CN100482268C - Medicinal composition for treating primary hypertension and preparing method of tea agent thereof - Google Patents
Medicinal composition for treating primary hypertension and preparing method of tea agent thereof Download PDFInfo
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- CN100482268C CN100482268C CNB200610076770XA CN200610076770A CN100482268C CN 100482268 C CN100482268 C CN 100482268C CN B200610076770X A CNB200610076770X A CN B200610076770XA CN 200610076770 A CN200610076770 A CN 200610076770A CN 100482268 C CN100482268 C CN 100482268C
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Abstract
A Chinese medicine in the form of tea for treating hypertension is prepared from 9 Chinese-medicinal materials including uncaria stem with hooks, red sage root, dogwood fruit, tetrandra root, etc through pulverizing and loading in bags.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relating to a kind of is the pharmaceutical composition of raw material treatment hypertension and the preparation method of medicinal tea thereof with the Chinese herbal medicine.
Technical background
Along with the raising of China's living standards of the people, the change of diet structure, the quickening of work rhythm, hypertensive sickness rate progressively rises, and China hyperpietic is just to increase 3,000,000 people's speed development every year newly at present.In the emergency case that threatens people's life, the most fearful will say so apoplexy and acute coronary, this emergency case mortality rate is high, and especially apoplexy extremely will not disabled yet, and what is to cause the most important risk factor of apoplexy so, is---hypertension!
Hypertension is that modal cardiovascular disease is the key factor that causes cerebral thrombosis, myocardial infarction, renal failure, apoplexy, hemiplegia, the case of dying suddenly because of hypertension is not remembered its number clinically, at present because most of patients is not enough to hypertensive understanding, control with Western medicine for a long time, but the inherent toxic and side effects of Western medicine is extremely damaged people's vitals such as heart and brain kidney.Simultaneously, hypertension is again the main pathogenic factors of acute coronary.In addition, hypertension also can cause serious renal failure.We can say that hypertension is again to destroy the heart, brain, " the invisible killer " of organs such as kidney.
Disclosed a kind of patent of invention on April 5th, 2004 and number be 96103057.7 " Tea containing traditional Chinese medicine " on the Chinese patent communique, it provides a kind of Tea containing traditional Chinese medicine of being made up of Folium Ziziphi Spinosae, Folium Juglandis, Folium Scutellariae, Folium Crataegi, Rhizoma Imperatae, Folium Arundinis donacis etc.Though it can treat neurasthenia, hypertension, Yin Yang balancing, adjustment human internal environment, its manufacture method more complicated, cure rate is lower.
Summary of the invention
In order to overcome the deficiencies in the prior art, the purpose of this invention is to provide a kind of be raw material cure rate height with the Chinese herbal medicine, have no side effect and have tranquillizing and allaying excitement, nourishing the lung and kidney, the simple pharmaceutical composition of technology.
Another object of the present invention provides a kind of preparation method of this pharmaceutical composition medicinal tea.
The object of the present invention is achieved like this: a kind of pharmaceutical composition for the treatment of hypertension, form by Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae, Fructus Viticis, Radix Salviae Miltiorrhizae, Stigma Maydis, Herba Apocyni veneti, Fructus Corni, Radix Stephaniae Tetrandrae, Cacumen Platycladi, according to listed as parts by weight, the drug component of this pharmaceutical composition is:
Ramulus Uncariae Cum Uncis 10～15, Herba Siegesbeckiaes 10～15, Fructus Viticis 10～15,
Radix Salviae Miltiorrhizae 10～15, Stigma Maydis 10～15, Herba Apocyni veneti 10～15,
Fructus Corni 10～15, Radix Stephaniae Tetrandrae 5～7.5, Cacumen Platycladi 5～7.5.
Optimum weight part proportioning of pharmaceutical composition of the present invention is:
Ramulus Uncariae Cum Uncis 12.5, Herba Siegesbeckiaes 12.5, Fructus Viticis 12.5,
Radix Salviae Miltiorrhizae 12.5, Stigma Maydis 12.5, Herba Apocyni veneti 12.5,
Fructus Corni 12.5, Radix Stephaniae Tetrandrae 6.25, Cacumen Platycladi 6.25.
What the pharmaceutical dosage form of pharmaceutical composition of the present invention adopted is medicinal tea, also can adopt any medically said dosage form.
The preparation method of pharmaceutical composition medicinal tea of the present invention is:
1. weighing: above-mentioned each Chinese crude drug carries out weighing according to weight portion.
