CN100431819C - 多井孔板的制造 - Google Patents
多井孔板的制造 Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/16—Making multilayered or multicoloured articles
- B29C45/1635—Making multilayered or multicoloured articles using displaceable mould parts, e.g. retractable partition between adjacent mould cavities
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
- B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
- B29C45/561—Injection-compression moulding
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
- B29C45/14336—Coating a portion of the article, e.g. the edge of the article
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- Health & Medical Sciences (AREA)
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Abstract
提供了一种形成多井孔板的方法,所述方法包括:形成一多井孔板本体,所述多井孔板本体具有一个延伸通过它的井孔阵列;以及对所述多井孔板本体注入—压缩一镜片,使其熔合于所述多井孔板本体,所述镜片覆盖至少一部分所述井孔。
Description
技术领域
本发明涉及形成多井孔板的技术,更具体地说是涉及多井孔板的模制。
背景技术
多井孔板在现有技术中是公知的,用于生物测定。在井孔的底部设置一透明镜片,以允许研究人员用光基分析技术来研究井孔内的物质(诸如组织培养),这在现有技术中也是公知的。
现在已开发出各种不同的技术,用以形成具有透明镜片的多井孔板。在一种技术中,多井孔板的本体(通常由不透明材料制成,以尽量减小反射比)与透明镜片分开形成,再将透明镜片粘接于本体。通常,这两个构件是注塑成形的。关于第二种技术,先注塑成形多井孔板的本体,但并不将其从模具中脱出。之后,将一薄膜放置于模具中,在该薄膜上模制有一透明塑料层而形成镜片部分。
然而,现有的技术存在若干不足。通常,在镜片上进行模制的工艺会造成镜片表面变形。另外,井孔与井孔之间的镜片平面度不一致,从而导致光的传输不均匀,并使所形成的焦平面在井孔阵列上(或在一单个井孔内)不一致,造成要求恒定焦距的测量工作变得较为困难。
发明内容
本发明提供一种利用注入-压缩工艺来形成具有透明镜片的多井孔板的方法。具体地说,该方法包括:形成一多井孔板本体,所述多井孔板本体具有一个延伸通过它的井孔阵列;以及对所述多井孔板本体注入-压缩一镜片,使其熔合于所述多井孔板本体,所述镜片覆盖至少一部分所述井孔。
多井孔板可以由不同的材料形成:例如,用于多井孔板本体的有色聚合物,以及用于透明镜片的、属于相同聚合物族的透明聚合物。或者,可以使用具有不同颜色的相同材料,诸如用有色的聚苯乙烯来形成多井孔板本体,用透明的聚苯乙烯来形成镜片。在选择材料时,必须考虑透明镜片和多井孔板本体的适当粘附性。
业已发现,与现有技术相比,该技术可以更为均匀地形成透明镜片,从而使光学记录中的光损失较少,并改善成像。而且,还发现该透明镜片中的模塑应力的大小要比用现有技术所得到的镜片低,从而有较好的光学特性。此外,利用注入-压缩,可以改善透明镜片的物理特性(例如挠曲模量),并可以获得更高的材料致密度。
参阅以下的详细描述和附图,可以更好地理解本发明的上述和其它特点。
附图说明
图1是一多井孔板的立体图;
图2是一多井孔板的局部剖视图。
图3是表示在第一模腔中形成多井孔板本体的示意图;
图4是表示调节模具元件以限定第二模腔的示意图;
图5是表示在第二模腔中设置一团熔融材料的示意图;
图6是表示模腔中的多井孔板的示意图。
具体实施方式
