CN100490839C - Chinese medicine preparation for curing cardio-cerebral vascular diseases - Google Patents
Chinese medicine preparation for curing cardio-cerebral vascular diseases Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine preparation for curing the diseases of coronary heart disease, angina pectoris and mycocardiac infarction with obvious therapeutic effect. The medicine has the functions of promoting blood circulation, removing stasis, removing obstruction in the channel and relieving pain, and is made up by using pure Chinese medicinal materials of tribulus fruit, ginseng stem and leaf, salvia root and borneol. Said invention also provides its preparation method.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, a kind of Chinese medicine preparation for the treatment of angina pectoris and cerebral infarction particularly is provided, belong to Chinese medicine treatment cardiovascular and cerebrovascular diseases medicament technical field.
Background technology:
Angina pectoris is a kind of common cardiovascular and cerebrovascular disease of serious harm human body health.Belong to motherland's medical science " thoracic obstruction " " pained " disease categories such as " cardiopalmus ", disease such as its clinical manifestation is angina pectoris, uncomfortable in chest, cardiopalmus, breathe hard.The cerebral infarction that modern medicine is referred to as is equivalent to the sick category of motherland's medical science cerebral infarction.It is a lot of that the paathogenic factor ancient Chinese medicine doctor is discussed, and primary disease is many owing to be worried angryly, or comfortable wine has a liking for fertile food, or chamber is hindered, overwork etc., so that YIN-deficiency in the lower part, liver-yang is opened cruelly, the endogenous wind turn, QI and blood is contrary disorderly, folder expectorant folder fire, the horizontal passages through which vital energy circulates of scurrying, hoodwink thinking and take place suddenly to fall forward dusk, all diseases of hemiplegia.Above disease nitroglycerin commonly used etc. have certain curative effect for emergent medicine rescues, and are the link clinical symptoms, but cure the symptoms, not the disease.Chinese medicine was being obtained significant progress aspect the treatment primary disease in the last few years, become one of important means of cardiovascular and cerebrovascular disease Comprehensive Treatments such as coronary heart disease, used medicine biases toward blood stasis heart arteries and veins, the resistance of breast sun numbness more, and the modern Chinese medicine theoretical research shows that the basic pathogenesis of coronary heart disease is a deficiency in origin and excess in superficiality, blood stasis due to qi deficiency.Therefore, most medicines have significant limitation in this disease of treatment, have influenced treatment of diseases.
Summary of the invention:
The invention provides a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease, have blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, evident in efficacy, the characteristics for the treatment of both the principal and the secondary aspects of a disease at the same time.
The present invention is according to the understanding of Chinese medicine to the cardiovascular and cerebrovascular vessel pathogenesis, and in conjunction with the research of QI and blood correlation theory, the basic pathogenesis of coronary heart disease is a deficiency in origin and excess in superficiality, blood stasis due to qi deficiency.At angina pectoris is in the majority with type of obstruction of heart-blood clinically, so start with, dispel in the blood stasis of blood and stagnate from blood circulation promoting and blood stasis dispelling, general rule not bitterly, to remove the heresy of mark reality.And notice " gas is handsome with blood ", " the capable then blood of gas is capable ", the deficiency of vital energy then blood walking retardation in children is slow, because of void causes this pathological characteristic of the stasis of blood, is used the product of QI invigorating, reaches blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time.Selected have an addendum motive, promoting blood circulation and stopping pain, and thin network is regulated the flow of vital energy, and nourishes heart and transfers the pure Chinese herbal medicine of blood, by the theory of Chinese medical science prescription, through the strictness screening, concocts respectively, combines in conjunction with modern advanced technologies method for making.Following consumption is weight portion, and basic recipe is as follows:
Fructus Tribuli 60-5, Stem and leaf of Radix Ginseng 2-30
Radix Salviae Miltiorrhizae 10-45, Borneolum Syntheticum 0.05-0.8.
