CN100415746C - 氨基吡啶衍生物作为可诱导的no-合酶抑制剂 - Google Patents

氨基吡啶衍生物作为可诱导的no-合酶抑制剂 Download PDF

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Publication number
CN100415746C
CN100415746C CNB2004800278079A CN200480027807A CN100415746C CN 100415746 C CN100415746 C CN 100415746C CN B2004800278079 A CNB2004800278079 A CN B2004800278079A CN 200480027807 A CN200480027807 A CN 200480027807A CN 100415746 C CN100415746 C CN 100415746C
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China
Prior art keywords
phenyl
imidazo
pyridin
methyl
alkyl
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Expired - Fee Related
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CNB2004800278079A
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English (en)
Chinese (zh)
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CN1856493A (zh
Inventor
R·贝尔
D·马克斯
W·-R·乌尔里希
M·埃尔策
R·纳夫
A·施特鲁布
U·格雷德勒
T·福赫斯
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Takeda GmbH
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Altana Pharma AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB2004800278079A 2003-10-01 2004-09-30 氨基吡啶衍生物作为可诱导的no-合酶抑制剂 Expired - Fee Related CN100415746C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022040 2003-10-01
EP03022040.4 2003-10-01

Publications (2)

Publication Number Publication Date
CN1856493A CN1856493A (zh) 2006-11-01
CN100415746C true CN100415746C (zh) 2008-09-03

Family

ID=34707254

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800278079A Expired - Fee Related CN100415746C (zh) 2003-10-01 2004-09-30 氨基吡啶衍生物作为可诱导的no-合酶抑制剂

Country Status (16)

Country Link
US (3) US7317021B2 (https=)
EP (1) EP1670798A1 (https=)
JP (1) JP2007507464A (https=)
KR (1) KR20060092219A (https=)
CN (1) CN100415746C (https=)
AU (1) AU2004303515A1 (https=)
BR (1) BRPI0415034A (https=)
CA (1) CA2540230A1 (https=)
EA (1) EA200600601A1 (https=)
IL (1) IL173628A0 (https=)
MX (1) MXPA06003345A (https=)
NO (1) NO20061789L (https=)
NZ (1) NZ546394A (https=)
RS (1) RS20060206A (https=)
WO (1) WO2005061496A1 (https=)
ZA (1) ZA200601140B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200600607A1 (ru) 2003-10-01 2006-10-27 Алтана Фарма Аг Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
BRPI0414972A (pt) 2003-10-01 2006-11-07 Altana Pharma Ag derivados de imidazopiridinas como inibidores de no-sintase induzìvel
DE602004014523D1 (de) 2003-10-01 2008-07-31 Nycomed Gmbh Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
EP1866306B1 (en) 2005-03-31 2009-06-17 Nycomed GmbH Imidazopyridine derivatives useful as inos inhibitors
WO2009005638A2 (en) * 2007-06-27 2009-01-08 Merck & Co., Inc. Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
US20100278751A1 (en) * 2009-04-30 2010-11-04 Washington University Radiolabeled 2-amino-4-alkyl-6-(haloalkyl)pyridine compounds and their use in diagnostic imaging
NZ603789A (en) * 2010-05-26 2015-03-27 Sunovion Pharmaceuticals Inc Heteroaryl compounds and methods of use thereof
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds
CN117215117A (zh) 2017-05-15 2023-12-12 索尼公司 照明单元和显示设备
US12240815B2 (en) * 2020-02-24 2025-03-04 Northwestern University Potent and selective human neuronal nitric oxide synthase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504252A1 (de) * 1974-02-18 1975-08-21 Haessle Ab Heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
EP0125756A2 (en) * 1983-03-22 1984-11-21 Fujisawa Pharmaceutical Co., Ltd. Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them
WO2000049015A1 (en) * 1999-02-17 2000-08-24 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds and their pharmaceutical use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
SE512835C2 (sv) * 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
NZ535959A (en) 2002-03-27 2006-05-26 Altana Pharma Ag Novel alkoxypyridine-derivatives as selective inhibitors of inducible nitric oxidase synthase NOS
EA200600607A1 (ru) 2003-10-01 2006-10-27 Алтана Фарма Аг Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
AU2004276013A1 (en) 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inducible no-synthase inhibitors
BRPI0414972A (pt) 2003-10-01 2006-11-07 Altana Pharma Ag derivados de imidazopiridinas como inibidores de no-sintase induzìvel
DE602004014523D1 (de) 2003-10-01 2008-07-31 Nycomed Gmbh Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504252A1 (de) * 1974-02-18 1975-08-21 Haessle Ab Heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
EP0125756A2 (en) * 1983-03-22 1984-11-21 Fujisawa Pharmaceutical Co., Ltd. Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them
WO2000049015A1 (en) * 1999-02-17 2000-08-24 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds and their pharmaceutical use

Also Published As

Publication number Publication date
US20080176894A1 (en) 2008-07-24
CA2540230A1 (en) 2005-07-07
CN1856493A (zh) 2006-11-01
AU2004303515A1 (en) 2005-07-07
IL173628A0 (en) 2006-07-05
KR20060092219A (ko) 2006-08-22
WO2005061496A1 (en) 2005-07-07
JP2007507464A (ja) 2007-03-29
HK1096968A1 (zh) 2007-06-15
BRPI0415034A (pt) 2006-12-12
US7781453B2 (en) 2010-08-24
EP1670798A1 (en) 2006-06-21
NZ546394A (en) 2009-08-28
EA200600601A1 (ru) 2006-10-27
NO20061789L (no) 2006-04-24
US20070043072A1 (en) 2007-02-22
MXPA06003345A (es) 2006-06-08
RS20060206A (sr) 2008-08-07
ZA200601140B (en) 2007-05-30
US7317021B2 (en) 2008-01-08
US20100280002A1 (en) 2010-11-04
WO2005061496A8 (en) 2006-02-16

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