-16
TWI270544B (en) 2007-01-11
CY1110417T1 (el) 2015-04-29
BR0114464A (pt) 2004-01-20
PL365679A1 (en) 2005-01-10
ATE409474T1 (de) 2008-10-15
AU9416201A (en) 2002-04-15
CL2001002303A1 (es) 2010-06-25
SK4042003A3 (en) 2003-09-11
PA8529801A1 (es) 2002-12-30
SI1331935T1 (sl) 2009-04-30
CR6968A (es) 2004-02-25
HUP0302616A2 (hu) 2003-11-28
EP1331935A4 (en) 2004-12-01
KR20030051689A (ko) 2003-06-25
DE60136003D1 (de) 2008-11-13
US20050020664A1 (en) 2005-01-27
BG107759A (bg) 2004-01-30
PT1331935E (pt) 2009-01-19
UA75091C2 (en) 2006-03-15
NO20031396L (no) 2003-03-27
HK1074163A1 (zh) 2005-11-04

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