Its preferred weight proportioning is:
Fructus Tribuli 30, Stem and leaf of Radix Ginseng 10
Radix Salviae Miltiorrhizae 15, Borneolum Syntheticum 0.1
Processing procedure of the present invention is as follows:
Get Radix Salviae Miltiorrhizae and all be ground into fine powder or partly beat powder, partly or entirely Radix Salviae Miltiorrhizae adds alcohol reflux, and concentration of alcohol is between the 10-90%; Stem and leaf of Radix Ginseng and Fructus Tribuli extracting in water extract 1-6 time, and concentrating under reduced pressure adds ethanol precipitation, concentration of alcohol 50%-90%; Filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and behind the thin up, filtrate is handled the good macroporous adsorptive resins of balance earlier by giving, colourless with washed with de-ionized water to effluent, discard cleanout fluid, use the 50-90% ethanol elution, collect eluent, collect ethanol elution, concentrating under reduced pressure is concentrated into relative density 1.10 (50 ℃), spray drying; With above-mentioned Radix Salviae Miltiorrhizae medicated powder or Radix Salviae Miltiorrhizae extract and appropriate amount of starch mixing, the reuse cover grinds method and Borneolum Syntheticum mixing, granulates, and makes granule, promptly gets medicine of the present invention.
Above-mentioned medicament can be a said dosage form on any pharmaceutics.
[function with cure mainly] blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain.Cure mainly stabbing pain over the chest, uncomfortable in chestly do not relax, palpitation and uneasiness, the dyspnea with shortness of breath hemiplegia, crooked mouth and tongue, stiff tongue and retardation in speech or is in silence felt to go down or disappears, has a dizzy spell, and dimly pale tongues etc. are with disease such as wind-phlegm stasis of blood resistance card grade.Be suitable for the angina pectoris stagnation of heart-blood disease and the cerebral infarction of obstruction of qi in the chest and cardialgia.
[usage and consumption] is oral, a 1-2 grain, 3 times on the one.
[specification] every dress 0.4g
[storage] is airtight, protection against the tide.
Angina pectoris that modern medicine is referred to as, belong to " thoracic obstruction ", " pained ", " cardiopalmus ", " precordial pain with cold limbs " category in motherland's medical science, motherland's medical science has the opinion of " gas is handsome with blood ", " the capable then blood of gas is capable ", gas with the blending of blood just like water and milk, all QI and blood are regulated then to seek and are defended harmony, and it sees the perverse then empty stasis of blood of QI and blood.Primary disease is more common in middle-aged and elderly people, and its cause of disease mainly is because stagnation of heart-blood, and depression of liver-QI is overworked, and loses and controls wrong treatment, can not agitate blood vessels, thrombosis, and the blood clots absorbing stagnates, the stasis of blood and obstructed, stagnation of QI and blood may bring about pain.Belong to deficiency in origin and excess in superficiality, blood stasis is this, and the deficiency of vital energy is mark.At thoracic obstruction disease clinically the card of stagnation of heart-blood, the suitable addendum motive of its Therapeutic Principle, promoting blood circulation and stopping pain are arranged more.Fructus Tribuli is a monarch drug in the side; Radix Salviae Miltiorrhizae is a ministerial drug; Stem and leaf of Radix Ginseng makes Borneolum Syntheticum for assistant, brings into play blood circulation promoting and blood stasis dispelling jointly, the merit of removing obstruction in the collateral to relieve pain.
Following pharmacological evaluation has confirmed that pharmaceutical preparation of the present invention has pharmacologically actives such as treatment angina pectoris disease treatment and analgesia:
The experiment medicine: the puncture ginseng capsule provides lot number by chemistry chamber, Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science: 20010101.
Positive control drug is an XINKESHU PIAN, produces lot number: 20010106 by the pharmaceutical factory of traditional Chinese medicine of Weifang, Shandong medicine Group Plc.
Laboratory animal: healthy adult hybrid dog, body weight 11-16kg, the male and female dual-purpose is provided by laboratory animal portion of Jilin University.Kunming mouse, the male and female dual-purpose.The Wistar rat, the male and female dual-purpose.Provide by Changchun High-technology Medical Animal Experiment Research Center.The animal quality quality certification number: 10-5,113 10-5112.
