CN100482241C - Quickly-acting defervescence plaster used for infants and preparation method thereof - Google Patents
Quickly-acting defervescence plaster used for infants and preparation method thereof Download PDFInfo
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- CN100482241C CN100482241C CNB2006102004515A CN200610200451A CN100482241C CN 100482241 C CN100482241 C CN 100482241C CN B2006102004515 A CNB2006102004515 A CN B2006102004515A CN 200610200451 A CN200610200451 A CN 200610200451A CN 100482241 C CN100482241 C CN 100482241C
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Abstract
The invention provides a quick-effective plaster for treating children's fever, which is prepared from polyvinyl alcohol, carbomer940, acacia gum, gelatin, tetraborate decahydrate, benorylate, ethyl p-hydroxybenzoate, boneol, glycerin, ethanol and purified water.
Description
Technical field:
The present invention relates to a kind of children's antipyretic and paste and preparation method thereof, belong to the pharmaceutical technology field.
Background technology:
Human body is kept normal body temperature, is a very complex physical chemical process.Normal person's body temperature is under the adjusting of human brain cortex and hypothalamus thermotaxic centre, by effect neural, body fluid, makes heat production and heat radiation keep dynamic equilibrium, reaches constant relatively; Heat production is too much, or it is very few to dispel the heat, and all can make body temperature exceed normal range and cause heating.The reason that causes the human body organism fever also is many and complicated, no matter is bacterial infection heat pyrexia, the heating of aseptic tissue injury etc., can cause that all tissue metabolism strengthens, the dyspepsia, muscular soreness, headache even central nervous system function disorder, unconsciousness appears sometimes, stupor etc.Physical temperature-lowering and take the importance that antipyretic analgesic is anti symptom treatment.Existing cooling and antipyretic analgesic side effect are big, mostly are oral administration greatly, are not easy to children's and use.
Summary of the invention:
The objective of the invention is to: provide a kind of children's antipyretic to paste and preparation method thereof, the present invention is that the hydrophilic macromolecule gel that has a good heat translation function with carbomer etc. is a carrier, and middle pharmaceutically active ingredient and natural refrigerant aromatic are added the gel adhesive of wherein making.This substrate and skin have excellent hydrophilic, and heat radiator is rapid, the effective ingredient uni-directional diffusion, and Transdermal absorption is applicable to the auxiliary treatment that a variety of causes generates heat.Have cold compress physical therapy, Physical temperature-lowering refreshment and medicine antipyretic-antalgic dual function.
The present invention constitutes like this: it with polyvinyl alcohol 690～710g, Acritamer 940 90～110g, arabic gum 140～160g, gelatin 140～160g, disodium tetraborate 590～610g, benorylate 25～35g, ethylparaben 5～15g, Borneolum Syntheticum 2～10g, glycerol is an amount of, ethanol is an amount of and purified water 8000ml makes.
Specifically, it with polyvinyl alcohol 700g, Acritamer 940 100g, arabic gum 150g, gelatin 150g, disodium tetraborate 600g, benorylate 30g, ethylparaben 10g, Borneolum Syntheticum 6g, glycerol is an amount of, ethanol is an amount of and purified water 8000ml makes.
The preparation method that children's antipyretic pastes is: get polyvinyl alcohol, Acritamer 940, arabic gum, gelatin, add the 7500ml purified water, leave standstill to place to send out in 24 hours and rise softeningly, 80-90 ℃ of heating in water bath stirring and dissolving becomes even rubber cement, add 150 order benorylate fine powders, mix into even rubber cement; Add the solution that ethylparaben, Borneolum Syntheticum and ethanol are made again, it is standby to be mixed into mixed mortar; With 500ml purified water heating for dissolving disodium tetraborate, glycerol, standby as cross-linking agent; Crosslinked at normal temperatures with cross-linking agent that makes and above-mentioned mixed mortar, become crosslinked rubber cement; Be cold-pressed into for the first time the preforming film in advance with crosslinked rubber cement,
Compound white non-woven fabrics is sticked one piece of cloth or paper on top of another and is served as a contrast and PE plastics embossing protecting film, and cold moudling for the second time divides metering die-cut, packs, promptly.
