CN100496552C - Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach, and method for preparing the same - Google Patents
Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach, and method for preparing the same Download PDFInfo
- Publication number
- CN100496552C CN100496552C CNB2005100319465A CN200510031946A CN100496552C CN 100496552 C CN100496552 C CN 100496552C CN B2005100319465 A CNB2005100319465 A CN B2005100319465A CN 200510031946 A CN200510031946 A CN 200510031946A CN 100496552 C CN100496552 C CN 100496552C
- Authority
- CN
- China
- Prior art keywords
- gained
- preparation
- volatile oil
- regulating
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention relates to Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach and method for preparing the same, wherein the preparation mainly comprises the components of snake bile and dried orange peel, and the preparing process comprises, distilling dried orange peel to obtain volatile oil, grilling the aqueous solution, filtering and concentrating the filtrate into clear cream, cooling down and charging ethanol, stewing and taking the supernatant fluid, charging ethanol into the precipitate and stirring, stewing and taking the supernatant fluid, merging the two supernatant fluids, condensating into thick form, drying, disintegrating into fines, mixing with snake bile juice homogenously, charging right amount of adjuvant, mixing homogenously, and spraying dried orange peel volatile oil.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation preparation method, relate in particular to the dispel the wind preparation method of Chinese medicine preparation of stomach function regulating of a kind of activating QI to eliminate phlegm.
Background technology:
Granule in the Chinese medicine preparation or drop pill or soft capsule or buccal tablet, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a powder, has listed the national drug standards in.
The dispel the wind technology features of Chinese medicine preparation preserved snake gall orange peel powder of stomach function regulating of existing activating QI to eliminate phlegm is that Pericarpium Citri Reticulatae is ground into fine powder, with Fel Serpentis mixing, drying, pulverizes, and sieves, promptly.
Existing activating QI to eliminate phlegm dispel the wind the Chinese medicine preparation preserved snake gall orange peel powder of stomach function regulating exist carry, take inconvenience, dose big, absorb slow, bioavailability is low, quality is not easy shortcomings such as control.
Summary of the invention:
The purpose of this invention is to provide the dispel the wind preparation method of Chinese medicine preparation of stomach function regulating of a kind of activating QI to eliminate phlegm, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The dispel the wind Chinese medicine preparation of stomach function regulating of activating QI to eliminate phlegm, it is that medicine material is granule or drop pill or the soft capsule or the buccal tablet of Fel Serpentis, Pericarpium Citri Reticulatae.
Its preparation method is:
(1) medicine material and percentage by weight thereof are as follows:
Fel Serpentis 10～20%, Pericarpium Citri Reticulatae (steaming) 80～90%;
Medicine material optimum weight percentage ratio is:
Fel Serpentis 14%, Pericarpium Citri Reticulatae (steaming) 86%;
(2) get Pericarpium Citri Reticulatae and extract volatile oil with steam distillation, standby; Aqueous solution after medicinal residues and the distillation is standby;
(3) get medicinal residues of (2) gained and the aqueous solution after the distillation and decoct with water 1～3 time, each 1～3 hour, collecting decoction filtered, filtrate decompression is condensed into clear paste, puts coldly, adds 1～3 times of amount 50～70% ethanol, stirs, left standstill 12～36 hours, and inclined and get supernatant, standby; The precipitate of gained adds 1～2 times of amount 50～70% ethanol and stirs, and leaves standstill 12～36 hours, inclines and gets supernatant, and is standby; Merge above-mentioned two kinds of clear liquids, cryoconcentration becomes the thick paste shape, and drying is pulverized, and with the Fel Serpentis mixing, gets fine drug powder;
(4) fine drug powder of getting (3) gained adds suitable adjuvant, sprays into the volatile oil of (2) gained, and mixing gets hybrid medicine, makes granule or drop pill or soft capsule or buccal tablet again;
Its particulate preparation method is; Get (3) gained fine drug powder, add appropriate amount of auxiliary materials, mixing is granulated, and drying sprays into the volatile oil of (2) gained, and granulate is promptly made granule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: stevioside, protein sugar, xylitol, high fructose, cyclamate, beta-schardinger dextrin-, dextrin, lactose, saccharin sodium, ethanol, water;
The preparation method of its drop pill is: one or more or other suitable adjuvant of getting stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (4) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
Its preparation of soft capsule method is: get (3) gained fine drug powder, add appropriate amount of auxiliary materials, mix homogeneously sprays into the volatile oil of (2) gained, compacting or drip and make soft capsule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
The preparation method of its buccal tablet is: gets the hybrid medicine fine powder of (3) gained, adds appropriate amount of auxiliary materials, and mix homogeneously, drying sprays into the volatile oil of (2) gained, is pressed into buccal tablet.