2. pulverize: the medical material after the weighing, earlier Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae and the stranding of Stigma Maydis difference medication hand hay cutter are coarser powder, cross 20 mesh sieves, standby; Be coarser powder with little pulverizer mill respectively with remaining Chinese crude drug again, cross 20 mesh sieves, standby.
3. bag: get the rectangle filter paper of long 24cm, wide 16cm, with the little paper bag of plastic packaging machine Feng Chengyi side opening, three side seals.
4. pack: after above-mentioned each pharmaceutical composition corase meal that has ground is mixed, be contained in the above-mentioned little paper bag every packed 16 gram mixed-powders, the encapsulation of reuse packer.
During use, every day, each was once taken after mixing it with water with 1500 milliliters of hot water sooner or later, and 30 days is a course of treatment.
An important feature of pharmaceutical composition of the present invention is to contain multiple biological activity and multivitamin, the example Ramulus Uncariae Cum Uncis, contain multiple alkaloid, as an ancient unit of weight rattan alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, hirsuteine, different Ramulus Uncariae Cum Uncis, corynoxein, different corynoxein, hair 9-methoxycorynantheidine., dehydrogenation hair 9-methoxycorynantheidine., pocket HUAMU alkali and dihydro pocket HUAMU alkali etc.Herba Siegesbeckiae, You Ming Herba Siegesbeckiae ， Han darutin-bitter and alkaloid.Fructus Viticis contains micro-alkaloid and vitamin A: still contain the Fructus Viticis Cannabifoliae flavone in the fruit; And contain a small amount of vitricin.Radix Stephaniae Tetrandrae, root contains mufangchine, and contains aristolochic acid A, contains multiple isoquinoline alkaloid.Radix Salviae Miltiorrhizae contains crystallinity furo phenanthrenequione class pigment, and main is TANSHINONES 1A, II B, cryptotanshinone, the quinones color element that dihydroisotanshinone I and multiple content are less; Other contains danshensu, carnosol, phenols branches such as protocatechualdehyde.In addition, contain vitamin E, B one sitosterol, steroid derivative tigogenin etc.Stigma Maydis, the another name maize must; Stigma Maydis contains compositions such as vitamin K, β-sitosterol, glucose, organic acid.Fructus Corni contains cornin, Saponin, tannin, ursolic acid, gallic acid, malic acid, tartaric acid and vitamin A.Cacumen Platycladi contains thujene, absinthol, fenchone, pinene, caryophyllene etc.Also contain tannin, resin, vitamin C etc.Contain volatile oil, flavone compound and waxiness etc.Herba Apocyni veneti, main component root contain cymarin, convallatoxigenin and K-strophanthus time glycoside-β.Leaf contains globulariacitrin, catechin, anthraquinone, glutamic acid, alanine, valine, potassium chloride etc., also contains Quercetin and Isoquercitrin.
The present invention makes full use of the effect that aforementioned pharmaceutical compositions supplements and complements each other, and reaches the effect of wholistic therapy jointly.The present invention utilizes Ramulus Uncariae Cum Uncis according to theory of Chinese medical science, and have another name called for Ramulus Uncariae cum Uncis, hang rattan etc., sweet in the mouth cool in nature, energy heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. have calmness, hypotensive effect.Herba Siegesbeckiae, You Ming Herba Siegesbeckiae, the pig cream certain kind of berries, Adeps Tigris etc.; Hollow, feeble QI, mildly bitter flavor; Have antiinflammatory, blood pressure lowering, can curing rheumatism, relieving rigidity of muscles and joints, blood pressure lowering, can control quadriplegia, bones and muscles pain, weakness of the waist and knees, malaria, acute hepatitis etc.Fructus Viticis, main component is camphene and pinene, and contains micro-alkaloid and vitamin A; Gas is special and fragrant, lightly seasoned, little suffering; Has dispelling wind and heat pathogens, the clear sharp head.Radix Stephaniae Tetrandrae has another name called and dissociates, carries monarch's row, Radix Stephaniae Tetrandrae; Feeble QI, bitter in the mouth, acrid in the mouth cold in nature is flat; Have the swollen tympanites of harnessing the river, hygropyretic beriberi, brothers' spasm and pain, the tinea scabies is swollen, energy inducing diuresis to remove edema, wind-damp dispelling pain relieving.Radix Salviae Miltiorrhizae, feeble QI, sweet in the mouth is little, returns few cloudy, cloudy vim and vigour medicine of fainting through, brothers; Have blood circulation promoting and blood stasis dispelling, the removing heat from blood eliminating carbuncle, relieving restlessness is calmed the nerves.Stigma Maydis, the flat slightly sweet flavor of property is nontoxic, return through: go into liver, kidney, gallbladder meridian, have diuresis, blood pressure lowering, promotion