CN100457113C - Preparation method of bacteriostatic agent sulfadiazine cerium - Google Patents
Preparation method of bacteriostatic agent sulfadiazine cerium Download PDFInfo
- Publication number
- CN100457113C CN100457113C CNB2005101073458A CN200510107345A CN100457113C CN 100457113 C CN100457113 C CN 100457113C CN B2005101073458 A CNB2005101073458 A CN B2005101073458A CN 200510107345 A CN200510107345 A CN 200510107345A CN 100457113 C CN100457113 C CN 100457113C
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- Prior art keywords
- sulfadiazine
- cerium
- preparation
- deionized water
- bacteriostatic agent
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Abstract
A process for preparing the sulfapyrimidine cerium used as bacterial depressant for promoting the healing of wound and preventing residual scar is prepared through dissolving sodium hydroxide in deionized water, adding sulfapyrimidine to obtain solution A, dissolving cerium nitrate in deionized water to obtain solution B, dripping the solution B in A, reaction to generate the deposit of sulfapyrimidine cerium, washing, drying in the air, pulverizing and sieving.
Description
Technical field
The present invention relates to contain the pharmaceutical product of organic active ingredient, particularly a kind of preparation method that has convergence and promote the bacteriostatic agent sulfadiazine cerium of wound healing, inhibition scar hyperplasia.
Background technology
Cerium ion has control infection and promotion wound healing and suppresses the effect of scar hyperplasia, be again the necessary trace element of body, it all has absorption, metabolism, division and the breeding etc. of effect, ribozyme and proteic synthetic, immunologic process, cell that effect is all arranged to the active function of a lot of enzymes and nucleic acid breeding etc.Cerium ion toxicity is low also to be compensated the interior cerium loss of body and keep the cerium balance, thereby the enhancing body opposing is infected and the ability of wound healing.Be not society's application but also there is sulfadiazine cerium to come out in the present sulfonamides antibacterial.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method that has convergence and promote the bacteriostatic agent sulfadiazine cerium of wound healing, inhibition scar hyperplasia.
Technical scheme of the present invention is finished as follows, a kind of preparation method of bacteriostatic agent sulfadiazine cerium, it is characterized in that: 1. preparation technology for dissolving by weight 0.015 part of sodium hydroxide is joined in 0.893 part the deionized water, adds 0.092 part sulfadiazine after the dissolving again and dissolve and make a sulfadiazine sodium water solution; 2. be to be mixed with the cerous nitrate aqueous solution at 1: 9 by weight with cerous nitrate and deionized water, 3. the cerous nitrate aqueous solution is splashed in the sulfadiazine sodium water solution, the precipitate that reaction generates is the wet product of sulfadiazine cerium, 4. the wet product of sulfadiazine cerium that reaction is generated are cleaned, air-dry under 75 ℃ of conditions, pulverized the 100-200 mesh sieve then, packing is finished product.
Sulfadiazine cerium of the present invention, effective component content be more than 96%, has stronger convergence and promote wound healing, suppress the effect of scar hyperplasia, can be used for the prevention of skin surface hypertrophic cicatrix after various burns, wound and the various operation.
The specific embodiment
The present invention has following embodiment:
Remove ionized water 2430 grams and pour in one 5000 liters the container, add 40 gram sodium hydroxide, take by weighing 250 gram sulfadiazines after the dissolving again and pour in the container, sulfadiazine is thoroughly dissolved, the concentration that obtains 2720 grams is 10% sulfadiazine aqueous solution; Pour in the container of 3000 liters of capacity with 990 gram deionized waters then, take by weighing 110 gram cerous nitrates adding containers then it is dissolved fully, obtain 1100 gram cerous nitrate aqueous solutions; Then the cerous nitrate aqueous solution is splashed in the sulfadiazine aqueous solution and react, generating the off-white color precipitate in the reaction is exactly the wet product of sulfadiazine cerium; Clean the wet product of sulfadiazine cerium at last, be placed in the dish under 75 ℃ of conditions hot air drying about 4 hours, pulverized the 100-200 mesh sieve with becoming yellowish sulfadiazine cerium after the drying, package spare.With above-mentioned raw materials sulfadiazine (pharmaceutical grade) 660 grams, cerous nitrate 360 grams and proper amount of deionized water and sodium hydroxide, can produce 500-800 gram sulfadiazine cerium.The scope of restraining fungi of this product is gram positive bacteria and gram negative bacteria, using method be direct spreading in wound surface, or make 2% cream and use, a consumption per day is no more than 30 grams, but the sulfonamides allergy sufferers is forbidden.
Claims (1)
1, a kind of preparation method of bacteriostatic agent sulfadiazine cerium, it is characterized in that: 1. preparation technology for dissolving by weight 0.015 part of sodium hydroxide is joined in 0.893 part the deionized water, adds 0.092 part sulfadiazine after the dissolving again and dissolve and make a sulfadiazine sodium water solution; 2. be to be mixed with the cerous nitrate aqueous solution at 1: 9 by weight with cerous nitrate and deionized water, 3. the cerous nitrate aqueous solution is splashed in the sulfadiazine sodium water solution, the precipitate that reaction generates is the wet product of sulfadiazine cerium, 4. the wet product of sulfadiazine cerium that reaction is generated are cleaned, air-dry under 75 ℃ of conditions, pulverized the 100-200 mesh sieve then, packing is finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101073458A CN100457113C (en) | 2005-12-23 | 2005-12-23 | Preparation method of bacteriostatic agent sulfadiazine cerium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101073458A CN100457113C (en) | 2005-12-23 | 2005-12-23 | Preparation method of bacteriostatic agent sulfadiazine cerium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1823790A CN1823790A (en) | 2006-08-30 |
| CN100457113C true CN100457113C (en) | 2009-02-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005101073458A Expired - Fee Related CN100457113C (en) | 2005-12-23 | 2005-12-23 | Preparation method of bacteriostatic agent sulfadiazine cerium |
Country Status (1)
| Country | Link |
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| CN (1) | CN100457113C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107041503A (en) * | 2017-03-13 | 2017-08-15 | 天津科技大学 | A kind of alliin catabolite bacteriostatic agent and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203229A (en) * | 1998-05-29 | 1998-12-30 | 郑州铁路局武汉中心医院 | Sulfadiazine copper and its preparing process and medicine thereof |
-
2005
- 2005-12-23 CN CNB2005101073458A patent/CN100457113C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203229A (en) * | 1998-05-29 | 1998-12-30 | 郑州铁路局武汉中心医院 | Sulfadiazine copper and its preparing process and medicine thereof |
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| Publication number | Publication date |
|---|---|
| CN1823790A (en) | 2006-08-30 |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090204 Termination date: 20181223 |
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| CF01 | Termination of patent right due to non-payment of annual fee |