参见图1,图中示出一通常的多井孔板10,它具有一多井孔板本体12,通过该本体形成有一井孔14的阵列。将多井孔板用于生物测定,这在现有技术中是众所周知的,该多井孔板10形成为其结构和尺寸与此类生物测定技术相适应。另外,现有技术中已认可了一定的井孔14阵列,包括96井孔的阵列、384井孔(如图1所示)的阵列和1536井孔的阵列。除了传统数量的井孔之外,还可以使用任何数量、任何阵列结构的井孔。
参见图2,多井孔板本体12最好由一热塑材料一体地形成,它包括一侧壁16和呈网格状的内壁18,这些内壁形成井孔14。内壁18最好呈锥形,从内壁18的上端20朝内壁的下端22扩张。因此,每个井孔14都呈向下收缩状。
一透明镜片24固定于内壁18的下部22,从而至少部分地覆盖井孔14,并封住其底部。最好,镜片24覆盖并封住所有的井孔14,使各井孔14之间不会发生相互混合。透明镜片24大体是平面的,具有相对的、基本平行的平表面26。如图2所示,最好,透明镜片24的所有部分都在内壁18以下,没有延伸入任何井孔14中的部分。而且,透明镜片24的厚度T最好在0.004英寸-0.015英寸的范围内。利用这种相对较小的厚度,以及透明镜片24优良的平面度,本发明可以实现非常合适的光学特性。
利用本发明,采用注入-压缩法将透明镜片24熔合于多井孔板本体12。因此,多井孔板本体12和透明镜片24的材料必须具有合适的粘附性。这两个构件可以使用相同的材料,诸如用有色聚苯乙烯形成多井孔板本体12,用透明聚苯乙烯形成透明镜片24。多井孔板本体12最好形成不透明的,以在任何光学测试中控制光照条件。
参见图3-6,图中示出一种形成多井孔板的方法。第一步,将模具元件28A、28B、28C布置成限定一第一模腔30,用于形成多井孔板本体12。虽然这里谈到的以及图中示出的是三个模具元件28A-28C,但本技术领域的技术人员知道,可以使用任何数量的模具元件,而同样符合本文所述的原理。采用公知的技术,最好是注塑法,在第一模腔30中形成多井孔板本体12。
图4-6示出了本发明的注入-压缩技术。参见图4,一旦多井孔板本体12形成,调节模具元件28A-28C,以相邻于内壁18的下部22形成一第二模腔32。例如,使模具元件28A和28B固定,并如图4中的箭头所示缩回模具元件28C。第二模腔32的容积应大于透明镜片24的容积。
而后,如图5所示,将一团熔融材料34注入第二模腔32。为帮助正确地注入材料团34,在注入之前和/或之时可对第二模腔32施加真空。材料团34构成用以形成透明镜片24的构成材料。在注入材料团34之后和/或之时,调节模具元件28A-28C,以减小第二模腔32的容积,使材料团34压缩。例如,可以使模具元件28C如图5中的箭头所示向前移动。如图6所示,第二模腔32容积的减小与作用于材料团34的压缩力一起,使材料团34填满容积减小的第二模腔32,从而形成透明镜片24。同时,透明镜片24熔合于内壁18的下部22。一旦充分冷却,便可将该组件从模具元件28A-28C中脱出。
如上所述,在透明镜片24的注入-压缩之前,最好不要将多井孔板本体12从模具元件28A-28C中脱出。较为有利的是,可在同一台模塑机中形成多井孔板本体12和透明镜片24。或者,这两个构件可以在分开的机器中形成,将一成形的多井孔板本体12放置于一适于进行透明镜片24的注入-压缩的设备中。
利用该注入-压缩技术,透明镜片24中的模塑应力大小低于现有技术,从而获得更佳的光学性能。而且,利用该注入-压缩工艺,可改善透明镜片24的物理特性(例如挠曲模量),并可获得较高的材料致密度。
本发明可以有各种不同的变化和改进,所有这些变化和改进应落在如所附权利要求书所限定的本发明范围之内。
Claims (14)
1.一种形成多井孔板的方法,所述方法包括:
形成一多井孔板本体,所述多井孔板本体具有一个延伸通过它的井孔阵列;以及
对所述多井孔板本体注入-压缩一镜片,使其熔合于所述多井孔板本体,所述镜片覆盖至少一部分所述井孔。
2.如权利要求1所述的方法,其特征在于,在一机器的第一模腔中进行所述的多井孔板本体的形成,并在所述机器的第二模腔中进行所述的镜片的注入-压缩。
3.如权利要求2所述的方法,其特征在于,在所述注入-压缩之前不将所述多井孔板本体从所述第一模腔中脱出。
4.如权利要求1所述的方法,其特征在于,形成所述多井孔板本体的材料包括聚合材料。
5.如权利要求4所述的方法,其特征在于,形成所述多井孔板本体的材料包括聚苯乙烯。
6.如权利要求1所述的方法,其特征在于,形成所述镜片的材料包括聚苯乙烯。
7.如权利要求1所述的方法,其特征在于,形成所述镜片的材料包括聚烯烃。
8.如权利要求1所述的方法,其特征在于,形成所述多井孔板本体的材料包括聚烯烃。
9.如权利要求1所述的方法,其特征在于,所述的多井孔板本体的形成包括模塑所述多井孔板本体。