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
Icing Sugar, lactose, mannitol, dextrin, aspartame, stevioside, starch, mucialga of arabic gummy, gelatine size, Mentholum (Herba Menthae essence), Borneolum Syntheticum, citric acid.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
The dispel the wind Chinese medicine preparation of stomach function regulating of a kind of activating QI to eliminate phlegm, it is that main component is granule or drop pill or the soft capsule or the buccal tablet of Fel Serpentis, Pericarpium Citri Reticulatae.
Chinese medicine preparation energy activating QI to eliminate phlegm of the present invention, stomach function regulating dispels the wind.Be mainly used in turbid phlegm obstructing in the lung, stomach-QI being unable to descend normally, cough, vomiting.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption thereof are as follows:
Fel Serpentis 50g, Pericarpium Citri Reticulatae (steaming) 300g;
(2) get Pericarpium Citri Reticulatae and extract volatile oil with steam distillation, standby; Aqueous solution after medicinal residues and the distillation is standby;
(3) get medicinal residues of (2) gained and the aqueous solution after the distillation and decoct with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate decompression is condensed into clear paste, put coldly, added 2 times of amount 60% ethanol, stirred, and left standstill 24 hours, inclined and got supernatant, and is standby; Precipitate adds 2 times of amount 60% ethanol, stirs, and leaves standstill 24 hours, inclines and gets supernatant, merges above-mentioned two kinds of clear liquids, and cryoconcentration becomes the thick paste shape, and drying is ground into fine powder, with the Fel Serpentis mixing, gets fine drug powder, and is standby;
(4) the dispel the wind Chinese medicine preparation granule of stomach function regulating of activating QI to eliminate phlegm is the preserved snake gall orange peel granule, and its preparation method is; Get (3) gained fine drug powder, add B-cyclodextrin 50g, add oligomeric lactose 70g and fully stir, mixing, spray drying adds the 1g stevioside, granulates, and drying sprays into the volatile oil of (2) gained, promptly makes granule;
(5) the dispel the wind Chinese medicine preparation drop pill of stomach function regulating of activating QI to eliminate phlegm is the preserved snake gall orange peel drop pill, and its preparation method is: get the fine drug powder of (3) gained, spray into the volatile oil of (2) gained, mixing, hybrid medicine; Taking polyethylene glycol PEG6000 250g, stearic acid 60g, Poloxamer188 30g, be heated to the hybrid medicine that adds above-mentioned gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(9) the dispel the wind Chinese medicine preparation soft capsule of stomach function regulating of activating QI to eliminate phlegm is the preserved snake gall orange peel soft capsule, its preparation method is: get (3) gained fine drug powder, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, spray into (2) gained volatile oil, suppress or drip and make soft capsule;
(10) the dispel the wind Chinese medicine preparation buccal tablet of stomach function regulating of activating QI to eliminate phlegm is the preserved snake gall orange peel buccal tablet, its preparation method is: the fine drug powder of getting (3) gained, add cane sugar powder 200g, abundant mixing, cross 60～80 mesh sieves, add the Herba Menthae essence of 100g starch and 20ml, granulation, granulate, oven dry simultaneously with the 100g mucialga of arabic gummy, spray into the volatile oil of (2) gained, be pressed into buccal tablet.
Advantage of the present invention is:
Carry, taking convenience, dose is few, absorption is fast, the bioavilability height, controllability and good stability have Be beneficial to the raising curative effect.