bile secretion, increase learn in thrombin and accelerate blood effect such as solidify; Stigma Maydis has the hypertensive effect of control, because contain a large amount of lysine and a kind of anticancer factor---glutathion in the Stigma Maydis.Cacumen Platycladi has another name called Cacumen Platycladi (Cacumen Biotae), Cong Baiye, Cacumen Platycladi etc., contains thujene, absinthol, fenchone, pinene, caryophyllene etc.Also contain tannin, resin, vitamin C etc.; Gas fragrance, acrid in the mouth.Have cooling blood for hemostasis, expelling phlegm for arresting cough.Herba Apocyni veneti is ellipticity lanceolar or ovum circle shape lanceolar, light green or celadon, and edge tool serration, Chang Fanjuan, vein is in the lower surface projection; Feeble QI, lightly seasoned.Have calming liver and clearing heat, clearing away heat and promoting diuresis effect.Fructus Corni has another name called another name for Sichuan Province Zao, Qi reality, Mus arrow etc., contains cornin, Saponin, tannin, ursolic acid, gallic acid, malic acid, tartaric acid and vitamin A; Feeble QI, sour in the mouth, puckery, little hardship; Have liver and kidney tonifying, astringent or styptic treatment for spontaneous sweating, antibiotic, the diuresis of convergence, blood pressure lowering.
Compared with the prior art, the present invention not only preparation technology simple, need not decoct, and the steady blood pressure lowering of tool, do not rebound, pure Chinese medicinal preparation, have no side effect.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
In order to show the therapeutic effect of pharmaceutical composition of the present invention,, utilize the present invention that 578 routine patients have been carried out clinical experiment from nineteen ninety-five to essential hypertension.
Case 1
Lee, woman, 50 years old, people from Xuzhou, the functionary, dizzy at ordinary times, cardiopalmus, anorexia, the soreness of waist and numb limbs and tense tendons are gone to a hospital to see a doctor when once catching a cold and are found the tachycardia blood pressure up to 130-160 millimetress of mercury through looking into, after done comprehensive inspection again and also found ventricular hypertrophy, be diagnosed as II phase hypertension, multi-treatment does not have effect.Calendar year 2001 has been taken " Hu Shi blood pressure lowering treasured " of the present invention medicinal tea, according to every day, sooner or later each was once, take after mixing it with water with 1500 milliliters of hot water, 30 days is a course of treatment, a large amount of condition of illness such as dizziness after 2 courses of treatment, cardiopalmus, anorexia obviously alleviates, after continue to have taken 1 the symptom complete obiteration course of treatment, stablely always so far do not see recurrence.
Case 2
The king so-and-so, the man, 62 years old, people from Nanjing, retired employees, headache uncomfortable in chest, the soreness of waist and the numb limbs and tense tendons of feeling suddenly in the stroll way in 2003 can not be walked, and have stayed slurred speech, the intelligence intellectual impairment, the life of oneself is looked after by the household entirely, it is invalid to control for a long time." Hu Shi blood pressure lowering treasured " of the present invention from having taken medicinal tea is after 2 courses of treatment, and life can be taken care of oneself, and can answer clear speech to express, after take three courses of treatment again continuously after, all are normal so far.
Case 3
Lee so-and-so, man, 40 years old, certain company manager is in cause has, because of Inheritance was suffered from hypertension 12 years, just begun panesthesia to headache, feeling of fullness in the head, cardiopalmus, have a sleepless night, have the pins and needles, when a cat fever,, just know and oneself suffered from hypertension at examination in hospital.He has taken some Western medicine subsequently.Treatment takes a turn for the better, recurrence again after the drug withdrawal, and a kind of medicine Time of Administration is long slightly just inoperative, develops immunity to drugs, and must change new drug.The uncontrollable state of an illness of various finally Western medicine develops gradually, causes the heart, brain, kidney some complication to occur, and oneself also is filled with despair.Taken " Hu Shi blood pressure lowering treasured " of the present invention medicinal tea from June, 2000, according to every day, sooner or later each was once, take after mixing it with water with 1500 milliliters of hot water, 30 days is a course of treatment, and after 3 courses of treatment, various syndromes also disappear thereupon, the people is as young ten years old once, recurrence is not seen in drug withdrawal now 5 years, does not see that other complication sign occurs yet.