10.如权利要求1所述的方法,其特征在于,所述多井孔板本体是不透明的。
11.如权利要求1所述的方法,其特征在于:
所述的多井孔板本体的形成包括布置多个模具元件而形成第一模腔,在所述第一模腔中形成所述多井孔板本体;并且
所述的镜片的注入-压缩包括:调节所述模具元件中的至少一个,以相邻于所述多井孔板本体而限定第二模腔;将一团熔融材料注入所述第二模腔;以及调节所述模具元件中的至少一个而减小所述第二模腔的容积和压缩所述熔融材料团。
12.如权利要求1所述的方法,其特征在于,所述镜片是透明的。
13.如权利要求11所述的方法,其特征在于,所述多井孔板本体是不透明的。
14.如权利要求11所述的方法,其特征在于,还包括在注入所述熔融材料团之前和/或之时对所述第二模腔施加一真空。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/107,826 US20030183958A1 (en) | 2002-03-28 | 2002-03-28 | Multi-well plate fabrication |
US10/107,826 | 2002-03-28 |
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CN1448258A CN1448258A (zh) | 2003-10-15 |
CN100431819C true CN100431819C (zh) | 2008-11-12 |
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US (1) | US20030183958A1 (zh) |
EP (1) | EP1348533B1 (zh) |
JP (1) | JP4398164B2 (zh) |
CN (1) | CN100431819C (zh) |
AU (1) | AU2003201949B2 (zh) |
CA (1) | CA2396449C (zh) |
DE (1) | DE60215762T2 (zh) |
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- 2002-07-17 DE DE60215762T patent/DE60215762T2/de not_active Expired - Lifetime
- 2002-07-17 EP EP02015910A patent/EP1348533B1/en not_active Expired - Lifetime
- 2002-07-29 CA CA2396449A patent/CA2396449C/en not_active Expired - Fee Related
- 2002-10-25 CN CNB021469342A patent/CN100431819C/zh not_active Expired - Fee Related
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2003
- 2003-02-21 JP JP2003044974A patent/JP4398164B2/ja not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
EP1348533A2 (en) | 2003-10-01 |
EP1348533A3 (en) | 2004-06-02 |
JP2003291172A (ja) | 2003-10-14 |
EP1348533B1 (en) | 2006-11-02 |
CA2396449A1 (en) | 2003-09-28 |
AU2003201949B2 (en) | 2008-10-02 |
DE60215762D1 (de) | 2006-12-14 |
CA2396449C (en) | 2012-03-20 |
DE60215762T2 (de) | 2007-09-06 |
AU2003201949A1 (en) | 2003-10-16 |
JP4398164B2 (ja) | 2010-01-13 |
US20030183958A1 (en) | 2003-10-02 |
CN1448258A (zh) | 2003-10-15 |
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