Claims (2)
1, a kind of activating QI to eliminate phlegm preparation method of Chinese medicine preparation of stomach function regulating of dispeling the wind, it is the preparation method of preserved snake gall orange peel granule or drop pill or soft capsule or buccal tablet, it is characterized in that:
(1) medicine material and percentage by weight thereof are as follows:
Fel Serpentis 10～20%, steaming Pericarpium Citri Reticulatae 80～90%;
(2) get Pericarpium Citri Reticulatae and extract volatile oil with steam distillation, standby; Aqueous solution after medicinal residues and the distillation is standby;
(3) get medicinal residues of (2) gained and the aqueous solution after the distillation and decoct with water 1～3 time, each 1～3 hour, collecting decoction filtered, filtrate decompression is condensed into clear paste, puts coldly, adds 1～3 times of amount 50～70% ethanol, stirs, left standstill 12～36 hours, and inclined and get supernatant, standby; The precipitate of gained adds 1～2 times of amount 50～70% ethanol and stirs, and leaves standstill 12～36 hours, inclines and gets supernatant, and is standby; Merge above-mentioned two kinds of clear liquids, cryoconcentration becomes the thick paste shape, and drying is pulverized, and with the Fel Serpentis mixing, gets fine drug powder;
(4) fine drug powder of getting (3) gained adds suitable adjuvant, sprays into the volatile oil of (2) gained, and mixing gets hybrid medicine, makes granule or drop pill or soft capsule or buccal tablet again;
Its particulate preparation method is; Get (3) gained fine drug powder, add appropriate amount of auxiliary materials, mixing is granulated, and drying sprays into the volatile oil of (2) gained, and granulate is promptly made granule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: stevioside, protein sugar, xylitol, high fructose, cyclamate, beta-schardinger dextrin-, dextrin, lactose, saccharin sodium, ethanol, water;
The preparation method of its drop pill is: one or more or other suitable adjuvant of getting stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol and be PEG4000 or PEG6000 or sodium stearate or glycerin gelatine or polyoxyethylene monostearate and being S-40 or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (4) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, going into liquid coolant by dropping-pill machine under heat-retaining condition is in liquid paraffin or methyl-silicone oil or vegetable oil or water or the ethanol, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
Its preparation of soft capsule method is: get (3) gained fine drug powder, add appropriate amount of auxiliary materials, mix homogeneously sprays into the volatile oil of (2) gained, compacting or drip and make soft capsule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
The preparation method of its buccal tablet is: gets the fine drug powder of (3) gained, adds appropriate amount of auxiliary materials, and mix homogeneously, drying sprays into the volatile oil of (2) gained, is pressed into buccal tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
Icing Sugar, lactose, mannitol, dextrin, aspartame, stevioside, starch, mucialga of arabic gummy, gelatine size, Mentholum, Borneolum Syntheticum, citric acid.
2, a kind of activating QI to eliminate phlegm according to claim 1 preparation method of Chinese medicine preparation of stomach function regulating of dispeling the wind is characterized in that the percentage by weight of its medicine material is:
Fel Serpentis 14%, steaming Pericarpium Citri Reticulatae 86%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100319465A CN100496552C (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach, and method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100319465A CN100496552C (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach, and method for preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1733048A CN1733048A (en) | 2006-02-15 |
| CN100496552C true CN100496552C (en) | 2009-06-10 |
Family
ID=36075803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100319465A Active CN100496552C (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach, and method for preparing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100496552C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101301385B (en) * | 2008-06-26 | 2011-08-31 | 广州奇星药业有限公司 | Detection method of compound preserved snake gall orange peel powder |