Case 4
Hainan Province, Haikou City, Mr. Wang Zhenhua of 42 years old, be the manager of certain company, at life's full flowering just, cause has, he feel sometimes causeless headache, feeling of fullness in the head, dizziness, cardiopalmus go to the hospital check after, find oneself to have suffered from hypertension, blood pressure 110-170 millimetress of mercury at that time, have to must take with Western medicine control treatment everyday, make troubles to life, Ou Ran chance once, learn that there is " Hu Shi blood pressure lowering treasured " medicinal tea in my hospital,, bought a course of treatment by the mode of mailing, according to every day, each was once taken after mixing it with water with 1500 milliliters of hot water sooner or later.Treatment back blood pressure stabilization, all clinical manifestations have disappeared.Follow up a case by regular visits to not recurrence so far.
Case 5
The Nanchang City, Jiangxi Province, Mr. Zhang 56 years old, national government functionary.Suffered from hypertension 9 years, concurrent coronary heart disease, cerebral infarction, numb hand and foot, can only keep by Western medicine usually, must go to the hospital hospitalization once in two to three months, and the maintenance dose of Western medicine increase gradually, this disease is filled with despair he, take the treatment of " Hu Shi blood pressure lowering treasured " medicinal tea through friend's introduction, through the treatment of 3 courses of treatment, it is normal that blood pressure recovers fully.
Be explanation medication effect of the present invention, the present invention takes pharmaceutical composition of the present invention " Hu Shi blood pressure lowering treasured " medicinal tea by 100 patients of picked at random and organizes as treatment, other selects 100 people and takes NAOLIQING and organize in contrast, the comparison of antihypertensive effect and the triglyceride tg (mmol/L) and cholesterol Ch (the mmol/L) (X ± SD) comparison of variation of treatment front and back blood fat have been carried out, be 20 days two groups of courses of treatment, observe 5 months courses of treatment, clinical effectiveness is as follows:
The comparison of table 1, two groups of patient's antihypertensive effects
| Group | The example number | Cure | Significantly | Effectively | Invalid | Total effective rate |
| The treatment group | 100 people | 55 | 26 | 15 | 4 | 96％ |
| Matched group | 100 people | 38 | 25 | 11 | 26 | 74％ |
Blood Lipid before and after table 2, two groups of clinical patients are treated (X ± SD)
Annotate: relatively preceding with the treatment of this group: P＜0.01.
As can be seen from the table: the present invention has tangible antihypertensive effect after treating.
Embodiment 1
At first the weight portion according to pharmaceutical composition takes by weighing Ramulus Uncariae Cum Uncis 10 Ke, Herba Siegesbeckiaes 10 grams, Fructus Viticis 10 grams, Radix Salviae Miltiorrhizae 10 grams, Stigma Maydis 10 grams, Herba Apocyni veneti 10 grams, Fructus Corni 10 grams, Radix Stephaniae Tetrandrae 5 grams, Cacumen Platycladi 5 grams respectively, after the weighing earlier with Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae and Stigma Maydis respectively the medication hand hay cutter be twisted into the coarser powder of 20 mesh sieves, be that 20 mesh sieve coarser powder mix with little pulverizer mill respectively with remaining Chinese crude drug again, every packed 16 gram mixed-powders are encapsulated in the rectangular little paper bag of long 24cm, wide 16cm.
During use, every day, each was once taken after mixing it with water with 1500 milliliters of hot water sooner or later, and 30 days is a course of treatment.
Embodiment 2
At first the weight portion according to pharmaceutical composition takes by weighing Ramulus Uncariae Cum Uncis 15 Ke, Herba Siegesbeckiaes 15 grams, Fructus Viticis 15 grams, Radix Salviae Miltiorrhizae 15 grams, Stigma Maydis 15 grams, Herba Apocyni veneti 15 grams, Fructus Corni 15 grams, Radix Stephaniae Tetrandrae 7.5 grams, Cacumen Platycladi 7.5 grams respectively, after the weighing earlier with Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae and Stigma Maydis respectively the medication hand hay cutter be twisted into the coarser powder of 20 mesh sieves, be that 20 mesh sieve coarser powder mix with little pulverizer mill respectively with remaining Chinese crude drug again, every packed 16 gram mixed-powders are encapsulated in the rectangular small offence filter paper bag of long 24cm, wide 16cm.
During use, every day, each was once taken after mixing it with water with 1500 milliliters of hot water sooner or later, and 30 days is a course of treatment.