Experimental apparatus: Japanese photoelectricity company produces RM-6000 type polygraph; Beijing Puli gives birth to LBY-self-cleaning rotary viscosimeter; The multi-functional platelet aggregation instrument of the Shanghai STA-4 of Kodak test instrunment factory type.
Experimental technique:
1. the puncture ginseng capsule is to the hemodynamic influence of anesthetized open-chest dog
30 of hybrid dogs are divided into 5 groups, 6 every group.Matched group waits the capacity normal saline, and the positive drug group is given XINKESHU PIAN 0.38g/kg, and experiment component is puncture ginseng capsule 5.10,2.55, three dosage groups of 1.28g crude drug/kg, all adopts duodenal administration.
With pentobarbital sodium 30mg/kg iv anesthesia, back of the body position is fixing, and skin of neck cuts, and tracheal intubation connects artificial respirator (WH-2 type, Tianjin medical apparatus and instruments factory produces), separates carotid artery, connects the AP-601 amplifier, measures blood pressure.Separate femoral artery, connect the AP-601 amplifier, carry out the ventricle interpolation pipe, measure left indoor pressure, end diastolic pressure, and through the maximum rate of change (± dp/dt max) of differential processor EQ-601G mensuration left indoor pressure.The 4th intercostal is executed thoracotomy in the left side, exposes heart, cuts off pericardium, does the pericardium art.Separate LCA and aortic root, place battery effusion meter probe (MFV-1100 type, Japanese photoelectricity company produces), measure coronary flow and aorta flow.Extremity connect limb lead, and bioassay standard II leads electrocardiogram, calculate heart rate.Separate duodenum, in order to administration.Above-mentioned each index synchronous recording is in polygraph (RM-6000 type, Japanese photoelectricity company produces).Art finishes, and stablizes 15 minutes, writes down before the administration and 5,10,20,30,45,60,90,120,150,180,240 minutes all indexs behind the medicine.Got tremulous pulse, venous blood in 30,60,120,180,240 minutes before administration and behind the medicine, measure oxygen content with blood oxygen instrument (Kang Ni-158, produced in USA).And, calculate two-level index: mean arterial pressure, cardiac index, SI, stroke work index, total peripheral resistance, coronary resistance, myocardial oxygen consumption, myocardial oxygen consumption index, myocardium oxygen uptake rate, myocardial flow etc. according to formula.Experimental data measured value and variation fraction values and matched group are relatively organized a t check analysis.
1.1 influence to heart rate, blood pressure
Each dosage group of puncture ginseng capsule is not obvious to the heart rate influence.See Table 1.
Each dosage group of puncture ginseng capsule is not obvious to the blood pressure influence.See Table 2.
1.2 influence to left indoor pressure, left chamber easypro end pressure and the work done of left chamber
Each dosage group of puncture ginseng capsule is not obvious to the left ventricular pressure influence.See Table 3.
Each dosage group of puncture ginseng capsule is pressed not have obviously to easypro end, left chamber and is acted on.See Table 4.
Each dosage group of puncture ginseng capsule does not have obvious effect to the work done of left chamber.See Table 13.
1.3 influence to maximum rate of change of left indoor pressure and total peripheral resistance
Each dosage group of puncture ginseng capsule does not all have obvious effect to the maximum rate of change of left indoor pressure.See Table 5, table 6.
The XINKESHU PIAN group changed percentage rate total peripheral resistance was acted on obviously (P＜0.05) at 90-120 minute, and other each groups do not have obvious effect.See Table 10.
1.4 influence to heart output, myocardial flow and coronary resistance
Each dosage group of puncture ginseng capsule is not obvious to the heart output influence.See Table 7.
The XINKESHU PIAN group changes percentage rate effect obvious (P＜0.05) in 45-90 minute to myocardial flow, and puncture ginseng capsule 1.28g crude drug/kg changes percentage rate and acted on obviously (P＜0.05) at 45-120 minute; Puncture ginseng capsule 2.55g crude drug/kg changes percentage rate effect obvious (P＜0.05) in 30-120 minute; Puncture ginseng capsule 5.10g crude drug/kg changes percentage rate effect obvious (P＜0.01) in 30-120 minute; Other each groups do not have obviously effect.See Table 8.
