GB2348622A - Moulded filter plates - Google Patents

Moulded filter plates Download PDF

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Publication number
GB2348622A
GB2348622A GB9906027A GB9906027A GB2348622A GB 2348622 A GB2348622 A GB 2348622A GB 9906027 A GB9906027 A GB 9906027A GB 9906027 A GB9906027 A GB 9906027A GB 2348622 A GB2348622 A GB 2348622A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
plate
filter
material
moulding
method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9906027A
Other versions
GB9906027D0 (en )
Inventor
Anthony Saunders
Mark Reid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
* MINERVA TECHNOLOGIES
MINERVA TECHNOLOGIES
Original Assignee
Minerva Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255Multi-well filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/14Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
    • B29C45/14336Coating a portion of the article, e.g. the edge of the article
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/14Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
    • B29C45/14336Coating a portion of the article, e.g. the edge of the article
    • B29C2045/14442Coating a portion of the article, e.g. the edge of the article injecting a grill or grid on the insert
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/14Filters

Abstract

The invention relates to a multiwell plate 1 where the base of each well 2 consists of a filter material 6 which is fixed to the plate by means of an insert moulding process. Another plate 7 is bonded to the filter material 6 and the plate 1 to provide exit tubes 8 below the filter and in line with each well.

Description

FILTER PLATES Summary of Invention This invention relates to a multiwell plate where the base of each well consists of a filter material which is fixed to the plate by means of an insert moulding process.

Background Multiwell plates have been used for many years in clinical and other laboratories for simultaneous analysis of a number of samples. Typical formats include 4,24,48,96 and 384 wells per plate. Initially, these plates had solid bases integrally moulded and liquid samples were pipetted into and out of the wells.

Plates with bases made from microporous membranes or other filter materials were developed in the 1980's. These'filter plates'gave a number of advantages over the solid bottomed versions. a) The through flow nature of use meant larger sample volumes could be processed since the sample size was not limited to the capacity of the well. b) Assays involving the use of reactive chemistry, such as immunoassays, became significantly more sensitive with the use of membranes. This is because the membranes have a much greater surface area in which to attach the reactant and the flow across the whole area increases the chance of an analyte seeing the reactant compared to when it is bound to the relatively low surface area of a solid bottomed plate. c) The filter also enables solid particulate to be separated out of a liquid as it passes through the well plate.

The methods previously used to attach the microporous materials to the base of the plate include ultrasonic welding, thermal fusion and mechanical clamping. These processes are carried out as a secondary operation to the injection moulding of the plate itself.

The Invention The invention we describe is a filter bottom plate whereby the filter is attached to the plate by means of moulding the plate over the pre-placed filter as an integral part of the injection moulding process (this process is known, generically, as'insert moulding').

This eliminates the need for a separate process to attach the filter to the base of the plate, thus saving production time and double handling of materials. The new one-stage process also means that the finished product is produced at the first stage of processing, thus also eliminating the need for separate storage of moulded plates and filter materials prior to the bonding step. A further advantage of this insert moulding system is that it enables a fully automatic system to be used, when appropriate, whereby a continuous roll of the filter material is fed directly to the moulding machine and is cut to size and bonded to the plate as part of the process.

In a preferred embodiment, a sheet of filter material is cut which is large enough to cover all the wells of the plate at the bottom.

This sheet is placed in the mould tool and is retained until the mould closes around the sheet and it is then held firmly in place as molten plastic is injected into the mould and flows over it. The molten plastic then fuses into the filter material and bonds to it as it solidifies. Thus is produced a formed plastic plate which incorporates a plurality of wells whose bases are made of the filter material.

The plastic used for the plate can be polystyrene or polypropylene or a range of other thermoplastic materials. The filter material is typically a nylon or a nitro-cellulose membrane filter or a fibrous matt material of polypropylene or polyester but can also be another porous sheet material.

In another version, the insert moulded plate and filter described above is further bonded to a secondary plate under the filter material. This secondary plate incorporates conical or tubular spouts which direct the flow of liquid exiting from the base of the multiwell plate. This secondary plate is bonded to the primary plate by means of insert moulding or by other suitable means such as ultrasonic welding.

Reference is now made to the accompanying drawings: Figure 1 is a partial section through a typical multiwell plate.

The plate 1 consists of a number of wells 2 which are enclosed by walls 3. The plate has a top surface 4 and the bottom surface of the walls of the wells is 5. The filter sheet material 6 is bonded to the bottom surface of the well walls and, in the second version, another plate 7 is further bonded to the filter material and the primary plate to provide exit tubes 8 below the filter and in line with each well.

Claims (5)

