CN100496570C - Medicine preparation for reducing blood sugar and its preparation method - Google Patents
Medicine preparation for reducing blood sugar and its preparation method Download PDFInfo
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- CN100496570C CN100496570C CNB2006101386156A CN200610138615A CN100496570C CN 100496570 C CN100496570 C CN 100496570C CN B2006101386156 A CNB2006101386156 A CN B2006101386156A CN 200610138615 A CN200610138615 A CN 200610138615A CN 100496570 C CN100496570 C CN 100496570C
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- Medicines Containing Plant Substances (AREA)
Abstract
A hypoglycemic medicine in the form of particles is prepared from chromium pyridylfomate, Se-enriched yeast, the extracts of 6 Chinese-medicinal materials including ginseng leaf, astragalus root, pueraria root, red sage root, etc. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical preparation and preparation method thereof with anti-blood glucose.
Background technology
Diabetes are a kind of whole body chronic progressive diseases.Because the normal excreting insulin of islet cells, thereby insulin relatively or absolute deficiency, and target cell is to the reduction of insulin sensitivity, and cause sugar, albumen, fat and water, metabolic disturbance of electrolyte, and hepatic glycogen and muscle glycogen can not be synthesized.Clinical manifestation is that blood sugar increasing, the glucose in urine positive and carbohydrate tolerance reduce, and classical symptom is " three-many-one-little ", i.e. polydipsia, polyuria, polyphagia and lose weight; For a long time it, in succession with a series of complication; The traditional Chinese medical science claims that diabetes are diabetes, the classical medical book of China---Huangdi's Internal Classics according to different pathogenesis, main symptoms call respectively that it " is quenched one's thirst ", " diseases due to endogenous heat of ZANG FU organs ", " diabetes involving in upper-JIAO ", " diabetes involving the upper-JIAO ", " in disappearing " etc., ancient medical book " origin of Chinese character is sick to be dredged down " is explained: " disappear, desire is drunk also." " disease was waited and dredged justice ancient times " explains: " ... body fluid is quenched one's thirst, so wish to get water also." name be diabetes, polyuria is its feature: " its people's one daily drink is a pipeful of, and it is also a pipeful of to urinate." Han dynasty Zhang Zhongjing " golden plaque " is loaded with: " drinking a great quantity of water but thirst unrelieved, ", " thirst with desire to drink water, dry mouth and tougue.", add: " the rapid digestion of food diet, stool must be hard, and urine must be counted.", Li Gao " secret record of the orchid chamber " says and quenches one's thirst: " stool closes puckery for dry mouth and tougue, frequent micturition, dry scleroma." add " and can eat and thin " these records are similar to the symptom of diabetes.So ancient Chinese medicine doctor calls diabetes to diabetes always.
Diabetes can betide any age, along with the course of disease prolongs, easy concurrent whole body nerve, blood capillary, macroangiopathy, and can cause the chronic progressive external pathological changes of histoorgans such as the heart, brain, kidney, nerve and eye, many complication increase day by day, degree increases the weight of, and is the endocrine metabolism sexual maladjustment of serious harm patient health and life.With China is example, bring up to present about 3% by 0.5% of the past, raising along with China's living standards of the people, great changes have taken place in people's dietary structure, long-term irrational diet, make the long-term secretion of intravital insulin more, cause the insulin target cell that the sensitivity of insulin is reduced gradually, thereby produced hyperglycemia, the sickness rate of diabetes also improves thereupon, at present, the medicine of treatment diabetes biases toward mostly stimulates islets of langerhans to produce insulin, and the target cell of insulin does not obtain basic improvement to the sensitivity of insulin, in case so after drug withdrawal a period of time, blood glucose is bounce-back once more often, simultaneously, because long-term prescription is to the stimulation of islets of langerhans, make islets of langerhans be in the duty of long-term anxiety, and finally cause the tired out of islet function, and cause the diabetes patient finally to have to help blood sugar lowering by external insulin, can further cause the part or all of forfeiture of islet function like this, rebound repeatedly owing to blood glucose simultaneously, the viscosity of blood is increased, and the heart finally still can take place in the microcirculation generation obstacle of blood, brain, the complication of aspect such as kidney and cutaneous nerve.
How making the blood glucose stable for extended periods of time of diabetic, is the important topic of pendulum in face of whole world medical personnel.