The XINKESHU PIAN group changes percentage rate effect obvious (P＜0.05) in 45-90 minute to coronary resistance; Measured value effect in 120 minutes is (P＜0.05) obviously; Puncture ginseng capsule 1.28g crude drug/kg changes percentage rate effect obvious (P＜0.05) in 90-120 minute; Puncture ginseng capsule 2.55g crude drug/kg changes percentage rate effect obvious (P＜0.05) in 45-120 minute; Effect in measured value 60-120 minute is (P＜0.05) obviously; Puncture ginseng capsule 5.10g crude drug/kg changes percentage rate effect obvious (P＜0.05) in 45-120 minute; Other each groups do not have obviously effect.See Table 9.
1.5 to cardiac index, SI, heart output influence
Each dosage group of puncture ginseng capsule is not obvious to the cardiac index influence.See Table 11.
Each dosage group of puncture ginseng capsule is not obvious to the SI influence.See Table 12.
Each dosage group of puncture ginseng capsule is not obvious to the heart output influence.See Table 14.
1.6 influence to myocardial oxygen consumption, myocardial oxygen consumption index and myocardium oxygen uptake rate
1.6.1 effect to myocardial oxygen consumption
The XINKESHU PIAN group changes percentage rate effect obvious (P＜0.05) in 30-90 minute to myocardial oxygen consumption; Measured value was effect obvious (P＜0.05) in 120 minutes; Puncture ginseng capsule 1.28g crude drug/kg changes percentage rate effect obvious (P＜0.05) in 30-45 minute; Puncture ginseng capsule 2.55g crude drug/kg changes percentage rate effect obvious (P＜0.05) in 30-45 minute; Puncture ginseng capsule 5.10g crude drug/kg changes percentage rate effect obvious (P＜0.01) in 30-90 minute; Measured value was effect obvious (P＜0.05) in 45 minutes; Other each groups do not have obviously effect.See Table 15.
1.6.2 to the exponential effect of myocardial oxygen consumption
Each dosage group of puncture ginseng capsule is not obvious to the influence of myocardial oxygen consumption index.See Table 16.
1.6.3 effect to myocardium oxygen uptake rate
The XINKESHU PIAN group changes percentage rate effect obvious (P＜0.01) in 30-90 minute to myocardium oxygen uptake rate; Measured value was effect obvious (P＜0.05) in 60-90 minute; Puncture ginseng capsule 1.28g crude drug/kg changes percentage rate effect obvious (P＜0.01) in 30-45 minute; Puncture ginseng capsule 2.55g crude drug/kg changes percentage rate effect obvious (P＜0.01) in 30-90 minute; Puncture ginseng capsule 5.10g crude drug/kg changes percentage rate effect obvious (P＜0.001) in 30-90 minute; Measured value is in obviously (P＜0.05) other each obviously effects of group nothing of effect in 45-90 minute.See Table 17.
Experimental result shows that the puncture ginseng capsule can obviously increase myocardial flow, reduces coronary resistance, reduce myocardial oxygen consumption and oxygen uptake rate.
2. the puncture ginseng capsule is to the influence of experimental myocardial infarction dog
Get 30 of hybrid dogs, be divided into 5 groups at random, 6 every group, anaesthetize with pentobarbital sodium 30mg/kg iv.Back of the body position is fixing, and skin of neck cuts, tracheal intubation, connect WM-2 type artificial respirator, separate 1/3 place under the left anterior descending coronary artery, threading causes myocardial infarction in order to ligation, with the wet cloth formula absorption method mapping EECG of multiple spot, 24 of mapping points divide normal district (control point), infraction marginal zone and infraction center, art finishes, and stablizes 15 minutes.Record each point EECG, simultaneously get blood from femoral vein, survey AST, CPK and LDH value, as being worth before the administration, behind the ligation coronary artery 15 minutes, through duodenal administration, matched group waits the capacity normal saline, and the positive drug matched group gives XINKESHU PIAN 0.38g/kg, puncture ginseng capsule 1.28g crude drug/kg, 2.55g crude drug/kg, three dosage groups of 5.10g crude drug/kg, the record administration after 5,10,20,30,45,60,90,120,150,180,210,240,300,360 minutes EECG, show ∑-ST with ST section total mV numerical table that raises, raise with the ST section number that leads of 2mV is N-ST.Write down after 360 minutes, get blood thought-read flesh three enzymes for the second time.Experiment finishes, and it is dirty to core, and claims to weigh whole-heartedly, cuts off trunk root and atrium along coronary sulcus, claims left ventricle heavy.Be cut into 5 with left ventricle is cross-section equably, place nitro tetrazole orchid (N-BT) dye liquor, dyeing is 15 minutes in 37 ℃ of constant water bath box.(36 points/cm2) are measured every myocardium bilateral infarct (the non-dyeing of N-BT district) and non-infarct (N-BT dye district) with the drop point method of quadrature, every cardiac muscle is weighed, calculate every myocardial area, the gross area of the ventricle gross area and infarct calculates infarct and ventricle and cardiac weight percentage ratio.