The reason of heating is many and complicated.Physical temperature-lowering and take the importance that antipyretic analgesic is anti symptom treatment.Borneolum Syntheticum of the present invention, suffering, cold, clearing away heat to alleviate pain, and the have one's ideas straightened out merit of refreshment, wind-dispelling heat-dissipating of tool.The local cool and comfortable of external application.And Western medicine benorylate stable in properties, untoward reaction is rare, is one of common antipyretic analgesic, Transdermal absorption performance curative effect.Above Integrative Chinese-Western has heat-clearing and toxic substances removing, the merit of promoting blood circulation and stopping pain.Emergent physical coolings such as fever auxiliary treatment that be used to generate heat, reasons such as headache, summer-heat high temperature causes and preventing heatstroke, good effect.
Children's antipyretic pastes essential structure and is made up of backing layer, gel layer, polymer protective film three parts.Wherein, gel layer is its main part, be by hydrophilic high-molecular gel (the false gelinite of macromolecule) as support frame, the water that is cured, natural refrigerant aromatic and medicine are inlayed or are embedded in this skeleton.This preparation has the dual function of bringing down a fever: (1) Physical temperature-lowering: hydrophilic gel has the excellent energy translation function, by hydrone vaporization heat absorption, carries out the energy exchange distribute heat, brings down a fever the protection brain cell rapidly; (2) Drug therapy: gel layer makes medicine with which enter blood circulation through skin by the transdermal enhancing effect of hydration and Percutaneous absorption enhancer, reaches comprehensive, persistent effect.
Children's antipyretic pastes has cold compress physical therapy, the refrigerant analgesic effect of having one's ideas straightened out, lower the temperature, and is the result of cold compress physical therapy (Physical temperature-lowering refreshment) and medicine antipyretic-antalgic dual function.This preparation has the auxiliary treatment effect to following indication: 1. the hyperpyrexia auxiliary temperature-reducing that causes such as flu, summer-heat, motion, and bring down a fever and protect brain; 2. brain overwork, tired back refreshment; 3. emergent physical cooling such as burn; 4. be used for headache, toothache and muscular soreness, play the effect of auxiliary analgesic.
Compared with prior art, the present invention is defervescence plaster used has a following advantage: 1. false gelinite of hydrophilic and skin have excellent biological compatibility, can reach cold compress physical therapy, Physical temperature-lowering, effects such as alleviating pain rapidly.2. have Physical temperature-lowering and Drug therapy double effects, alleviate brain hyperpyrexia symptom rapidly, the harm of avoiding hyperpyrexia to bring for the human body brain.3. easily subsides are easily taken off, and paste after taking off again, and are convenient during subsides, painless seamless when taking off, and safe ready is all-ages.
In order to ensure the effect of preparation of the present invention, the applicant has carried out following experimental study:
One, Study on Preparation
The present invention adopts water retting technology, helps the leaching of ingredient and shortens dip time.Add mixed-forming in the high-molecular gel that incoming wave nurse 940 makes behind benorylate, Borneolum Syntheticum, Mentholum and glycerol, the dissolve with ethanol.Adopt this preparation technology, through secular evidence, medicine stability is good, adapts to industrialized great production, produces stable, quality controllable.
Two, preliminarily stabilised investigation
Since in November, 2003,, investigate according to three batches of preparations of the present invention that fixed preparation technology produces according to pilot-scale according to the index of intending the quality standard draft certainly and method, the result shows the present invention's steady quality under the room temperature natural conditions.
Three, pharmacological toxicology research
The acute toxicity test of rat skin single administration, rat skin administration subacute toxicity test, the test of rabbit single administration skin irritation, multiple dosing is to the irritation test of damaged skin, the guinea pig skin hypersensitive test, and the result all shows: children's antipyretic pastes when adopting percutaneous drug delivery approach, used dosage, the used course of treatment, toxicity is little, non-stimulated, non-sensitization, safety range is big.