Summary of the invention
For these reasons, we are through secular experimentation, from traditional differential diagnosis in tcm opinion method, and modern chemistry composition, bioactivity research angle analysis, Chinese medicine Folium Ginseng, the Radix Astragali, Radix Puerariae, Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Folium Mori extraction are obtained extract, and compatibility chromium picolinate and yeast rich in selenium are prepared into hypoglycemic drug.
The object of the invention is to provide a kind of pharmaceutical preparation with hypoglycemic activity.
The present invention also aims to provide a kind of preparation method of hypoglycemic pharmaceutical preparation.
The present invention is achieved by the following scheme.
Preparation of the present invention is prepared by following crude drug: Folium Ginseng 3-4 weight portions, the Radix Astragali 3-4 weight portions, Radix Puerariae 3-4 weight portions, Radix Salviae Miltiorrhizae 3-4 weight portions, the Rhizoma Anemarrhenae 1-2 weight portions, Folium Mori 1-2 weight portions, chromium picolinate 0.5 * 10
-3-0.6 * 10
-3Weight portion, yeast rich in selenium 5 * 10
-3-6 * 10
-3Weight portion wherein contains chromium 12%-13% in the chromium picolinate, contains selenium 0.2%-0.3% in the yeast rich in selenium.
Preparation of the present invention is prepared by following crude drug: Folium Ginseng 3.33 weight portions, the Radix Astragali 3.33 weight portions, Radix Puerariae 3.33 weight portions, Radix Salviae Miltiorrhizae 3.33 weight portions, the Rhizoma Anemarrhenae 1.67 weight portions, Folium Mori 1.67 weight portions, chromium picolinate 0.541 * 10
-3Weight portion, yeast rich in selenium 5.86 * 10
-3Weight portion wherein contains chromium 12.32% in the chromium picolinate, contain selenium 0.2277% in the yeast rich in selenium.
Folium Ginseng bitter but slightly sweet taste in the side is gone into lung, stomach, spleen, the heart, all warps of kidney, " property of medicine is examined " meaning; " lung heat clearing, promote the production of body fluid, quench the thirst." the supplementary Amplifications of the Compendium of Materia Medica meaning: " and invigorating middle warmer band table, to give birth to stomach Tianjin, asthenic fire falls in the gas that drives away summer heat greatly, the sharp extremity head; Liquor-saturated back food, separate awake." its pharmacological action shows delaying sanility, resisting fatigue, endocrine regulation and metabolic function, studies confirm that extract of Radix Ginseng stem and leaf can obviously suppress the hyperglycemia due to rabbit and the rat adrenal gland, the hypoglycemia of the rabbit that insulin is caused has the rise effect.The blood sugar lowering because the tonifying QI to produce body fluid of Folium Ginseng quenches the thirst, we be monarch drug.Radix Astragali sweet in the mouth slightly warm in nature, " herbal classic " goes into lung, spleen channel, has the merit that consolidating superficial resistance is defended in invigorating the spleen and replenishing QI, benefit, " pearl sac " meaning: " stomach reinforcing gas, go hungry heat." Radix Astragali is except that systems such as immunity, cardiovascular, hemopoietic are had the effect, mainly has the effect of two-ways regulation blood glucose, the blood sugar level of the mice behind the glucose load is significantly descended, and the mouse blood sugar level that can obviously cause antiadrenergic drug raises.The collaborative Folium Ginseng tonifying QI to produce body fluid of the Radix Astragali is a ministerial drug.The Folium Mori sweet-bitter flavor, cold in nature, return lung, Liver Channel." herbal classic " meaning: " master quenches one's thirst high fever of the body ... separate all poison ", " Treatise on Dietetic Therapy " meaning " quenching the thirst ", Compendium of Material Medica " is fried in shallow oil juice for tender tea leaves, can only be quenched one's thirst "; " process the ripe drink of frying in shallow oil, quench the thirst " for tea." medicine origin " " removes the taste deficiency-heat and thirsty." pharmaceutical research proves, Folium Mori have and suppress the effect that blood glucose rises, and can be used for prevention and treatment diabetes.Alkaloid in the Folium Mori and polysaccharide are hypoglycemic main active.Classic in conjunction with modern, we are ministerial drug with Folium Mori.Folium Ginseng, the Radix Astragali, Folium Mori, the system of getting " interior warp " monarch one minister two, and auxilliary monarch's meaning minister, the Radix Astragali is similar with Radix Ginseng, principal and subordinate's QI invigorating, and the Folium Mori principal and subordinate is quenched the thirst, the controlling of common weak, excessive thirst at diabetes.The Radix Salviae Miltiorrhizae hardship is slightly cold, GUIXIN, pericardium, Liver Channel, and effect promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, relieving restlessness clears away heart-fire.The diabetes later stage, pathological changes was gone into blood system more, and Radix Salviae