2.1 influence to EECG
2.1.1 to the influence of degree of ischemia (∑-ST)
The XINKESHU PIAN group acted on obviously (P＜0.05) to the degree of ischemia measured value at 45-180 minute; Puncture ginseng capsule 1.28g crude drug/kg was effect obvious (P＜0.05) in 60-180 minute; Puncture ginseng capsule 2.55g crude drug/kg was effect obvious (P＜0.05) in 45-180 minute; Puncture ginseng capsule 5.10g crude drug/kg was effect obvious (P＜0.01) in 30-180 minute; Other each groups do not have obviously effect.See Table 18
2.1.2 influence to ischemia scope (N-ST)
The XINKESHU PIAN group acted on obviously (P＜0.05) to ischemia scope measured value at 45-180 minute; Puncture ginseng capsule 1.28g crude drug/kg was effect obvious (P＜0.05) in 60-180 minute; Puncture ginseng capsule 2.55g crude drug/kg was effect obvious (P＜0.05) in 45-180 minute; Change percentage rate and acted on obviously (P＜0.05) at 30-180 minute at obvious (P＜0.05) the puncture ginseng capsule 5.10g crude drug/kg of effect in 30-45 minute; Other each groups do not have obviously effect.See Table 19.
2.2 influence to MIS
XINKESHU PIAN group, middle dosage group, heavy dose of group all can obviously reduce infraction/reach whole-heartedly infraction/left heart area (P＜0.05).Other each groups do not have obviously effect.See Table 20.
2.3 to myocardium three enzymes (AST, CPK, influence LDH)
The XINKESHU PIAN group, puncture ginseng capsule 1.28g crude drug/kg, 5.10g crude drug/Kg can obviously reduce the content (P＜0.01) of serum AST.Other each groups do not have obviously effect.See Table 21.
The XINKESHU PIAN group, puncture ginseng capsule 1.28g crude drug/kg, 5.10g crude drug/Kg can obviously reduce the content (P＜0.05) of serum CK.Other each groups do not have obviously effect.See Table 22.
Each dosage group of puncture ginseng capsule is not obvious to the Serum LDH influence.See Table 23.
Experimental result proves that the puncture ginseng capsule is through duodenal administration, and (∑-ST), reduce myocardial ischemia scope (N-ST) dwindles myocardial infarct size (MIS), reduces serum AST, the content of CPK obviously to reduce degree of myocardial ischemia.Alleviate myocardial cell injury.Thereby myocardial infarct size dwindles, and destructiveness reduces, and ischemic myocardium is had protective effect.
3. to the influence of clotting time of mice
Get 50 of mices, be divided into five groups at random, dosage sees Table 24, and every day 1 time, continuous irrigation stomach 15 days behind the last medicine 1 hour, adopts slide method to measure clotting time.The results are shown in Table 24.
The influence of table 24. pair clotting time of mice
Annotate: with relatively * P＜0.05 * * P＜0.01 * * * P＜0.001 as follows summary of matched group
Experimental result proves: the puncture ginseng capsule can make clotting time of mice prolong, and is remarkable with normal control group comparing difference.