The rat long term toxicity test: children's antipyretic pastes high dose (be equivalent to clinical Coming-of-Age Day consumption 200 times), middle dosage (be equivalent to clinical Coming-of-Age Day consumption 195 times), low dosage (be equivalent to clinical Coming-of-Age Day consumption 100 times) continuous 4 all skin administrations, the general situation of animal, body weight, appetite, hematological indices no abnormality seen; The above-mentioned observation in 2 weeks of drug withdrawal is no abnormality seen also.Administration group result of the test and vehicle group compare, difference that there are no significant.Long-term toxicity test for animals shows that when children's antipyretic pasted clinical employing percutaneous drug delivery approach, used dosage, the used course of treatment, toxicity was little, and safety range is big.In view of the above result of the test as can be seen the present invention do not have the toxicology meaning, thereby provide the drug safety foundation for clinical verification.
Four, pharmacodynamic study
1, anti-damage test: the result shows that children's antipyretic pastes and obviously improves soft tissue injury place healing score value, obviously alleviates the animal injury place and organizes blood stasis, edema and myofibrillar degeneration and necrosis.
2, analgesic test: mouse writhing method analgesic test, mice formaldehyde method analgesic test.Result of the test: obvious analgesic activity is all arranged.
3, antiinflammatory test: anti-mice ear swelling test, the swollen test of Chinese People's Anti-Japanese Military and Political College's Mus chondrus ocellatus Holmes colloidality foot, the swollen test of Chinese People's Anti-Japanese Military and Political College's Mus bud.Result of the test: children's antipyretic pastes all has the obvious suppression effect to inflammation.
4, anti-mouse peritoneal capillary permeability test: the result shows that children's antipyretic pastes the optical density that can reduce mouse peritoneal, and the mouse peritoneal capillary permeability is had tangible reduction effect.
Conclusion: children's antipyretic posts anti-damage, antiinflammatory, analgesic activity.Thereby, provide experimental basis for determining function of the present invention, curing mainly and the clinical application scope.
In a word, by to main result of study of the present invention, preparation of the present invention is safe in utilization, and determined curative effect is quality controllable, and each production link carries out in strict accordance with operation SOP, thereby has reached controlled, even, the stable purpose of process.
The specific embodiment:
Embodiments of the invention: polyvinyl alcohol 700g, Acritamer 940 100g, arabic gum 150g, gelatin 150g, disodium tetraborate 600g, benorylate 30g, ethylparaben 10g, Borneolum Syntheticum 6g, glycerol is an amount of, ethanol is an amount of, purified water 8000ml.
Get polyvinyl alcohol (PVA17-88), Acritamer 940, arabic gum, gelatin, add the 7500ml purified water, leave standstill to place to send out in 24 hours and rise softeningly, 80-90 ℃ of heating in water bath stirring and dissolving becomes even rubber cement, add 150 order benorylate fine powders, mix into even rubber cement; Add the solution that ethylparaben, Borneolum Syntheticum and ethanol are made again, it is standby to be mixed into mixed mortar; With 500ml purified water heating for dissolving disodium tetraborate, glycerol, standby as cross-linking agent; Crosslinked at normal temperatures with cross-linking agent that makes and above-mentioned mixed mortar, become crosslinked rubber cement; Be cold-pressed into for the first time the preforming film in advance with crosslinked rubber cement, compound white non-woven fabrics is sticked one piece of cloth or paper on top of another and is served as a contrast and PE plastics embossing protecting film, and cold moudling for the second time divides metering die-cut, packs, and makes 1000 subsides, promptly.
Claims (3)
- [claim 1] a kind of children's antipyretic pastes, and it is characterized in that: it with polyvinyl alcohol 690～710g, Acritamer 940 90～110g, arabic gum 140～160g, gelatin 140～160g, disodium tetraborate 590～610g, benorylate 25～35g, ethylparaben 5～15g, Borneolum Syntheticum 2～10g, glycerol is an amount of, ethanol is an amount of and purified water 8000ml makes.
- [claim 2] pastes according to the described children's antipyretic of claim 1, it is characterized in that: it with polyvinyl alcohol 700g, Acritamer 940 100g, arabic gum 150g, gelatin 150g, disodium tetraborate 600g, benorylate 30g, ethylparaben 10g, Borneolum Syntheticum 6g, glycerol is an amount of, ethanol is an amount of and purified water 8000ml makes.