Embodiment 3
At first the weight portion according to pharmaceutical composition takes by weighing Ramulus Uncariae Cum Uncis 12.5 Ke, Herba Siegesbeckiaes 12.5 grams, Fructus Viticis 12.5 grams, Radix Salviae Miltiorrhizae 12.5 grams, Stigma Maydis 12.5 grams, Herba Apocyni veneti 12.5 grams, Fructus Corni 12.5 grams, Radix Stephaniae Tetrandrae 6.25 grams, Cacumen Platycladi 6.25 grams respectively, after the weighing earlier with Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae and Stigma Maydis respectively the medication hand hay cutter be twisted into the coarser powder of 20 mesh sieves, be that 20 mesh sieve coarser powder mix with little pulverizer mill respectively with remaining Chinese crude drug again, every packed 16 gram mixed-powders are encapsulated in the rectangular filtration paper bag of long 24cm, wide 16cm.
During use, every day, each was once taken after mixing it with water with 1500 milliliters of hot water sooner or later, and 30 days is a course of treatment.
Claims (3)
1, a kind of pharmaceutical composition for the treatment of hypertension is made up of Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae, Fructus Viticis, Radix Salviae Miltiorrhizae, Stigma Maydis, Herba Apocyni veneti, Fructus Corni, Radix Stephaniae Tetrandrae, Cacumen Platycladi, and according to listed as parts by weight, the drug component of this pharmaceutical composition is:
Ramulus Uncariae Cum Uncis 10～15, Herba Siegesbeckiaes 10～15, Fructus Viticis 10～15,
Radix Salviae Miltiorrhizae 10～15, Stigma Maydis 10～15, Herba Apocyni veneti 10～15,
Fructus Corni 10～15, Radix Stephaniae Tetrandrae 5～7.5, Cacumen Platycladi 5～7.5.
2, a kind of pharmaceutical composition for the treatment of hypertension according to claim 1 is characterized in that the weight portion proportioning of pharmaceutical composition is:
Ramulus Uncariae Cum Uncis 12.5, Herba Siegesbeckiaes 12.5, Fructus Viticis 12.5,
Radix Salviae Miltiorrhizae 12.5, Stigma Maydis 12.5, Herba Apocyni veneti 12.5,
Fructus Corni 12.5, Radix Stephaniae Tetrandrae 6.25, Cacumen Platycladi 6.25.
3, a kind of method for preparing pharmaceutical composition of the present invention:
1. weighing: each drug component carries out weighing according to weight portion;
2. pulverize: the medical material after the weighing, earlier Ramulus Uncariae Cum Uncis, Herba Siegesbeckiae and the stranding of Stigma Maydis difference medication hand hay cutter are coarser powder, it is standby to cross 20 mesh sieves, and remaining Chinese crude drug being ground with little pulverizer respectively is coarser powder again, crosses 20 mesh sieves, standby;
3. bag: get the rectangle filter paper of long 24cm, wide 16cm, make the little paper bag of a side opening, three side seals with plastic packaging machine;
4. pack: after each pharmaceutical composition corase meal that will grind mixes, be contained in the little paper bag every packed 16 gram mixed-powders, the encapsulation of reuse packer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610076770XA CN100482268C (en) | 2006-04-20 | 2006-04-20 | Medicinal composition for treating primary hypertension and preparing method of tea agent thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610076770XA CN100482268C (en) | 2006-04-20 | 2006-04-20 | Medicinal composition for treating primary hypertension and preparing method of tea agent thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN1861178A CN1861178A (en) | 2006-11-15 |
| CN100482268C true CN100482268C (en) | 2009-04-29 |
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| CNB200610076770XA Expired - Fee Related CN100482268C (en) | 2006-04-20 | 2006-04-20 | Medicinal composition for treating primary hypertension and preparing method of tea agent thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103055012A (en) * | 2012-11-15 | 2013-04-24 | 新乡医学院 | Traditional Chinese medicine for treating liver-yang hyperactivity syndrome headache caused by hypertensive disease and preparation method of traditional Chinese medicine |
| CN103920025A (en) * | 2014-05-05 | 2014-07-16 | 陈永奇 | Pharmaceutical composition for treating hypertension and application thereof |
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2006
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Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗高血压病进展. 史连和.内蒙古民族大学学报(自然科学版)，第18卷第3期. 2003 |
| 中医药治疗高血压病进展. 史连和.内蒙古民族大学学报(自然科学版)，第18卷第3期. 2003 * |
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