Miltiorrhizae is controlled for it.Rhizoma Anemarrhenae bitter in the mouth is cold in nature, returns lung, stomach, kidney channel, effect clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, the relieving restlessness of quenching the thirst." herbal classic " meaning: " main quenching one's thirst pined for ... tonifying for the deficiency, QI invigorating ".Radix Puerariae is sweet hot cool, returns the taste warp, effect expelling pathogenic factors from muscles for reducing heat, the rash of promoting the production of body fluid, yang invigorating antidiarrheal." herbal classic " meaning: " main quench one's thirst, heat ".Three medicines are adjuvant altogether.All medicines share, at deficiency of both QI and YIN, the stagnation of blood stasis of diabetes, disease see weakly breathe hard, disease such as xerostomia excessive thirst.The disease combination, the combination of medicine card, pathology combines with pharmacology, just amounts to the quench the thirst effect of blood stasis dispelling of tonifying QI to produce body fluid entirely.Current research finds that chromium picolinate can improve the quantity of a kind of active A MP protein kinase (AMPK) relevant with metabolic pathway in the Skeletal Muscle Cell, thereby improves the energy balance and insulin function; Yeast rich in selenium has good hypoglycemic activity;
One. process recipes
(1) gets Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 8-12 times for the first time, boil 1-2 hours time of carrying, amount of water is 6-10 times for the second time, boils 0.5-1.5 hours time of carrying, collecting decoction, filter, it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(2) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 8-12 times for the first time, boils 1-2 hours time of carrying, amount of water is 6-10 times for the second time, boil 0.5-1.5 hours time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 50%-70% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(3) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes finished product.
Two. toxicological experiment
1. mice LD50 measures
Get 60 of healthy mices, male and female half and half, body weight 18-22g is divided into 6 groups at random, 10 every group.Each group is respectively by the dosage of 0.375g/kg, 0.75g/kg, 1.5g/kg, 3g/kg, 6g/kg, 12g/kg (6.25 times, 12.5 times, 25 times, 50 times, 100 times of the dosage that is equivalent to respectively to be grown up, 200 times), be mixed with respective concentration, be 0.25ml/10g with amount of liquid medicine at every turn, all animals is gastric infusion once a day, continuous 7 days.Observe during the medication animal activity, diet, two just, hair color, figure etc. there is no unusual.Animal was all put to death dissection in the 7th day, observe each important organ and organize also no abnormality seen.Illustrate that the application's granule is far longer than 12g/kg (be equivalent to be grown up dosage 200 times) to mice LD50.
2. mice maximum tolerance determination
Get 20 of healthy mices, male and female half and half, body weight 18-22g.With the application's granule medicated powder with dissolved in distilled water after, water-soluble to 50% concentration, with gastric infusion behind whole mice fasting 12h, each 0.7ml, every day 2 times, continuous irrigation stomach 7 days.Observation animal activity, diet, two just wait all normal, put to death the dissection animal and observe each important organ and organize also no abnormal.Illustrate that the application's granule is 35g/kg (be equivalent to be grown up dosage 583.3 times) to the mice maximum tolerated dose.
3. long term toxicity test
Get 80 of healthy rats, body weight 90-110g, male and female half and half are divided into four groups at random, i.e. high, medium and low dosage group of the application's granule and normal control group, 20 every group.Each group is irritated stomach respectively with 3g/kg.1.5g/kg, 0.75g/kg the application's granule medicated powder suspension and etc. the dosage normal saline. each 3ml/100g, every day 1 time, per 2 weeks weigh 1 time, to adjust dosage, successive administration is after 12 weeks, and 1-No. 10 sacrificed by decapitation of each treated animal are got hematometry routine blood test and liver function, kidney merit.Dissect perusal main organs form after getting blood; Take out successively and weigh.Calculate and write down dirty body ratio; Take out bladder, get urine from bladder and do routine urianlysis; Main organs is fixed with 10% formalin, and histological examination is done in section.After residue is respectively organized 11-No. 20 animal drug withdrawals and observed for two weeks, use above-mentioned steps and method equally, obtain every experimental data.All animals blood, routine urinalysis and liver, renal function compare there was no significant difference all in normal range between group as a result; Each main organs perusal form is no abnormal.Histological examination cellular morphology structure is normal, and no pathologic changes; Dirty body is than each group there was no significant difference.