4. to the hemorheological influence of blood stasis rat model
Get the wistar rat, male and female half and half are divided into six groups at random, press the gastric infusion of dosage shown in the table 25, every day 1 time, continuous 15 days.Behind the last medicine 1 hour, except that the normal control group, all the other respectively organize rat skin lower injection epinephrine 0.08ml/100g, inject 1 time in 4 hours at interval, between the biphasic injection epinephrine (front and back each 2 hours at interval) again, whole rats were immersed in the frozen water 5 minutes, dispose the back fasting, inferior rat aorta blood sampling in morning, anticoagulant heparin, give birth to LBY-N6A from clear rotary viscosimeter with Beijing Puli, measure rat whole blood viscosity and plasma viscosity.
The table 25. pair hemorheological influence of blood stasis rat model (X ± SD)
The result shows that the puncture ginseng capsule can make blood stasis rat model whole blood viscosity reduce, and is remarkable with the model group comparing difference, and little to the plasma viscosity influence.
5. to the influence (turbidimetry) of rat platelet aggregation function
Get 50 of rats, be divided into five groups at random, press the gastric infusion of dosage shown in the table 26, every day 1 time, continuous 15 days, behind the last medicine 1 hour, with 3% pentobarbital sodium difference anesthetized rat (30mg/kg), through ventral aorta blood sampling, preparation PRP and PPP, putting the multi-functional platelet aggregation instrument of SPA-4 afterwards, is that derivant is measured platelet aggregation rate (5 minutes) with ADP.
The influence of table 26. pair rat platelet aggregation function
The result shows that the puncture ginseng capsule can make the inductive platelet aggregation of ADP be suppressed, and is remarkable with the matched group comparing difference.
Experiment conclusion:
Laboratory observation the puncture ginseng capsule to effects such as normal anesthetized open-chest dog hemodynamics and myocardial oxygen consumption.Experimental result shows that the puncture ginseng capsule can obviously increase myocardial flow, reduces coronary resistance, reduce myocardial oxygen consumption and oxygen uptake rate.These effects of puncture ginseng capsule, relevant with direct coronary artery dilating, make it myocardial flow and increase.Can reduce cardiac energy and oxygen consumption, oxygen uptake rate is reduced.The directly raising of reflection cardiac pumping function, the peripheral blood vessel expansion is relevant.Prompting puncture ginseng capsule can improve systema cariovasculare functional, regulates heart blood supply oxygen supply balance, and is to preventing and treating cardiovascular disease, significant as commonly encountered diseases such as coronary heart disease, myocardial ischemia.
Experiment adopts ligation anterior descending coronary (LAD) to cause acute myocardial infarction model.With epimyocardium electrograph mapping degree of myocardial ischemia and scope, the variation of sero-enzyme after quantitative tissue mensuration myocardial infarct size and the myocardial infarction.Experimental result proves that the puncture ginseng capsule is through duodenal administration, and (∑-ST), reduce myocardial ischemia scope (N-ST) dwindles myocardial infarct size (MIS), reduces serum AST, the content of CK obviously to reduce degree of myocardial ischemia.Alleviate myocardial cell injury.Thereby myocardial infarct size dwindles, and destructiveness reduces, and ischemic myocardium is had protective effect.Prompting puncture ginseng capsule has function of resisting myocardial ischemia.Simultaneously, the puncture ginseng capsule can prolong clotting time of mice, and blood stasis rat model whole blood viscosity is reduced, and the puncture ginseng capsule can make the inductive platelet aggregation of ADP be suppressed.Prompting puncture ginseng capsule has good function of promoting blood circulation to disperse blood clots.
Laboratory observation the puncture ginseng capsule to effects such as normal anesthetized open-chest dog hemodynamics and myocardial oxygen consumption.Experimental result shows that the puncture ginseng capsule can obviously increase myocardial flow, reduces coronary resistance, reduce myocardial oxygen consumption and oxygen uptake rate.These effects of puncture ginseng capsule are with the content of direct coronary artery dilating.Alleviate myocardial cell injury.Thereby myocardial infarct size dwindles, and destructiveness reduces, and ischemic myocardium is had protective effect.Prompting puncture ginseng capsule has function of resisting myocardial ischemia.Simultaneously, the puncture ginseng capsule can prolong clotting time of mice, and blood stasis rat model whole blood viscosity is reduced, and the puncture ginseng capsule can make the inductive platelet aggregation of ADP be suppressed.Prompting puncture ginseng capsule has good function of promoting blood circulation to disperse blood clots.