  1. CLAIMS 1. A method of manufacture of a filter bottomed plate whereby the filter is attached to the plate by means of moulding the plate over a pre-placed filter as an integral part of the injection moulding process.
    2. A method as in Claim 1 where the injection moulding process uses a plastics material.
    3. A method as in Claim 1 or 2 where the plastics material is polystyrene, polypropylene or another thermoplastic material 4. A method as in Claim 1 where the filter is nylon or nitrocellulose or other polymeric membrane filter material.
    <RTI>5.</RTI> A method as in Claim 1 where the filter is a fibrous mat material such as polypropylene or polyester or another porous sheet material.
    6. A method as described in Claims 1-5 where additionally a further plate is bonded to the insert moulded plate and filter construction to provide an exit structure.
    7. A method as described in Claim 6 where bonding is by insert moulding or ultrasonic welding.
    Amendments to the claims have been filed as follows CLAIMS 1. A one step method of manufacture of a multiwell filter bottomed plate by injection moulding whereby the filter is bonded to the plate by means of moulding the plate over a pre-placed filter as an integral part of the injection moulding process.
  2. 2. A method as in Claim 1 where the injection moulding process uses a plastics material.
  3. 3. A method as in Claim <RTI>1</RTI> or 2 where the plastics material is polystyrene, polypropylene or another thermoplastic material
  4. 4. A method as in Claim <RTI>1</RTI> where the filter is nylon or nitro-cellulose or other polymeric membrane filter material.
  5. 5. A method as in Claim 1 where the filter is a fibrous mat material such as polypropylene or polyester or another porous sheet material.
GB9906027A 1999-03-16 1999-03-16 Filter plate Withdrawn GB9906027D0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9906027A GB9906027D0 (en) 1999-03-16 1999-03-16 Filter plate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9906027A GB9906027D0 (en) 1999-03-16 1999-03-16 Filter plate

Publications (2)

Publication Number Publication Date
GB9906027D0 GB9906027D0 (en) 1999-05-12
GB2348622A true true GB2348622A (en) 2000-10-11

Family

ID=10849716

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9906027A Withdrawn GB9906027D0 (en) 1999-03-16 1999-03-16 Filter plate

Country Status (1)

Country Link
GB (1) GB9906027D0 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008100A1 (en) * 2001-07-17 2003-01-30 Vivascience Ag Device for simultaneous processing of discrete quantities of flowable material
EP1348533A2 (en) * 2002-03-28 2003-10-01 Becton Dickinson and Company Multi-well plate fabrication
US6742659B2 (en) * 2000-05-18 2004-06-01 Millipore Corporation Multiple well plate with adhesive bonded filter
GB2411367A (en) * 2004-02-17 2005-08-31 Nationwide Filter Company Insert moulded frame for filter element
DE102004026240B4 (en) * 2004-05-25 2007-10-04 Eppendorf Ag Microtiter plate and method for manufacturing of a microtiter plate
EP2842714A3 (en) * 2013-08-16 2015-05-06 Oxyphen AG Pressure equalising element

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007606A1 (en) * 1985-06-18 1986-12-31 Genemed Technology, Inc. Multiwell test plate
EP0448876A2 (en) * 1990-03-29 1991-10-02 Minnesota Mining And Manufacturing Company Filter cartridge
EP0508645A2 (en) * 1991-03-27 1992-10-14 Pall Corporation Filters and filter units
WO1994008716A1 (en) * 1992-10-09 1994-04-28 Baxter Diagnostics Inc. Assay cartridge
JPH07214593A (en) * 1994-02-07 1995-08-15 Toyoda Gosei Co Ltd Forming of insert molding
US5474742A (en) * 1992-06-10 1995-12-12 Labsystems Oy Apparatus for removing solid bodies from an array of reaction vessels
WO1999020450A1 (en) * 1997-10-17 1999-04-29 Minnesota Mining And Manufacturing Company Injection mold for insert-molding a synthetic material around a filter material, filter for the filtration of fluids and method for producing such filter

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007606A1 (en) * 1985-06-18 1986-12-31 Genemed Technology, Inc. Multiwell test plate
EP0448876A2 (en) * 1990-03-29 1991-10-02 Minnesota Mining And Manufacturing Company Filter cartridge
EP0508645A2 (en) * 1991-03-27 1992-10-14 Pall Corporation Filters and filter units
US5474742A (en) * 1992-06-10 1995-12-12 Labsystems Oy Apparatus for removing solid bodies from an array of reaction vessels
WO1994008716A1 (en) * 1992-10-09 1994-04-28 Baxter Diagnostics Inc. Assay cartridge
JPH07214593A (en) * 1994-02-07 1995-08-15 Toyoda Gosei Co Ltd Forming of insert molding
WO1999020450A1 (en) * 1997-10-17 1999-04-29 Minnesota Mining And Manufacturing Company Injection mold for insert-molding a synthetic material around a filter material, filter for the filtration of fluids and method for producing such filter

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6742659B2 (en) * 2000-05-18 2004-06-01 Millipore Corporation Multiple well plate with adhesive bonded filter
WO2003008100A1 (en) * 2001-07-17 2003-01-30 Vivascience Ag Device for simultaneous processing of discrete quantities of flowable material
EP1348533A2 (en) * 2002-03-28 2003-10-01 Becton Dickinson and Company Multi-well plate fabrication
EP1348533A3 (en) * 2002-03-28 2004-06-02 Becton Dickinson and Company Multi-well plate fabrication
CN100431819C (en) 2002-03-28 2008-11-12 贝克顿迪肯森公司 Multi-well plate fabrication
GB2411367A (en) * 2004-02-17 2005-08-31 Nationwide Filter Company Insert moulded frame for filter element
GB2411367B (en) * 2004-02-17 2008-06-04 Nationwide Filter Company Filter unit
US8696783B2 (en) 2004-02-17 2014-04-15 Nationwide Filter Company (Specialist Products) Limited Filter unit
DE102004026240B4 (en) * 2004-05-25 2007-10-04 Eppendorf Ag Microtiter plate and method for manufacturing of a microtiter plate
EP2842714A3 (en) * 2013-08-16 2015-05-06 Oxyphen AG Pressure equalising element

Also Published As

Publication number Publication date Type
GB9906027D0 (en) 1999-05-12 grant

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Legal Events

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)