Experiment conclusion: the acute toxicity testing result shows: mice LD50 is far longer than 12g/kg (be equivalent to people's consumption 200 times), and the mice maximum tolerated dose reaches 35g/kg (be equivalent to people's consumption 583.3 times).The long term toxicity test results suggest: experimental rat routine blood test and liver, renal function there are not obvious influence, harmless to each internal organs of experimental rat.Illustrate that the application's granule does not have obvious toxic-side effects.
Three. pharmacological evaluation
Experiment material
Laboratory animal: Japanese purebred large ear rabbit, male and female half and half, female person does not have pregnant, body weight 2kg ± 0.2kg; Kunming mouse, male and female half and half, body weight 20g ± 2g; The SD rat, male and female half and half, body weight 100g ± 10g.Above animal and feedstuff provide by Wuhan medical university medical experiment animal center.The place is raised in experiment: central laboratory of Hubei College Of Traditional Chinese Medicine.
The experiment medicine: the application's granule, every bag of 9g contains crude drug amount 16.2g; Diabetes pill, the heavy 0.25g of every ball, produced lot number by Jilin Province's Baishan pharmaceutical factory of traditional Chinese medicine: 05010225, buy by Hospital Attached to Hubei Chinese Medicine College's Chinese Prepared Medicine Dispensary.
Main agents: alloxan, U.S. SIGMA chemical company produces, and is granted by Hubei Prov. Inst. of Traditional Chinese Medicine; The adrenalin hydrochloride injection. every 1ml, contain 1mg, Wuhan Pharmaceutical Factory produces, lot number: 960805, buy by Hospital Attached to Hubei Chinese Medicine College's pharmaceutical chemists; The blood glucose test kit is produced by Baoding Clinical Laboratory preparation company; Serum insulin radioimmunoassay medicine box is provided by Xijing hospital of The Fourth Military Medical University endocrine control laboratory.
Key instrument: 721 type spectrophotometers, Shanghai the 3rd analytical tool factory produces; Put and exempt from detector, provide by Xijing hospital of The Fourth Military Medical University endocrine control laboratory; Generic centrifuge, three water incubators, automatic biochemistry analyzer are provided by clinical laboratory of Hospital Attached to Hubei Chinese Medicine College.
Experiment 1
Influence to alloxan diabetes man rabbit blood glucose and serum insulin release
Choose 68 of healthy rabbits, body weight 1.85-2.15kg, male and female half and half behind the fasting 12h, inject 5% alloxan normal saline solution 120mg/kg, 8 be left intact (normal control group) in addition for wherein 60 auricular veins.Behind the modeling 64h, all animals is fasting 12h again, and heart extracting blood is measured fasting blood with the ortho-aminotoluene method and warded off fast.Higher and 20 lower rejectings with blood glucose in the modeling rabbit, (blood glucose value is 14.11-20.84mmol/L) to choose 40 of the approaching hyperglycemia rabbit of blood sugar level, be divided into five groups at random, 8 every group, be respectively the high, medium and low dosage group of model control group, diabetes pill group and the application's granule.Normal control group and model control group normal saline 5ml/kg; Diabetes pill group 1.5g/kg diabetes pill; The high, medium and low dosage group of the application's granule is used 2.4g/kg, 1.2g/kg, 0.6g/kg the application granule medicated powder respectively.All be mixed with suspension. by the consumption of per kilogram of body weight 5ml, gastric infusion once a day, continuously around.During perfusion, all give normal diet, and note strengthening output.After around the administration completely, fasting 12h measures rabbit fasting glucose (BG) and serum insulin (IRI) value with all animals heart extracting blood.The results are shown in Table 1
Table 1 the application granule granule is to the shadow noon of alloxan diabetes rabbit fasting glucose and serum insulin levels
Annotate: compare with the model matched group
*P＜0.05
*P＜0.01; Compare △ P＜0.05 △ △ P＜0.01 with the diabetes pill group
By table 1 as seen, each group of diabetes pill and the application's granule all has the effect of obvious reduction diabetic rabbit blood sugar level, and the application's granule hypoglycemic activity slightly is better than diabetes pill.Each group of diabetes pill and the application's granule compares with model group, and the release action of the serum insulin of promotion is all arranged, and the application's granule high dose group slightly is better than other each group.