| CN101422596B (en) * | 2008-11-07 | 2013-01-02 | 江西百神昌诺药业有限公司 | Preserved snake gall orange peel oral liquid and quality control method thereof |
| CN105362410B (en) * | 2015-03-04 | 2020-02-28 | 山东省药学科学院 | Traditional Chinese medicine preparation for treating burns and scalds and preparation method |
| CN113796440A (en) * | 2021-09-17 | 2021-12-17 | 湖南中医药大学 | Soluble snake gall chrysanthemum tea and preparation method thereof |
-
2005
- 2005-07-29 CN CNB2005100319465A patent/CN100496552C/en active Active
Non-Patent Citations (5)
| Title |
|---|
| 《国家新药注册数据》（1985-2000）. ，国家药监局. 2001 中华人民共和国卫生部药品标准 中药成方制剂 第5册. 160，药典委员会. 1991 |
| 《国家新药注册数据》（1985-2000）. ，国家药监局. 2001 * |
| 中华人民共和国卫生部药品标准 中药成方制剂 第5册. 160，药典委员会. 1991 * |
| 陈皮挥发油与橙皮苷提取工艺的实验研究. 井由林.基层中药杂志，第15卷第1期. |
| 陈皮挥发油与橙皮苷提取工艺的实验研究. 井由林.基层中药杂志，第15卷第1期. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1733048A (en) | 2006-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106418106B (en) | Instant ginger solid beverage and preparation method thereof | |
| CN101327009B (en) | Liver-boosting cold tea and preparation thereof | |
| CN102058480B (en) | Oral effervescent tablet and preparation method thereof | |
| CN101288483B (en) | Preparation method of ginger and jujube granule | |
| CN100496552C (en) | Chinese medicinal preparation for regulating qi, reducing phlegm, expelling pathologic wind and regulating stomach, and method for preparing the same | |
| CN103933116A (en) | Preparation process of herba leonuri paste | |
| JP2021535912A (en) | Chinese herbal medicine composition and its preparation method and application | |
| CN101284120A (en) | Process for preparing Pingxiao preparation | |
| CN102240385A (en) | Traditional Chinese medicine dripping pill for treating woman postpartum disease and preparation method thereof | |
| CN101966316B (en) | Gujin pill pellet and preparation method thereof | |
| CN109078026A (en) | A kind of production method of ultra micro birch young pilose antler powder and the purposes for the birch young pilose antler powder being prepared using this method | |
| CN101254226B (en) | Duliang compound chinese medicine soft capsules | |
| CN100404041C (en) | Medicinal composition for treating coronary heart disease | |
| CN1977944A (en) | Red ginseng and lilyturf root soft capsule and its preparing method | |
| CN101647844B (en) | Vinegar milk essence micro effervescent granules and preparation method thereof | |
| CN101396389A (en) | Senecio cannabifolius effective constituent extraction method and preparation method of granules thereof | |
| CN101371875B (en) | Method for extracting and preparing total saponin of compound abnormal savda mature agent | |
| CN102119996A (en) | Preparation method of sugarless fritillaria cirrhosa-fructus momordicae granules for relieving cough | |
| CN103750302A (en) | Lycium chinense alcohol extract as well as preparation method and application thereof | |
| CN102120016B (en) | Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets | |
| CN101919919A (en) | Fukean dispersible tablet and preparation method thereof | |
| CN108295131B (en) | Plant extract composition with blood pressure reducing effect, preparation method and application thereof | |
| CN103127389B (en) | Compound liver protection jewel orchid submicron powder and preparation method thereof | |
| CN112402515A (en) | Chinese medicinal extract containing insect medicine and preparation method of preparation thereof | |
| CN112402470A (en) | Chimonanthus nitens leaf concentrated pill and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150930 Address after: 410331 Hunan province Changsha city Changsha national biological industry base Kang Road No. 109 Patentee after: HuNan TianDiHengYi Pharmacy Co., Ltd Address before: Shaoshan City, Hunan province 410007 Changsha Road No. 39 Victoria Star City Taurus room 1202 Patentee before: Wang Hengxin |
|
| CP03 | Change of name, title or address |
Address after: 410331 No. 109 Kangtian Road, Changsha National Biological Industrial Base, Hunan Province Patentee after: Tiandi Hengyi Pharmaceutical Co., Ltd. Address before: 410331 No. 109 Kangtian Road, Changsha National Biological Industrial Base, Changsha City, Hunan Province Patentee before: HuNan TianDiHengYi Pharmacy Co., Ltd |
|
| CP03 | Change of name, title or address |