The specific embodiment:
Embodiment 1
Get Radix Salviae Miltiorrhizae 161g and be ground into fine powder, standby; Other gets Radix Salviae Miltiorrhizae 612g and adds 7 times of amount 90% ethanol, and reflux, extract, was once extracted 1 hour, filter, filtrate recycling ethanol is standby, and medicinal residues add 8 times of water gagings, decoct three times, filter, filtrate is concentrated into the clear paste that relative density is 1.20-1.30 (80 ℃), adding ethanol to determining alcohol is 70%, places, and filters, reclaim ethanol, merge with above-mentioned medicinal liquid, evaporate to dryness, standby; Get Stem and leaf of Radix Ginseng and Fructus Tribuli and add 10 times of water gagings, soaked 0.5 hour, decoct 2 times, each 1 hour, collecting decoction was evaporated to relative density and is (800C), add ethanol to determining alcohol and reach 70%, filter, decompression filtrate recycling ethanol is to there not being the alcohol flavor, behind the thin up, filter, filtrate is handled the good macroporous adsorptive resins of balance earlier by giving, and is colourless to effluent with washed with de-ionized water, discard cleanout fluid, use 70% ethanol elution, collect eluent, colourless to effluent, merge 70% ethanol elution, collect effluent, reclaim ethanol, concentrating under reduced pressure, be concentrated into relative density 1.10 (50 ℃), spray drying; With above-mentioned medicated powder and Radix Salviae Miltiorrhizae medicated powder and appropriate amount of starch mixing, the reuse cover grinds method and Borneolum Syntheticum mixing, granulates, and makes 1000, promptly.
Table 20. puncture ginseng capsule to the influence of myocardial infarction dog myocardial infarction area (X ± SD, n=6)
Annotate: with the relatively * P＜0.05**P＜0.01 as follows summary of normal control group
Table 21. puncture ginseng capsule to the influence of ASDT (IU/L) in the myocardial infarction dog serum (X ± SD, n=6)
Table 22. puncture ginseng capsule to the influence of CPK (IU/L) in the myocardial infarction dog serum (X ± SD, n=6)
Table 23. puncture ginseng capsule to the influence of LDH (IU/L) in the myocardial infarction dog serum (X ± SD, n=6)
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is characterized in that being made by ratio of weight and the number of copies by following medicine:
Fructus Tribuli 60-5, Stem and leaf of Radix Ginseng 2-30
Radix Salviae Miltiorrhizae 10-45, Borneolum Syntheticum 0.05-0.8.
2, Chinese medicine preparation according to claim 1 is characterized in that being made by ratio of weight and the number of copies by following medicine:
Fructus Tribuli 30, Stem and leaf of Radix Ginseng 10,
Radix Salviae Miltiorrhizae 15, Borneolum Syntheticum 0.1.
3, according to the production technology of claim 1 or 2 described Chinese medicine preparation, may further comprise the steps: get Radix Salviae Miltiorrhizae powder and be broken into fine powder, add alcohol reflux, concentration of alcohol is between the 10-90%; Stem and leaf of Radix Ginseng and Fructus Tribuli extracting in water extract 1-6 time, and concentrating under reduced pressure adds ethanol precipitation, concentration of alcohol 50%-90%; Filter, decompression filtrate recycling ethanol is to there not being the alcohol flavor, behind the thin up, filtrate is handled the good macroporous adsorptive resins of balance earlier by giving, and is colourless to effluent with washed with de-ionized water, discard cleanout fluid, use the 50-90% ethanol elution, collect ethanol elution, concentrating under reduced pressure, be concentrated into 50 ℃ of relative densities 1.10, spray drying; With above-mentioned Radix Salviae Miltiorrhizae extract and appropriate amount of starch mixing, the reuse cover grinds method and Borneolum Syntheticum mixing, makes granule.
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