Experiment 2
Influence to adrenal gland's disposition hyperglycemia mouse blood sugar level
Get 60 of healthy mices, body weight 18-22g, male and female half and half are divided into 6 groups at random, 10 every group, are respectively the high, medium and low dosage group of normal control group, model control group, diabetes pill group and the application's granule.Normal group and model group are irritated stomach respectively with the 0.25ml/10g normal saline.Diabetes pill group 2.5g/kg diabetes pill; The high, medium and low dosage group of the application's granule is used 3g/kg, 1.5g/kg, 0.75g/kg the application granule medicated powder respectively.More than 4 groups of suspensions that are mixed with variable concentrations respectively, all roll over the 0.25ml/10g volume.Each organizes all gastric infusion once a day, a continuous week, behind last administration 1h, except that normal group, give the equal lumbar injection epinephrine of all the other each treated animals 0.2mg/kg, and the equal eye socket of all animals is got blood behind the 30min, measures blood sugar concentration with the ortho-aminotoluene method.The results are shown in Table 2
Table 2 the application granule granule is to adrenal gland's disposition hyperglycemia mouse blood sugar horizontal shadow noon
Annotate: compare with the model matched group
*P＜0.05
*P＜0.01; Compare △ P＜0.05 △ △ P＜0.01 with the diabetes pill group
By table 2 as seen, the application's granule can make adrenal gland's disposition hyperglycemia mouse blood sugar level reduce. and compare with diabetes pill, its blood sugar reducing function is slightly excellent.
3. to the influence of normal mouse fasting glucose
Get 50 of healthy mices, body weight 18-22g, male and female half and half are divided into 5 groups at random, 10 every group, are respectively the high, medium and low dosage group of normal control group, diabetes pill group and the application's granule.All animals gives normal diet.Each group is irritated stomach medication and dosage with experiment 2.2, gastric infusion once a day, and fasting 12h after continuous 7 days adopts the eye socket blood sampling, to measure fasting glucose concentration, the results are shown in Table 3
Table 3 the application granule is to the influence of normal mouse fasting blood glucose level
By table 3 as seen, each is organized fasting blood sugar and learns processing, P by statistics〉0.05, there was no significant difference between group shows that the application's granule does not have obvious influence to the normal mouse fasting blood glucose level.
Experimental result: the application's granule all has obvious hypoglycemic activity to alloxan diabetes rabbit and adrenal gland's disposition hyperglycemia mice. and the alloxan diabetes rabbit there is the release action of the serum insulin of promotion, and normal mouse blood sugar is not had obvious influence.Prompting the application's granule hypoglycemic main mechanism may be by to the cytoprotection of beta Cell of islet and promote beta Cell of islet repair function and regeneration to promote β cell uelralante, and unusual carbohydrate metabolism is had the glycogenolysis of inhibition and glyconeogenesis.
Four. preparation embodiment
Embodiment 1
(1) Folium Ginseng 3.2kg, Radix Astragali 3.2kg, Radix Puerariae 3.2kg, Radix Salviae Miltiorrhizae 3.2kg, Rhizoma Anemarrhenae 1.5kg, Folium Mori 1.5kg, chromium picolinate 0.55 * 10
-3Kg, yeast rich in selenium 5.5 * 10
-3Kg wherein contains chromium 12.5% in the chromium picolinate, contain selenium 0.25% in the yeast rich in selenium;
(2) get Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 9 times for the first time, boil the 1 hour time of carrying, amount of water is 7 times for the second time, boils the 1 hour time of carrying, collecting decoction filters, and it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(3) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 9 times for the first time, boils the 1 hour time of carrying, amount of water is 6-10 times for the second time, boil the 0.8 hour time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 55% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(4) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes 1000 bags of finished products.
