ATE446311T1 - Selektiv p-selectin bindende peptidische verbindungen - Google Patents
Selektiv p-selectin bindende peptidische verbindungenInfo
- Publication number
- ATE446311T1 ATE446311T1 AT02758940T AT02758940T ATE446311T1 AT E446311 T1 ATE446311 T1 AT E446311T1 AT 02758940 T AT02758940 T AT 02758940T AT 02758940 T AT02758940 T AT 02758940T AT E446311 T1 ATE446311 T1 AT E446311T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- selectin
- selective
- binding
- peptidic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101000622137 Homo sapiens P-selectin Proteins 0.000 abstract 1
- 108010035766 P-Selectin Proteins 0.000 abstract 1
- 102000008212 P-Selectin Human genes 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000001476 gene delivery Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203314A EP1288222A1 (en) | 2001-09-03 | 2001-09-03 | Peptidic compounds selectively binding to P-selectin |
| PCT/NL2002/000566 WO2003020753A1 (en) | 2001-09-03 | 2002-08-28 | Peptidic compounds selectively binding to p-selectin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446311T1 true ATE446311T1 (de) | 2009-11-15 |
Family
ID=8180873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02758940T ATE446311T1 (de) | 2001-09-03 | 2002-08-28 | Selektiv p-selectin bindende peptidische verbindungen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7531516B2 (enExample) |
| EP (2) | EP1288222A1 (enExample) |
| JP (1) | JP4227520B2 (enExample) |
| CN (1) | CN100413883C (enExample) |
| AT (1) | ATE446311T1 (enExample) |
| BR (1) | BR0212219A (enExample) |
| CA (1) | CA2459230C (enExample) |
| DE (1) | DE60234108D1 (enExample) |
| ES (1) | ES2337663T3 (enExample) |
| HR (1) | HRP20040127A2 (enExample) |
| HU (1) | HUP0401728A2 (enExample) |
| MX (1) | MXPA04002055A (enExample) |
| NO (1) | NO20040905L (enExample) |
| PL (1) | PL369030A1 (enExample) |
| WO (1) | WO2003020753A1 (enExample) |
| ZA (1) | ZA200400956B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60318585T2 (de) * | 2002-08-09 | 2009-01-08 | Astellas Pharma Europe B.V. | Verbindungen die p-selectin binden |
| ES2334220T3 (es) | 2002-10-11 | 2010-03-08 | Astellas Pharma Europe B.V. | Compuestos basados en glucosa con afinidad por la p-selectiva. |
| EP1481683A1 (en) * | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | P-selectin targeting ligand and compositions thereof |
| US9107963B2 (en) * | 2012-04-13 | 2015-08-18 | Case Western Reserve University | Heteromultivalent nanoparticle compositions |
| US9833518B2 (en) | 2012-04-13 | 2017-12-05 | Case Western Reserve University | Heteromultivalent particle compositions |
| US10279347B2 (en) * | 2014-04-08 | 2019-05-07 | Dna Medicine Institute, Inc. | Fluidics module |
| US11879012B2 (en) | 2018-03-02 | 2024-01-23 | Peter GILLIES | Method of modulating cell proliferation |
| CN111671905B (zh) * | 2020-06-23 | 2022-05-27 | 中国医学科学院医学实验动物研究所 | P-选择蛋白糖蛋白配体-1作为靶点在制备预防和/或治疗动脉瘤的药物中的应用 |
| WO2022223969A1 (en) * | 2021-04-20 | 2022-10-27 | Bicycletx Limited | Bicyclic peptide ligands specific for p-selectin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
| WO1994005269A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| WO1994014836A1 (en) * | 1992-12-18 | 1994-07-07 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| JPH10502349A (ja) * | 1994-06-29 | 1998-03-03 | テキサス・バイオテクノロジー・コーポレイシヨン | インテグリンα▲下４▼β▲下１▼のＶＣＡＭ−１またはフィブロネクチンへの結合を阻害する方法 |
| US5663144A (en) * | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
| US6114517A (en) * | 1998-12-10 | 2000-09-05 | Isis Pharmaceuticals Inc. | Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules |
| US20020152495A1 (en) * | 1999-01-15 | 2002-10-17 | Toshiro Ito | Plants having seedless fruit |
-
2001
- 2001-09-03 EP EP01203314A patent/EP1288222A1/en not_active Withdrawn
-
2002
- 2002-08-28 AT AT02758940T patent/ATE446311T1/de not_active IP Right Cessation
- 2002-08-28 US US10/488,509 patent/US7531516B2/en not_active Expired - Fee Related
- 2002-08-28 HR HR20040127A patent/HRP20040127A2/hr not_active Application Discontinuation
- 2002-08-28 CN CNB028171934A patent/CN100413883C/zh not_active Expired - Fee Related
- 2002-08-28 WO PCT/NL2002/000566 patent/WO2003020753A1/en not_active Ceased
- 2002-08-28 ES ES02758940T patent/ES2337663T3/es not_active Expired - Lifetime
- 2002-08-28 DE DE60234108T patent/DE60234108D1/de not_active Expired - Lifetime
- 2002-08-28 MX MXPA04002055A patent/MXPA04002055A/es not_active Application Discontinuation
- 2002-08-28 EP EP02758940A patent/EP1423413B1/en not_active Expired - Lifetime
- 2002-08-28 BR BR0212219-7A patent/BR0212219A/pt not_active IP Right Cessation
- 2002-08-28 PL PL02369030A patent/PL369030A1/xx not_active Application Discontinuation
- 2002-08-28 CA CA2459230A patent/CA2459230C/en not_active Expired - Fee Related
- 2002-08-28 HU HU0401728A patent/HUP0401728A2/hu unknown
- 2002-08-28 JP JP2003525023A patent/JP4227520B2/ja not_active Expired - Fee Related
-
2004
- 2004-02-05 ZA ZA200400956A patent/ZA200400956B/en unknown
- 2004-03-02 NO NO20040905A patent/NO20040905L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005501544A (ja) | 2005-01-20 |
| CA2459230C (en) | 2011-11-08 |
| HRP20040127A2 (en) | 2004-06-30 |
| CN1549824A (zh) | 2004-11-24 |
| US20050004035A1 (en) | 2005-01-06 |
| HUP0401728A2 (hu) | 2004-11-29 |
| CN100413883C (zh) | 2008-08-27 |
| EP1423413A1 (en) | 2004-06-02 |
| ES2337663T3 (es) | 2010-04-28 |
| MXPA04002055A (es) | 2004-07-08 |
| ZA200400956B (en) | 2005-04-18 |
| EP1288222A1 (en) | 2003-03-05 |
| EP1423413B1 (en) | 2009-10-21 |
| NO20040905L (no) | 2004-05-26 |
| JP4227520B2 (ja) | 2009-02-18 |
| BR0212219A (pt) | 2004-09-21 |
| DE60234108D1 (en) | 2009-12-03 |
| CA2459230A1 (en) | 2003-03-13 |
| PL369030A1 (en) | 2005-04-18 |
| US7531516B2 (en) | 2009-05-12 |
| WO2003020753A1 (en) | 2003-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |