CN100413883C - 选择性地与p-选择蛋白结合的肽化合物 - Google Patents

选择性地与p-选择蛋白结合的肽化合物 Download PDF

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Publication number
CN100413883C
CN100413883C CNB028171934A CN02817193A CN100413883C CN 100413883 C CN100413883 C CN 100413883C CN B028171934 A CNB028171934 A CN B028171934A CN 02817193 A CN02817193 A CN 02817193A CN 100413883 C CN100413883 C CN 100413883C
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CN
China
Prior art keywords
compound
selectin
amino acid
compounds
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028171934A
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English (en)
Chinese (zh)
Other versions
CN1549824A (zh
Inventor
T·J·M·莫勒纳尔
J·柯伊伯
T·J·C·范贝克尔
E·A·L·比森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Europe BV
Original Assignee
Yamanouchi Europe BV
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Publication date
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Publication of CN1549824A publication Critical patent/CN1549824A/zh
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Publication of CN100413883C publication Critical patent/CN100413883C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028171934A 2001-09-03 2002-08-28 选择性地与p-选择蛋白结合的肽化合物 Expired - Fee Related CN100413883C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203314A EP1288222A1 (en) 2001-09-03 2001-09-03 Peptidic compounds selectively binding to P-selectin
EP01203314.8 2001-09-03

Publications (2)

Publication Number Publication Date
CN1549824A CN1549824A (zh) 2004-11-24
CN100413883C true CN100413883C (zh) 2008-08-27

Family

ID=8180873

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028171934A Expired - Fee Related CN100413883C (zh) 2001-09-03 2002-08-28 选择性地与p-选择蛋白结合的肽化合物

Country Status (16)

Country Link
US (1) US7531516B2 (enExample)
EP (2) EP1288222A1 (enExample)
JP (1) JP4227520B2 (enExample)
CN (1) CN100413883C (enExample)
AT (1) ATE446311T1 (enExample)
BR (1) BR0212219A (enExample)
CA (1) CA2459230C (enExample)
DE (1) DE60234108D1 (enExample)
ES (1) ES2337663T3 (enExample)
HR (1) HRP20040127A2 (enExample)
HU (1) HUP0401728A2 (enExample)
MX (1) MXPA04002055A (enExample)
NO (1) NO20040905L (enExample)
PL (1) PL369030A1 (enExample)
WO (1) WO2003020753A1 (enExample)
ZA (1) ZA200400956B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60318585T2 (de) * 2002-08-09 2009-01-08 Astellas Pharma Europe B.V. Verbindungen die p-selectin binden
ES2334220T3 (es) 2002-10-11 2010-03-08 Astellas Pharma Europe B.V. Compuestos basados en glucosa con afinidad por la p-selectiva.
EP1481683A1 (en) * 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. P-selectin targeting ligand and compositions thereof
US9107963B2 (en) * 2012-04-13 2015-08-18 Case Western Reserve University Heteromultivalent nanoparticle compositions
US9833518B2 (en) 2012-04-13 2017-12-05 Case Western Reserve University Heteromultivalent particle compositions
US10279347B2 (en) * 2014-04-08 2019-05-07 Dna Medicine Institute, Inc. Fluidics module
US11879012B2 (en) 2018-03-02 2024-01-23 Peter GILLIES Method of modulating cell proliferation
CN111671905B (zh) * 2020-06-23 2022-05-27 中国医学科学院医学实验动物研究所 P-选择蛋白糖蛋白配体-1作为靶点在制备预防和/或治疗动脉瘤的药物中的应用
WO2022223969A1 (en) * 2021-04-20 2022-10-27 Bicycletx Limited Bicyclic peptide ligands specific for p-selectin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031210A1 (en) * 1994-05-11 1995-11-23 Affymax Technologies Nv Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (elam-1)
WO2000034303A1 (en) * 1998-12-10 2000-06-15 Isis Pharmaceuticals, Inc. METHODS OF MODULATING TUMOR NECROSIS FACTOR α-INDUCED EXPRESSION OF CELL ADHESION MOLECULES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005269A1 (en) * 1992-09-08 1994-03-17 Centocor, Inc. Peptide inhibitors of selectin binding
WO1994014836A1 (en) * 1992-12-18 1994-07-07 Centocor, Inc. Peptide inhibitors of selectin binding
JPH10502349A (ja) * 1994-06-29 1998-03-03 テキサス・バイオテクノロジー・コーポレイシヨン インテグリンα▲下４▼β▲下１▼のＶＣＡＭ−１またはフィブロネクチンへの結合を阻害する方法
US5663144A (en) * 1995-05-03 1997-09-02 The Trustees Of The University Of Pennsylvania Compounds that bind to p185 and methods of using the same
US20020152495A1 (en) * 1999-01-15 2002-10-17 Toshiro Ito Plants having seedless fruit

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031210A1 (en) * 1994-05-11 1995-11-23 Affymax Technologies Nv Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (elam-1)
WO2000034303A1 (en) * 1998-12-10 2000-06-15 Isis Pharmaceuticals, Inc. METHODS OF MODULATING TUMOR NECROSIS FACTOR α-INDUCED EXPRESSION OF CELL ADHESION MOLECULES

Also Published As

Publication number Publication date
JP2005501544A (ja) 2005-01-20
CA2459230C (en) 2011-11-08
HRP20040127A2 (en) 2004-06-30
CN1549824A (zh) 2004-11-24
US20050004035A1 (en) 2005-01-06
HUP0401728A2 (hu) 2004-11-29
EP1423413A1 (en) 2004-06-02
ES2337663T3 (es) 2010-04-28
MXPA04002055A (es) 2004-07-08
ATE446311T1 (de) 2009-11-15
ZA200400956B (en) 2005-04-18
EP1288222A1 (en) 2003-03-05
EP1423413B1 (en) 2009-10-21
NO20040905L (no) 2004-05-26
JP4227520B2 (ja) 2009-02-18
BR0212219A (pt) 2004-09-21
DE60234108D1 (en) 2009-12-03
CA2459230A1 (en) 2003-03-13
PL369030A1 (en) 2005-04-18
US7531516B2 (en) 2009-05-12
WO2003020753A1 (en) 2003-03-13

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SE01 Entry into force of request for substantive examination
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080827

Termination date: 20130828