Embodiment 2
(1) Folium Ginseng 3.8kg, Radix Astragali 3.8kg, Radix Puerariae 3.8kg, Radix Salviae Miltiorrhizae 3.8kg, Rhizoma Anemarrhenae 1.89kg, Folium Mori 1.89kg, chromium picolinate 0.59 * 10
-3Kg, yeast rich in selenium 5.9 * 10
-3Kg wherein contains chromium 12.2% in the chromium picolinate, contain selenium 0.23% in the yeast rich in selenium;
(2) get Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 11 times for the first time, boil the 1.8 hours time of carrying, amount of water is 9 times for the second time, boils the 1.4 hours time of carrying, collecting decoction filters, and it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(3) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 11 times for the first time, boils the 1.8 hours time of carrying, amount of water is 9 times for the second time, boil the 1.4 hours time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 65% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(4) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes 1000 bags of finished products.
Embodiment 3
(1) Folium Ginseng 33.3kg, Radix Astragali 33.3kg, Radix Puerariae 33.3kg, Radix Salviae Miltiorrhizae 33.3kg, Rhizoma Anemarrhenae 16.7kg, Folium Mori 16.7kg, chromium picolinate 5.41 * 10
-3Kg, yeast rich in selenium 58.6 * 10
-3Kg wherein contains chromium 12.32% in the chromium picolinate, contain selenium 0.2277% in the yeast rich in selenium.
(2) get Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 10 times for the first time, boil the 1.5 hours time of carrying, amount of water is 8 times for the second time, boils the 1 hour time of carrying, collecting decoction filters, and it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(3) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 10 times for the first time, boils the 1.5 hours time of carrying, amount of water is 8 times for the second time, boil the 1 hour time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 60% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(4) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes 10000 bags of finished products.
Embodiment 4
(1) Folium Ginseng 3kg, Radix Astragali 3kg, Radix Puerariae 3kg, Radix Salviae Miltiorrhizae 3kg, Rhizoma Anemarrhenae 1kg, Folium Mori 1kg, chromium picolinate 0.5 * 10
-3Kg, yeast rich in selenium 5 * 10
-3Kg wherein contains chromium 13% in the chromium picolinate, contain selenium 0.3% in the yeast rich in selenium;
(2) get Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 8 times for the first time, boil the 1 hour time of carrying, amount of water is 6 times for the second time, boils the 0.5 hour time of carrying, collecting decoction filters, and it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(3) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 8 times for the first time, boils the 1 hour time of carrying, amount of water is 6 times for the second time, boil the 0.5 hour time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 50% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(4) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes 1000 bags of finished products.
Embodiment 5
(1) Folium Ginseng 4kg, Radix Astragali 4kg, Radix Puerariae 4kg, Radix Salviae Miltiorrhizae 4kg, Rhizoma Anemarrhenae 2kg, Folium Mori 2kg, chromium picolinate 0.6 * 10
-3Kg, yeast rich in selenium 6 * 10
-3Kg wherein contains chromium 12% in the chromium picolinate, contain selenium 0.2% in the yeast rich in selenium;
(2) get Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 12 times for the first time, boil the 2 hours time of carrying, amount of water is 10 times for the second time, boils the 1.5 hours time of carrying, collecting decoction filters, and it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(3) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 12 times for the first time, boils the 2 hours time of carrying, amount of water is 10 times for the second time, boil the 1.5 hours time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 70% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(4) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes 1000 bags of finished products.
Embodiment 6
(1) Folium Ginseng 3.33kg, Radix Astragali 3.33kg, Radix Puerariae 3.33kg, Radix Salviae Miltiorrhizae 3.33kg, Rhizoma Anemarrhenae 1.67kg, Folium Mori 1.67kg, chromium picolinate 0.541 * 10
-3Kg, yeast rich in selenium 5.86 * 10
-3Kg wherein contains chromium 12.32% in the chromium picolinate, contain selenium 0.2277% in the yeast rich in selenium.
(2) get Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 10 times for the first time, boil the 1.5 hours time of carrying, amount of water is 8 times for the second time, boils the 1 hour time of carrying, collecting decoction filters, and it is the clear paste of 1.28-1.32 that filtrate is concentrated into 60 ℃ of heat survey relative densities;
(3) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water is 10 times for the first time, boils the 1.5 hours time of carrying, amount of water is 8 times for the second time, boil the 1 hour time of carrying, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 60% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(4) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes 1000 bags of finished products.