- [claim 3] is the preparation method of children's antipyretic subsides as claimed in claim 1 or 2, it is characterized in that: get polyvinyl alcohol, Acritamer 940, arabic gum, gelatin, add the 7500ml purified water, leaving standstill 24 hours of placements rises softening, 80-90 ℃ of heating in water bath stirring and dissolving becomes even rubber cement, add 150 order benorylate fine powders, mix into even rubber cement; Add the solution that ethylparaben, Borneolum Syntheticum and ethanol are made again, it is standby to be mixed into mixed mortar; With 500ml purified water heating for dissolving disodium tetraborate, glycerol, standby as cross-linking agent; Crosslinked at normal temperatures with cross-linking agent that makes and above-mentioned mixed mortar, become crosslinked rubber cement; Be cold-pressed into for the first time the preforming film in advance with crosslinked rubber cement, compound white non-woven fabrics is sticked one piece of cloth or paper on top of another and is served as a contrast and PE plastics embossing protecting film, and cold moudling for the second time divides metering die-cut, packs, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006102004515A CN100482241C (en) | 2006-05-15 | 2006-05-15 | Quickly-acting defervescence plaster used for infants and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2006102004515A CN100482241C (en) | 2006-05-15 | 2006-05-15 | Quickly-acting defervescence plaster used for infants and preparation method thereof |
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| CN1879665A CN1879665A (en) | 2006-12-20 |
| CN100482241C true CN100482241C (en) | 2009-04-29 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879148B (en) * | 2010-06-25 | 2012-07-18 | 东华大学 | Method for preparing bacterial cellulose hydrogel temperature-reducing plaster and product thereof |
| CN103316315B (en) * | 2013-06-20 | 2014-12-31 | 朱坤福 | Cooling paste |
| CN104784653A (en) * | 2014-01-17 | 2015-07-22 | 佛山市盛世泰康医药科技有限公司 | Defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce, and preparation method thereof |
| CN103877168A (en) * | 2014-02-26 | 2014-06-25 | 高雄英 | Health-care fever cooling patch |
| CN103893271A (en) * | 2014-02-26 | 2014-07-02 | 高雄英 | Child fever cooling patch |
| CN103784247A (en) * | 2014-03-05 | 2014-05-14 | 绍兴康宸医疗器械有限公司 | Cold therapy gel |
| CN105213087A (en) * | 2015-09-24 | 2016-01-06 | 江门市新时代外用制剂有限公司 | One is defervescence plaster used and preparation method thereof |
| GB2568920A (en) * | 2017-11-30 | 2019-06-05 | Jenarron Therapeutics Ltd | Stable wound care formulation |
| CN110393622A (en) * | 2019-08-12 | 2019-11-01 | 天津捷热消健康科技有限公司 | A kind of production method of medical anvil of bringing down a fever and anvil of bringing down a fever |
| CN111616856A (en) * | 2020-07-15 | 2020-09-04 | 重庆美莱整形美容医院有限公司 | Multi-effect cold compress plaster |
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2006
- 2006-05-15 CN CNB2006102004515A patent/CN100482241C/en active Active
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| 中药巴布剂研究现状分析及展望. 刘淑芝.中医外治杂志，第14卷第5期. 2005 |
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| CN1879665A (en) | 2006-12-20 |
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Address after: 6 floor, No. 85 Zhonghua Road, Guiyang, Guizhou 550001, China Patentee after: Guizhou Baiqiang Pharmaceutical Co., Ltd. Address before: 6 floor, No. 85 Zhonghua Road, Guiyang, Guizhou 550001, China Patentee before: Guizhou Baiqiang Pharmaceutical Co., Ltd. |
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Address after: 550001, East 9, Longgang International Center, 117 Zhonghua Road, Guiyang, Guizhou Patentee after: Guizhou Baiqiang Pharmaceutical Co., Ltd. Address before: 6 floor, No. 85 Zhonghua Road, Guiyang, Guizhou 550001, China Patentee before: Guizhou Baiqiang Pharmaceutical Co., Ltd. |