Claims (3)
1. pharmaceutical preparation with hypoglycemic activity is characterized in that being prepared from by following its crude drug: Folium Ginseng 3-4 weight portions, the Radix Astragali 3-4 weight portions, Radix Puerariae 3-4 weight portions, Radix Salviae Miltiorrhizae 3-4 weight portions, the Rhizoma Anemarrhenae 1 one 2 weight portions, Folium Mori 1-2 weight portions, chromium picolinate 0.5 * 10
-3-0.6 * 10
-3Weight portion, yeast rich in selenium 5 * 10
-3-6 * 10
-3Weight portion wherein contains chromium 12%-13% in the chromium picolinate, contains selenium 0.2%-0.3% in the yeast rich in selenium.
2. a kind of pharmaceutical preparation with hypoglycemic activity according to claim 1 is prepared from by following raw material medicaments: Folium Ginseng 3.33 weight portions, the Radix Astragali 3.33 weight portions, Radix Puerariae 3.33 weight portions, Radix Salviae Miltiorrhizae 3.33 weight portions, the Rhizoma Anemarrhenae 1.67 weight portions, Folium Mori 1.67 weight portions, chromium picolinate 0.541 * 10
-3Weight portion, yeast rich in selenium 5.86 * 10
-3Weight portion wherein contains chromium 12.32% in the chromium picolinate, contain selenium 0.2277% in the yeast rich in selenium.
3. a kind of pharmaceutical preparation according to claim 1 with hypoglycemic activity, its preparation method is:
(1) gets Folium Ginseng, the Radix Astragali, the Rhizoma Anemarrhenae, Folium Mori four Chinese medicine, decoct with water 2 times, amount of water is 8-12 times for the first time, boil 1-2 hours time of carrying, amount of water is 6-10 times for the second time, boils 0.5-1.5 hours time of carrying, collecting decoction, filter, relative density was the clear paste of 1.28-1.32 when filtrate was concentrated into 60 ℃;
(2) get Radix Puerariae, Radix Salviae Miltiorrhizae two flavor medicines and decoct with water 2 times, amount of water 8-12 doubly boils 1-2 hours time of carrying for the first time, amount of water is 6-10 times for the second time, boil and carry time 0.5-1.5 hour, collecting decoction filters, being evaporated to 60 ℃ of heat survey relative densities is 1.05-1.10, adding ethanol is 50%-70% to containing the alcohol amount, and standing over night is got supernatant, reclaim ethanol, being concentrated into 60 ℃ of heat, to survey relative densities be 1.28-1.32 clear paste;
(3) two kinds of clear paste are mixed, vacuum drying is pulverized the back and is crossed 80 mesh sieves, and powder gets dry extract, get chromium picolinate, yeast rich in selenium, the dried cream powder mix homogeneously that adds chromium picolinate, yeast rich in selenium equal weight, Using such method adds dextrin and stevioside with equivalent incremental method mixing dried cream powder, do wetting agent with ethanol, make granule, pack makes finished product.
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| CN106620374A (en) * | 2015-10-31 | 2017-05-10 | 边海云 | Traditional Chinese medicine composition for regulating type 2 diabetes |
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| CN102488202B (en) * | 2011-12-13 | 2013-10-16 | 北京阳光一佰生物技术开发有限公司 | Medicinal composition for treating diabetes and preparation method thereof |
| CN103082298B (en) * | 2013-01-17 | 2014-08-13 | 吉林省中药制剂工程研究中心有限公司 | Health-care food for reducing blood glucose in assisted mode and preparation method thereof |
| CN104223060A (en) * | 2014-08-25 | 2014-12-24 | 湖州大港天明投资有限公司 | Novel health product used for lowering blood glucose and enhancing immunity |
| CN106072639A (en) * | 2016-06-27 | 2016-11-09 | 吉林亚泰明星制药有限公司 | A kind of auxiliary hyperglycemic selenium sheet and preparation method thereof |
| CN109331113A (en) * | 2018-09-21 | 2019-02-15 | 深圳市红瑞生物科技有限公司 | Assist in the treatment of the prescription cream and preparation method thereof of pet diabetes |
| CN113599457A (en) * | 2021-09-25 | 2021-11-05 | 赣州药食同源健康管理有限公司 | A Chinese medicinal composition for treating diabetes, and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106620374A (en) * | 2015-10-31 | 2017-05-10 | 边海云 | Traditional Chinese medicine composition for regulating type 2 diabetes |
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